375. Brain Activity During Childhood May Predict Future PTSD Symptoms in Early Adolescent Females, but Not Males: Insights From a Longitudinal Study

Trauma exposure during childhood may alter brain activity associated with inhibitory control, leading to an increased vulnerability to post-traumatic stress disorder (PTSD). Furthermore, there may be developmental sex differences related to this susceptibility. We used longitudinal data in trauma-exposed children to investigate inhibitory control and future PTSD symptomatology. We hypothesized that a) differential patterns of brain activation at Visit 1 would be associated with increased PTSD symptoms 2 years later (Visit 2), and b) that these patterns would differ between males and females.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Manessa Riser, Charis Wiltshire, William Davie, Mariam Reda, John France, Tamera Burnett, Cassandra Wanna, Sterling Winters, Anais Stenson, Tanja Jovanovic Source Type: research