Cancers, Vol. 15, Pages 871: Risk of Cancer in Patients with Inflammatory Bowel Diseases and Keys for Patient Management
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Chronic inflammation in patients with Inflammatory Bowel Disease (IBD) leads to an increased risk of colorectal cancer, small bowel cancer, intestinal lymphoma and cholangiocarcinoma. However, treatments for IBD have also been associated with an increased risk of neoplasms. Patients receiving Thiopurines (TPs) have an increased risk of hematologic malignancies, non-melanoma skin cancer, urinary tract neoplasms and cervical cancer. Anti-TNFs have been associated with a higher risk of neoplasms, mainly lymphomas and melanomas; however, the data are controversial, and some recent studies do not confirm the associa...
Source: Cancers - January 31, 2023 Category: Cancer & Oncology Authors: Viviana Laredo Sandra Garc ía-Mateo Samuel J. Mart ínez-Domínguez Julia L ópez de la Cruz Carla J. Gargallo-Puyuelo Fernando Gomoll ón Tags: Review Source Type: research
Bowel cancer knowledge gaps evident among Irish residents: results of a national questionnaire survey
ConclusionThis survey emphasises the need to improve the awareness of bowel cancer as gaps in this specific cancer knowledge were evident among Irish residents. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 19, 2023 Category: General Medicine Source Type: research
People with early-onset colorectal cancer describe primary care barriers to timely diagnosis: a mixed-methods study of web-based patient reports in the United Kingdom, Australia and New Zealand
CONCLUSIONS: Wider dissemination of information about early-onset colorectal cancer at primary care level is imperative given the increasing incidence of the disease, the frequency of diagnostic delay, the rates of late-stage diagnosis and the dissatisfaction with patient experience reported by patients whose diagnosis is delayed. Patient education about diagnostic protocols may help to pre-empt or resolve tensions between GPs' enactment of value-based care and patients' concerns about cancer. The challenges of diagnosing early-onset colorectal cancer are significant and will become more pressing for GPs, who will usually ...
Source: Primary Care - January 14, 2023 Category: Primary Care Authors: Klay Lamprell Diana Fajardo Pulido Gaston Arnolda Br óna Nic Giolla Easpaig Yvonne Tran Syeda Somyyah Owais Winston Liauw Jeffrey Braithwaite Source Type: research
Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: ASCO Endorsement of College of American Pathologists Guideline
J Clin Oncol. 2023 Jan 5:JCO2202462. doi: 10.1200/JCO.22.02462. Online ahead of print.ABSTRACTPURPOSE: The College of American Pathologists (CAP) has developed a guideline on testing for mismatch repair (MMR) and microsatellite instability (MSI) for patients considered for immune checkpoint inhibitor therapy. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations.METHODS: The CAP guideline was reviewed for developmental rigor by methodologists. An ASCO Endorsement Panel subsequently reviewed the content and the recommendations.RESULTS:...
Source: Clinical Colorectal Cancer - January 5, 2023 Category: Cancer & Oncology Authors: Praveen Vikas Hans Messersmith Carolyn Compton Lynette Sholl Russell R Broaddus Anjee Davis Maria Estevez-Diz Rohan Garje Panagiotis A Konstantinopoulos Aliza Leiser Anne M Mills Barbara Norquist Michael J Overman Davendra Sohal Richard C Turkington Tyler Source Type: research
Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: ASCO Endorsement of College of American Pathologists Guideline
J Clin Oncol. 2023 Jan 5:JCO2202462. doi: 10.1200/JCO.22.02462. Online ahead of print.ABSTRACTPURPOSE: The College of American Pathologists (CAP) has developed a guideline on testing for mismatch repair (MMR) and microsatellite instability (MSI) for patients considered for immune checkpoint inhibitor therapy. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations.METHODS: The CAP guideline was reviewed for developmental rigor by methodologists. An ASCO Endorsement Panel subsequently reviewed the content and the recommendations.RESULTS:...
Source: Clinical Colorectal Cancer - January 5, 2023 Category: Cancer & Oncology Authors: Praveen Vikas Hans Messersmith Carolyn Compton Lynette Sholl Russell R Broaddus Anjee Davis Maria Estevez-Diz Rohan Garje Panagiotis A Konstantinopoulos Aliza Leiser Anne M Mills Barbara Norquist Michael J Overman Davendra Sohal Richard C Turkington Tyler Source Type: research
Bowel cancer screening
Colorectal cancer (CRC) is the third most common cancer in both males and females in the UK giving rise to over 40,000 new cancer cases per year. It arises from polyps as part of the adenoma –carcinoma sequence. Early detection can aid treatment and improve outcomes. Faecal immunochemical tests (FIT) and direct imaging using colonoscopy/sigmoidoscopy has been shown to be advantageous in the detection of polyps and earlier cancer. We review the evidence and provide summaries of current strategies as well as future potential developments. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - December 13, 2022 Category: Surgery Authors: Samim Al-Zubaidi, Niamh McKigney, Peter E. Coyne Tags: Intestinal surgery – I Source Type: research
Evaluation of a real-time computer-aided polyp detection system during screening colonoscopy: AI-DETECT study
Conclusions In high-performing colonoscopists in a BCSP who routinely used Endocuff Vision, CADe improved PDR but not ADR. CADe appeared to have limited benefit in a BCSP setting where procedures are performed by experienced colonoscopists. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - December 12, 2022 Category: Gastroenterology Authors: Ahmad, Ahmir Wilson, Ana Haycock, Adam Humphries, Adam Monahan, Kevin Suzuki, Noriko Thomas-Gibson, Siwan Vance, Margaret Bassett, Paul Thiruvilangam, Kowshika Dhillon, Angad Saunders, Brian P. Tags: Original article Source Type: research
Colonoscopies in Australia - how much does the National Bowel Cancer Screening Program contribute to colonoscopy use?
Public Health Res Pract. 2022 Dec 8:32342216. doi: 10.17061/phrp32232216. Online ahead of print.NO ABSTRACTPMID:36477980 | DOI:10.17061/phrp32232216 (Source: Cancer Control)
Source: Cancer Control - December 8, 2022 Category: Cancer & Oncology Authors: Joachim Worthington Emily He Jie-Bin Lew James St John Christopher Horn Paul Grogan Karen Canfell Eleonora Feletto Source Type: research
Pathology of colorectal polyps and cancer
This article highlights the pathology-related aspects of CRC that are most relevant to colorectal surgeons. This includes sections on epidemiology, aetiology, presentation, macroscopic and microscopic features, pathological staging, prognosis, precursor lesions and molecular pathways, follow-up and bowel cancer screening. The main section on CRC is preceded by a description of the types of colorectal polyp that are most commonly encountered in clinical practice, many of which are associated with the development of CRC. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - November 23, 2022 Category: Surgery Authors: Adrian C. Bateman Tags: Basic science Source Type: research
Parenchymal liver metastasis in advanced ovarian cancer: can bowel involvement influence the frequency and the related mortality rate?
Ovarian Cancer (OC) is usually diagnosed in an advanced stage (FIGO stage IIIC-IV) [1]. Debulking surgery followed by chemotherapy or neoadjuvant chemotherapy followed by interval surgery is the gold standard. The complete cytoreductive surgery (CRS) of all visible diseases is considered the cornerstone treatment affecting dramatically the disease-free survival (DFS) and the overall survival (OS) rates [2,3]. To achieve an RT0, bowel resection is needed in 10-70% of all advanced OC [4,5]. In patients with Advanced Ovarian Cancer (AOC), bowel involvement shows some peculiarities in contrast to primitive bowel cancer. (Sourc...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 11, 2022 Category: OBGYN Authors: Gaetano Valenti, Francesco Sopracordevole, Benito Chiofalo, Sara Forte, Fabio Ciancio, Maria Fiore, Giorgio Giorda Source Type: research
Chronic diarrhea - The poetic masquerade
We present such a case of chronic diarrhea in a middle-aged man, who was eventually diagnosed to have POEMS syndrome. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - November 4, 2022 Category: Internal Medicine Authors: S Bhattacharjee I Siyad BV Maramattom Source Type: research
Outcome Quality After Colorectal Cancer Resection in German Certified Bowel Cancer Centres-Patient-Reported and Short-Term Clinical Outcomes
CONCLUSION: Clinicians can use these findings to identify patients at higher risk for poorer patient-reported outcomes. The differences among cancer centers that were found imply that measures for quality improvement would be desirable.PMID:36321583 | DOI:10.3238/arztebl.m2022.0325 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 2, 2022 Category: General Medicine Authors: Christoph Kowalski Nora Tabea Sibert Clara Breidenbach Anna Hagemeier Rebecca Roth Thomas Seufferlein Stefan Benz Stefan Post Robert Siegel Armin Wiegering Raphael Winkels Stefanie Bieck-Messemer J örg Fahlke Christoph Reissfelder Martin Fuchs Torsten He Source Type: research
Outcome Quality After Colorectal Cancer Resection in German Certified Bowel Cancer Centres –Patient-Reported and Short-Term Clinical Outcomes
CONCLUSION: Clinicians can use these findings to identify patients at higher risk for poorer patient-reported outcomes. The differences among cancer centers that were found imply that measures for quality improvement would be desirable.PMID:36321583 | DOI:10.3238/arztebl.m2022.0325 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 2, 2022 Category: General Medicine Authors: Christoph Kowalski Nora Tabea Sibert Clara Breidenbach Anna Hagemeier Rebecca Roth Thomas Seufferlein Stefan Benz Stefan Post Robert Siegel Armin Wiegering Raphael Winkels Stefanie Bieck-Messemer J örg Fahlke Christoph Reissfelder Martin Fuchs Torsten He Source Type: research
