Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome
ConclusionOur study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients. Finally, our study reveals that LC disproportionally affects females more than males, as evidenced by nearly 70% of our LC patients being female. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 18, 2024 Category: Allergy & Immunology Source Type: research
Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces chronic pain in a rat model of myalgic encephalomyelitis... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2024 Category: Neurology Authors: Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi and Hiroshi Kiyama Tags: Research Source Type: research
Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis
ConclusionThe results indicate that CBT for CFS is effective in reducing fatigue, fatigue related impairment, and severity of depression and anxiety. Conclusions on efficacy at follow-ups are still limited. However, adherence is high in CBT. The results may help to inform clinical practice. Future research should focus on examining the maintenance of effects, while also emphasizing the importance of treatment acceptance. (Source: International Journal of Behavioral Medicine)
Source: International Journal of Behavioral Medicine - January 16, 2024 Category: Psychiatry Source Type: research
Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy
CONCLUSIONS: These results provide insight into the dissociable neural mechanisms underlying fatigue and pain symptoms in ME/CFS and how they are affected by CBT in successfully treated patients. Further investigation of how and in whom behavioral and biomedical treatments affect these networks is warranted to improve and individualize existing or new treatments for ME/CFS.PMID:38193344 | DOI:10.1017/S0033291723003690 (Source: Psychological Medicine)
Source: Psychological Medicine - January 9, 2024 Category: Psychiatry Authors: Marieke E van der Schaaf Linda Geerligs Ivan Toni Hans Knoop Joukje M Oosterman Source Type: research
Efficacy of dual-task augmented reality rehabilitation in non-hospitalized adults with self-reported long COVID fatigue and cognitive impairment: a pilot study
ConclusionThe preliminary results from this study suggest that dual-task rehabilitation could be a feasible protocol to support cognitive symptoms recovery after COVID-19 and could be helpful in those individuals suffering from persisting and invalidating symptoms. (Source: Neurological Sciences)
Source: Neurological Sciences - January 9, 2024 Category: Neurology Source Type: research
In vitro B cell experiments explore the role of CD24, CD38, and energy metabolism in ME/CFS
DiscussionThe immunophenotype results suggested the triggering of a stress response in ME/CFS B cells associated with the increased usage of additional substrates to maintain necessary ATP levels. Disturbances in energy metabolism in ME/CFS B cells were thus confirmed in a dynamic in vitro model, providing the basis for further mechanistic investigations. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 8, 2024 Category: Allergy & Immunology Source Type: research
Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 8, 2024 Category: Research Authors: Jin-Seok Lee, Ji-Yun Kang, Samuel-Young Park, Seung-Ju Hwang, Sung-Jin Bae and Chang-Gue Son Tags: Research Source Type: research
Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls
BMC Res Notes. 2024 Jan 4;17(1):17. doi: 10.1186/s13104-023-06616-4.ABSTRACTOBJECTIVE: Myalgic Encephalomyelitis (ME; sometimes referred to as Chronic Fatigue Syndrome) is a chronic disease without laboratory test, detailed aetiological understanding or effective therapy. Its symptoms are diverse, but it is distinguished from other fatiguing illnesses by the experience of post-exertional malaise, the worsening of symptoms even after minor physical or mental exertion. Its frequent onset after infection suggests autoimmune involvement or that it arises from abnormal T-cell activation.RESULTS: To test this hypothesis, we sequ...
Source: Cell Research - January 4, 2024 Category: Cytology Authors: Joshua J Dibble Ben Ferneyhough Matthew Roddis Sam Millington Michael D Fischer Nick J Parkinson Chris P Ponting Source Type: research
Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls
Myalgic Encephalomyelitis (ME; sometimes referred to as Chronic Fatigue Syndrome) is a chronic disease without laboratory test, detailed aetiological understanding or effective therapy. Its symptoms are divers... (Source: BMC Research Notes)
Source: BMC Research Notes - January 4, 2024 Category: Research Authors: Joshua J Dibble, Ben Ferneyhough, Matthew Roddis, Sam Millington, Michael D Fischer, Nick J Parkinson and Chris P Ponting Tags: Research Note Source Type: research
The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome
Mol Med. 2024 Jan 3;30(1):1. doi: 10.1186/s10020-023-00766-8.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsible for contributing to the formation of mucosal membranes throughout the body. These mucosal pathways contribute to the body's defense mechanisms involving pathogenic onset. When compromised by pathogens the epithelium releases numerous cytokines and enters a ...
Source: Molecular Medicine - January 3, 2024 Category: Molecular Biology Authors: Kaylin Huitsing Tara Tritsch Francisco Javier Carrera Arias Fanny Collado Kristina K Aenlle Lubov Nathason Mary Ann Fletcher Nancy G Klimas Travis J A Craddock Source Type: research
Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 3. doi: 10.1007/s00406-023-01734-3. Online ahead of print.ABSTRACTPost-acute sequelae of COVID-19 can present as multi-organ pathology, with neuropsychiatric symptoms being the most common symptom complex, characterizing long COVID as a syndrome with a significant disease burden for affected individuals. Several typical symptoms of long COVID, such as fatigue, depressive symptoms and cognitive impairment, are also key features of other psychiatric disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and major depressive disorder (MDD). However, clinically...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 3, 2024 Category: Psychiatry Authors: Dario Lucas Helbing Eva-Maria Dommaschk Lena Vera Danyeli Edgars Liepinsh Alexander Refisch Z ümrüt Duygu Sen Liga Zvejniece Tonia Rockt äschel Leonie Karoline Stabenow Helgi B Schi öth Martin Walter Maija Dambrova Bianca Besteher Source Type: research
Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review
AbstractPost-acute sequelae of COVID-19 can present as multi-organ pathology, with neuropsychiatric symptoms being the most common symptom complex, characterizing long COVID as a syndrome with a significant disease burden for affected individuals. Several typical symptoms of long COVID, such as fatigue, depressive symptoms and cognitive impairment, are also key features of other psychiatric disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and major depressive disorder (MDD). However, clinically successful treatment strategies are still lacking and are often inspired by treatment options for dis...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 3, 2024 Category: Neuroscience Source Type: research
