Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight ...
Source: Frontiers in Psychiatry - November 9, 2023 Category: Psychiatry Source Type: research

How many in the U.S. are disabled? Proposed census changes would greatly decrease count
The U.S. Census Bureau may soon change the way one of its nationwide surveys asks about disability. But alarm bells are ringing for many researchers and activists, because the proposed change would dramatically decrease the official number of people in the United States who are considered disabled. “Disabled people are already underserved,” says Scott Landes, a sociologist at Syracuse University who studies disability. Altering the way the Census Bureau gathers disability statistics, he argues, will generate “inaccurate information.” In an 18 October letter , he and other disability researchers and ...
Source: Science of Aging Knowledge Environment - November 8, 2023 Category: Geriatrics Source Type: research

Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis
Psychol Med. 2023 Nov 6:1-10. doi: 10.1017/S0033291723003148. Online ahead of print.ABSTRACTDebate is ongoing on the efficacy of cognitive behavior therapy (CBT) for myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). With an individual patient data (IPD) meta-analysis we investigated whether the effect of CBT varied by patient characteristics. These included post-exertional malaise (PEM), a central feature of ME/CFS according to many. We searched for randomized controlled trials similar with respect to comparison condition, outcomes and treatment-protocol. Moderation on fatigue severity (Checklist Individual S...
Source: Psychological Medicine - November 6, 2023 Category: Psychiatry Authors: T A Kuut L M Buffart A M J Braamse I Csorba G Bleijenberg P Nieuwkerk R Moss-Morris F M üller H Knoop Source Type: research

Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis
Psychol Med. 2023 Nov 6:1-10. doi: 10.1017/S0033291723003148. Online ahead of print.ABSTRACTDebate is ongoing on the efficacy of cognitive behavior therapy (CBT) for myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). With an individual patient data (IPD) meta-analysis we investigated whether the effect of CBT varied by patient characteristics. These included post-exertional malaise (PEM), a central feature of ME/CFS according to many. We searched for randomized controlled trials similar with respect to comparison condition, outcomes and treatment-protocol. Moderation on fatigue severity (Checklist Individual S...
Source: Psychological Medicine - November 6, 2023 Category: Psychiatry Authors: T A Kuut L M Buffart A M J Braamse I Csorba G Bleijenberg P Nieuwkerk R Moss-Morris F M üller H Knoop Source Type: research

Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis
Psychol Med. 2023 Nov 6:1-10. doi: 10.1017/S0033291723003148. Online ahead of print.ABSTRACTDebate is ongoing on the efficacy of cognitive behavior therapy (CBT) for myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). With an individual patient data (IPD) meta-analysis we investigated whether the effect of CBT varied by patient characteristics. These included post-exertional malaise (PEM), a central feature of ME/CFS according to many. We searched for randomized controlled trials similar with respect to comparison condition, outcomes and treatment-protocol. Moderation on fatigue severity (Checklist Individual S...
Source: Psychological Medicine - November 6, 2023 Category: Psychiatry Authors: T A Kuut L M Buffart A M J Braamse I Csorba G Bleijenberg P Nieuwkerk R Moss-Morris F M üller H Knoop Source Type: research

Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis
Psychol Med. 2023 Nov 6:1-10. doi: 10.1017/S0033291723003148. Online ahead of print.ABSTRACTDebate is ongoing on the efficacy of cognitive behavior therapy (CBT) for myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). With an individual patient data (IPD) meta-analysis we investigated whether the effect of CBT varied by patient characteristics. These included post-exertional malaise (PEM), a central feature of ME/CFS according to many. We searched for randomized controlled trials similar with respect to comparison condition, outcomes and treatment-protocol. Moderation on fatigue severity (Checklist Individual S...
Source: Psychological Medicine - November 6, 2023 Category: Psychiatry Authors: T A Kuut L M Buffart A M J Braamse I Csorba G Bleijenberg P Nieuwkerk R Moss-Morris F M üller H Knoop Source Type: research

Head-down tilt reduces the heart rate in postural tachycardia syndrome in acute setting: a pilot study
ConclusionsIn the acute setting, HDT is safe. HDT reduces the heart rate presumably by modulating baroreflex by enhancing preload and stroke volume, which in turn increases thoracic blood volume with a net effect of parasympathetic cardiovagal activation and/or sympathetic withdrawal. This pilot study provides a foundation to proceed with longitudinal studies exploring the long-term effect of repetitive HDT in conditions associated with preload failure such as POTS, ME/CSF, and PASC. (Source: Neurological Sciences)
Source: Neurological Sciences - November 3, 2023 Category: Neurology Source Type: research

GSE245661 Deep phenotyping of Post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Contributors : Brian Walitt ; Komudi Singh ; Mark Hallett ; Steve Jacobson ; Kong Chen ; Yoshimi E Akahata ; Richard Apps ; Jennifer J Barb ; Patrick Bedard ; Robert J Brychta ; Ashura W Buckley ; Peter D Burbelo ; Brice Calco ; Brianna Cathay ; Li Chen ; Jinguo Chen ; Foo Cheung ; Snigdha Chigurupati ; Lisa M Chin ; Benjamin W Coleman ; Amber B Courville ; Madeleine S Deming ; Bart Drinkard ; Li R Feng ; Luigi Ferrucci ; Scott A Gabel ; Angelique Gavin ; David S Goldstein ; Shahin Hassanzadeh ; Sean C Horan ; Silvina G Horovitz ; Kory R Johnson ; Anita J Govan ; Kristine M Knutson ; Joy D Kreskow ; Samuel...
Source: GEO: Gene Expression Omnibus - October 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study
ConclusionsThis large study reveals that AYAC survivors, on average 9  years after their cancer diagnosis, require more frequent follow-up care for neurological complications compared to non-cancer individuals. However, the management of neuropathy, memory loss, and chronic fatigue is hindered by a lack of mechanism-based effective therapies. (Source: Cancer Medicine)
Source: Cancer Medicine - October 30, 2023 Category: Cancer & Oncology Authors: Ivann Agapito, Ding Quan Ng, Joel Milam, Argyrios Ziogas, Hoda Anton ‐Culver, Alexandre Chan Tags: RESEARCH ARTICLE Source Type: research

Evaluation of viral infection as an etiology of ME/CFS: a systematic review and meta-analysis
CONCLUSION: This study comprehensively evaluated the risk of viral infections associated with ME/CFS, and identified BDV. These results provide valuable reference data for future studies investigating the role of viruses in the causation of ME/CFS.PMID:37898798 | DOI:10.1186/s12967-023-04635-0 (Source: Herpes)
Source: Herpes - October 29, 2023 Category: Infectious Diseases Authors: Jae-Hyun Hwang Jin-Seok Lee Hyeon-Muk Oh Eun-Jung Lee Eun-Jin Lim Chang-Gue Son Source Type: research

A Review Article on Exercise Intolerance in Long COVID: Unmasking the Causes and Optimizing Treatment Strategies
Med Sci Monit. 2023 Oct 28;29:e941079. doi: 10.12659/MSM.941079.ABSTRACTThere is a growing body of research on SARS-CoV-2 (PASC), previously known as the post-COVID syndrome, a chronic condition characterized by symptoms that persist after SARS-CoV-2 infection. Among these symptoms, feelings of physical exhaustion and prolonged fatigue are particularly prevalent and can significantly impact patients' quality of life. These symptoms are associated with reduced overall physical capacity, decreased daily physical activity, malaise after intense training, and intolerance to physical activity (IFA). IFA, described as a reduced ...
Source: Medical Science Monitor - October 28, 2023 Category: Research Authors: Veronika Koleni čová Martina Sebalo V ňuková Martin Anders Marta Fi šerová Ji ří Raboch Radek Pt áček Source Type: research

Evaluation of viral infection as an etiology of ME/CFS: a systematic review and meta-analysis
Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a long-term disabling illness without a medically explained cause. Recently during COVID-19 pandemic, many studies have confirmed the symptoms similar ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - October 28, 2023 Category: Research Authors: Jae-Hyun Hwang, Jin-Seok Lee, Hyeon-Muk Oh, Eun-Jung Lee, Eun-Jin Lim and Chang-Gue Son Tags: Review Source Type: research

Late Breaking Abstract - Replication and validation of a rebreathing experiment to investigate post-COVID symptoms
In conclusion, our findings validate the improved setup for the rebreathing paradigm. This is essential for its diagnostic use, which is already providing first hints on specific alterations and relationships between breathing and perception in patients with long-lasting symptoms after COVID-19. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Schaefer, D., Jörres, R., Nowak, D., Van Den Bergh, O., Bogaerts, K., Glasauer, S., Lehnen, N., Von Werden, D. Tags: Respiratory function technologists/scientists Source Type: research

CT findings as prediction of long covid
Conclusions: It is possible to predict long covid in patient with early subpleural fibrosis. Patients with chronic fatigue syndrome were often with Omicron strain. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Ivkovic, A., Milosavljevic, T., Svilarov, I., Ivkovic, S., Ivkovic, D. Tags: Imaging Source Type: research