Intra brainstem connectivity is impaired in chronic fatigue syndrome
Publication date: Available online 19 October 2019Source: NeuroImage: ClinicalAuthor(s): Leighton R Barnden, Zack Y Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep BhutaAbstractIn myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), abnormal MRI correlations with symptom severity and autonomic measures have suggested impaired nerve signal conduction within the brainstem. Here we analyse fMRI correlations to directly test connectivity within and from the brainstem. Resting and task functional MRI (fMRI) were acquired for 45 ME/CFS (Fukuda criteria) and 27 healthy controls...
Source: NeuroImage: Clinical - October 19, 2019 Category: Radiology Source Type: research

Is a diagnostic blood test for chronic fatigue syndrome on the horizon?
Authors: Maes M, Rodriguez LA, Morris G PMID: 31617771 [PubMed - as supplied by publisher] (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 17, 2019 Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research

Chapter Five - Qigong exercise for chronic fatigue syndrome
Publication date: 2019Source: International Review of Neurobiology, Volume 147Author(s): Jessie S.M. Chan, Siu-Man Ng, Lai-Ping Yuen, Cecilia L.W. ChanAbstractChronic fatigue syndrome (CFS) is often overlooked, has unclear etiology and no effective cure except some symptomatic treatments. Additionally, most people with CFS do not seek medical attention. Qigong exercise, an ancient Eastern body-mind-spirit practice, has been long practiced in Chinese communities and may powerfully trigger the self-healing process. Using full baseline data (n = 1409), the average Hong Kong CFS respondent was found to be female, mar...
Source: International Review of Neurobiology - October 12, 2019 Category: Neuroscience Source Type: research

Chronic Lyme disease may be a misdiagnosis of chronic fatigue syndrome
People who think they have a long-lasting form of Lyme disease are taking antibiotics for many months and may be treating the wrong disease (Source: New Scientist - Health)
Source: New Scientist - Health - October 9, 2019 Category: Consumer Health News Source Type: research

Exercise therapy for chronic fatigue syndrome.
CONCLUSIONS: Exercise therapy probably has a positive effect on fatigue in adults with CFS compared to usual care or passive therapies. The evidence regarding adverse effects is uncertain. Due to limited evidence it is difficult to draw conclusions about the comparative effectiveness of CBT, adaptive pacing or other interventions. All studies were conducted with outpatients diagnosed with 1994 criteria of the Centers for Disease Control and Prevention or the Oxford criteria, or both. Patients diagnosed using other criteria may experience different effects. PMID: 31577366 [PubMed - as supplied by publisher] (Source: Co...
Source: Cochrane Database of Systematic Reviews - October 2, 2019 Category: General Medicine Authors: Larun L, Brurberg KG, Odgaard-Jensen J, Price JR Tags: Cochrane Database Syst Rev Source Type: research

How demands and resources impact chronic fatigue in the maritime industry. The mediating effect of acute fatigue, sleep quality and recovery
Publication date: January 2020Source: Safety Science, Volume 121Author(s): Daniela M. Andrei, Mark A. Griffin, Michelle Grech, Andrew NealAbstractThe aim of the present study was to examine how different work demands and resources characteristic to the maritime industry are related to chronic fatigue in seafarers. Moreover, we investigated the role of different fatigue related processes, such as acute fatigue, sleep problems and inter-shift recovery in explaining the association between work characteristics and chronic fatigue. 199 seafarers working for the marine operations of a large global mining company participated in...
Source: Safety Science - September 27, 2019 Category: Occupational Health Source Type: research

Successful Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome with Chronic Febricula Using the Traditional Japanese Medicine Shosaikoto.
Authors: Numata T, Miura K, Akaishi T, Arita R, Ishizawa K, Saito N, Sasaki H, Kikuchi A, Takayama S, Tobita M, Ishii T Abstract We herein report the case of a 14-year-old girl who had been experiencing chronic fatigue, febricula, and social withdrawal for 20 months. No notable abnormalities were identified during routine checkups at a general pediatric hospital; symptomatic treatments did not affect her condition. She was diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Based on the concepts of Japanese traditional medicine, she was administered shosaikoto-based treatment. After several ...
Source: Internal Medicine - September 21, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders
Conclusions: Nasal drop vitamin B12 administration resulted in a significant increase in vitamin B12 serum levels and therefore may be effective. This pilot study suggest that the nasal drops may be used as an alternative to injections because two thirds of ME/CFS patients reported a positive effect, accompanied by an increased number of steps, improvement of the RAND-36 physical functioning scale and the CIS20r fatigue scale, and a significant increase in serum vitamin B12 levels. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 20, 2019 Category: Drugs & Pharmacology Source Type: research

Work-Related Predictors of Sleep Quality in Chinese Nurses: Testing a Path Analysis Model
Conclusions/Implications for Practice Sleep quality in Chinese nurses is influenced directly and indirectly by various modifiable work-related factors. Interventions such as adjusting work shifts and reducing job burdens should be prioritized by administrative staff to ensure the sleep quality and clinical performance of Chinese nurses and to subsequently improve nursing care quality. (Source: Journal of Nursing Research)
Source: Journal of Nursing Research - September 17, 2019 Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research

Chronic fatigue syndrome: identification of transcription factor (TFs) associated with gene expression for drug signature prediction
This study also found that small-molecules BRD-A94756469, S1205, Sotalol hydrochloride, methylandrostenediol and BRD-A94756469 can potentiall y reverse gene expression in CFS disease. (Source: Network Modeling Analysis in Health Informatics and Bioinformatics)
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - September 17, 2019 Category: Bioinformatics Source Type: research

Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - September 13, 2019 Category: Neuroscience Authors: De Gang Yang Rui Gu Jin Kubo Wataru Kakuda Source Type: research

The Efficacy and Safety of Myelophil, an Ethanol Extract Mixture of Astragali Radix and Salviae Radix, for Chronic Fatigue Syndrome: A Randomized Clinical Trial
Background: There is a strong demand for therapeutics to treat chronic fatigue syndrome (CFS), although there are limitations. Myelophil, which is a combination of extracts from Astragali Radix and Salviae Miltiorrhizae Radix, has been clinically used to treat fatigue-related disorders in South Korea. We conducted a randomized controlled clinical trial of Myelophil in patients with CFS and evaluated its efficacy and safety in two hospitals.Methods: We enrolled 98 participants (M: 38, F: 60) with CFS in a phase 2 trial of oral Myelophil (2 g daily) or placebo for 12 weeks. The primary end point was a change in the Chalder f...
Source: Frontiers in Pharmacology - September 10, 2019 Category: Drugs & Pharmacology Source Type: research

Psychometric properties of the PROMIS ® Fatigue Short Form 7a among adults with myalgic encephalomyelitis/chronic fatigue syndrome
AbstractPurposeTo evaluate the psychometric properties of the Patient-Reported Outcome Measurement Information System ® Fatigue Short Form 7a (PROMIS F-SF) among people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).MethodsAnalyses were conducted using data from the Multi-Site Clinical Assessment of ME/CFS study, which recruited participants from seven ME/CFS specialty clinics across the US. Baseline and follow-up data from ME/CFS participants and healthy controls were used. Ceiling/Floor effects, internal consistency reliability, differential item functioning (DIF), known-groups validity, and respons...
Source: Quality of Life Research - September 10, 2019 Category: Health Management Source Type: research

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: From Pathophysiological Insights to Novel Therapeutic Opportunities
Publication date: Available online 8 September 2019Source: Pharmacological ResearchAuthor(s): Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Catherine Mazza, Michael BerkAbstractMyalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a common and disabling condition with a paucity of effective and evidence-based therapies reflecting a major unmet need. Cognitive behavioural therapy and graded exercise are of modest benefit for only some ME/CFS patients, and many sufferers report aggravation of symptoms of fatigue with exercise. The presence of a multiplicity of patho...
Source: Pharmacological Research - September 9, 2019 Category: Drugs & Pharmacology Source Type: research

[Use of Modafinil in Co-existing Major Depression and ErectileDysfunction: A Case Report].
Abstract Erectile dysfunction is a sexual dysfunction which is commonlycomorbid with major depression. Antidepressant treatment does notalways improve comorbid sexual dysfunctions in major depression. Infact, sexual dysfunction may worsen or get complicated following theintroduction of antidepressants. Modafinil is a drug with stimulanteffect on the central nervous system by binding to norepinephrineand dopamine transporters and consequently increasing synapticnorepinephrine and dopamine levels. Modafinil is primarily used inthe treatment of narcolepsy and chronic fatigue syndrome. In addition,it is known for its ...
Source: Turkish Journal of Psychiatry - September 7, 2019 Category: Psychiatry Authors: Karaş H, Kaşer M Tags: Turk Psikiyatri Derg Source Type: research

Inflammatory proteins are altered in chronic fatigue syndrome—A systematic review and meta-analysis
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): Rebecca Strawbridge, Maria-Laura Sartor, Fraser Scott, Anthony J. CleareAbstractImmune dysfunction has been posited as a key element in the aetiology of chronic fatigue syndrome (CFS) since the illness was first conceived. However, systematic reviews have yet to quantitatively synthesise inflammatory biomarkers across the literature.We undertook a systematic review and meta-analysis to quantify available data on circulating inflammatory proteins, examining studies recruiting patients with a CFS diagnosis and a non-affected...
Source: Neuroscience and Biobehavioral Reviews - September 5, 2019 Category: Neuroscience Source Type: research

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society
ConclusionCertain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - September 2, 2019 Category: Research Source Type: research

Service based comparison of group cognitive behavior therapy to waiting list control for chronic fatigue syndrome with regard to symptom reduction and positive psychological dimensions
Background: Although chronic fatigue syndrome (CFS) sometimes referred to as myalgic encephalomyelitis (ME) is a very challenging condition to treat, there is evidence that individual cognitive behavioral therapy (ICBT) can be effective for treatment and management of its symptoms. Furthermore, group cognitive behavioral therapy (GCBT) is emerging as promising treatment for the condition. The aim of the present study was to explore further the effectiveness of GCBT in a routine clinical setting and to investigate associated positive psychological effects related to GCBT. Methods: In this pragmatic, non-randomized, co...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Modern-Day Relics of Psychiatry
Constantly shifting cultural views influence public perceptions of psychiatric diagnoses, sometimes accommodated by changes in diagnostic terminology. Evolving scientific knowledge of the era is at times used to justify and support mental illnesses. Too often, however, remasked nomenclatures fail to alter social stigma, in part because political arguments are used. Scientific validations of variant behaviors as symptoms with a pathologic status are unfortunately overshadowed. Examples of cultural bias effects on recurring diagnostic challenges illustrate a need for scientific validation. Renaming fails to improve stigma or...
Source: The Journal of Nervous and Mental Disease - August 30, 2019 Category: Psychiatry Tags: Original Article Source Type: research

Neurasthenia: Modern Malady or Historical Relic?
Neurasthenia was a popular diagnosis from 1869 through 1930. Despite being discarded, the core symptoms of neurasthenia can still be found throughout modern society. The present article reviews the symptoms, common course, proposed causes, and common treatments for neurasthenia. Similarities are seen in several familiar diagnoses, including depression, chronic fatigue syndrome, and fibromyalgia. Through reviewing the trends of neurasthenia, modern doctors may learn more about the subtleties of the diagnostic process, as well as the patient-physician relationship. The goal is to learn from the past as it relates to current ...
Source: The Journal of Nervous and Mental Disease - August 30, 2019 Category: Psychiatry Tags: Review Articles Source Type: research

Inflammatory proteins are altered in chronic fatigue syndrome – a systematic review and meta-analysis
Publication date: Available online 26 August 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rebecca Strawbridge, Maria-Laura Sartor, Fraser Scott, Anthony J. CleareAbstractImmune dysfunction has been posited as a key element in the aetiology of chronic fatigue syndrome (CFS) since the illness was first conceived. However, systematic reviews have yet to quantitatively synthesise inflammatory biomarkers across the literature.We undertook a systematic review and meta-analysis to quantify available data on circulating inflammatory proteins, examining studies recruiting patients with a CFS diagnosis and a non-af...
Source: Neuroscience and Biobehavioral Reviews - August 27, 2019 Category: Neuroscience Source Type: research

Retrospective Analysis of Risk Factors for Periodic Limb Movements in a Large Cohort of Insomnia and Chronic Fatigue Patients
Discussion This retrospective study adds supportive evidence to the association of drug classes with PLMS and PLMD. These findings may impact on clinical management of patients with a combined anxiety or mood disorder in need for these drug classes on the one hand and a significant sleep architecture disturbance through PLMS, potentially contributing to daytime symptoms, on the other hand. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 27, 2019 Category: Psychiatry Authors: Tobback, Els Desmet, Olivier Hanoulle, Ignace Delesie, Liesbeth Pevernagie, Dirk Vogelaers, Dirk Mariman, An Tags: Original Paper Source Type: research

A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)
Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ... (Source: BMC Neurology)
Source: BMC Neurology - August 24, 2019 Category: Neurology Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, H élène Cabanas and Sonya Marshall-Gradisnik Tags: Research article Source Type: research

Evidence for similarity in symptoms and mechanism: The extra ‐pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia
ConclusionsPatients with severe asthma have numerous extra ‐pulmonary symptoms similar in type and pattern to the symptoms of fibromyalgia. The similarity of the symptom pattern between asthma and fibromyalgia increases as the number of extra‐pulmonary symptoms increases as predicted by network theory and previously shown to be the case with other funct ional disorders. These findings support the hypothesis that functional disorders and extra‐pulmonary asthma symptoms have a common complexity or network aetiology. Evidence based behavioural interventions for fibromyalgia may be helpful for patients with severe a...
Source: Immunity, Inflammation and Disease - August 23, 2019 Category: Allergy & Immunology Authors: Michael E. Hyland, Joseph W. Lanario, Yinghui Wei, Rupert C. Jones, Matthew Masoli Tags: ORIGINAL RESEARCH Source Type: research

Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by myalgia and a sometimes severe limitation of physical activity and cognition. It is exacerbated by physical and mental activity. Its cause is unknown, but frequently starts with an infection. The eliciting infection (commonly infectious mononucleosis or an upper respiratory infection) can be more or less well diagnosed. Among the human herpesviruses (HHV-1-8), HHV-4 (Epstein-Barr virus; EBV), HHV-6 (including HHV-6A and HHV-6B) and HHV-7, have been implicated in the pathogenesis of ME/CFS. It was ther...
Source: Frontiers in Immunology - August 14, 2019 Category: Allergy & Immunology Source Type: research

Prevalence of functional somatic syndromes and bodily distress syndrome in the Danish population: the DanFunD study.
Conclusions: FSS and BDS are prevalent in the adult Danish population, and cases have high risk of poor self-perceived health, limitation in daily activities, and psychiatric comorbidity. These associations were particularly strong for cases with multiple FSS and multi-organ BDS. PMID: 31409218 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Public Health)
Source: Scandinavian Journal of Public Health - August 14, 2019 Category: International Medicine & Public Health Authors: Petersen MW, Schröder A, Jørgensen T, Ørnbøl E, Dantoft TM, Eliasen M, Carstensen TW, Falgaard Eplov L, Fink P Tags: Scand J Public Health Source Type: research

How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain.
Conclusion: Training and above all awareness raising strategies are needed to address health professionals' prejudices regarding the existence of contested illnesses such as Multiple Chemical Sensitivity. These prejudices hinder diagnosis and medical follow-up, and add negative emotions to the physical limitations already suffered by patients. IMPLICATIONS FOR REHABILITATION Multiple Chemical Sensitivity It is important to promote a compassionate and empathetic attitude among health providers, in order to avoid rejection and delegitimization of the experiences of women with Multiple Chemical Sensitivity. Multiple Chemical ...
Source: Disability and Rehabilitation - August 13, 2019 Category: Rehabilitation Authors: Briones-Vozmediano E, Espinar-Ruiz E Tags: Disabil Rehabil Source Type: research

Fatigue, Sleep, and Autoimmune and Related Disorders
Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cau...
Source: Frontiers in Immunology - August 6, 2019 Category: Allergy & Immunology Source Type: research

Factors associated with work status in chronic fatigue syndrome
ConclusionsMany patients with CFS were not working. This was exacerbated by high levels of depressive symptoms. Health professionals should assess co-morbid mental health conditions and consider treatment options when patients with CFS present themselves. The early involvement of occupational health practitioners is recommended to maximize the chances of maintaining employment. (Source: Occupational Medicine)
Source: Occupational Medicine - August 3, 2019 Category: Respiratory Medicine Source Type: research

Interpretation of B 12 Status After a Roux-en-Y Gastric Bypass
A 37-year-old woman with a history of depression and Roux-en-Y gastric bypass 16 years earlier presented with chronic fatigue, weight loss, irregular periods lasting 7 to 10 days, a vitamin B12 level of 149 pg/mL, and an iron level of 13 µg/dL. She reported a daily total calorie intake of less than 500 kcal and less than 20 g of protein. How do you interpret these results? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - July 26, 2019 Category: General Medicine Source Type: research

Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue
Publication date: Available online 16 July 2019Source: Social Science & MedicineAuthor(s): Sara F. Milrad, Daniel L. Hall, Devika R. Jutagir, Emily G. Lattie, Sara J. Czaja, Dolores M. Perdomo, Gail Ironson, Brian D. Doss, Armando Mendez, Mary Ann Fletcher, Nancy Klimas, Michael H. AntoniAbstractRationaleRelationship dissatisfaction has been linked with worse health outcomes in many patient populations, though the mechanism(s) underlying this effect are unclear. Among patients with chronic fatigue syndrome (CFS) and their partners, there is evidence for a bi-directional association between poorer relationship satisfact...
Source: Social Science and Medicine - July 16, 2019 Category: Psychiatry & Psychology Source Type: research

Child and adolescent chronic fatigue syndrome/myalgic encephalomyelitis: where are we now?
Purpose of review The current review aims to determine the recent evidence regarding cause, impact, effective treatment and prognosis of children and young people (CYP) affected by chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) at a time when the National Institute for Clinical Excellence guidelines in the United Kingdom are being reviewed and more research is called for worldwide. Recent findings CFS/ME is a debilitating illness with no clear cause. This review describes the heterogeneous clinical picture and the effects on the young person and family. Comorbidities such as mood disorders and pain are di...
Source: Current Opinion in Pediatrics - July 12, 2019 Category: Pediatrics Tags: ADOLESCENT MEDICINE: Edited by Sara F. Forman and Sarah Pitts Source Type: research

Biomarker Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome affects at least 2 million people in the United States. Despite its prevalence, there ’s no laboratory test for the disease, and its diagnosis is based on symptoms like exhaustion, unrefreshing sleep, and light sensitivity. For patients with this debilitating condition, getting a diagnosis is often a long and expensive process. Now, a long-awaited biomarker-based test for the myste rious disease could be on the horizon. (Source: JAMA)
Source: JAMA - July 9, 2019 Category: General Medicine Source Type: research

Conceptualizing the benefits of a group exercise program developed for those with chronic fatigue: a mixed methods clinical evaluation.
Conclusions: The concept maps have depicted key concepts relating to the successful delivery of a novel exercise program for people with fatigue and identified specific targets for future program enhancements. Implications for rehabilitation Orthostatic symptoms are common in those with fatigue and might be a target for group-based exercise programs. People with fatigue value a group-based exercise program that targets orthostatic symptoms. The key concepts of a group-based exercise program valued by those with fatigue are the exercises, group atmosphere, physical benefits, self-management support, acceptance, education an...
Source: Disability and Rehabilitation - July 9, 2019 Category: Rehabilitation Authors: Strassheim V, Deary V, Webster DA, Douglas J, Newton JL, Hackett KL Tags: Disabil Rehabil Source Type: research

Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome
This Viewpoint reviews new findings presented at a 2019 NIH conference about neuroendocrine, metabolic, immunologic, and physiologic abnormalities that contribute to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - July 5, 2019 Category: General Medicine Source Type: research

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue of at least 6 months, in addition to symptoms such as muscle pain and muscle weakness. There is no treatment provides long-term benefits to most patients. Recently, clinical research suggested the involvement of pyruvate dehydrogenase (PDH) in ME/CFS. PDH is a crucial enzyme in the mitochondria matrix that links glycolysis to the tricarboxylic acid cycle and oxidative phosphorylation. However, it is little known whether PDH could be a therapeutic target. The purpose of this study was to establish ME/CFS in mi...
Source: Biological and Pharmaceutical Bulletin - July 3, 2019 Category: Drugs & Pharmacology Authors: Ohba T, Domoto S, Tanaka M, Nakamura S, Shimazawa M, Hara H Tags: Biol Pharm Bull Source Type: research

Clinical observation of moving cupping on the back for patients with chronic fatigue syndrome-related sleep disorders
AbstractObjectiveTo observe the clinical efficacy of moving cupping on the back for patients with chronic fatigue syndrome (CFS)-related sleep disorders.MethodsA total of 60 patients with CFS-related sleep disorders were randomized into a control group and an observation group, with 30 cases in each group. The control group was treated with oral administration of fluoxetine hydrochloride capsule. The observation group was treated with moving cupping on the back, once every other day. The efficacy was observed after 4 weeks of treatment. The fatigue scale-14 (FS-14) and Pittsburgh sleep quality index (PSQI) were assessed be...
Source: Journal of Acupuncture and Tuina Science - July 1, 2019 Category: Complementary Medicine Source Type: research

Performance of the American College of Rheumatology 2016 criteria for fibromyalgia in a referral care setting
AbstractThe American College of Rheumatology (ACR) 2016 criteria for fibromyalgia (FM) is recommended for use in primary and referral setting. However, neither the ACR 2016 nor its predecessor ACR 2010 criteria have been validated in a referral setting. We hypothesized that the presence of higher comorbidities in the referral care setting may affect the performance of the ACR 2016. All patients referred to a tertiary care hospital with widespread pain for more than 3  months were screened using (1) the ACR 2016 criteria and (2) by a blinded expert physician (using ACR 1990 criteria). Using the ACR 1990 as reference st...
Source: Rheumatology International - June 28, 2019 Category: Rheumatology Source Type: research

The clinical value of cytokines in chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. Th... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 28, 2019 Category: Research Authors: Tiansong Yang, Yan Yang, Delong Wang, Chaoran Li, Yuanyuan Qu, Jing Guo, Tianyu Shi, Wang Bo, Zhongren Sun and Tetsuya Asakawa Tags: Review Source Type: research

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review.
Authors: Larrimore C, Ramnot A, Jaghab A, Sarduy S, Guerrero G, Troccoli P, Hilton K, Bested A Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating syndrome of unknown origin, characterized by profound postexertional malaise and fatigue, unrefreshing sleep, cognitive impairments, immune dysfunction, pain, autonomic dysfunction, and neuroendocrine symptoms. Although ME/CFS is well documented within the medical literature, it remains difficult to diagnosis and manage. Some of the current challenges include an absence of diagnostic markers, differing diagnostic criteria, and an overal...
Source: Journal of the American Osteopathic Association - June 25, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

Acupuncture for chronic fatigue syndrome: a systematic review and meta-analysis.
CONCLUSION: Our review indicated that acupuncture was more effective than sham acupuncture and other interventions (Chinese herbal medicine, mainly), but no firm conclusion could be reached owing to limited data, poor quality and potentially exaggerated effect size evaluation. Further large, rigorously designed and reported RCTs are required. PMID: 31204859 [PubMed - as supplied by publisher] (Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society)
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - June 17, 2019 Category: Complementary Medicine Authors: Zhang Q, Gong J, Dong H, Xu S, Wang W, Huang G Tags: Acupunct Med Source Type: research

Antidepressant-Like Activity of Myelophil via Attenuation of Microglial-Mediated Neuroinflammation in Mice Undergoing Unpredictable Chronic Mild Stress
Myelophil, a 30% ethanol extract that has an equal rate in both Astragali Radix and Salviae Radix, is a remedy for the treatment of fatigue-linked disorders in traditional Oriental medicine. The majority of patients with chronic fatigue have a risk of comorbidity with depression symptoms. To evaluate the anti-depressant activity of Myelophil, mice were subjected to unpredictable chronic mild stress (UCMS, eight different stresses) for 3 weeks with daily administration of distilled water, Myelophil (25, 50, or 100 mg/kg) or n-acetyl-l-cysteine (100 mg/kg). After the final stress exposure, three behavioral tests, including t...
Source: Frontiers in Pharmacology - June 13, 2019 Category: Drugs & Pharmacology Source Type: research

Correction: A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jiabao Xu, Michelle Potter, Cara Tomas, Joanna L. Elson, Karl J. Morten, Joanna Poulton, Ning Wang, Hanqing Jin, Zhaoxu Hou, Wei E. Huang To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 7, 2019 Category: Chemistry Authors: Jiabao Xu Source Type: research

Patients with fibromyalgia and chronic fatigue syndrome show increased hsCRP compared to healthy controls
Publication date: Available online 7 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Nina Groven, Egil A. Fors, Solveig Klæbo ReitanAbstractChronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) are both chronic disorders that have a devastating effect on the lives of the affected patients and their families. Both conditions have overlapping clinical features that partly resemble those of inflammatory disorders. The etiology is still not understood, and it is suggested that the immune system might be a contributing factor. So far, the results are inconclusive. The purpose of this study was to compare the two c...
Source: Brain, Behavior, and Immunity - June 7, 2019 Category: Neurology Source Type: research

[From neurasthenia to post-exertion disease: Evolution of the diagnostic criteria of chronic fatigue syndrome/myalgic encephalomyelitis].
te JV Abstract Changes in the terminology and diagnostic criteria for chronic fatigue syndrome/myalgic encephalomyelitis are explained in this paper. This syndrome is a complex and controversial entity of unknown origins. It appears in the medical literature in 1988, although clinical pictures of chronic idiopathic fatigue have been identified since the nineteenth century with different names, from neurasthenia, epidemic neuromyasthenia, and benign myalgic encephalomyelitis up to the current proposal of disease of intolerance to effort (post-effort). All of them allude to a chronic state of generalised fatigue of ...
Source: Atencion Primaria - June 7, 2019 Category: Primary Care Authors: Murga Í, Lafuente JV Tags: Aten Primaria Source Type: research

Musculoskeletal Pain in Individuals With Inflammatory Bowel Disease Reflects Three Distinct Profiles
Conclusions: Study results suggest multiple mechanisms contributing to pain experiences in IBD, to include central mechanisms. Features related to demographics, extraintestinal manifestations, IBD subtype, and clinical IBD features were not predictors of subgroup membership. However, total comorbidity demonstrated association with pain subgroups in this population. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Neuropsychological dysfunction in chronic fatigue syndrome and the relation between objective and subjective findings.
This study aimed to explore the relationship between self-reported cognitive difficulties, objective neuropsychological test performances, and subjective health complaints in chronic fatigue syndrome (CFS) and to examine the degree of impaired cognitive functions. Method: A total of 236 consecutively recruited outpatients, 18−62 years of age, completed the tests. Self-administered questionnaires were used for assessing fatigue, pain, depression, anxiety and subjective cognitive complaints (Everyday Memory Questionnaire [EMQ]). Also, neuropsychological tests, that is, Stroop I−IV, California Verbal Learning Test...
Source: Neuropsychology - June 6, 2019 Category: Neurology Source Type: research

Chronic fatigue is characterized by a relative lack of abnormalities in biological markers
Publication date: Available online 4 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Vegard Bruun Bratholm Wyller (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - June 6, 2019 Category: Neurology Source Type: research

Patients with fibromyalgia and chronic fatigue syndrome show increased hsCRP compared to healthy controls.
an S Abstract Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) are both chronic disorders that have a devastating effect on the lives of the affected patients and their families. Both conditions have overlapping clinical features that partly resemble those of inflammatory disorders. The etiology is still not understood, and it is suggested that the immune system might be a contributing factor. So far, the results are inconclusive. The purpose of this study was to compare the two conditions and investigate the level of the inflammatory marker high-sensitivity CRP (hsCRP) in CFS and FM patients compared to healt...
Source: Brain, Behavior, and Immunity - June 6, 2019 Category: Neurology Authors: Groven N, Fors EA, Klæbo Reitan S Tags: Brain Behav Immun Source Type: research