292. A Multi-Modal Neuroimaging-Based Brain Age Model From Early to Mid-Childhood

Early life experiences shape neurodevelopment, which predicts later life outcomes. Neuroimaging-based brain age models show associations with outcomes at the individual level, where deviations from expected brain age represent disruptions to typical development. While the early to mid-childhood period is widely acknowledged as a period of high plasticity, normative neurodevelopmental trajectories for this critical period are not well understood. We built brain age models over ages 4.4 to 8.0 years and assessed whether the inclusion of multi-modal neuroimaging data improved model performance.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Shi Yu Chan, Pei Huang, Zhen Ming Ngoh, Janice J.Y. Lee, Jasmine Chuah, Aisleen M.A. Manahan, Marielle V. Fortier, Dennis Wang, Michael J. Meaney, Ai Peng Tan Source Type: research