Use of unlicensed drugs in a Swiss Pediatric University Hospital and associated prescribing error rates - a retrospective observational study
CONCLUSIONS: Unlicensed drugs are frequently prescribed in this paediatric hospital setting in Switzerland. Around every tenth prescription is an unlicensed drug. Because unlicensed drugs showed a significantly higher rate of prescribing errors, licensed drugs are favourable in terms of medication safety and should be prescribed whenever possible. If no licensed drug is available, imported drugs should be favoured over formula drugs due to lower prescribing error rates. To increase medication safety in paediatrics in Switzerland, efforts are necessary to increase the number of suitable licensed drug formulations for paedia...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Aylin Satir Miriam Pfiffner Christoph R Meier Angela Caduff Good Source Type: research
Untargeted LC-MS metabolomics reveals the metabolic responses in the Eriocheir sinensis gills exposed to salinity and alkalinity stress
This study investigated the metabolic changes in puberty-molting E. sinensis gills exposed to freshwater (FW), sodium chloride salinity of 5 ppt (SW), and carbonate alkalinity 10.00 mmol/L (AW) for 50 days using untargeted liquid chromatography-mass spectrometry metabolomics (LC-MS). A total of 5802 (positive-ion mode) and 6520 (negative-ion mode) peaks were extracted by LC-MS, respectively. A total of 188 (50 upregulated and 138 downregulated), 141 (94 upregulated and 47 downregulated), and 130 (87 upregulated and 43 downregulated) significantly regulated metabolites (SRMs) were observed in the FW-SW, FW-AW, and SW-AW tre...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 5, 2024 Category: Biochemistry Authors: Shihui Wang Yingying Song Liang Luo Rui Zhang Kun Guo Zhigang Zhao Source Type: research
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
CONCLUSIONS: Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.PMID:38578867 | DOI:10.1213/ANE.0000000000006932 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Lucas Carvalho Pereira Igor Carvalho Pereira Thamiris Dias Delfino Cabral Patricia Viana Arthur Mendon ça Ribeiro Sara Amaral Source Type: research
Use of unlicensed drugs in a Swiss Pediatric University Hospital and associated prescribing error rates - a retrospective observational study
CONCLUSIONS: Unlicensed drugs are frequently prescribed in this paediatric hospital setting in Switzerland. Around every tenth prescription is an unlicensed drug. Because unlicensed drugs showed a significantly higher rate of prescribing errors, licensed drugs are favourable in terms of medication safety and should be prescribed whenever possible. If no licensed drug is available, imported drugs should be favoured over formula drugs due to lower prescribing error rates. To increase medication safety in paediatrics in Switzerland, efforts are necessary to increase the number of suitable licensed drug formulations for paedia...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Aylin Satir Miriam Pfiffner Christoph R Meier Angela Caduff Good Source Type: research
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
CONCLUSIONS: Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.PMID:38578867 | DOI:10.1213/ANE.0000000000006932 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Lucas Carvalho Pereira Igor Carvalho Pereira Thamiris Dias Delfino Cabral Patricia Viana Arthur Mendon ça Ribeiro Sara Amaral Source Type: research
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
CONCLUSIONS: Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.PMID:38578867 | DOI:10.1213/ANE.0000000000006932 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Lucas Carvalho Pereira Igor Carvalho Pereira Thamiris Dias Delfino Cabral Patricia Viana Arthur Mendon ça Ribeiro Sara Amaral Source Type: research
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
CONCLUSIONS: Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.PMID:38578867 | DOI:10.1213/ANE.0000000000006932 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Lucas Carvalho Pereira Igor Carvalho Pereira Thamiris Dias Delfino Cabral Patricia Viana Arthur Mendon ça Ribeiro Sara Amaral Source Type: research
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
CONCLUSIONS: Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.PMID:38578867 | DOI:10.1213/ANE.0000000000006932 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Lucas Carvalho Pereira Igor Carvalho Pereira Thamiris Dias Delfino Cabral Patricia Viana Arthur Mendon ça Ribeiro Sara Amaral Source Type: research
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
CONCLUSIONS: Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.PMID:38578867 | DOI:10.1213/ANE.0000000000006932 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Lucas Carvalho Pereira Igor Carvalho Pereira Thamiris Dias Delfino Cabral Patricia Viana Arthur Mendon ça Ribeiro Sara Amaral Source Type: research
Zinc oxide nanoparticles influence on plant tolerance to salinity stress: insights into physiological, biochemical, and molecular responses
AbstractA slight variation in ecological milieu of plants, like drought, heavy metal toxicity, abrupt changes in temperature, flood, and salt stress disturbs the usual homeostasis or metabolism in plants. Among these stresses, salinity stress is particularly detrimental to the plants, leading to toxic effects and reduce crop productivity. In a saline environment, the accumulation of sodium and chloride ions up to toxic levels significantly correlates with intracellular osmotic pressure, and can result in morphological, physiological, and molecular alterations in plants. Increased soil salinity triggers salt stress signals ...
Source: Environmental Geochemistry and Health - April 5, 2024 Category: Environmental Health Source Type: research
Membrane-based inverse-transition purification facilitates a rapid isolation of various spider-silk elastin-like polypeptide fusion proteins from extracts of transgenic tobacco
Transgenic Res. 2024 Apr 4. doi: 10.1007/s11248-024-00375-z. Online ahead of print.ABSTRACTPlants can produce complex pharmaceutical and technical proteins. Spider silk proteins are one example of the latter and can be used, for example, as compounds for high-performance textiles or wound dressings. If genetically fused to elastin-like polypeptides (ELPs), the silk proteins can be reversibly precipitated from clarified plant extracts at moderate temperatures of ~ 30 °C together with salt concentrations > 1.5 M, which simplifies purification and thus reduces costs. However, the technologies developed around this mechani...
Source: Transgenic Research - April 4, 2024 Category: Genetics & Stem Cells Authors: H M Gruchow P Opdensteinen J F Buyel Source Type: research
Membrane-based inverse-transition purification facilitates a rapid isolation of various spider-silk elastin-like polypeptide fusion proteins from extracts of transgenic tobacco
Transgenic Res. 2024 Apr 4. doi: 10.1007/s11248-024-00375-z. Online ahead of print.ABSTRACTPlants can produce complex pharmaceutical and technical proteins. Spider silk proteins are one example of the latter and can be used, for example, as compounds for high-performance textiles or wound dressings. If genetically fused to elastin-like polypeptides (ELPs), the silk proteins can be reversibly precipitated from clarified plant extracts at moderate temperatures of ~ 30 °C together with salt concentrations > 1.5 M, which simplifies purification and thus reduces costs. However, the technologies developed around this mechani...
Source: Cell Research - April 4, 2024 Category: Cytology Authors: H M Gruchow P Opdensteinen J F Buyel Source Type: research
Dissolution of cellulose in imidazolium-based double salt ionic liquids
Int J Biol Macromol. 2024 Apr 2:131331. doi: 10.1016/j.ijbiomac.2024.131331. Online ahead of print.ABSTRACTThe dissolution of cellulose in double salt ionic liquids (DSILs) was studied in detail and compared with the dissolution in individual constituent ionic liquids (ILs). The DSILs, [C4mim](CH3CO2)xCl1-x (x is the mole fraction of the single component ILs), were synthesized using acetate and chloride salts of 1-butyl-3-methylimidazolium. These DSILs were then used for the investigation of the solubility of cellulose in the whole mole fraction range. Commercial cellulose (CC) powder, kraft pulp (KP), and prehydrolysis kr...
Source: International Journal of Biological Macromolecules - April 4, 2024 Category: Biochemistry Authors: M Mahbubur Rahman M Sarwar Jahan Md Mominul Islam Md Abu Bin Hasan Susan Source Type: research
Chloride ions in health and disease
Biosci Rep. 2024 Apr 4:BSR20240029. doi: 10.1042/BSR20240029. Online ahead of print.ABSTRACTChloride is a key anion involved in cellular physiology by regulating its homeostasis and rheostatic processes. Changes in cellular Cl- concentration result in differential regulation of cellular functions such as transcription and translation, post-translation modifications, cell cycle and proliferation, cell volume, and pH levels. In intracellular compartments, Cl- modulates the function of lysosomes, mitochondria, endosomes, phagosomes, the nucleus, and the endoplasmic reticulum. In extracellular fluid (ECF), Cl- is present in bl...
Source: Bioscience Reports - April 4, 2024 Category: Biomedical Science Authors: Satish K Raut Kulwinder Singh Shridhar Sanghvi Veronica Loyo-Celis Liyah Varghese Ekam R Singh Shubha Gururaja Rao Harpreet Singh Source Type: research
Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort
CONCLUSIONS: Our findings suggest that specific toxic air pollutants may be associated with increase breast cancer risk.PMID:38574449 | DOI:10.1016/j.ijheh.2024.114362 (Source: International Journal of Hygiene and Environmental health)
Source: International Journal of Hygiene and Environmental health - April 4, 2024 Category: Environmental Health Authors: Julia E Heck Di He Sam E Wing Beate Ritz Chandra D Carey Juan Yang Daniel O Stram Lo ïc Le Marchand Sungshim Lani Park Iona Cheng Anna H Wu Source Type: research
