345. Childhood Trauma and Emotional Neglect Impairs the Adolescent Development of Gray Matter Microstructure

Early life adversity (ELA; childhood trauma, abuse and neglect) impacts the development of brain macrostructure, including cortical thickness and (sub)cortical volumes as measured using MRI. However, less is known about gray matter microstructure, including myelination, with preliminary animal and post-mortem human studies suggesting less myelination in adulthood after ELA. Here, we present the first longitudinal study of ELA and brain microstructure in adolescence.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research