Synaptic pruning in schizophrenia is not classical
Brain Behav Immun. 2024 May 22:S0889-1591(24)00421-5. doi: 10.1016/j.bbi.2024.05.033. Online ahead of print.NO ABSTRACTPMID:38788966 | DOI:10.1016/j.bbi.2024.05.033 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 24, 2024 Category: Neurology Authors: Agnieszka Kalinowski Alexander E Urban Source Type: research
Virtual reality exposure therapy reduces inflammation and symptoms in social anxiety disorder: Is the future here already?
Brain Behav Immun. 2024 May 22:S0889-1591(24)00420-3. doi: 10.1016/j.bbi.2024.05.032. Online ahead of print.NO ABSTRACTPMID:38788965 | DOI:10.1016/j.bbi.2024.05.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 24, 2024 Category: Neurology Authors: Jessica L Maples-Keller Vasiliki Michopoulos Source Type: research
A retrospective review of sex differences of white matter hyperintensities in brain MRI of patients with migraine
CONCLUSION: This study suggests that females with migraine may be more likely to have WMHs and experience constipation than males with migraine. Migraine frequency and severity were not different between sexes, nor were they significantly associated with the presence of WMHs. The findings of this study do not support a specific etiology of WMH development in individuals with migraine that differs from findings in the general population. Further studies are warranted.PMID:38785411 | DOI:10.1111/head.14714 (Source: Headache)
Source: Headache - May 24, 2024 Category: Neurology Authors: Ye Su Victoria Q Tay Satinderpal Singh Megan C Leary Vitaliy Koss Hope M Kincaid Hussam A Yacoub John Castaldo Source Type: research
Dysregulated expression of cholesterol biosynthetic genes in Alzheimer's disease alters epigenomic signatures of hippocampal neurons
Neurobiol Dis. 2024 May 22:106538. doi: 10.1016/j.nbd.2024.106538. Online ahead of print.ABSTRACTAging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations as a contributing factor. Here, we compared transcriptomic/epigenomic changes in the hippocampus, modified by aging and by tauopathy, an AD-related feature. We show that the cholesterol biosynthesis pathway is severely impaired in hippocampal neurons of tauopathic but not of aged mice pointing to vulnerability of these neurons in the disease. At the epigenomic level, histone hyperacetylation was observed...
Source: Neurobiology of Disease - May 24, 2024 Category: Neurology Authors: Isabel Paiva Jonathan Seguin Iris Grgurina Akash Kumar Singh Brigitte Cosquer Damien Plassard Laura Tzeplaeff Stephanie Le Gras Ludovica Cotellessa Charles Decraene Johanne Gambi Rafael Alcala-Vida Muthusamy Eswaramoorthy Luc Bu ée Jean-Christophe Cassel Source Type: research
MRI-derived brain iron, grey matter volume, and risk of dementia and Parkinson's disease: Observational and genetic analysis in the UK Biobank cohort
Neurobiol Dis. 2024 May 22:106539. doi: 10.1016/j.nbd.2024.106539. Online ahead of print.ABSTRACTBACKGROUND: Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload (haemochromatosis) causing HFE p.C282Y variant have increased risk of dementia and PD. Whether brain iron deposition is causal or secondary to the neurodegenerative processes in the general population is unclear.METHODS: We analysed 39,533 UK Biobank participants of European genetic ancestry with brain MRI data. We studied brain iron estimated by R2* and quantit...
Source: Neurobiology of Disease - May 24, 2024 Category: Neurology Authors: Francesco Casanova Qu Tian Daniel S Williamson Yong Qian David Zweibaum Jun Ding Janice L Atkins David Melzer Luigi Ferrucci Luke C Pilling Source Type: research
rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels
This study tested the hypothesis that novel JDNI8 replication-defective herpes simplex-1 viral vectors (rdHSV) carrying a CA8 transgene (vHCA8) reduce primary afferent neuronal excitability. Whole-cell current clamp recordings in small DRG neurons showed that vHCA8 transduction caused prolongation of their afterhyperpolarization (AHP), an essential regulator of neuronal excitability. This AHP prolongation was completely reversed by the specific Kv7 channel inhibitor XE-991. Voltage clamp recordings indicate an effect via Kv7 channels in vHCA8-infected small DRG neurons. These data demonstrate for the first time that vHCA8 ...
Source: Herpes - May 24, 2024 Category: Infectious Diseases Authors: Munal B Kandel Gerald Z Zhuang William F Goins Marco Marzulli Mingdi Zhang Joseph C Glorioso Yuan Kang Alexandra E Levitt Wai-Meng Kwok Roy C Levitt Konstantinos D Sarantopoulos Source Type: research
New technology to address affected vs nonaffected arm contributions to ergometer performance in people poststroke
CONCLUSIONS: Poststroke participants pedaled faster with their affected arm unilaterally versus bilateral pedaling, suggesting interhemispheric interference that reduces the ability to recruit the paretic arm during bilateral exercise.PMID:38785263 | DOI:10.1080/10749357.2024.2356415 (Source: Topics in Stroke Rehabilitation)
Source: Topics in Stroke Rehabilitation - May 24, 2024 Category: Neurology Authors: Christen J Mendonca Brandon L Kane Kimberly A Smith Sangeetha Mohanraj Laurie A Malone Mohanraj Thirumalai James Rimmer David A Brown Source Type: research
Islands and bridges in healthcare: the importance of general neurology
Pract Neurol. 2024 May 24:pn-2023-004080. doi: 10.1136/pn-2023-004080. Online ahead of print.NO ABSTRACTPMID:38789257 | DOI:10.1136/pn-2023-004080 (Source: Practical Neurology)
Source: Practical Neurology - May 24, 2024 Category: Neurology Authors: Rui Ara újo Nens van Alfen Saskia Middeldorp Bastiaan R Bloem Source Type: research
Welcome to the mainland: general neurology's role in rescue from the islands of subspecialisation
Pract Neurol. 2024 May 24:pn-2024-004206. doi: 10.1136/pn-2024-004206. Online ahead of print.NO ABSTRACTPMID:38789256 | DOI:10.1136/pn-2024-004206 (Source: Practical Neurology)
Source: Practical Neurology - May 24, 2024 Category: Neurology Authors: Steven Lewis Source Type: research
PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury
In conclusion, we find that, when PTEN inhibition is targeted at a chronic time point following cervical contusion, our non-invasive PAP4 strategy can successfully promote significant regrowth of damaged respiratory neural circuitry and also partial recovery of diaphragm motor function.PMID:38789023 | DOI:10.1016/j.expneurol.2024.114816 (Source: Experimental Neurology)
Source: Experimental Neurology - May 24, 2024 Category: Neurology Authors: Pauline Michel-Flutot Lan Cheng Samantha J Thomas Brianna Lisi Harrison Schwartz Sandy Lam Megan Lyttle David A Jaffe George Smith Shuxin Li Megan C Wright Angelo C Lepore Source Type: research
Cholesterol Modulation Attenuates the AD-like Phenotype Induced by Herpes Simplex Virus Type 1 Infection
In conclusion, these findings highlight the connection between cholesterol, neurodegeneration, and HSV-1 infection, providing valuable insights into the underlying mechanisms of AD.PMID:38786010 | DOI:10.3390/biom14050603 (Source: Herpes)
Source: Herpes - May 24, 2024 Category: Infectious Diseases Authors: Blanca Salgado Beatriz Izquierdo Alba Zapata Isabel Sastre Henrike Kristen Julia Terreros V íctor Mejías Mar ía J Bullido Jes ús Aldudo Source Type: research
Risk factors for status epilepticus after brain disorders in adults: A multi-cohort national register study
CONCLUSION: SE-risk increases with disorder severity and number of CNS comorbidities. These findings can guide treatment strategy by allowing identification of high-risk patients. Pathophysiological studies are needed to better understand remote symptomatic SE.PMID:38788662 | DOI:10.1016/j.yebeh.2024.109840 (Source: Herpes)
Source: Herpes - May 24, 2024 Category: Infectious Diseases Authors: Johan Bjellvi Andr é Idegård Johan Zelano Source Type: research
Japanese medaka (Oryzias latipes) Nectin4 plays an important role against red spotted grouper nervous necrosis virus infection
In this study, nectin4 gene was cloned from medaka (OlNectin4). OlNectin4 was located on chromosome 18 and contained 11 exons, with a total genome length of 25754 bp, coding sequences of 1689 bp, coding 562 amino acids and a molecular weight of 65.5 kDa. OlNectin4 contained four regions, including an Immunoglobulin region, an Immunoglobulin C-2 Type region, a Transmembrane region and a Coiled coil region. OlNectin4 shared 47.18% and 25.00% identity to Paralichthys olivaceus and Mus musculus, respectively. In adult medaka, the transcript of nectin4 was predominantly detected in gill. During red spotted grouper nervous necro...
Source: Herpes - May 24, 2024 Category: Infectious Diseases Authors: Ronggui Dai Bilin Xia Mengyang Wang Mingxi Huang Lei Chen Yan Huang Tiansheng Chen Source Type: research
Neonatal resveratrol treatment in cerebral palsy model recovers neurodevelopment impairments by restoring the skeletal muscle morphology and decreases microglial activation in the cerebellum
This study aimed to investigate the effects of neonatal resveratrol treatment on neurodevelopment, skeletal muscle morphology, and cerebellar damage in CP model. Wistar rat pups were allocated to four experimental groups (n = 15/group) according CP model and treatment: Control+Saline (CS), Control+Resveratrol (CR), CP + Saline (CPS), and CP + Resveratrol (CPR). CP model associated anoxia and sensorimotor restriction. CP group showed delay in the disappearance of the palmar grasp reflex (p < 0.0001) and delay in the appearance of reflexes of negative geotaxis (p = 0.01), and free-fall righting (p < 0.0001), reduced lo...
Source: Experimental Neurology - May 24, 2024 Category: Neurology Authors: Sabrina da Concei ção Pereira Vanessa da Silva Souza Caio Matheus Santos da Silva Calado Beatriz Souza de Silveira Let ícia Nicoly Ferreira Barbosa Luz Torner Omar Guzm án-Quevedo Raul Manh ães-de-Castro Ana Elisa Toscano Source Type: research
Establishment of a novel cellular model for Alzheimer's disease in vitro studies
CONCLUSION: We can infer that the MEK1/2-ERK and NF-κβ pathways, respectively, are directly activated by the PAF C-16 and BetA chemicals. The activation of MEK1/2-ERK pathway results in the activation of the APP gene, which in turn activates the β. Amyloid protein, which in turn results in plaque. Furthermore, NF-κβ activation results in the activation of the MAPT gene, which leads to Tau and p-Tau protein activation, which ultimately results in tangles. This can be put into practice in just three days, with a high level of activity and stability that is passed down to the next three generations (subculture), with sig...
Source: Experimental Neurology - May 24, 2024 Category: Neurology Authors: Rady E El-Araby Komal Wasif Rebecca Johnson Qisheng Tu Tarek Aboushousha Zoe Xiaofang Zhu Jake Chen Source Type: research
