Incidence of Ophthalmological Complications in NF-1 Patients Treated with MEK Inhibitors
Curr Oncol. 2024 May 7;31(5):2644-2649. doi: 10.3390/curroncol31050199.ABSTRACTMEK inhibitors (MEKi) represent innovative and promising treatments for managing manifestations of neurofibromatosis type 1 (NF1). To mitigate potential ophthalmic side effects, such as MEKi-associated retinopathy (MEKAR), patients undergoing MEKi therapy routinely receive ophthalmology evaluations. Our study aims to assess the necessity of this regular screening within a predominantly pediatric NF1 population by examining the occurrence of ocular adverse events (OAE). A retrospective study evaluated 45 NF1 patients receiving MEKi. Inclusion cri...
Source: Current Oncology - May 24, 2024 Category: Cancer & Oncology Authors: Lena Hummel May Ameri Shaikha Alqahtani Zsila Sadighi Nagham Al-Zubidi Source Type: research
Pan-Canadian Analysis of Practice Patterns in Small Cell Carcinoma of the Cervix: Insights from a Multidisciplinary Survey
The objective of this study was to evaluate practice patterns in the management of SCNECC. A 23-question online survey on management of SCNECC was disseminated to Canadian gynecologic oncologists (GO), radiation oncologists (RO) and medical oncologists (MO). In total, 34 practitioners from eight provinces responded, including 17 GO, 13 RO and four MO. During staging and diagnosis, 74% of respondents used a trimodality imaging approach, and 85% tested for neuroendocrine markers. In early-stage (1A1-1B2) SCNECC, 87% of practitioners used a surgical-based approach with various adjuvant and neoadjuvant treatments. In locally a...
Source: Current Oncology - May 24, 2024 Category: Cancer & Oncology Authors: Kevin Yijun Fan Rania Chehade Andrew Yuanbo Wang Anjali Sachdeva Helen J MacKay Amandeep S Taggar Source Type: research
Patients with Leptomeningeal Carcinomatosis and Hydrocephalus-Feasibility of Combined Ventriculoperitoneal Shunt and Reservoir Insertion for Intrathecal Chemotherapy
Curr Oncol. 2024 Apr 24;31(5):2410-2419. doi: 10.3390/curroncol31050180.ABSTRACTTherapeutic management of patients with leptomeningeal carcinomatosis (LC) may require treatment of concomitant hydrocephalus (HC) in addition to intrathecal chemotherapy (ITC). Ventriculoperitoneal shunts (VPS) equipped with a valve for manual deactivation of shunt function and a concomitant reservoir for application of ITC pose an elegant solution to both problems. The present study evaluates indication, feasibility, and safety of such a modified shunt/reservoir design (mS/R). All patients with LC aged ≥ 18 years who had undergone mS/R impl...
Source: Current Oncology - May 24, 2024 Category: Cancer & Oncology Authors: Matthias Schneider Christian Wispel Anna-Laura Potthoff Muriel Heimann Valeri Borger Christina Schaub Ulrich Herrlinger Hartmut Vatter Patrick Schuss Niklas Sch äfer Source Type: research
Recent advances in potential therapeutic targets of ferroptosis ‑associated pathways for the treatment of stroke (Review)
In conclusion, the present review provides a comprehensive overview of the potential therapeutic targets afforded by ferroptosis‑associated pathways in stroke, offering new insights into how ferroptosis may be exploited in the treatment of stroke.PMID:38785160 | DOI:10.3892/mmr.2024.13252 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 24, 2024 Category: Molecular Biology Authors: Hao Dong Ya-Ping Ma Mei-Mei Cui Zheng-Hao Qiu Mao-Tao He Bao-Gang Zhang Source Type: research
Association of gut dysbiosis with first ‑episode psychosis (Review)
Mol Med Rep. 2024 Jul;30(1):130. doi: 10.3892/mmr.2024.13254. Epub 2024 May 24.ABSTRACTThe gut‑microbiota‑brain axis is a complex bidirectional communication system linking the gastrointestinal tract to the brain. Changes in the balance, composition and diversity of the gut‑microbiota (gut dysbiosis) have been found to be associated with the development of psychosis. Early‑life stress, along with various stressors encountered in different developmental phases, have been shown to be associated with the abnormal composition of the gut microbiota, leading to irregular immunological and neuroendocrine functions, which ...
Source: Molecular Medicine Reports - May 24, 2024 Category: Molecular Biology Authors: Christos Theleritis Maria-Ioanna Stefanou Marina Demetriou Evangelos Alevyzakis Konstantinos Triantafyllou Nikolaos Smyrnis Demetrios A Spandidos Emmanouil Rizos Source Type: research
Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases
DISCUSSION: In cSVD subtypes, distinct alterations of kw and Ktrans were observed. The combination of Ktrans and kw can depict the heterogeneous BBB dysfunction.HIGHLIGHTS: We measured BBB leakage to gadolinium-based contrast agent (Ktrans) and water exchange rate (kw) across BBB in three subtypes of cSVD. CADASIL is characterized by lower kw, HTRA1-related cSVD exhibits both higher Ktrans and lower kw, while sporadic cSVD is distinguished by higher Ktrans. There are distinct alterations in kw and Ktrans among subtypes of cSVD, indicating the heterogeneous nature of BBB dysfunction.PMID:38787758 | DOI:10.1002/alz.13874 (So...
Source: The Journal of Alzheimers Association - May 24, 2024 Category: Psychiatry Authors: Yunqing Ying Yingying Li Tingyan Yao Xingfeng Shao Weijun Tang Axel Montagne Hugues Chabriat Danny J J Wang Chaodong Wang Qi Yang Xin Cheng Source Type: research
Neuroticism and inflammatory skin diseases: a bidirectional Mendelian randomization study
Arch Dermatol Res. 2024 May 24;316(6):213. doi: 10.1007/s00403-024-03017-w.ABSTRACTPrevious observational studies have linked inflammatory skin diseases with mental health issues and neuroticism. However, the specific impact of neuroticism and its subclusters (i.e. worry, depressed affect, and sensitivity to environmental stress and adversity) on these conditions remains underexplored. In this work, we explored causal associations between common inflammatory skin diseases and neuroticism. We conducted a two-sample, bidirectional Mendelian randomization (MR) analysis using data from genome-wide association studies in psoria...
Source: Cell Research - May 24, 2024 Category: Cytology Authors: Charalabos Antonatos Alexandros Pontikas Adam Akritidis Sophia Georgiou Alexander J Stratigos Ileana Afroditi Kleidona Stamatis Gregoriou Katerina Grafanaki Yiannis Vasilopoulos Source Type: research
The donepezil transdermal system for the treatment of patients with mild, moderate, or severe Alzheimer's disease: a critical review
Expert Rev Neurother. 2024 Jun;24(6):607-614. doi: 10.1080/14737175.2024.2355981. Epub 2024 May 24.ABSTRACTINTRODUCTION: Cholinesterase inhibitors, along with memantine, are the mainstay of symptomatic treatment for AD (Alzheimer's disease); however, these medications are typically administered orally, which can be difficult for people with AD and their caregivers.AREAS COVERED: In this drug profile and narrative review, the authors trace the development of the new FDA-approved transdermal donepezil. The authors discuss the studies showing its bioequivalence with the oral formulation, including two double-blinded placebo c...
Source: Expert Review of Neurotherapeutics - May 24, 2024 Category: Neurology Authors: Austin Buck Kayvon Rezaei Aman Quazi Gary Goldmeier Bret Silverglate George T Grossberg Source Type: research
Design and radiological confirmation of 3-column cortical bone trajectory in the lumbar spine
CONCLUSIONS: Moderating adjustment of the original screw parameters by reducing LAs and CAs to penetrate the anterior, middle, and posterior columns of the vertebral body using the 3-column CBT screw is feasible, especially in the lower lumbar spine.PMID:38788239 | DOI:10.3171/2024.2.SPINE231208 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - May 24, 2024 Category: Neurosurgery Authors: Jia-Qi Wang Ren-Jie Zhang Lu-Ping Zhou Chong-Yu Jia Bo Zhang Rui Sheng Shu Fang Cai-Liang Shen Source Type: research
Do expandable cage size and number of cages matter in transforaminal lumbar interbody fusion at L5-S1? A comparative biomechanical analysis using finite element modeling
CONCLUSIONS: The authors' study shows that using a large unilateral TLIF cage may offer better stability than the bilateral insertion of smaller cages. While large bilateral cages increase adjacent-segment motion, they also provide a uniform stress distribution on the endplates. These findings deepen our understanding of the biomechanics of the available expandable TLIF cages.PMID:38788233 | DOI:10.3171/2024.2.SPINE231116 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - May 24, 2024 Category: Neurosurgery Authors: Mohamad Bakhaidar Balaji Harinathan Karthik Banurekha Devaraj Narayan Yoganandan Saman Shabani Source Type: research
Pedicled omental flaps for complex wound reconstruction following surgery for primary spine tumors of the mobile spine and sacrum
CONCLUSIONS: The pedicled omentum is an effective local tissue graft that can be used for complex wound reconstruction and management of high-risk closures in primary spine tumors. This technique may have a lower rate of complications than other approaches and may influence surgical planning and flap selection in challenging cases.PMID:38788228 | DOI:10.3171/2024.2.SPINE231134 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - May 24, 2024 Category: Neurosurgery Authors: Elie Massaad Shalin S Patel Margaret Sten Jane Shim Ali Kiapour John T Mullen Daniel G Tobert Shannon MacDonald Francis J Hornicek John H Shin Source Type: research
Shunt-dependent hydrocephalus and shunt failure rate in patients with aneurysmal subarachnoid hemorrhage in Korea
CONCLUSIONS: The rate of shunt-dependent hydrocephalus after aneurysmal SAH was 15.0% in this study using a medical claims database in Korea. The shunt surgery rate was highest in patients in their 60s and 70s. Shunt failure occurred in 11.3% of the patients, and a lumboperitoneal shunt was most related to the need for revision surgery.PMID:38788231 | DOI:10.3171/2024.2.JNS232933 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - May 24, 2024 Category: Neurosurgery Authors: Yu Deok Won Jin Whan Cheong Yung Ki Park Byul-Hee Yoon Jae Hoon Kim Hee In Kang Source Type: research
Contemporary cohort of cerebral cavernous malformations: natural history and utility of follow-up MRI
CONCLUSIONS: In a contemporary cohort of adult patients with CCM, the authors report 5-year SH and severe SH rates, rates of second prospective hemorrhage, and predictors of SH. Persistent or new hyperintensity on T1-weighted MRI may be a useful marker of disease activity.PMID:38788238 | DOI:10.3171/2024.2.JNS232750 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - May 24, 2024 Category: Neurosurgery Authors: Kelly D Flemming Robert D Brown Giuseppe Lanzino Source Type: research
Federal and foundational research funding trends for cerebrovascular neurosurgeons: the decline of the cerebrovascular surgeon-scientist?
CONCLUSIONS: The number of CV surgeons is increasing over time. While there has been a concomitant increase in the number of NIH-funded CV surgeons and the number of NIH grants awarded per CV surgeon in the past 12 years, there has also been a significant decrease in CV surgeons with K08, K12, and K23 career development awards and a downtrend in CV-focused K12 and early-career NREF applications and awarded grants. The latter findings suggest that the pipeline for future NIH-funded CV surgeons may be in decline.PMID:38788229 | DOI:10.3171/2024.2.JNS232287 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - May 24, 2024 Category: Neurosurgery Authors: Sangami Pugazenthi Anja I Srienc Luke Cantu Anna L Huguenard Emad Eskandar William J Mack Sepideh Amin-Hanjani Ananth K Vellimana Joshua W Osbun Gregory J Zipfel Source Type: research
Limited awareness of hallucinations in patients with Alzheimer's disease
DISCUSSION: Our findings highlight the deficits in insight into hallucinations among AD patients, specifically indicating that AD patients have limited awareness of their own hallucinations. Furthermore, our findings support the idea that deficits in insight into hallucinations are associated with the progression of AD.PMID:38787633 | DOI:10.1080/13546805.2024.2357065 (Source: Cognitive Neuropsychiatry)
Source: Cognitive Neuropsychiatry - May 24, 2024 Category: Psychiatry Authors: Mohamad El Haj Frank Lar øi Guillaume Chapelet Source Type: research
