The Efficacy of Group Cognitive-Behavioral Therapy plus Duloxetine for Generalized Anxiety Disorder Versus Duloxetine Alone.
Authors: Xie ZJ, Han N, Law S, Li ZW, Chen SY, Xiao JP, Zhang Y, Gao BL, Jiang SS, Gao HM, Huang XB Abstract OBJECTIVE: To explore whether and how group cognitive-behavioural therapy (GCBT) plus medication differs from medication alone for the treatment of generalized anxiety disorder (GAD). METHODS: 170 patients were randomly assigned to the GCBT plus duloxetine (n=89) or duloxetine group (n=81). The primary outcomes were Hamilton Anxiety Scale (HAMA) response and remission rates. The explorative secondary measures included score reductions from baseline in the HAMA total, psychic and somatic anxiety subscales...
Source: Acta Neuropsychiatrica - August 15, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Establishing an effective dose for chronic intracerebroventricular administration of clozapine in mice.
CONCLUSION: Our findings indicate that 7 mg/ml may be the optimal dose for chronic icv delivery of clozapine in mice, allowing comparison to screen for novel antipsychotic compounds. PMID: 31364522 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 1, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

The menstrual cycle may not be limited to the endometrium but also may impact gut permeability.
DISCUSSION: Menstrual cycle-associated changes in IgA directed against LPS and by inference bacterial translocation may be driven by effects of progesterone on transcellular, paracellular and vascular pathways (leaky gut) thereby contributing to the severity of physio-somatic and anxiety symptoms as well as fatigue, breast swelling and food cravings. PMID: 31364524 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 1, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Brain glutathione levels and age at onset of illness in chronic schizophrenia.
CONCLUSION: Our findings are consistent with a possible compensatory upregulation of the antioxidant defense system with longer duration of illness, and suggests the antioxidant defense system may play a role in schizophrenia. PMID: 31364526 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 1, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Psychological distress and C-reactive protein in a South African national survey.
CONCLUSION: Psychological distress was associated with elevated levels of CRP among South African adults. However, the association was confounded by a range of factors, with demographic variables (age, sex and population group) having the largest confounding effect. These findings indicate that CRP is not a useful biomarker of psychological distress, and that additional work is needed on the underlying psychobiology of psychological distress. PMID: 31307562 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 18, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease.
CONCLUSION: PD carriers of GBA variants are at high risk for cognitive decline and depression. Screening for these variants may facilitate early identification, and effective management of these non-motor symptoms. The molecular mechanisms underlying favourable cognitive functioning in LRRK2 rs34637584 variant carriers warrant further investigation. PMID: 31292011 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 14, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Serum cholesterol levels preceding to suicide death in Japanese workers: A nested case-control study.
CONCLUSION: These results suggest that a low serum TC level in recent past is associated with an increased risk of suicide death. PMID: 31258109 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 2, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Reduced grey matter volume in frontal and temporal areas in depression: contributions from voxel-based morphometry study.
CONCLUSIONS: Using VBM the present study was able to replicate decreases in GM volume restricted to frontal and temporal regions in patients with mood disorders, mainly major depression, compared with healthy controls. PMID: 31234950 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 28, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Esketamine and Rapastinel, but not Imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression.
CONCLUSION: The present data confirms development of a resistance to treatment following chronic ACTH administration. In addition, the study confirms the possible effectiveness of s-ketamine and rapastinel as treatment options in treatment resistant depression. Moreover, it highlights the importance of the glutamatergic system in the neurobiology of depression. Further studies are necessary to evaluate how repeated treatment with ACTH leads to a depressed condition resistant to monoaminergic antidepressants. PMID: 31230597 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 25, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Selective serotonin reuptake inhibitors are still harmful and ineffective. Responses to the comments by Hieronymus et al.
Authors: Kiran Kumar K, Naqash Javaid S, Janus Christian J, Christian G Abstract In this response, we address point by point the additional issues raised by Hieronymus et al. in their second round of critique of our systematic review on selective serotonin reuptake inhibitors for major depression. We repulse that we are biased or mistaken in any major ways. We acknowledge that we missed a few small, mostly unpublished trials, and we made a few minor errors in our systematic review. However, these omissions and errors neither have any impact on our overall results nor on our conclusions. The critique by Hieronymus e...
Source: Acta Neuropsychiatrica - June 25, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Seclusion versus mechanical restraint in psychiatry - a systematic review.
CONCLUSION: Based on the available literature, it cannot be determined whether seclusion is superior to mechanical restraint or vice versa. Further studies using stringent methodology are required to answer this question. A cautious conclusion based on this review is that the availability of both methods seems necessary - as both have their pros and cons. PMID: 31190673 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 15, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Inflammation, insulin resistance and neuroprogression in depression.
Authors: Leonard BE, Wegener G Abstract Chronic low-grade inflammation has been observed in major depression and other major psychiatric disorders and has been implicated in metabolic changes that are commonly associated with these disorders. This raises the possibility that the effects of dysfunctional metabolism may facilitate changes in neuronal structure and function which contribute to neuroprogression. Such changes may have implications for the progress from major depression to dementia in the elderly patient. The purpose of this review is to examine the contribution of inflammation and hypercortisolaemia, wh...
Source: Acta Neuropsychiatrica - June 14, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia.
CONCLUSION: The present findings of change in antioxidant levels in the acute versus stable phase of schizophrenia the present findings suggest that redox regulation is dynamic and changes during different phases of the disorder. PMID: 31178002 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 12, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Efficacy of intervention at traffic schools reducing impulsive action, and association with candidate gene variants.
CONCLUSIONS: Brief impulsivity-centred intervention appears as a promising strategy for preventing risk-taking behaviour in novice drivers and can be fully integrated to driving school curriculum. PMID: 31182183 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 12, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Correlation between white blood cell count and mood-stabilising treatment response in two bipolar disorder trials.
CONCLUSIONS: An overall immune system marker did not predict differential treatment response to four different treatment approaches for bipolar disorder all lasting 24 weeks. PMID: 31169098 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 8, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Bipolar disorder and the endocannabinoid system.
CONCLUSION: The probable role of the ECS has been almost neglected in BD; however, from data available which suggest a role of ECS in mood control, it is justified to support conducting comprehensive studies to determine whether ECS manipulation could positively affect BD. Based on the limited available data, we suggest that activation of CB2 may stabilise mood in this disorder. PMID: 31159897 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 5, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Scientific debate instead of beef; challenging misleading arguments about the efficacy of antidepressants.
Authors: Hengartner MP PMID: 31159906 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 5, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Associations between autistic-like traits and polymorphisms in NFKBIL1.
CONCLUSION: The shown associations between polymorphisms in NFKBIL1 and ALTs are supporting an influence of the immune system on neuropsychiatric symptoms. PMID: 31162003 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - June 5, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Gene-environment interactions between HPA-axis genes and stressful life events in depression: a systematic review.
CONCLUSIONS: Our results suggest that genetic variation in three genes in the HPA-axis possibly moderate the effects of SLEs in depression. PMID: 31106715 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 22, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat.
CONCLUSION: Psilocin and psilocybin showed no antidepressant-like effect in the FSL rats, despite a positive effect in humans. This suggests that other animal models of depression and other behavioural tests may be more appropriate for translational studies in the effects of psilocybin. PMID: 31106729 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 22, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Predicting psychogenic non-epileptic seizures from serum levels of neuropeptide Y and adrenocorticotropic hormone.
CONCLUSIONS: The ability to diagnose PNES irrespective of convulsive events would represent an important step considering its feasibility and affordability in daily clinical practice. PMID: 30929648 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - April 3, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

A new way of rapidly screening for depression in multiple sclerosis using Emotional Thermometers.
CONCLUSION: ET are quick, sensitive and useful screening tools for depression in this MS population, to be complemented by further questioning or more detailed psychiatric assessment where indicated. Given that ET4 and ET7 perform equally well, we recommend the use of ET4 as it is briefer. It has the potential to be widely implemented across busy neurology clinics to assist in depression screening in this under diagnosed group. PMID: 30914071 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 29, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Efficacy of ethyl-EPA as a treatment for Huntington disease: A systematic review and meta-analysis.
CONCLUSION: Meta-analysis indicated a significant improvement of motor scores only after 12 months. These results should be interpreted cautiously because only two studies had assessed the efficacy of ethyl-EPA after 12 months with one of them having six months open-label phase. PMID: 30890195 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 22, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades.
CONCLUSION: Our data support the hypothesis that NMDA blockade induces an antidepressant-like effect that requires mTOR but not Trk signalling into the vmPFC-PL. The antidepressant-like effect induced by local NOS inhibition is independent on both Trk and mTOR signalling in the vmPFC-PL. PMID: 30890202 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 22, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Differential semantic processing in patients with schizophrenia versus bipolar disorder: An N400 study.
CONCLUSION: Results indicated differences in semantic processing between BD and SZ. Further studies with larger populations are needed in order to develop neurophysiological markers of these disorders. PMID: 30887935 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Preventing plane-assisted suicides through the lessons of research on homicide and suicide –homicide
Review ArticlesTimothy R Rice, Leo Sher,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 195-198Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Association between AUTS2 haplotypes and alcohol dependence in a Japanese population
Research ArticlesShin Narita, Kenta Nagahori, Daisuke Nishizawa, Eiji Yoshihara, Atsuko Kawai, Kazutaka Ikeda, Kazuhiko Iwahashi,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 214-220Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Neuroanatomical assessment of the impact of negative emotion on implicit memory in patients with obsessive compulsive disorder
Research ArticlesShin-Eui Park, Jong-Chul Yang, Gwang-Woo Jeong,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 206-213Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Exposure pattern influences the degree of drug-seeking behaviour after withdrawal
Research ArticlesSunghyun In, Rong Jie Zhao, Hye Ryeong Han, Chae Ha Yang, Hee Young Kim, Young S. Gwak, Bong Hyo Lee,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 199-205Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Asenapine at low doses as a treatment for psychotic anxiety
LetterMar ía Robles Martínez, Marta Fernández Monge, María Joaquina Lloreda Morillo,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 246-247Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle
LetterFlorian Daniel Zepf, R.M. Stewart, G. Guillemin, J.L. Ruas,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 244-245Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

The role of MMP genes in recurrent depressive disorders and cognitive functions
Research ArticlesKinga Bobi ńska, Janusz Szemraj, Piotr Gałecki, Monika Talarowska,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 221-231Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Neuropeptidase activities in plasma after acute restraint stress. Interaction with cortico-limbic areas
Rapid CommunicationAna Bel én Segarra, Joaquín Hernández, Isabel Prieto, Marc de Gasparo, Manuel Ramírez-Sánchez,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 239-243Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions
Research ArticlesSoumaya Bourgou, Soumeyya Halayem, Isabelle Amado, Racha Triki, Marie Chantal Bourdel, Nicolas Franck, Marie Odile Krebs, Karim Tabbane, Asma Bouden,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 232-238Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Neurophysiological investigations for the diagnosis of non-epileptic attack disorder in neuropsychiatry services: from safety standards to improved effectiveness
Review ArticlesAndrea E. Cavanna, Stefano Seri,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 185-194Abstract (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 20, 2019 Category: Neurology Source Type: research

Decreased percentage of CD4+ lymphocytes expressing chemokine receptors in bipolar disorder.
CONCLUSION: Our findings reinforce the hypothesis that immune pathways, especially involving CD4+ lymphocytes, are involved in the physiopathology of BD. PMID: 30867081 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 16, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats.
CONCLUSION: These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young or middle-aged rats. PMID: 30854991 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 13, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Antidepressants; what's the beef?
Authors: Goodwin GM, Nutt D PMID: 30843500 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 9, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Corrigendum to "Neurological soft signs significantly differentiate schizophrenia patients from healthy controls"; [Acta Neuropsychiatrica 2018;30(2):97-105].
Corrigendum to "Neurological soft signs significantly differentiate schizophrenia patients from healthy controls"; [Acta Neuropsychiatrica 2018;30(2):97-105]. Acta Neuropsychiatr. 2019 Jan 09;:1 Authors: Fountoulakis KN, Panagiotidis P, Gonda X, Kimiskidis V, Nimatoudis I PMID: 30621804 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 11, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Obsessive-compulsive symptoms in schizophrenia: a review.
CONCLUSION: This review suggests that OCS/OCD is highly prevalent among patients with schizophrenia and there is limited good quality evidence to make any specific recommendations for management. PMID: 30558683 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 19, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Neuropeptide Y and religious commitment in healthy young women.
CONCLUSIONS: The present study provides preliminary evidence that neuropeptide Y is a biological correlate of religious commitment. PMID: 30558684 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 19, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Cognitive and affective theory of mind in Korsakoff's syndrome.
CONCLUSION: KS patients have large impairments in both cognitive and affective aspects of social cognition. Their ability to recognise emotions, take the perspective of others, and understand socially awkward situations is vastly compromised. The impairments in ToM functioning are to a large degree functionally discrepant from executive disorders that are commonly present in KS. This study therefore highlights the importance to properly index ToM functioning in neuropsychological assessments for individuals with a possible KS diagnosis. PMID: 30558689 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 19, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

A comprehensive study of oxidative stress in patients with somatic symptom disorder.
CONCLUSION: This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder. PMID: 30558690 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 19, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Reliable and efficient recording of the error-related negativity with a speeded Eriksen Flanker Task.
CONCLUSIONS: The modified task provides reliable and efficient recording of the ERN, facilitating its use as a psychiatric biomarker. PMID: 30561291 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 19, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

ECT in schizophrenia: a review of the evidence.
Authors: Grover S, Sahoo S, Rabha A, Koirala R Abstract Electroconvulsive therapy (ECT) was initially used for the treatment of schizophrenia, but over the years with the advent of antipsychotics, its use in schizophrenia has been limited. Treatment guidelines vary in their recommendations for the use of ECT in schizophrenia. The usual indications of its use among patients with schizophrenia include treatment resistance, to augment pharmacotherapy, to manage catatonia, suicidal behaviour, severe agitation and clozapine-resistant schizophrenia. Available literature, including meta-analysis and systematic reviews, su...
Source: Acta Neuropsychiatrica - December 8, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment.
CONCLUSION: Our data demonstrate that increased brain levels of CGRP are present in a well-established rat model of depression. Given that antidepressants have virtually no effect on the brain level of this peptide, our study indicates that further research is needed to evaluate the functional role of CGRP in the FSL model for depression. PMID: 30509331 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 6, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity.
CONCLUSIONS: Established biological markers of alcohol use and impulsivity can be reliably associated with everyday traffic behaviour and help in contributing to the understanding of the need for more personalized prevention activities. PMID: 30472966 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 28, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Effects of prenatal alcohol exposure on language, speech and communication outcomes: a review longitudinal studies.
CONCLUSION: Evidence from the longitudinal studies reviewed suggest that PAE influenced delays in receptive and expressive communication up to 36 months. Contextual risk factors played a significant role in language development over time and especially as children approached school age. PMID: 30449293 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 21, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Selective serotonin reuptake inhibition increases noise burst-induced unconditioned and context-conditioned freezing.
CONCLUSION: The data suggest that freezing in rats exposed to a stimulus inducing relatively mild fear may be enhanced by acute pretreatment with an SSRI regardless of whether the freezing displayed by the animals is an acute unconditioned response to the stimulus in question or a conditioned response to the same stimulus. PMID: 30404671 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 9, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Reconsidering the seizure threshold? A retrospective study about seizure quality among patients with maintenance ECT.
CONCLUSION: Lowering the energy delivered led to an overall increase of seizure quality among our sample. This highlights the necessity and utility of retitration during ECT maintenance, possibly leading to better management of our patients. PMID: 30398129 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 8, 2018 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research