Clinical features, cerebrospinal fluid changes, and prognosis in Chinese patients with autoimmune encephalitis
ConclusionThere are differences in age, gender, clinical characteristics, and CSF results in different subtypes of AE. First-line therapy failure would have poor functional recovery, and delayed therapy would increase the risk of relapse. Chloride ion content and white blood cell count in cerebrospinal fluid are positively correlated with the patient's exacerbation and admission to ICU. These indicators have certain clinical value for the prognosis of AE patients. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 18, 2024 Category: Neurology Source Type: research
Ammonia-responsive chitosan/polymethacrylamide double network hydrogels with high-stretchability, fatigue resistance and anti-freezing for real-time chicken breast spoilage monitoring
Int J Biol Macromol. 2024 Apr 15:131617. doi: 10.1016/j.ijbiomac.2024.131617. Online ahead of print.ABSTRACTHydrogels are a promising option for detecting food spoilage in humid conditions, but current indicators are prone to mechanical flaws, posing a concern for packaging systems that require strong mechanical properties. Herein, a double network hydrogel was prepared by polymerizing methacrylamide in a chitosan system with aluminum chloride and glycerol. The resulting hydrogel demonstrated high stretchability (strain >1500 %), notch insensitivity, excellent fatigue resistance, and exceptional anti-freezing capabiliti...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Siyao Luo Chang-Ying Hu Xiaowen Xu Source Type: research
Exploring Bacillus mycoides PM35 efficacy in enhancing rice (Oryza sativa L.) response to different types of microplastics through gene regulation and cellular fractionation
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33229-6. Online ahead of print.ABSTRACTSoil contamination with microplastics (MPs) is a persistent threat to crop production worldwide. With a wide range of MP types, including polystyrene (PS), polyvinyl chloride (PVC) and polyethylene (PE), contaminating our environment, it is important to understand their impact on agricultural productivity. The present study was conducted to investigate the effects of different types of MPs (PS, PVC and PE) on various aspects of plant growth. Specifically, we examined growth and biomass, photosynthetic pigments, gas excha...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Dalal Nasser Binjawhar Rana M Alshegaihi Aishah Alatawi Muneefah Abdullah Alenezi Abida Parveen Muhammad Adnan Baber Ali Khalid Ali Khan Shah Fahad Eman Fayad Source Type: research
On the performance of Sargassum-derived calcium alginate ion exchange resins for Pb < sup > 2+ < /sup > adsorption: batch and packed bed applications
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33314-w. Online ahead of print.ABSTRACTDriven by climate change and human activity, Sargassum blooming rates have intensified, producing copious amount of the invasive, pelagic seaweed across the Caribbean and Latin America. Battery recycling and lead-smelter wastes have heavily polluted the environment and resulted in acute lead poisoning in children through widespread heavy metal contamination particular in East Trinidad. Our study details a comprehensive investigation into the use of Sargassum (S. natans), as a potential resource-circular feedstock for the...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Akeem Mohammed Chantal Mohammed Andreas Mautner Matika Kistow Pooran Chaitram Alexander Bismarck Keeran Ward Source Type: research
Compartmental neuronal degeneration in the ventral striatum induced by status epilepticus in young rats' brain in comparison with adults
Int J Dev Neurosci. 2024 Apr 17. doi: 10.1002/jdn.10331. Online ahead of print.ABSTRACTAccording to experimental and clinical studies, status epilepticus (SE) causes neurodegenerative morphological changes not only in the hippocampus and other limbic structures, it also affects the thalamus and the neocortex. In addition, several studies reported atrophy, metabolic changes, and neuronal degeneration in the dorsal striatum. The literature lacks studies investigating potential neuronal damage in the ventral component of the striatopallidal complex (ventral striatum [VS] and ventral pallidum) in SE experimentations. To better...
Source: International Journal of Developmental Neuroscience - April 17, 2024 Category: Neuroscience Authors: Azzat Al-Redouan Martin Salaj Hana Kubova Rastislav Druga Source Type: research
Uremia Impedes Skeletal Myocyte Myomixer Expression and Fusogenic Activity
In patients with chronic kidney disease (CKD), skeletal muscle mass and function are known to occasionally decline. However, the muscle regeneration and differentiation process in uremia has not been extensively studied. In mice with CKD induced by adenine-containing diet, the tibialis anterior muscle injured using a barium chloride injection method recovered poorly as compared to control mice. In the cultured murine skeletal myocytes, stimulation with indoxyl sulfate (IS), a representative uremic toxin, morphologically jeopardized the differentiation, which was counteracted by L-ascorbic acid (L-AsA) treatment. (Source: A...
Source: American Journal of Pathology - April 17, 2024 Category: Pathology Authors: Takaaki Higashihara, Motoki Odawara, Hiroshi Nishi, Takehito Sugasawa, Yumika Suzuki, Satoshi Kametaka, Reiko Inagi, Masaomi Nangaku Tags: Regular Article Source Type: research
Cardioprotective Effects of Aloysia polystachya Essential Oil on a Rat Model with Multiple Cardiovascular Risk Factors
This study aimed to investigate the protective effects of the essential oil extracted from the leaves of A. polystachya in a rat model that simulates multiple cardiovascular risk factors. We evaluate the acute toxicity, as well as the cardioprotective effects, by giving different doses of A. polystachya essential oil (1.47 mg/kg, 4.40 mg/kg, and 13.20 mg/kg) over a period of 42 days. The control group was treated with rosuvastatin (5 mg/kg). At the end of the treatments, the renal function, electrocardiography, blood pressure, vascular reactivity, serum biochemical profile, and organ histopathology were evaluated...
Source: Planta Medica - April 17, 2024 Category: Drugs & Pharmacology Authors: Moreno, Karyne Garcia Tafarelo Marques, Aline Aparecida Macedo da Silva, Gabriela Pereira Bertoncelo, Luana Ale Pessoal, Luciane Barbosa Gon çalves, Larissa Dantas dos Santos, Ariany Carvalho Souza, Roosevelt Isa ías Carvalho Silva, Denise Brentan Gaspa Tags: Original Papers Source Type: research
Submicron aerosol pollution in Greater Cairo (Egypt): A new type of urban haze?
Environ Int. 2024 Mar 27;186:108610. doi: 10.1016/j.envint.2024.108610. Online ahead of print.ABSTRACTGreater Cairo, the largest megacity of the Middle East North Africa (MENA) region, is currently suffering from major aerosol pollution, posing a significant threat to public health. However, the main sources of pollution remain insufficiently characterized due to limited atmospheric observations. To bridge this knowledge gap, we conducted a continuous 2-month field study during the winter of 2019-2020 at an urban background site, documenting for the first time the chemical and physical properties of submicron (PM1) aerosol...
Source: Environment International - April 16, 2024 Category: Environmental Health Authors: Aliki Christodoulou Spyros Bezantakos Efstratios Bourtsoukidis Iasonas Stavroulas Michael Pikridas Konstantina Oikonomou Minas Iakovides Salwa K Hassan Mohamed Boraiy Mostafa El-Nazer Ali Wheida Magdy Abdelwahab Roland Sarda-Est ève Martin Rigler Giorgos Source Type: research
< em > Z < /em > -selective radical difunctionalization of aromatic alkynes: synthesis of multi-substituted triarylethenes
Chem Commun (Camb). 2024 Apr 16. doi: 10.1039/d4cc01315h. Online ahead of print.ABSTRACTAn efficient method for the radical difunctionalization of aromatic alkynes has been developed, resulting in the synthesis of a range of valuable triarylethenes. This approach utilizes strategically designed aryldiazonium salts with tertiary alcohol substitution as bifunctional reagents, along with cost-effective cuprous chloride as a catalyst. The method demonstrates remarkable Z-selectivity and is capable of gram-scale preparation. Additionally, a novel spin-trapping reagent has been developed based on the synthesized product.PMID:386...
Source: Chemical Communications - April 16, 2024 Category: Chemistry Authors: Xinxin Wang Jie Wang Meishan Ji Xinxin Wu Chen Zhu Source Type: research
Anion-Coordination Foldamer-Based Polymer Network: from Molecular Spring to Elastomer
Angew Chem Int Ed Engl. 2024 Apr 16:e202400989. doi: 10.1002/anie.202400989. Online ahead of print.ABSTRACTFoldamer is a scaled-down version of coil spring, which can absorb and release energy by conformational change. Here, polymer networks with high-density of molecular springs were developed by employing anion-coordination-based foldamers as the monomer. The coiling of the foldamer is controlled by oligourea ligands coordinating to chloride ions; subsequently, the folding and unfolding of foldamer conformations endow the polymer network with excellent energy dissipation and toughness. The mechanical performance of the c...
Source: Angewandte Chemie - April 16, 2024 Category: Chemistry Authors: Jiangping Qin Yongming Wang Tian Wang Na Wang Wenhua Xu Lin Cheng Wei Yu Xuzhou Yan Lingyan Gao Bo Zheng Biao Wu Source Type: research
Selective Arylation of RNA 2'-OH Groups via SNAr Reaction with Trialkylammonium Heterocycles
Angew Chem Int Ed Engl. 2024 Apr 16:e202403496. doi: 10.1002/anie.202403496. Online ahead of print.ABSTRACTSmall-molecule reactions at the 2'-OH groups of RNA enable useful applications for transcriptome technology and biology. To date, all reactions have involved carbonyl acylation and mechanistically related sulfonylation, limiting the types of modifications and properties that can be achieved. Here we report that electron-deficient heteroaryl species selectively react with 2'-OH groups of RNA in water via SNAr chemistry. In particular, trialkyl-ammonium (TAA)-activated aromatic heterocycles, prepared in one step from ar...
Source: Angewandte Chemie - April 16, 2024 Category: Chemistry Authors: Sayantan Chatterjee Lu Xiao Wenrui Zhong Sheng Feng Eric T Kool Source Type: research
Submicron aerosol pollution in Greater Cairo (Egypt): A new type of urban haze?
Environ Int. 2024 Mar 27;186:108610. doi: 10.1016/j.envint.2024.108610. Online ahead of print.ABSTRACTGreater Cairo, the largest megacity of the Middle East North Africa (MENA) region, is currently suffering from major aerosol pollution, posing a significant threat to public health. However, the main sources of pollution remain insufficiently characterized due to limited atmospheric observations. To bridge this knowledge gap, we conducted a continuous 2-month field study during the winter of 2019-2020 at an urban background site, documenting for the first time the chemical and physical properties of submicron (PM1) aerosol...
Source: Environment International - April 16, 2024 Category: Environmental Health Authors: Aliki Christodoulou Spyros Bezantakos Efstratios Bourtsoukidis Iasonas Stavroulas Michael Pikridas Konstantina Oikonomou Minas Iakovides Salwa K Hassan Mohamed Boraiy Mostafa El-Nazer Ali Wheida Magdy Abdelwahab Roland Sarda-Est ève Martin Rigler Giorgos Source Type: research
Depth-Specific Hypoxic Responses to Spreading Depolarizations in Gyrencephalic Swine Cortex Unveiled by Photoacoustic Imaging
AbstractSpreading depolarizations (SDs) are a marker of brain injury and have a causative effect on ischemic lesion progression. The hemodynamic responses elicited by SDs are contingent upon the metabolic integrity of the affected tissue, with vasoconstrictive reactions leading to pronounced hypoxia often indicating poor outcomes. The stratification of hemodynamic responses within different cortical layers remains poorly characterized. This pilot study sought to elucidate the depth-specific hemodynamic changes in response to SDs within the gray matter of the gyrencephalic swine brain. Employing a potassium chloride –indu...
Source: Translational Stroke Research - April 16, 2024 Category: Neurology Source Type: research
Skeletal rearrangement of 6,8-dioxabicyclo[3.2.1]octan-4-ols promoted by thionyl chloride or Appel conditions
Abstract
A skeletal rearrangement of a series of 6,8-dioxabicyclo[3.2.1]octan-4-ols has been developed using SOCl2 in the presence of pyridine. An oxygen migration from C5 to C4 was observed when the C4 alcohols were treated with SOCl2/pyridine, giving a 2-chloro-3,8-dioxabicyclo[3.2.1]octane ring-system via the chlorosulfite intermediate. Analogous allylic alcohols with endocyclic and exocyclic unsaturations underwent chlorination without rearrangement due to formation of allylic cations. The rearrangement was also demonstrated using Appel conditions, which gave similar results via the alkoxytriphenylphosphonium intermedi...
Source: Beilstein Journal of Organic Chemistry - April 16, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: bicyclic ring cyrene levoglucosenone rearrangement thionyl chloride Full Research Paper Source Type: research
