Gut microbiota is necessary for pair-housing to protect against post-stroke depression in mice
Exp Neurol. 2024 May 22:114834. doi: 10.1016/j.expneurol.2024.114834. Online ahead of print.ABSTRACTThe goal of this study is to investigate the role of microbiota-gut-brain axis involved in the protective effect of pair-housing on post-stroke depression (PSD). PSD model was induced by occluding the middle cerebral artery (MCAO) plus restraint stress for four weeks. At three days after MCAO, the mice were restrained 2 h per day. For pair-housing (PH), each mouse was pair housed with a healthy isosexual cohabitor for four weeks. While in the other PH group, their drinking water was replaced with antibiotic water. On day 35 ...
Source: Experimental Neurology - May 24, 2024 Category: Neurology Authors: Su-Ting Jiang Yao-Huan Sun Ya Li Meng-Qing Wang Xu-Yang Wang Yin-Feng Dong Source Type: research
Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study
CONCLUSION: This study identifies C-C motif chemokine 4 and glial cell line-derived neurotrophic factor as potential protective biomarkers for TAO, whereas C-C motif chemokine 23 emerges as a suggestive risk marker. These findings elucidate potential causal relationships and highlight the significance of these proteins in the pathogenesis and prospective therapeutic strategies for TAO.PMID:38788766 | DOI:10.1055/s-0044-1786809 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 24, 2024 Category: Hematology Authors: Bihui Zhang Rui He Ziping Yao Pengyu Li Guochen Niu Ziguang Yan Yinghua Zou Xiaoqiang Tong Min Yang Source Type: research
Scottish Intercollegiate Guidelines Network (SIGN) Guidance on Dementia. The investigation of suspected dementia (SIGN 168) with focus on biomarkers
Thromb Haemost. 2024 May 24. doi: 10.1055/a-2332-6426. Online ahead of print.ABSTRACTThis is an executive summary of the recent guidance produced by the SIGN dementia guideline group with regards to the investigation of suspected dementia. This is a sub-section of the broader SIGN 168 guideline released in November 2023. The guideline group included clinicians with expertise in Old Age Psychiatry, Neurology, Radiology and Nuclear Medicine supported by colleagues from the SIGN and Healthcare Improvement Scotland (HIS) teams. There was representation from carers and support organisations with experience of dementia, to ensur...
Source: Thrombosis and Haemostasis - May 24, 2024 Category: Hematology Authors: Graham Andrew Mackay Claire Gall Ravi Jampana Carolyn Sleith Gregory Lip Source Type: research
Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats
CONCLUSIONS: The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.PMID:38789891 | DOI:10.1007/s43440-024-00604-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 24, 2024 Category: Drugs & Pharmacology Authors: Francesca Frescura Tibor Stark Edoardo Tiziani Serena Di Martino Jana Ruda-Kucerova Filippo Drago Luca Ferraro Vincenzo Micale Sarah Beggiato Source Type: research
Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT)
Eur J Pharm Sci. 2024 May 23;199:106803. doi: 10.1016/j.ejps.2024.106803. Online ahead of print.ABSTRACTThere is considerable evidence from the literature that psychedelics, such as N,N-dimethyltryptamine (DMT), are safe and effective treatments for depression. However, clinical administration to induce psychedelic effects and expensive psychotherapy-assisted treatments likely limit accessibility to the average patient. There is emerging evidence that DMT promotes positive behavioral changes in vivo at sub-hallucinogenic dosages, and depending on the target indication, subjecting patients to high, bolus dosages may not be ...
Source: European Journal of Pharmaceutical Sciences - May 24, 2024 Category: Drugs & Pharmacology Authors: Christopher G Witowski Mika R Hess Nate T Jones Molly C Pellitteri Hahn John Razidlo Riya Bhavsar Christina Beer Natalie Gonzalez-Velazquez Cameron O Scarlett Cody J Wenthur Jacqueline L von Salm Source Type: research
Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients
Neurobiol Aging. 2024 May 18;140:130-139. doi: 10.1016/j.neurobiolaging.2024.05.008. Online ahead of print.ABSTRACTIn older patients, delirium after surgery is associated with long-term cognitive decline (LTCD). The neural substrates of this association are unclear. Neurodegenerative changes associated with dementia are possible contributors. We investigated the relationship between brain atrophy rates in Alzheimer's disease (AD) and cognitive aging signature regions from magnetic resonance imaging before and one year after surgery, LTCD assessed by the general cognitive performance (GCP) score over 6 years post-operativel...
Source: Neurobiology of Aging - May 24, 2024 Category: Geriatrics Authors: Michele Cavallari Alexandra Touroutoglou Yuta Katsumi Tamara G Fong Eva Schmitt Thomas G Travison Mouhsin M Shafi Towia A Libermann Edward R Marcantonio David C Alsop Richard N Jones Sharon K Inouye Bradford C Dickerson SAGES study group Source Type: research
Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain
This study utilized post-mortem brain tissue from rhesus monkeys that died after decades on a 30 % reduced calorie diet. We found that CR subjects had significantly fewer cells with oxidative damage within the corpus callosum and the cingulum bundle. Oligodendrocytes specifically showed the greatest response to CR with a robust reduction in DNA damage. Additionally, we observed alterations in microglia morphology with CR subjects having a higher proportion of ramified, homeostatic microglia and fewer pro-inflammatory, hypertrophic microglia relative to controls. Furthermore, we determined that the observed attenuation in d...
Source: Neurobiology of Aging - May 24, 2024 Category: Geriatrics Authors: Ana T Vitantonio Christina Dimovasili Farzad Mortazavi Kelli L Vaughan Julie A Mattison Douglas L Rosene Source Type: research
Concerning neuromodulation as treatment of neurological and neuropsychiatric disorder: Insights gained from selective targeting of the subthalamic nucleus, para-subthalamic nucleus and zona incerta in rodents
Neuropharmacology. 2024 May 22:110003. doi: 10.1016/j.neuropharm.2024.110003. Online ahead of print.ABSTRACTNeuromodulation such as deep brain stimulation (DBS) is advancing as a clinical intervention in several neurological and neuropsychiatric disorders, including Parkinson´s disease, dystonia, tremor, and obsessive-compulsive disorder (OCD) for which DBS is already applied to alleviate severely afflicted individuals of symptoms. Tourette syndrome and drug addiction are two additional disorders for which DBS is in trial or proposed as treatment. However, some major remaining obstacles prevent this intervention from reac...
Source: Neuropharmacology - May 24, 2024 Category: Drugs & Pharmacology Authors: Alessia Ricci Eleonora Rubino Gian Pietro Serra Åsa Wallén-Mackenzie Source Type: research
Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice
In this study we investigated whether DLT ameliorated PIPN-like symptoms in mice and the underlying mechanisms. PIPN was induced in male mice by injection of PTX (4 mg/kg, i.p.) every other day for 4 times. The mice exhibited 50% reduction in mechanical threshold, paw thermal response latency and paw cold response latency compared with control mice. PIPN mice were treated with DLT (10, 20 mg/kg, i.p.) 30 min before each PTX administration in the phase of establishing PIPN mice model and then administered daily for 4 weeks after the model was established. We showed that DLT administration dose-dependently elevated the mecha...
Source: Acta Pharmacologica Sinica - May 24, 2024 Category: Drugs & Pharmacology Authors: Jian Lu Xue-Jian Zhao Yuan Ruan Xiao-Jing Liu Xuan Di Rui Xu Jia-Ying Wang Min-Yi Qian Hong-Ming Jin Wen-Jun Li Xu Shen Source Type: research
Investigating GABA neuron-specific androgen receptor knockout in two hyperandrogenic models of PCOS
Endocrinology. 2024 May 23:bqae060. doi: 10.1210/endocr/bqae060. Online ahead of print.ABSTRACTAndrogen excess is a hallmark feature of polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility. Clinical and preclinical evidence links developmental or chronic exposure to hyperandrogenism with programming and evoking the reproductive and metabolic traits of PCOS. While critical androgen targets remain to be determined, central GABAergic neurons are postulated to be involved. Here, we tested the hypothesis that androgen signalling in GABAergic neurons is critical in PCOS pathogenesis in two well-chara...
Source: Endocrinology - May 24, 2024 Category: Endocrinology Authors: Irene E Sucquart Chris Coyle Valentina Rodriguez Paris Melanie Prescott Kelly A Glendining Kyoko Potapov Denovan P Begg Robert B Gilchrist Kirsty A Walters Rebecca E Campbell Source Type: research
Bibliometric and visualized analysis of the applications of exosomes based drug delivery
Biomed Pharmacother. 2024 May 23;176:116803. doi: 10.1016/j.biopha.2024.116803. Online ahead of print.ABSTRACTExosomes, endogenous vesicles secreted by cells, possess unique properties like high biocompatibility, low immunogenicity, targeting ability, long half-life, and blood-brain barrier permeability. They serve as crucial intercellular communication vectors in physiological processes and disease occurrence. Our comprehensive analysis of exosome-based drug delivery research from 2013 to 2023 revealed 2,476 authors from 717 institutions across 33 countries. Keyword clustering identified five research areas: drug delivery...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2024 Category: Drugs & Pharmacology Authors: Bohua Wei Haonan Huang Qian Cao Xiaoyu Song Zhichang Zhang Source Type: research
Pharmacological inhibition of PDGF-C/neuropilin-1 interaction: A novel strategy to reduce melanoma metastatic potential
Biomed Pharmacother. 2024 May 23;176:116766. doi: 10.1016/j.biopha.2024.116766. Online ahead of print.ABSTRACTActivation of neuropilin-1 (NRP-1) by platelet derived growth factor (PDGF)-C sustains melanoma invasiveness. Therefore, in the search of novel agents capable of reducing melanoma spreading, PDGF-C/NRP-1 interaction was investigated as a potential druggable target. Since the PDGF-C region involved in NRP-1 binding is not yet known, based on the sequence and structural homology between PDGF-C and vascular endothelial growth factor-A (VEGF-A), we hypothesized that the NRP-1 b1 domain region involved in the interactio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2024 Category: Drugs & Pharmacology Authors: Claudia Ceci Federica Ruffini Mattia Falconi Maria Grazia Atzori Andrea Falzon Flavia Lozzi Federico Iacovelli Stefania D'Atri Grazia Graziani Pedro Miguel Lacal Source Type: research
A peripheral system disease-Pulmonary hypertension
Biomed Pharmacother. 2024 May 22;175:116787. doi: 10.1016/j.biopha.2024.116787. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a cardiovascular disorder characterized by substantial morbidity and mortality rates. It is a chronic condition characterized by intricate pathogenesis and uncontrollable factors. We summarized the pathological effects of estrogen, genetics, neuroinflammation, intestinal microbiota, metabolic reorganization, and histone modification on PH. PH is not only a pulmonary vascular disease, but also a systemic disease. The findings emphasize that the onset of PH is not exclusively confined t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2024 Category: Drugs & Pharmacology Authors: Yang Sun Chen Chen Qian Yan Siying Wang Yong Tan Junpeng Long Yuting Lin Shuangcheng Ning Jin Wang Shusheng Zhang Qidi Ai Shasha Liu Source Type: research
Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a/LC3 pathway
In this study, we determined changes in NAMPT on cerebral ischemic injuries with diabetes using a db/db mouse model of type 2 diabetes and then identified the underlying mechanisms using Neuro2a cells. The expression of inflammatory cytokine mRNAs was increased in db/db and db/+ middle cerebral artery occlusion and reperfusion (MCAO/R) mice. Although NeuN-positive cells were decreased after MCAO/R, the number of NAMPT and NeuN double-positive cells in NeuN-positive neuronal cells increased in db/db MCAO/R mice. Next, the role of NAMPT in Neuro2a cells under conditions of high glucose (HGC) and oxygen-glucose deprivation (O...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2024 Category: Drugs & Pharmacology Authors: Yui Iwatani Hideki Hayashi Haruno Oba Maho Oba Ann Sawamura Yoshiyuki Moriyama Norio Takagi Source Type: research
"Status trigeminal neuralgia": Analysis of 39 cases and proposal for diagnostic criteria
CONCLUSION: STN is a rare clinical presentation of TN. We proposed criteria and a new denomination for this condition.PMID:38789382 | DOI:10.1016/j.neurol.2024.03.014 (Source: Revue Neurologique)
Source: Revue Neurologique - May 24, 2024 Category: Neurology Authors: Z Poullet S Redon R Gravier-Dumonceau A Donnet Source Type: research
