The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
Efficacy of supervised immersive virtual reality-based training for the treatment of chronic fatigue in post-COVID syndrome: study protocol for a double-blind randomized controlled trial (IFATICO Trial)
The treatment of persistent fatigue after COVID-19 infection is complex. On the one hand, it involves maintaining a sufficient level of physical and mental activity to counteract possible degenerative processe... (Source: Trials)
Source: Trials - April 3, 2024 Category: General Medicine Authors: Jonas Tesarz, Hannah Lange, Marietta Kirchner, Axel G örlach, Wolfgang Eich and Hans-Christoph Friederich Tags: Study protocol Source Type: research
Time-dependent complexity characterisation of activity patterns in patients with Chronic Fatigue Syndrome
Chronic Fatigue Syndrome patients suffer from symptoms that cannot be explained by a single underlying biological cause. It is sometimes claimed that these symptoms are a manifestation of a disrupted autonomic... (Source: BioPsychoSocial Medicine)
Source: BioPsychoSocial Medicine - April 2, 2024 Category: Psychiatry & Psychology Authors: Paloma Rabaey, Peter Decat, Stefan Heytens, Dirk Vogelaers, An Mariman and Thomas Demeester Tags: Research Source Type: research
Association between illness perception and social alienation among maintenance hemodialysis patients: The mediating role of fear of progression
ConclusionsIllness perception directly predicts social alienation in MHD patients and exerts an indirect effect through the mediating role of fear of progression. Suggests that healthcare professionals should concentrate on MHD patients with high negative illness perceptions to alleviate their fear of progression, thereby decreasing the level of social alienation and enhancing their integration into society. (Source: PLoS One)
Source: PLoS One - April 2, 2024 Category: Biomedical Science Authors: Beisha Zhu Source Type: research
Exploring levels of TSH and FT4 in patients with chronic fatigue syndrome (CFS), fibromyalgia (FM) and healthy controls did not reveal any associations between fatigue score and level of thyroid hormones
CONCLUSION: As one might clinically and physiologically expect an association between thyroid function and fatigue, which may be associated with clinical disorders such as CFS and FM, we suggest future studies to examine the field further by exploring the influence of thyroid receptors and responses of the thyroid hormone cascade.PMID:38557370 | DOI:10.1080/08039488.2024.2332442 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Elias Skorpen Nora Bugge Pasca Solveig Kl æbo Reitan Nina Groven Source Type: research
Development Of a Mouse Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex clinical condition characterized by overwhelming fatigue and associated symptoms like pain lasting greater than 6 months. ME/CFS is often initiated after an illness, exacerbated by stress, and associated with immune system changes. The purpose of this study was to develop a clinically relevant mouse model of ME/CFS. We hypothesized that pairing stress with an illness-like immune stimulation would generate long-term fatigue and pain, and thus tested effects of combining one-day of acute restraint stress with the immune activator lipopolysaccharide (LPS...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Adam J. Janowski, Ashley N. Plumb, Kazuhiro Hayashi, Joseph B. Lesnak, Angela F. Smith, Lynn Rasmussen, Kathleen A. Sluka Source Type: research
Influence of Proximity to Veterans Affairs Hospitals on Chronic Overlapping Pain Condition Diagnoses in Veterans: Insights from the Million Veteran Program
The geographic distribution of chronic overlapping pain conditions (COPCs), including migraine, tension headache, temporomandibular disorder, chronic fatigue syndrome, fibromyalgia, back pain, and chronic prostatitis/chronic pelvic pain syndrome, remains underexplored. Electronic health record data from 619,079 US Veterans enrolled in the Million Veteran Program (MVP) was used to construct a Veteran ’s lifetime COPC history and summarize it into a count ranging from 0 to 7 COPCs. Aggregate COPC prevalence was evaluated in terms of geographic distribution and proximity to Veteran’s Affairs (VA) healthcare facilities. (S...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Armand Gerstenberger, Niloofar Afari, Marianna Gasperi, on behalf of the Million Veteran Program Source Type: research
Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-Acute Sequelae of Severe Acute Respiratory Syndrome 2 Infection
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-acute sequelae of SARS-CoV-2 infection (PASC) are complex clinical conditions sharing several symptoms hallmarked by post-exertional malaise (PEM). PEM is a severe exacerbation of symptoms after minor physical or mental exertion starting 6-24 hours after activity and can last for days or even weeks. Little is known about the relationship between PEM severity and fatigue, pain, function, and psychological measures. Our purpose was to compare two methods of collecting PEM data: (1) DePaul Symptom Questionnaire – PEM (DSQ-PEM) taken at baseline and (2) a s...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kathleen A. Sluka, Adam J. Janowski, Giovanni Berardi, Samuel McNally Source Type: research
Impact of an Individualized Low-to-Moderate Exercise Task on Post-Exertional Malaise in Post-Acute Sequelae of SARS-CoV-2 Infection and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This study examined tolerance to a tailored low-to-moderate intensity exercise task using age-predicted maximal heart rate guided by symptom-based intensity modifications in individuals with PASC and ME/CFS. Thirty individuals with PASC, ME/CFS, and controls completed a bout of whole-body exercise on an upright cycle ergometer for 25-minutes. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Giovanni Berardi, Adam Janowski, Samuel McNally, Kathleen Sluka Source Type: research
High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial
by Palle Bager, Lars Bossen, Rasmus Gantzel, Henning Gr ønbæk
Background& aimsFatigue has high negative impact on many patients with primary biliary cholangitis (PBC) and treatment options are limited. Recently we showed favorable effects of four weeks of high-dose thiamine treatment on fatigue in patients with inflammatory bowel disease. We aimed to investigate the effect and safety of high-dose (600 –1800 mg daily) oral thiamine treatment on chronic fatigue in patients with PBC. MethodsRandomized, double-blinded, placebo-controlled crossover trial including patients with severe PBC-related fatigue. Participants were ...
Source: PLoS One - March 29, 2024 Category: Biomedical Science Authors: Palle Bager Source Type: research
The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives
Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is a severe multisystemic disease for which specific diagnostic markers or therapeutic concepts have not been established. Despite numerous indications of post-infectious neurological, immunological, endocrinal, and metabolic deviations, the exact causes and pathophysiology remain unclear. To date, there is a paucity of data, that changes in the composition and function of the gastroi...
Source: Frontiers in Immunology - March 28, 2024 Category: Allergy & Immunology Source Type: research
Plasma and peritoneal fluid cytokine profiles in patient with Essure ® implant: Towards a molecular signature?
CONCLUSIONS: The chemokine MCP-1 as well as the pro-inflammatory TNF-α, are known to be increased in patients with fibromyalgia and chronic fatigue syndrome. Since patients with Essure® may exhibit symptoms similar to fibromyalgia, MCP-1 and TNF-α may be relevant markers in symptomatic patients with Essure®. Because of the lack of longitudinal data (no evaluation of postoperative cytokine profile and no assessment of the level of clinical improvement), other studies are needed to confirm these preliminary results.PMID:38537321 | DOI:10.1016/j.ejogrb.2024.03.031 (Source: Reproductive Biology)
Source: Reproductive Biology - March 27, 2024 Category: Reproduction Medicine Authors: Lorna Garnier Fran çois Parant Claire Bulteau Remi Pescarmona Emanuele Cerruto Stephanie Moret Chloe Miguet-Bensouda Erdogan Nohuz Gautier Chene Source Type: research
