Estimates of Incidence and Predictors of Fatiguing Illness after SARS-CoV-2 Infection
This study aimed to estimate the incidence rates of post-COVID-19 fatigue and chronic fatigue and to quantify the additional incident fatigue caused by COVID-19. We analyzed electronic health records data of 4,589 patients with confirmed COVID-19 during February 2020-February 2021 who were followed for a median of 11.4 (interquartile range 7.8-15.5) months and compared them to data from 9,022 propensity score-matched non-COVID-19 controls. Among COVID-19 patients (15% hospitalized for acute COVID-19), the incidence rate of fatigue was 10.2/100 person-years and the rate of chronic fatigue was 1.8/100 person-years. Compared ...
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Quan M Vu Annette L Fitzpatrick Jennifer R Cope Jeanne Bertolli Nona Sotoodehnia T Eoin West Nikki Gentile Elizabeth R Unger Source Type: research
Estimates of Incidence and Predictors of Fatiguing Illness after SARS-CoV-2 Infection
This study aimed to estimate the incidence rates of post-COVID-19 fatigue and chronic fatigue and to quantify the additional incident fatigue caused by COVID-19. We analyzed electronic health records data of 4,589 patients with confirmed COVID-19 during February 2020-February 2021 who were followed for a median of 11.4 (interquartile range 7.8-15.5) months and compared them to data from 9,022 propensity score-matched non-COVID-19 controls. Among COVID-19 patients (15% hospitalized for acute COVID-19), the incidence rate of fatigue was 10.2/100 person-years and the rate of chronic fatigue was 1.8/100 person-years. Compared ...
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Quan M Vu Annette L Fitzpatrick Jennifer R Cope Jeanne Bertolli Nona Sotoodehnia T Eoin West Nikki Gentile Elizabeth R Unger Source Type: research
The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review
CONCLUSION: The findings highlight a paucity of higher-level studies documenting exercise for POTS management in people with joint hypermobility and related conditions. Results from the wider POTS population demonstrate exercise is safe and effective. Large, well-designed clinical studies exploring exercise for POTS management adapting to meet the complex musculoskeletal and non-musculoskeletal features of symptomatic joint hypermobility are needed.PMID:38401460 | DOI:10.1016/j.autneu.2024.103156 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - February 24, 2024 Category: Neuroscience Authors: Karen C Peebles Charl Jacobs Logan Makaroff Verity Pacey Source Type: research
The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review
CONCLUSION: The findings highlight a paucity of higher-level studies documenting exercise for POTS management in people with joint hypermobility and related conditions. Results from the wider POTS population demonstrate exercise is safe and effective. Large, well-designed clinical studies exploring exercise for POTS management adapting to meet the complex musculoskeletal and non-musculoskeletal features of symptomatic joint hypermobility are needed.PMID:38401460 | DOI:10.1016/j.autneu.2024.103156 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - February 24, 2024 Category: Neuroscience Authors: Karen C Peebles Charl Jacobs Logan Makaroff Verity Pacey Source Type: research
The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review
CONCLUSION: The findings highlight a paucity of higher-level studies documenting exercise for POTS management in people with joint hypermobility and related conditions. Results from the wider POTS population demonstrate exercise is safe and effective. Large, well-designed clinical studies exploring exercise for POTS management adapting to meet the complex musculoskeletal and non-musculoskeletal features of symptomatic joint hypermobility are needed.PMID:38401460 | DOI:10.1016/j.autneu.2024.103156 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - February 24, 2024 Category: Neuroscience Authors: Karen C Peebles Charl Jacobs Logan Makaroff Verity Pacey Source Type: research
The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review
CONCLUSION: The findings highlight a paucity of higher-level studies documenting exercise for POTS management in people with joint hypermobility and related conditions. Results from the wider POTS population demonstrate exercise is safe and effective. Large, well-designed clinical studies exploring exercise for POTS management adapting to meet the complex musculoskeletal and non-musculoskeletal features of symptomatic joint hypermobility are needed.PMID:38401460 | DOI:10.1016/j.autneu.2024.103156 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - February 24, 2024 Category: Neuroscience Authors: Karen C Peebles Charl Jacobs Logan Makaroff Verity Pacey Source Type: research
The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review
CONCLUSION: The findings highlight a paucity of higher-level studies documenting exercise for POTS management in people with joint hypermobility and related conditions. Results from the wider POTS population demonstrate exercise is safe and effective. Large, well-designed clinical studies exploring exercise for POTS management adapting to meet the complex musculoskeletal and non-musculoskeletal features of symptomatic joint hypermobility are needed.PMID:38401460 | DOI:10.1016/j.autneu.2024.103156 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - February 24, 2024 Category: Neuroscience Authors: Karen C Peebles Charl Jacobs Logan Makaroff Verity Pacey Source Type: research
People with Long Covid and ME/CFS Exhibit Similarly Impaired Dexterity and Bimanual Coordination: A Case-Case-Control Study
Dexterity and bimanual coordination had not previously been compared between people with long COVID and people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Therefore, this study determined dexterity and bimanual coordination in people with long COVID ( ∼16 month illness duration; n=21) and ME/CFS (∼16 year illness duration; n=20), versus age-matched healthy controls (n=20). (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 23, 2024 Category: General Medicine Authors: Nilihan E.M. Sanal-Hayes, Lawrence D. Hayes, Marie Mclaughlin, Ethan C.J. Berry, Nicholas F. Sculthorpe Source Type: research
Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid
This study suggests that VNS may play a role in regulating neuroinflammation and somatosensory and cognitive functions in poly(I:C)-injected animals. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - February 22, 2024 Category: Neurology Source Type: research
Sweeping chronic fatigue study brings clues but not clarity to mysterious syndrome
The deepest dive yet into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) offers a complex view of this mysterious condition. ME/CFS produces crushing exhaustion, particularly after even mild exertion. Many patients struggle to find care, or doctors who believe their symptoms aren’t imagined.
The new work, published this week in
Nature Communications
, affirms that ME/CFS is
unquestionably biologically rooted
, says Avindra Nath, clinical director of the U.S. National Institute of Neurological Disorders and Stroke, who led the study. It revealed brain activity differences, along with...
Source: Science of Aging Knowledge Environment - February 21, 2024 Category: Geriatrics Source Type: research
The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review
Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia. It may occur in isolation, but frequently co-exists in individuals with hypermobile variants of Ehlers-Danlos Syndrome (EDS) and related conditions (chronic fatigue syndrome [CFS] and fibromyalgia). Exercise is recommended for non-pharmacological POTS management but needs to be individualised. This scoping review explores the current literature on use and effectiveness of exercise-based management for POTS, with specific focus on individuals with joint hypermobility and related conditions who experience hypermobility, and/or pain, and/or fatigue. (...
Source: Autonomic Neuroscience: Basic and Clinical - February 12, 2024 Category: Neuroscience Authors: Karen C. Peebles, Charl Jacobs, Logan Makaroff, Verity Pacey Tags: Review Article Source Type: research
Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?
Dysautonomia, or dysfunction of the autonomic nervous system (ANS), may occur following an infectious insult and can result in a variety of debilitating, widespread, and often poorly recognized symptoms. Dysautonomia is now widely accepted as a complication of COVID-19 and is an important component of Post-Acute Sequelae of COVID-19 (PASC or long COVID). PASC shares many overlapping clinical features with other infection-associated chronic illnesses including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Treatment Lyme Disease Syndrome (PTLDS), suggesting that they may share common underlying mechani...
Source: Frontiers in Neurology - February 8, 2024 Category: Neurology Source Type: research
U.S. Census Bureau scraps proposed changes to disability questions
Related article
How many in the U.S. are disabled? Proposed census changes would greatly decrease count
BY
Phie Jacobs
The U.S. Census Bureau will not be changing the way it asks about disability on one of its nationwide surveys, the agency
announced yesterday
, after critics of a proposed revision said it would greatly underestimate the official number of people in the United States who are considered disabled.
Bonnielin Swenor, director of Johns Hopkins University’s Disabili...
Source: Science of Aging Knowledge Environment - February 7, 2024 Category: Geriatrics Source Type: research
Is reduced heart rate variability associated with functional somatic disorders? A cross-sectional population-based study; DanFunD
Conclusion
The study supports a sympathetic predominance in persons with FSD, which could not be entirely explained by chronic stress. However, it is not possible to conclude whether the association is a causal factor to or a consequence of FSD. (Source: BMJ Open)
Source: BMJ Open - February 7, 2024 Category: General Medicine Authors: Jorgensen, T., Dantoft, T. M., Petersen, M. W., Gormsen, L., Winter-Jensen, M., Fink, P., Linneberg, A., Benros, M. E., Eplov, L. F., Bjerregaard, A. A., Schovsbo, S. U., Brinth, L. S. Tags: Open access, Epidemiology Source Type: research
Clinical and Laboratory Characteristics of Fatigue-dominant Long-COVID subjects: A Cross-Sectional Study
Long-COVID is defined by persistent symptoms following COVID-19 infection. Approximately 71% of individuals with long-COVID experience ongoing fatigue, post-exertional malaise, and cognitive impairments, which share pathological similarities with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This similarity has prompted studies to explore the characteristics of long-COVID to gain a better understanding of ME/CFS. To gain insights, we investigated the clinical and laboratory characteristics of individuals with fatigue-dominant long-COVID. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 6, 2024 Category: General Medicine Authors: Jin-Seok Lee, Yujin Choi, Jin-Yong Joung, Chang-Gue Son Tags: Clinical Research Study Source Type: research
