Low frequency rTMS, inhibits the antidepressive effect of ECT. A pilot study.
CONCLUSION: The addition of low frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low frequency rTMS could inhibit the antidepressant effect of ECT. PMID: 32713367 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 28, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Involvement of nlrp3 inflammasome in schizophrenia-like behavior in young animals after maternal immune activation.
CONCLUSION: This study show that MIA may be associated with a schizophrenia-like behavior. This behavior can be induced to a neuroinflamatory profile in brain. These evidences may base future studies on the relationship between neuroinflammation and psychiatric disorders. PMID: 32660670 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 16, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Increased Psychological Well-being after the Apex of the COVID-19 Pandemic.
Authors: Sønderskov KM, Dinesen PT, Santini ZI, Østergaard SD PMID: 32624036 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 7, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder.
CONCLUSION: Participants with lower IL-6 levels at baseline had a better response to the adjunctive treatment with the mitochondrial-enhancing agents in terms of improvements in MADRS and CGI-I outcomes. PMID: 32600481 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 1, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Psychiatric Symptoms Related to the COVID-19 Pandemic.
Authors: Rohde C, Hougaard Jefsen O, Nørremark B, Aalkjær Danielsen A, Østergaard SD PMID: 32434604 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 22, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Effect of the monoaminergic stabiliser (-)-OSU6162 on mental fatigue following stroke or traumatic brain injury.
CONCLUSION: The most obvious beneficial effects of (-)-OSU6162 was on the patients' activity level, illustrated by the improvement on the FAI scale. Moreover, a subgroup of patients showed substantial improvements on the Mental Fatigue Scale. Based on these observed therapeutic effects, in conjunction with the good tolerability of (-)-OSU6162, this compound may offer promise for treating at least part of the symptomatology in patients suffering from stroke- or TBI-induced mental fatigue. PMID: 32418546 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 19, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Interleukin-4 and Anxiety in Adults with Atopic Dermatitis.
Authors: Gray NA, Naude PJ, Esterhuizen TM, Khumalo NP, Stein DJ PMID: 32390578 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 12, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Anti-HIV drugs promote β-amyloid deposition and impair learning and memory in BALB/c mice.
CONCLUSION: Our results suggest that chronic exposure to tenofovir disoproxil fumarate and nevirapine contributes to hippocampal lipid peroxidation and β-amyloid accumulation, respectively, as well as spatial learning and memory deficits in mice even in the absence HIV-infection. These findings further support a possible link between antiretroviral drug toxicity, β-amyloid accumulation and the persistence of HIV associated neurocognitive disorders. PMID: 32378496 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 8, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Exploring test batteries for depression- and anxiety-like behaviors in female and male ICR and black Swiss mice.
CONCLUSIONS: The results cast some doubt on the utility of behavioral test batteries to represent different facets of emotional behavior in healthy intact outbred mice, without any interventions or treatments. Additional studies are designed to explore whether stronger relationship between the tests will appear after manipulations or drug treatments. PMID: 32378506 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 8, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Are COVID-19 survivors at increased risk for suicide?
Authors: Sher L PMID: 32364491 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 5, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Differentiating Depression and ADHD without Depression in Adults with Processing-Speed Measures.
CONCLUSIONS: The cognitive-processing speed (colour-form) and shift-cost measures before treatment proved most sensitive in differentiating patients with depression and ADHD. Reductions in naming times for the depression group were suggested to reflect improved psycho-motor skills rather than improved cognitive control. PMID: 32338233 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - April 28, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Reward sensitivity, Affective Neuroscience Personality, symptoms of attention deficit/hyperactivity disorder, and TPH2 -703G/T (rs4570625) genotype.
CONCLUSIONS: Behaviours sensitive to rewards are separable to the components of variability and fixation, and these components are differentially related to affective aspects of personality, attention and hyperactivity as well as to TPH2 genotype. PMID: 32338242 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - April 28, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia.
CONCLUSION: The results of the present study suggest that multi-systemic mitochondrial dysfunction may be an underlying mechanism involved in schizophrenia. PMID: 32329429 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - April 25, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

The depressive state of Denmark during the COVID-19 pandemic.
Authors: Sønderskov KM, Dinesen PT, Santini ZI, Østergaard SD PMID: 32319879 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - April 24, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Association Between GLP-1 Receptor Gene Polymorphisms with Reward Learning, Anhedonia, and Depression Diagnosis.
CONCLUSION: Findings suggest a possible association of rs1042044 with anhedonia, but no association with depression diagnosis. PMID: 32213216 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 29, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Systematic review of gene expression studies in people with Lewy Body Dementia.
Authors: Chowdhury A, Rajkumar AP Abstract OBJECTIVES: Lewy body dementia (LBD) is the second most prevalent neurodegenerative dementia, and it causes more morbidity and mortality than Alzheimer's disease. Several genetic associations of LBD have been reported, and their functional implications remain uncertain. Hence, we aimed to do a systematic review of all gene expression studies that investigated people with LBD for improving our understanding of LBD molecular pathology and for facilitating discovery of novel biomarkers and therapeutic targets for LBD. METHODS: We systematically reviewed five online databa...
Source: Acta Neuropsychiatrica - March 19, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Monocyte count in schizophrenia and related disorders: a systematic review and meta-analysis.
CONCLUSIONS: Monocyte count can be considered an indirect marker of microglia activation in the central nervous system. Thus, the observed higher monocyte count in patients could be considered as a possible peripheral marker of microglia's activation in schizophrenia disorder. PMID: 32178747 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - March 19, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

How to increase the role of social workers in suicide preventive interventions.
CONCLUSION: Recommendations are provided for how the social work profession can improve upon suicide prevention while incorporating universal, selective, and indicated suicide preventive interventions. Social work research efforts should focus on how to increase the role of social workers in suicide prevention and the management of suicidal patients. Social work education programs should modify their curricula and increase their attention on suicide prevention. Mental health social workers need to educate the patient and their family on suicide risk factors. Furthermore, mental health and non-mental health social workers n...
Source: Acta Neuropsychiatrica - March 18, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Disregard the Authorship Criteria or Perish.
Authors: Østergaard SD PMID: 32063232 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - February 20, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Expression of 22 serotonin-related genes in rat brain after subacute serotonin depletion or reuptake inhibition.
CONCLUSION: With some notable exceptions, the expression of most of the studied genes is left unchanged by short-term modulation of extracellular levels of serotonin. PMID: 32063244 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - February 20, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Auditory Brainstem Response (ABR) Profiling in Schizoaffective Disorder.
CONCLUSION: With the ABR profiling test a minority of patients with schizoaffective disorder tested positive for schizophrenia. In contrast a majority (85%) of patients with schizophrenia in a previous study tested positive. These preliminary results leave us ignorant whether schizoaffective disorder should be regarded as a schizophrenia-like disorder or a psychotic mood disorder and add to the questions regarding the validity of this diagnostic entity. However, the ABR profiling method is still in its infancy and its exploration in a range of psychiatric disorders is warranted. PMID: 32063251 [PubMed - as supplied by ...
Source: Acta Neuropsychiatrica - February 20, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Post-hoc analysis of a randomized, placebo-controlled, active-reference 6-week study of brexpiprazole in acute schizophrenia.
CONCLUSION: Pre-specified sensitivity analyses showed separation from placebo for brexpiprazole at Week 6. A post-hoc analysis suggested a potential confounding of efficacy rating towards symptom improvement in patients who experience known side effects of quetiapine XR. PMID: 32054559 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - February 15, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Pharmacological treatments for social anxiety disorder in adults: a systematic review and network meta-analysis.
CONCLUSION: The differences between drugs and placebo were small, apart from a significant reduction in symptom severity and response for paroxetine. We suggest paroxetine as a first line treatment of SAD, with the consideration of future research on the drug olanzapine as well as brofaromine, bromazepam, clonazepam, escitalopram, fluvoxamine, phenelzine, and sertraline because we observed a response to treatment. PMID: 32039743 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - February 11, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Gene expression in peripheral blood in treatment-free major depression.
DISCUSSION: GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry. PMID: 32039744 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - February 11, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Role of D-serine in the beneficial effects of repetitive transcranial magnetic stimulation in post-stroke patients.
CONCLUSIONS: The results suggest that rTMS can modulate NMDAR-related amino acids in blood, producing beneficial effects. PMID: 31992382 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 31, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Prenatal restraint stress impairs recognition memory in adult male and female offspring.
CONCLUSION: Present findings support the view that maternal restraint-stress during late pregnancy impairs recognition memory in both male and female offspring, and in females this cognitive deficit is dependent on the estrous cycle phase. Ultimately, these data reinforce that PNS is an aetiological component of psychiatric disorders associated with memory deficits. PMID: 31992385 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 31, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Gene-environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review.
CONCLUSIONS: We find that genetic variation in four HPA-axis genes may influence the effects of CM in depression. PMID: 31902387 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 8, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Prenatal alcohol exposure is associated with early motor, but not language development in a South African cohort.
CONCLUSION: PAE has potentially important consequences for motor development in the first 2 years of life, a period during which the most rapid growth and maturation occurs. These findings highlight the importance of identifying high-risk families in order to provide preventive interventions, particularly in antenatal clinics and early intervention services. PMID: 31902391 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 8, 2020 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

The Food Addiction Denmark (FADK) Project: a combined survey and register-based study.
DISCUSSION: We expect that the FADK Project will contribute significantly to our understanding of FA. PMID: 31796135 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 6, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Intrinsic functional connectivity, CSF biomarker profiles and their relation to cognitive function in mild cognitive impairment.
In conclusion, our results indicate, that CSF protein profiles seem to be more closely related to cognitive decline than alterations in resting state activity. Thus, resting state connectivity might not be a reliable biomarker for early stages of AD. PMID: 31801648 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 6, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Low cholesterol levels in children predict impulsivity in young adulthood.
CONCLUSIONS: Serum lipid levels could have an impact on development of maladaptive impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood. PMID: 31787117 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - December 5, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Neuroimmunological antibody-mediated encephalitis and implications for diagnosis and therapy in neuropsychiatry.
Authors: Marinas JE, Matveychuk D, Dursun SM, Baker GB Abstract The past decade has seen a surge of reports and investigations into cases of autoimmune-mediated encephalitis. The increasing recognition of these disorders is especially of relevance to the fields of neurology and psychiatry. Autoimmune encephalitis involves antibodies against synaptic receptors, neuronal cell surface proteins and intracellular targets. These disorders feature prominent symptoms of cognitive impairment and behavioural changes, often associated with presence of seizures. Early in the clinical course, autoimmune encephalitis may manifes...
Source: Acta Neuropsychiatrica - December 5, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Dorsolateral and Ventrolateral Prefrontal Cortex Structural Changes relative to Suicidal Ideation in Patients with Depression.
CONCLUSIONS: Our findings demonstrated that left DLPFC reductions were associated with MDD and suicidal ideation, and diminished GMV reductions in the right DLPFC and right VLPFC were only associated with suicidal ideation. These results help us better understand the neuropathological changes in MDD with suicidal ideation. PMID: 31753044 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 23, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

In major depression, increased kappa and mu opioid receptor levels are associated with immune activation.
CONCLUSION: Our findings suggest that in MDD, immune activation is associated with a simultaneous activation of dynorphin/KOR and β-endorphin/MOR signaling and that these opioid systems may participate in the pathophysiology of depression by a) exerting immune regulatory activities attenuating the primary immune response; and b) modulating reward responses and mood as well as emotional and behavioral responses to stress. PMID: 31753054 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 23, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile.
CONCLUSION: IPV during pregnancy is associated with altered bacterial profiles in infant and maternal faecal bacteria. These findings may provide insights in the involvement of the gut bacteria linking maternal psychological adversity and the maturing infant brain. PMID: 31753055 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 23, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation.
CONCLUSIONS: In line with previous studies, we show that LPS administration induces anxiety and cognitive dysfunctions in mice that however were not reversed by chronic blockade of IDO1 or TDO2 at the doses used. PMID: 31753057 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 23, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Characterization and outcome of neuropsychiatric symptoms in patients with anti-nmdar encephalitis.
CONCLUSIONS: Neuropsychiatric symptoms profile in ANMDARE was associated with the early onset of euphoria/exaltation and disinhibition, accompanied by marked psychomotor agitation. When ANMDARE was suspected, the presence of excited-type catatonia and delirium showed a tendency to predict definitive ANMDARE. At discharged, most patients recovered from catatonia, delirium, and psychosis, but marked cognitive symptoms, anxiety, and depression persisted at discharge. PMID: 31753060 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 23, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Good news regarding ssri safety in danish meta-analysis.
GOOD NEWS REGARDING SSRI SAFETY IN DANISH META-ANALYSIS. Acta Neuropsychiatr. 2019 Nov 08;:1-8 Authors: Hieronymus F, Lisinski A, Näslund J, Eriksson E Abstract In two previous letters on an SSRI meta-analysis conducted by the Copenhagen Trial Unit at Copenhagen University Hospital, we have commented on a large number of errors, almost all of which have tilted the results in an anti-drug direction, that unfortunately mar this publication. While the authors have acknowledged many of these mishaps, and may now be expected to submit an extensive errata list to the journal where their paper was once p...
Source: Acta Neuropsychiatrica - November 10, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

ABSTRACTS IL SIMP ÓSIO BRASILEIRO DE NEUROPSICOFARMACOLOGIA FLORIANÓPOLIS-SC 15 a 17 de maio de 2019.
ABSTRACTS IL SIMPÓSIO BRASILEIRO DE NEUROPSICOFARMACOLOGIA FLORIANÓPOLIS-SC 15 a 17 de maio de 2019. Acta Neuropsychiatr. 2019 Aug;31(s2):1-54 Authors: PMID: 31663494 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 31, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

3Rs as part of preclinical neuropsychiatric translational crisis, and ARRIVE guidelines as part of solution.
CONCLUSION: This may together with systematic reviews and well-designed and well-performed animal studies and accurate reporting of the results indeed contribute to solving the translational crisis in preclinical research. PMID: 31647038 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 26, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

ABSTRACTS SCANDINAVIAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY SCNP 60th Annual Meeting, 24 - 26 April, 2019 Gothenburg, Denmark.
Authors: PMID: 31642800 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 24, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Molecular pathway analysis associates alterations in obesity related genes and antipsychotic-induced weight gain.
Authors: Corfitsen HT, Krantz B, Larsen A, Drago A Abstract OBJECTIVE: Antipsychotics often induce excessive weight gain. We hypothesized that individuals with genetic variations related to known obesity-risk genes have an increased risk of excessive antipsychotic-induced weight gain. This hypothesis was tested in a subset of the CATIE trial data-set. METHODS: The CATIE trial compared effects and side effects of five different antipsychotics through an 18 month period. Based on the maximum weight gain recorded, excessive weight gain was defined as>7% weight-gain. Cytoscape and GeneMania were instrumental in ...
Source: Acta Neuropsychiatrica - October 19, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs.
CONCLUSION: Cytokine levels were associated with level of mental distress as measured by the GSI scores, but this relationship was not present among those using anti-inflammatory drugs. We found no association between cytokine levels and development of GSI score over time. PMID: 31576798 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 4, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Mitochondrial Calcium Uniporter as a potential therapeutic strategy for Alzheimer's disease (AD).
Authors: Anila V, Mahalaxmi I, Venkatesh B, Balachandar V Abstract Alzheimer's disease (AD), a neurodegenerative disorder is the leading cause of dementia in the world whose etiology is still unclear. AD was always related to aging though there have been instances where people at an early age also succumb to this disease. With medical advancements, the mortality rate has significantly reduced which also makes people more prone to AD. AD is rare, yet the prominent disease has been widely studied with several hypotheses trying to understand the workings of its onset. The most recent and popular hypothesis in AD is th...
Source: Acta Neuropsychiatrica - September 27, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Stimulation-induced side effects after Deep Brain Stimulation - a systematic review.
CONCLUSION: DBS of subthalamic nucleus should be seen as the most hazardous place of implantation. As a result there is a strong need of "gold standards" based on the connectivity research and closer cooperation of scientists and clinicians. PMID: 31452489 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 30, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

The Efficacy of Group Cognitive-Behavioral Therapy plus Duloxetine for Generalized Anxiety Disorder Versus Duloxetine Alone.
Authors: Xie ZJ, Han N, Law S, Li ZW, Chen SY, Xiao JP, Zhang Y, Gao BL, Jiang SS, Gao HM, Huang XB Abstract OBJECTIVE: To explore whether and how group cognitive-behavioural therapy (GCBT) plus medication differs from medication alone for the treatment of generalized anxiety disorder (GAD). METHODS: 170 patients were randomly assigned to the GCBT plus duloxetine (n=89) or duloxetine group (n=81). The primary outcomes were Hamilton Anxiety Scale (HAMA) response and remission rates. The explorative secondary measures included score reductions from baseline in the HAMA total, psychic and somatic anxiety subscales...
Source: Acta Neuropsychiatrica - August 15, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Establishing an effective dose for chronic intracerebroventricular administration of clozapine in mice.
CONCLUSION: Our findings indicate that 7 mg/ml may be the optimal dose for chronic icv delivery of clozapine in mice, allowing comparison to screen for novel antipsychotic compounds. PMID: 31364522 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 1, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

The menstrual cycle may not be limited to the endometrium but also may impact gut permeability.
DISCUSSION: Menstrual cycle-associated changes in IgA directed against LPS and by inference bacterial translocation may be driven by effects of progesterone on transcellular, paracellular and vascular pathways (leaky gut) thereby contributing to the severity of physio-somatic and anxiety symptoms as well as fatigue, breast swelling and food cravings. PMID: 31364524 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 1, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Brain glutathione levels and age at onset of illness in chronic schizophrenia.
CONCLUSION: Our findings are consistent with a possible compensatory upregulation of the antioxidant defense system with longer duration of illness, and suggests the antioxidant defense system may play a role in schizophrenia. PMID: 31364526 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 1, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Psychological distress and C-reactive protein in a South African national survey.
CONCLUSION: Psychological distress was associated with elevated levels of CRP among South African adults. However, the association was confounded by a range of factors, with demographic variables (age, sex and population group) having the largest confounding effect. These findings indicate that CRP is not a useful biomarker of psychological distress, and that additional work is needed on the underlying psychobiology of psychological distress. PMID: 31307562 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - July 18, 2019 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research