Copper perchlorate catalyzed oxidative cyclisation of a novel bishydrazone ligand, formation of an unusual copper complex and in vitro biological implications
J Inorg Biochem. 2024 Mar 22;255:112538. doi: 10.1016/j.jinorgbio.2024.112538. Online ahead of print.ABSTRACTA novel hexadentate bishydrazone ligand, 1,10-bis(di(2-pyridyl)ketone) adipic acid dihydrazone (H2L1) is synthesized and characterized. With copper perchlorate as a catalytic oxidant, the ligand undergoes oxidative cyclisation and resulted in the formation of an unusual copper complex [Cu(L1a)2Cl]ClO4 (1), where L1a is 3-(2-pyridyl)triazolo[1,5-a]-pyridine. The Cu(II) complex was characterized physicochemically, while the molecular structure was confirmed by single crystal X- ray diffraction. In the complex cation, ...
Source: Journal of Inorganic Biochemistry - March 28, 2024 Category: Biochemistry Authors: Lakshmi V Menon E Manoj Source Type: research
Synthesis, antimicrobial, and in silico studies of c5'- < em > O < /em > -substituted cytidine derivatives: cinnamoylation leads to improvement of antimicrobial activity
In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N,N-dimethylformamide, and trimethylamine to obtain 5'-O-(cinnamoyl)cytidine, which was further treated with several acylating agents to obtain a series of 2',3'-di-O-acyl derivatives. The chemical structures of the synthesized compounds were established through spectral, analytical, and physicochemical techniques. In vitro antimicrobial efficacy was evaluated, and the antimicrobial effect was greater than that of the precursor compound; in particular, compound 3 exhibited the most promising activity. Cytotoxicity measurements revealed that t...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 28, 2024 Category: Biochemistry Authors: Tahmida Sultana Bhuiyan Mohamed A Said Md Z H Bulbul Sumeer Ahmed Ajmal R Bhat Mohammed Chalkha Sarkar M A Kawsar Source Type: research
Effect of a single small volume fluid bolus with balanced or un-balanced fluids on chloride and acid-base status: a prospective randomized pilot study (the FLURES-trial)
CONCLUSION: Even a single, small bolus of saline, administered to critically ill patients, causes a significant increase in chloride concentration and a decrease in apparent strong ion difference and base excess, and an increase in the number of patients developing hyperchloremia. No difference in effect on urinary output, blood pressure or vasopressor need was observed between the two groups.EUDRACT NUMBER: 2014-001005-41; date of registration: 28/10/2014.LOCAL EC APPROVAL: EC project number 2014/038.PMID:38546940 | DOI:10.1007/s40620-024-01912-z (Source: Journal of Nephrology)
Source: Journal of Nephrology - March 28, 2024 Category: Urology & Nephrology Authors: M Raes J A Kellum R Colman S Wallaert M Crivits F Viaene M Hemeryck D Benoit J Poelaert E Hoste Source Type: research
Efficient fluoride removal using nano MgO: mechanisms and performance evaluation
This study enhances our profound understanding of the defluorination effectiveness and mechanisms of nano MgO.PMID:38538999 | DOI:10.1007/s11356-024-33083-6 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 28, 2024 Category: Environmental Health Authors: BoWen Liu Li Ai Ming Lei Hongfei Lin Source Type: research
Congo red dye degradation using Fe-containing mineral as a reactive material derived from waste foundry dust
This study investigated the applicability of industrial waste. The high affinity of Fe-based products is widely used for industrial effluents because of their capability to oxidize contaminants. Waste foundry dust (WFD) is an Fe oxide that has been investigated as a potential reactive material that causes the generation of reactive oxidants. We aimed to investigate the physicochemical properties of WFD and the feasibility in the Fenton oxidation process. The WFD was used as a catalyst for removing Congo red (CR), to evaluate the generation of •OH and dissolution of Fe during the oxidation process. The linkage of •OH ge...
Source: Environmental Science and Pollution Research International - March 28, 2024 Category: Environmental Health Authors: Hyunsoo Kim Chulhyun Park Nagchoul Choi Kanghee Cho Source Type: research
