Sandwich-like voltametric immunosensing of interleukin-8 based on β-cyclodextrin/carbon nanotubes and methylthionine chloride@UIO-66 framework
Anal Sci. 2024 Apr 25. doi: 10.1007/s44211-024-00574-y. Online ahead of print.ABSTRACTThe level of interleukin-8 (IL-8) in the body is an effective factor for the early diagnosis of acute tubular necrosis and oral tumor. In this work, a novel sandwich-like voltametric immunosensor (SVS) of IL-8 was constructed by preparing β-cyclodextrin/carbon nanotube (CD/CNT) to immobilize primary antibody (PAb) of IL-8 and UIO-66-NH2 MOFs structure to immobilize second antibody (SAb) and methylene blue (Mb) probe. In this designed SVS, the prepared CD/CNT nanohybrid with large surface area and conductivity can immobilize PAb via simpl...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - April 25, 2024 Category: Chemistry Authors: Zhihua Zhou Jiajia Lin Daoping Yue Huaiyu Chen Sheng Chen Source Type: research
Planar Tetranuclear Uranium Hydride Cluster Supported by ansa-Bis(cyclopentadienyl) Ligands
Angew Chem Int Ed Engl. 2024 Apr 25:e202405494. doi: 10.1002/anie.202405494. Online ahead of print.ABSTRACTPolynuclear metal hydride clusters play important roles in various catalytic processes, with most of the reported polynuclear metal hydride clusters adopting a polyhedral three-dimensional structure. Herein, we report the first example of a planar tetranuclear uranium hydride cluster [(CpCMe2CMe2Cp)U]4(μ2-H)4(μ3-H)4 (U4H8). It was synthesized by reacting an ansa-bis(cyclopentadienyl) ligand-supported uranium chloride precursor [(CpCMe2CMe2Cp)U]3(μ2-Cl)3(μ3-Cl)2 with NaHBEt3. The presence of hydrides in U4H8 was co...
Source: Angewandte Chemie - April 25, 2024 Category: Chemistry Authors: Kai Li Iker Del Rosal Yue Zhao Laurent Maron Congqing Zhu Source Type: research
Design of Solid Polycationic Electrolyte to Enable Durable Chloride-Ion Batteries
Angew Chem Int Ed Engl. 2024 Apr 25:e202405750. doi: 10.1002/anie.202405750. Online ahead of print.ABSTRACTThe high energy density and cost-effectiveness of chloride-ion batteries (CIBs) make them promising alternatives to lithium-ion batteries. However, the development of CIBs is greatly restricted by the lack of compatible electrolytes to support cost-effective anodes. Herein, we present a rationally designed solid polycationic electrolyte (SPE) to enable room-temperature chloride-ion batteries utilizing aluminum (Al) metal as an anode. This SPE endows the CIB configuration with improved air stability and safety (i.e. fr...
Source: Angewandte Chemie - April 25, 2024 Category: Chemistry Authors: Xu Yang Zhiqiang Fu Ran Han Yaojie Lei Shijian Wang Xin Zhao Yuefeng Meng Hao Liu Dong Zhou Doron Aurbach Guoxiu Wang Source Type: research
Sandwich-like voltametric immunosensing of interleukin-8 based on β-cyclodextrin/carbon nanotubes and methylthionine chloride@UIO-66 framework
Anal Sci. 2024 Apr 25. doi: 10.1007/s44211-024-00574-y. Online ahead of print.ABSTRACTThe level of interleukin-8 (IL-8) in the body is an effective factor for the early diagnosis of acute tubular necrosis and oral tumor. In this work, a novel sandwich-like voltametric immunosensor (SVS) of IL-8 was constructed by preparing β-cyclodextrin/carbon nanotube (CD/CNT) to immobilize primary antibody (PAb) of IL-8 and UIO-66-NH2 MOFs structure to immobilize second antibody (SAb) and methylene blue (Mb) probe. In this designed SVS, the prepared CD/CNT nanohybrid with large surface area and conductivity can immobilize PAb via simpl...
Source: Anal Sci - April 25, 2024 Category: Chemistry Authors: Zhihua Zhou Jiajia Lin Daoping Yue Huaiyu Chen Sheng Chen Source Type: research
Synergistic antibacterial effect and mechanism between Cu < sub > 2 < /sub > O nanoparticles and quaternary ammonium salt in moisture-curable acrylic coatings
Colloids Surf B Biointerfaces. 2024 Apr 12;238:113914. doi: 10.1016/j.colsurfb.2024.113914. Online ahead of print.ABSTRACTCombining with various antibacterial mechanisms is the preferred strategy to fabricate coatings with effective antibacterial performance. Herein, Cu2O nanoparticles and dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride, a kind of quaternary ammonium salt (QAS), were simultaneously incorporated into a moisture-curable acrylic resin in order to achieve both contact-killing and release-killing abilities for antibacterial coatings. The surface morphology, surface composition and basic propert...
Source: Colloids and Surfaces - April 25, 2024 Category: Biotechnology Authors: Haofeng Xiao Shuxue Zhou Source Type: research
Molecules, Vol. 29, Pages 1983: High-Temperature Hydrothermal Extraction of Phenolic Compounds from Brewer & rsquo;s Spent Grain and Malt Dust Biomass Using Natural Deep Eutectic Solvents
This study proposes an innovative one-step hydrothermal extraction (HTE) at a high temperature (120 &deg;C), utilizing environmentally friendly acidic natural deep eutectic solvents (NADESs) to replace conventional harmful pre-treatment chemicals and organic solvents. Brewer&rsquo;s spent grain (BSG) and novel malt dust (MD) biomass sources, both obtained from beer production, were characterized and studied for their potential as PC sources. HTE, paired with mild acidic malic acid/choline chloride (MA) NADES, was compared against conventional (heated and stirred maceration) and modern (microwave-assisted ex...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Dries Bleus Heike Blockx Emma Gesquiere Peter Adriaensens Pieter Samyn Wouter Marchal Dries Vandamme Tags: Article Source Type: research
Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial
Recent randomized clinical trials suggest that the effect of using cetylpyridinium chloride (CPC) mouthwashes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in COVID-19 patients... (Source: BMC Oral Health)
Source: BMC Oral Health - April 25, 2024 Category: Dentistry Authors: Daisuke Onozuka, Satoko Takatera, Hiroo Matsuo, Hisao Yoshida, Shigeto Hamaguchi, Shungo Yamamoto, Ryuichi Minoda Sada, Koichiro Suzuki, Keiji Konishi and Satoshi Kutsuna Tags: Research Source Type: research
LncRNA PART1 Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating TFAP2C/DUSP5 Axis via miR-302a-3p
CONCLUSION: PART1 improved the autophagy and apoptosis in H/R-exposed AC16 cells through miR-302a-3p/TFAP2C/DUSP5 axis, which might provide novel targets for MIRI treatment.PMID:38654453 | DOI:10.4070/kcj.2023.0131 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Min Zeng Xin Wei Jinchao Zhou Siqi Luo Source Type: research
Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity
This study aimed to evaluate the effects of prednisolone treatment on epileptic seizures and investigate the effect of this drug on the bacterial diversity of the intestinal microbiota and markers of inflammatory processes in intestinal tissue. We used Male Wistar rat littermates (n = 31, 90-day-old) divided into four groups: positive control treated with 2 mg/kg of diazepam (n = 6), negative control treated with 0.9 g% sodium chloride (n = 6), and the remaining two groups were subjected to treatment with prednisolone, with one receiving 1 mg/kg (n = 9) and the other 5 mg/kg (n = 10). All administrations were performed int...
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Amanda Muliterno Domingues Louren ço de Lima Gabriel de Lima Rosa Edson Fernando M üller Guzzo Rafael Bremm Padilha Milena Conci de Araujo Rodrigo Costa da Silva Adriana Simon Coitinho Sueli Teresinha Van Der Sand Source Type: research
Triphenyltin chloride exposure inhibits meiotic maturation of mouse oocytes by disrupting cytoskeleton assembly and cell cycle progression
This study aimed to elucidate the mechanisms underlying the toxicological effects of TPTCL on oocytes. The obtained findings revealed that TPTCL exposure reduced polar body extrusion (PBE) and induced meiotic arrest. Mechanistically, TPTCL disrupted meiotic spindle assembly and chromosome alignment. Further analysis indicated a significant decrease in p-MAPK expression, and disturbances in the localization of Pericentrin and p-Aurora A in TPTCL exposed oocytes, which suggesting impaired microtubule organizing center (MTOC)function. Moreover, TPTCL exposure enhance microtubule acetylation and microtubule instability. Theref...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Cong Ma Hongzhen Ruan Huiru Cheng Zuying Xu Caiyun Wu Dan Liang Huifen Xiang Yunxia Cao Zhiming Ding Source Type: research
Impact of Combined Aerobic Training and Magnesium Supplementation on Serum Biomarkers and microRNA-155 and microRNA-21 Expression in Adipose Tissue of Type 2 Diabetic Rats: An Eight-Week Interventional Study
CONCLUSION: The combination of AT and Mg supplementation provides a synergistic effect that improves serum biomarkers and downregulates pro-inflammatory microRNAs in the VAT of T2DM rats. Meanwhile, Mg supplementation alone does not have a significant effect on pro-inflammatory microRNAs in the VAT. These findings suggest that such combined interventions could be a promising strategy for managing T2DM, potentially ameliorating inflammatory states and improving metabolic health.PMID:38658451 | DOI:10.1007/s12011-024-04186-5 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 24, 2024 Category: Biology Authors: Rasha Raed Hamid Rastegar Hoseini Hiwa Ahmed Rahim Source Type: research
LncRNA PART1 Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating TFAP2C/DUSP5 Axis via miR-302a-3p
CONCLUSION: PART1 improved the autophagy and apoptosis in H/R-exposed AC16 cells through miR-302a-3p/TFAP2C/DUSP5 axis, which might provide novel targets for MIRI treatment.PMID:38654453 | DOI:10.4070/kcj.2023.0131 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Min Zeng Xin Wei Jinchao Zhou Siqi Luo Source Type: research
Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity
This study aimed to evaluate the effects of prednisolone treatment on epileptic seizures and investigate the effect of this drug on the bacterial diversity of the intestinal microbiota and markers of inflammatory processes in intestinal tissue. We used Male Wistar rat littermates (n = 31, 90-day-old) divided into four groups: positive control treated with 2 mg/kg of diazepam (n = 6), negative control treated with 0.9 g% sodium chloride (n = 6), and the remaining two groups were subjected to treatment with prednisolone, with one receiving 1 mg/kg (n = 9) and the other 5 mg/kg (n = 10). All administrations were performed int...
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Amanda Muliterno Domingues Louren ço de Lima Gabriel de Lima Rosa Edson Fernando M üller Guzzo Rafael Bremm Padilha Milena Conci de Araujo Rodrigo Costa da Silva Adriana Simon Coitinho Sueli Teresinha Van Der Sand Source Type: research
Triphenyltin chloride exposure inhibits meiotic maturation of mouse oocytes by disrupting cytoskeleton assembly and cell cycle progression
This study aimed to elucidate the mechanisms underlying the toxicological effects of TPTCL on oocytes. The obtained findings revealed that TPTCL exposure reduced polar body extrusion (PBE) and induced meiotic arrest. Mechanistically, TPTCL disrupted meiotic spindle assembly and chromosome alignment. Further analysis indicated a significant decrease in p-MAPK expression, and disturbances in the localization of Pericentrin and p-Aurora A in TPTCL exposed oocytes, which suggesting impaired microtubule organizing center (MTOC)function. Moreover, TPTCL exposure enhance microtubule acetylation and microtubule instability. Theref...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Cong Ma Hongzhen Ruan Huiru Cheng Zuying Xu Caiyun Wu Dan Liang Huifen Xiang Yunxia Cao Zhiming Ding Source Type: research
Impact of Combined Aerobic Training and Magnesium Supplementation on Serum Biomarkers and microRNA-155 and microRNA-21 Expression in Adipose Tissue of Type 2 Diabetic Rats: An Eight-Week Interventional Study
CONCLUSION: The combination of AT and Mg supplementation provides a synergistic effect that improves serum biomarkers and downregulates pro-inflammatory microRNAs in the VAT of T2DM rats. Meanwhile, Mg supplementation alone does not have a significant effect on pro-inflammatory microRNAs in the VAT. These findings suggest that such combined interventions could be a promising strategy for managing T2DM, potentially ameliorating inflammatory states and improving metabolic health.PMID:38658451 | DOI:10.1007/s12011-024-04186-5 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 24, 2024 Category: Biology Authors: Rasha Raed Hamid Rastegar Hoseini Hiwa Ahmed Rahim Source Type: research
