Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country
Eur J Nutr. 2024 Apr 23. doi: 10.1007/s00394-024-03371-5. Online ahead of print.ABSTRACTFolate-mediated one-carbon metabolism (FOCM) plays an important role in colorectal carcinogenesis. Previous studies have assessed the role of folate-mediated one-carbon metabolism (FOCM)-related gene-diet interaction in the aetiology of colorectal cancer (CRC), however, the results remained inconclusive. Thus, this study aimed to investigate dietary factors and genetic variants related to FOCM, as well as potential nutrient-gene and nutrient-lifestyle interactions, on CRC risk. This observational study included 229 patients diagnosed wi...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Sara Corchero-Palacios Iker Alegria-Lertxundi Marian M de Pancorbo Marta Arroyo-Izaga Source Type: research
Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country
AbstractFolate-mediated one-carbon metabolism (FOCM) plays an important role in colorectal carcinogenesis. Previous studies have assessed the role of folate-mediated one-carbon metabolism (FOCM)-related gene-diet interaction in the aetiology of colorectal cancer (CRC), however, the results remained inconclusive. Thus, this study aimed to investigate dietary factors and genetic variants related to FOCM, as well as potential nutrient-gene and nutrient-lifestyle interactions, on CRC risk. This observational study included 229 patients diagnosed with CRC and 229 age- and sex-matched subjects as controls from a population-based...
Source: European Journal of Nutrition - April 23, 2024 Category: Nutrition Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
CONCLUSIONS: Our data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation.PMID:38615286 | DOI:10.1007/s10147-024-02518-y (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2024 Category: Cancer & Oncology Authors: Tetsuya Ito Tatsuro Yamaguchi Kensuke Kumamoto Okihide Suzuki Noriyasu Chika Satoru Kawakami Tomonori Nagai Tsukasa Igawa Kenji Fujiyoshi Yoshito Akagi Tomio Arai Kiwamu Akagi Hidetaka Eguchi Yasushi Okazaki Hideyuki Ishida Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
CONCLUSIONS: Our data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation.PMID:38615286 | DOI:10.1007/s10147-024-02518-y (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 14, 2024 Category: Cancer & Oncology Authors: Tetsuya Ito Tatsuro Yamaguchi Kensuke Kumamoto Okihide Suzuki Noriyasu Chika Satoru Kawakami Tomonori Nagai Tsukasa Igawa Kenji Fujiyoshi Yoshito Akagi Tomio Arai Kiwamu Akagi Hidetaka Eguchi Yasushi Okazaki Hideyuki Ishida Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
ConclusionsOur data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 14, 2024 Category: Cancer & Oncology Source Type: research
The National Bowel Cancer Screening Programme: a service for the asymptomatic or a pathway acting as a safety net?
Clin Med (Lond). 2023 Nov;23 Suppl 6:8. doi: 10.7861/clinmed.23-6-s8.NO ABSTRACTPMID:38614753 | DOI:10.7861/clinmed.23-6-s8 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Solange Serna Tania Baldwin Ajay Verma Source Type: research
Platelet –lymphocyte ratio as a predictor of lymph node metastasis in small bowel cancer
AbstractThe purpose of this research was to investigate the potential predictive value of preoperative systemic inflammatory indexes in identifying lymph node metastasis among patients diagnosed with small bowel cancer. A retrospective analysis of clinical data was conducted on small bowel cancer patients who underwent surgical treatment at the gastrointestinal surgery department of our hospital between January 2010 and June 2021. Patients were divided into groups based on the presence or absence of lymph node metastasis as confirmed by postoperative pathological results. The study compared the differences in preoperative ...
Source: Journal of Robotic Surgery - April 13, 2024 Category: Surgery Source Type: research
Colorectal cancer: features and investigation
Colorectal cancer (CRC) is very common, affecting>40,000 people a year in the UK. The pathogenesis is mostly sporadic, but hereditary genes and inflammatory bowel disease are well-known causative factors. The symptoms can be very variable, are based on the location of the lesion and tend to be more obscure if they are right sided. Symptoms also overlap with benign conditions so luminal imaging, mainly colonoscopy as the gold standard, is needed. Bowel cancer screening programmes are designed to detect the earlier stages of CRC. (Source: Medicine)
Source: Medicine - March 27, 2024 Category: Internal Medicine Authors: Kris J Jourand, Justin Davies Tags: Colorectal cancer Source Type: research
Effects of a self-affirmation intervention on responses to bowel cancer screening information
CONCLUSION: There was some evidence of the effect of health-based self-affirmation on lowering anxiety; however, further research is needed to explore the effectiveness of different self-affirmation interventions in larger samples.PMID:38519876 | DOI:10.1080/08870446.2024.2332265 (Source: Cancer Control)
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Elizabeth Travis Laura Ashley Daryl B O'Connor Source Type: research
Effects of a self-affirmation intervention on responses to bowel cancer screening information
. (Source: Psychology and Health)
Source: Psychology and Health - March 23, 2024 Category: Psychiatry & Psychology Authors: Elizabeth TravisLaura AshleyDaryl B. O ’Connora School of Psychology, University of Leeds, Leeds, UKb School of Humanities & Social Sciences, Leeds Beckett University, Leeds, UK Source Type: research
MorphGI: A Self-Propelling Soft Robotic Endoscope Through Morphing Shape
We present the MorphGI, a robotic endoscope system that is self-propelling and made of soft material, thus easy to operate and inherently safe to patient. After verifying kinematic control of the distal bending segment, the system was evaluated in: a benchtop colon simulator, using multiple colon configurations; a colon simulator with force sensors; and surgically removed pig colon tissue. In the colon simulator, the MorphGI completed a colonoscopy in an average of 10.84 min. The MorphGI showed an average of 77% and 62% reduction in peak forces compared to a CC in high- and low-stiffness modes, respectively. Self-propulsio...
Source: Cancer Control - March 14, 2024 Category: Cancer & Oncology Authors: Julius E Bernth Guokai Zhang Dionysios Malas George Abrahams Bu Hayee Hongbin Liu Source Type: research
The hunt is on to learn why bowel cancer in young people is rising
Something in the environment seems to be causing a rise in early-onset cases of bowel cancer. Now the hunt is on to find out what it is (Source: New Scientist - Health)
Source: New Scientist - Health - March 6, 2024 Category: Consumer Health News Source Type: research
Multimodality imaging features of small bowel cancers complicating Crohn ’s disease: a pictorial review
AbstractPatients with Crohn ’s disease (CD) are at increased risk of developing small bowel cancer, since chronic inflammation may trigger the histopathological sequence that begins from low-grade dysplasia of the intestinal epithelium and may eventually lead to malignant transformation. Owing to their location in a portion of the gastrointestinal tract which is not easily accessible to conventional endoscopic techniques, the detection of CD-related small bowel cancers is still a clinical challenge. The radiological features of CD-related small bowel adenocarcinoma (SBA) in patients with CD have been described in some pr...
Source: Abdominal Imaging - March 5, 2024 Category: Radiology Source Type: research
Educational interventions to improve bowel cancer awareness and screening in Organisation for Economic Co-operation and Development countries: A scoping review
CONCLUSIONS: Lay community health educators, brochures, and mass media campaigns occurring multiple times a year may be effective interventions in improving screening and/or awareness. Such approaches should be considered when developing community education. Education interventions should include multiple components suggested above to maximise improvements of awareness and screening.PMID:38384964 | PMC:PMC10879007 | DOI:10.1016/j.pmedr.2024.102653 (Source: Rural Remote Health)
Source: Rural Remote Health - February 22, 2024 Category: Rural Health Authors: Nicola Gadd Simone Lee Matthew J Sharman Kehinde Obamiro Source Type: research
The National Bowel Cancer Screening Programme: a service for the asymptomatic or a pathway acting as a safety net?
Clin Med (Lond). 2023 Nov;23(Suppl 6):8. doi: 10.7861/clinmed.23-6-s8.NO ABSTRACTPMID:38182224 | DOI:10.7861/clinmed.23-6-s8 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - January 5, 2024 Category: Cancer & Oncology Authors: Solange Serna Tania Baldwin Ajay Verma Source Type: research
