487. Suicide Methods in Crisis Text Line Texters: Use of Natural Language Processing (NLP) to Understand Gender Differences in Children and Adolescents
Understanding which methods suicidal individuals consider is important for prevention and intervention. There are known differences between men and women in methods used in suicide attempts and in deaths by suicide. Less is known about when these gender differences emerge developmentally. In young people experiencing suicidal crises, we analyzed planned suicide methods. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ignacio Tripodi, Greg Buda, Lili T örök, Margaret Meagher, Elizabeth Olson Source Type: research
365. Prospective Biomarkers of Posttraumatic Stress Disorder in Children and Adolescents: A Systematic Review
Children and young people (CYP) exposed to trauma are vulnerable to developing posttraumatic stress disorder (PTSD), which can present a significant threat to a young person ’s developmental trajectory. Identification of biomarkers prospectively associated with onset and progression of PTSD will be essential in identifying CYP vulnerable to persistent symptoms, and the mechanisms by which risk is conferred. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Tamsin Sharp, Megan Bailey, Chloe Burke, Sarah Halligan Source Type: research
277. Permissive Parenting Mediates the Association Between Maternal Depression and Anhedonia in Children
Anhedonia, the inability to experience pleasure, has been gaining traction as one of the key neurobiological manifestations that underpin a range of psychiatric disorders, including depression and schizophrenia. Measures of anhedonia, rather than the overarching clinical diagnoses, could provide unique insights into the underlying neural and developmental pathways. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Aisleen M.A. Manahan, Shi Yu Chan, Zhen Ming Ngoh, Jasmine Chuah, Michael J. Meaney, Ai Peng Tan, Michelle Z.L. Kee, Pei Huang Source Type: research
303. Functional Brain Mapping and Decoding With High-Density Diffuse Optical Tomography and Naturalistic Stimuli in Adults and Young Children
Studies of early brain development and clinical applications of functional neuroimaging have been constrained by mainstream neuroimaging approaches. MRI presents logistical challenges for imaging in young children and at the bedside, while alternative modalities like functional near-infrared spectroscopy have traditionally lacked image quality due to sparse sampling. We developed and evaluated high-density diffuse optical tomography (HD-DOT) as a high-performance optical neuroimaging method for mapping and decoding brain function in adults and young children viewing naturalistic stimuli. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kalyan Tripathy, Morgan Fogarty, Zachary Markow, Alexandra Svoboda, Mariel Schroeder, Sean Rafferty, Andrew Fishell, Edward Richter, Jason Trobaugh, Christopher Smyser, Adam Eggebrecht, Bradley Schlaggar, Joseph Culver Source Type: research
81. Nucleus Accumbens Volume Mediates the Association Between Prenatal Adversity and Attention Problems in Youth
The prenatal environment plays an important and enduring role in children ’s development. Exposure to adversity during the prenatal period is associated with children’s cognitive and emotional difficulties; the neurobiological pathways underlying these associations, however, are not yet clear. Given the central role of the nucleus accumbens (NAcc) in reward processing , we examined here whether NAcc volume at age six mediates the relation between prenatal adversity and subsequent attention problems in offspring. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Chase Antonacci, Jessica L. Buthmann, Lauren Borchers, Ai Peng Tan, Michael Meaney, Ian H. Gotlib Source Type: research
90. Social and Joint Attention During Shared Book Reading in Young Autistic Children: A Potential Marker for Social Development and Response to Oxytocin Social Interventions
Atypical patterns of social engagement and joint attention behaviors are diagnostic criteria for autism. Experimental tasks using eye tracking methodologies have, however, shown inconsistent results. The development of tasks with greater ecological validity with relevance for developmentally appropriate social milestones have been identified as important for the field and to be trialed for detecting response in intervention trials. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kelsie Boulton, Zahava Ambarchi, Rinku Thapa, Joanne Arciuli, Marilena DeMayo, Emma Thomas, Ian Hickie, Adam Guastella Source Type: research
375. Brain Activity During Childhood May Predict Future PTSD Symptoms in Early Adolescent Females, but Not Males: Insights From a Longitudinal Study
Trauma exposure during childhood may alter brain activity associated with inhibitory control, leading to an increased vulnerability to post-traumatic stress disorder (PTSD). Furthermore, there may be developmental sex differences related to this susceptibility. We used longitudinal data in trauma-exposed children to investigate inhibitory control and future PTSD symptomatology. We hypothesized that a) differential patterns of brain activation at Visit 1 would be associated with increased PTSD symptoms 2 years later (Visit 2), and b) that these patterns would differ between males and females. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Manessa Riser, Charis Wiltshire, William Davie, Mariam Reda, John France, Tamera Burnett, Cassandra Wanna, Sterling Winters, Anais Stenson, Tanja Jovanovic Source Type: research
364. Timing of Exposure to Childhood Maltreatment Differentially Impacts Brain Age Acceleration Later in Life: Evidence for Sensitive Periods
Experiencing adversity early in life, particularly in the form of childhood maltreatment, is a significant risk factor for developing neuropsychiatric disorders later in life. Further, previous investigations have shown that childhood maltreatment has significant influences on both the structure and functioning of the brain that extend well into adulthood. Brain age, in particular, serves as a useful metric for quantifying the neurobiological consequences of childhood trauma. Although the effects of trauma on brain development can be largely dependent upon the age at which the individual experiences the trauma in question,...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Leland Fleming, Kyoko Ohashi, Seyma Katrinli, Alicia Smith, Michelle Bosquet Enlow, Karlen Lyons-Ruth, Martin Teicher, Torsten Klengel, Kerry Ressler Source Type: research
345. Childhood Trauma and Emotional Neglect Impairs the Adolescent Development of Gray Matter Microstructure
Early life adversity (ELA; childhood trauma, abuse and neglect) impacts the development of brain macrostructure, including cortical thickness and (sub)cortical volumes as measured using MRI. However, less is known about gray matter microstructure, including myelination, with preliminary animal and post-mortem human studies suggesting less myelination in adulthood after ELA. Here, we present the first longitudinal study of ELA and brain microstructure in adolescence. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Anders Thorsen, Florence Boehmisch, Dag Aln æs, Andreas Dahl, Lars T. Westlye, Olga Therese Ousdal Source Type: research
292. A Multi-Modal Neuroimaging-Based Brain Age Model From Early to Mid-Childhood
Early life experiences shape neurodevelopment, which predicts later life outcomes. Neuroimaging-based brain age models show associations with outcomes at the individual level, where deviations from expected brain age represent disruptions to typical development. While the early to mid-childhood period is widely acknowledged as a period of high plasticity, normative neurodevelopmental trajectories for this critical period are not well understood. We built brain age models over ages 4.4 to 8.0 years and assessed whether the inclusion of multi-modal neuroimaging data improved model performance. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Shi Yu Chan, Pei Huang, Zhen Ming Ngoh, Janice J.Y. Lee, Jasmine Chuah, Aisleen M.A. Manahan, Marielle V. Fortier, Dennis Wang, Michael J. Meaney, Ai Peng Tan Source Type: research
305. Microbiome-Gut-Brain Axis and Internalizing in Early Childhood
Internalizing disorders have developmental origins, but little is known about how microbiome-gut-brain axis development contributes to internalizing symptoms in childhood. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Francesca Querdasi, Jessica Uy, Jennifer Labus, Ai Peng Tan, Birit F.P. Broekman, Peter D. Gluckman, Yap Seng Chong, Helen Chen, Marielle Fortier, Lourdes Mary Daniel, Fabian Yap, Johan G. Ericksson, Shirong Cai, Mary Foong-Fong Chong, Jia Ying Toh, Keith Source Type: research
309. Stability of Limbic Structure Alteration in Adolescents Reporting Childhood Maltreatment
Childhood maltreatment is related to pervasive developmental consequences and structural alterations in adult limbic regions. However, the consequences for general-population adolescents are unclear, as most studies concern clinical samples. In addition, there are no longitudinal studies on the effects of maltreatment on the adolescent brain structure. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Julia Ruiz-Fern ández, Aveline Aouidad, Marie-Laure Paillère Martinot, Jean-Luc Martinot, David Cohen, Eric Artiges, IMAGEN consortium Source Type: research
310. Higher Infant Cortisol Levels Associated With Maternal Childhood Neglect and Larger Limbic Volumes
This study examined whether a) maternal childhood abuse or neglect is associated with infant cortisol output, b) infant cortisol is associated with infant limbic brain volumes, and c) infant cortisol mediates any relation between maternal childhood maltreatment and infant limbic brain volumes. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Miriam Chasson, Jennifer Khoury, Banu Ahtam, Leland Fleming, Yangming Ou, Michelle Bosquet Enlow, Ellen Grant, Karlen Lyons-Ruth Source Type: research
318. Intergenerational Stress Moderates Child Brain Development
Intergenerational stress (IGS) is the transfer of the physiological and behavioral consequences of stress from one generation to the next. Data suggest that IGS could amplify the risk for psychiatric disorders in offspring. Herein we sought to identify some of the neurobiological bases of IGS by applying a whole brain analytic approach to resting state fMRI data collected from mother-child dyads, which could be the basis for the development of novel, brain-targeted prevention strategies for childhood psychiatric disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nicholas Bustos, Sydney Taylor, Sarah Bennett, Martine Fontaine, Catherine Monk, Marisa Spann, Rachel Marsh Source Type: research
Nonword Repetition in Children With Developmental Language Disorder: Revisiting the Case of Cantonese
CONCLUSIONS: NWR can capture TD/DLD group differences in Cantonese-speaking children. Lexicality and sublexicality effects must be considered in designing NWR stimuli for TD/DLD group differentiation. Future studies should replicate the present study on a larger sample size and a younger population as well as examine the diagnostic accuracy of this NWR test.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25529371.PMID:38683057 | DOI:10.1044/2024_JSLHR-22-00397 (Source: Journal of speech, language, and hearing research : JSLHR)
Source: Journal of speech, language, and hearing research : JSLHR - April 29, 2024 Category: Speech-Language Pathology Authors: Nga Ching Fu Si Chen Kamila Poli šenská Angel Chan Rachel Kan Shula Chiat Source Type: research
