Extracolonic tumours in a pedigree with EPCAM-related Lynch Syndrome
This report illustrates the existence of intrafamilial clinical heterogeneity among carriers of this EPCAM alteration, and hence the difficulty in predicting phenotype for EPCAM-associated Lynch syndrome.PMID:35367635 | DOI:10.1016/j.ejmg.2022.104479 (Source: European Journal of Medical Genetics)
Source: European Journal of Medical Genetics - April 3, 2022 Category: Genetics & Stem Cells Authors: Joana Alves da Silva S érgio Castedo Isabel Pedroto Ricardo Marcos-Pinto Source Type: research
The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer
Stem Cell Res Ther. 2022 Apr 1;13(1):138. doi: 10.1186/s13287-022-02811-5.ABSTRACTBACKGROUND: Mesenchymal stem cells (MSCs) therapy is a novel treatment strategy for cancer and a wide range of diseases with an excessive immune response such as ulcerative colitis (UC), due to its powerful immunomodulatory properties and its capacity for tissue regeneration and repair. One of the promising therapeutic options can focus on MSC-secreted exosomes (MSC-Exo), which have been identified as a type of paracrine interaction. In light of a wide variety of recent experimental studies, the present review aims to seek the recent research...
Source: Cell Research - April 2, 2022 Category: Cytology Authors: Gang Guo Zhaobang Tan Yaping Liu Feiyu Shi Junjun She Source Type: research
The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer
Stem Cell Res Ther. 2022 Apr 1;13(1):138. doi: 10.1186/s13287-022-02811-5.ABSTRACTBACKGROUND: Mesenchymal stem cells (MSCs) therapy is a novel treatment strategy for cancer and a wide range of diseases with an excessive immune response such as ulcerative colitis (UC), due to its powerful immunomodulatory properties and its capacity for tissue regeneration and repair. One of the promising therapeutic options can focus on MSC-secreted exosomes (MSC-Exo), which have been identified as a type of paracrine interaction. In light of a wide variety of recent experimental studies, the present review aims to seek the recent research...
Source: Cell Research - April 2, 2022 Category: Cytology Authors: Gang Guo Zhaobang Tan Yaping Liu Feiyu Shi Junjun She Source Type: research
The role of microvesicles as biomarkers in the screening of colorectal neoplasm
ConclusionsMicrovesicles as biomarkers for the early and accurate detection of CRC is a simple and effective tool that yields a potential breakthrough in clinical management. (Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2022 Category: Cancer & Oncology Authors: Mohammad M. R. Eddama,
Rijan Gurung,
Konstantinos Fragkos,
Paula Lorgelly,
Richard Cohen,
Marilena Loizidou,
Lucie Clapp Tags: RESEARCH ARTICLE Source Type: research
The Gut Microbiota Influenced by the Intake of Probiotics and Functional Foods with Prebiotics Can Sustain Wellness and Alleviate Certain Ailments like Gut-Inflammation and Colon-Cancer
Microorganisms. 2022 Mar 20;10(3):665. doi: 10.3390/microorganisms10030665.ABSTRACTThe gut microbiota is composed of several microbial strains, with diverse and variable combinations in healthy and sick persons, changing at different stages of life. A healthy balance between host and gut microorganisms must be maintained in order to perform the normal physiological, metabolic, and immune functions and prevent disease development. Disturbances in the balance of the gut microbiota by diverse reasons initiate several health issues and promote the progression of certain diseases. This review is based on published research and ...
Source: Cancer Control - March 26, 2022 Category: Cancer & Oncology Authors: Divakar Dahiya Poonam Singh Nigam Source Type: research
Characteristics of patients aged 50-74 years with a request for an immunochemical faecal occult blood test in the Australian general practice setting
ConclusionsThis study describes the patient characteristics, reasons and outcomes associated with GP-requested FOBTs, identifies under-screened population sub-groups, and suggests involvement of GPs to improve participation in the NBCSP.PMID:35220996 | DOI:10.1071/AH21129 (Source: Australian Health Review)
Source: Australian Health Review - February 28, 2022 Category: Hospital Management Authors: Allan Pollack Doreen Busingye Jill Thistlethwaite Suzanne Blogg Kendal Chidwick Source Type: research
Characteristics of patients aged 50-74 years with a request for an immunochemical faecal occult blood test in the Australian general practice setting
ConclusionsThis study describes the patient characteristics, reasons and outcomes associated with GP-requested FOBTs, identifies under-screened population sub-groups, and suggests involvement of GPs to improve participation in the NBCSP.PMID:35220996 | DOI:10.1071/AH21129 (Source: Australian Health Review)
Source: Australian Health Review - February 28, 2022 Category: Hospital Management Authors: Allan Pollack Doreen Busingye Jill Thistlethwaite Suzanne Blogg Kendal Chidwick Source Type: research
Characteristics of patients aged 50-74 years with a request for an immunochemical faecal occult blood test in the Australian general practice setting
ConclusionsThis study describes the patient characteristics, reasons and outcomes associated with GP-requested FOBTs, identifies under-screened population sub-groups, and suggests involvement of GPs to improve participation in the NBCSP.PMID:35220996 | DOI:10.1071/AH21129 (Source: Australian Health Review)
Source: Australian Health Review - February 28, 2022 Category: Hospital Management Authors: Allan Pollack Doreen Busingye Jill Thistlethwaite Suzanne Blogg Kendal Chidwick Source Type: research
IJERPH, Vol. 19, Pages 1497: Public Awareness of Bowel Cancer Risk Factors, Symptoms and Screening in Tasmania, Australia: A Cross-Sectional Study
This study measured awareness levels of bowel cancer risk factors, symptoms and screening in Tasmania. An online survey of 3703 participants aged 18 years and older found that alcohol consumption, low physical activity levels, and having diabetes were the least known risk factors for bowel cancer. Over half of all participants were unaware the risk of bowel cancer increased with age, and 53 percent were not confident they would notice a bowel cancer symptom. Over a third of survey respondents did not know that screening commenced at the age of 50. The results indicate that a targeted campaign to increase bowel cancer aware...
Source: International Journal of Environmental Research and Public Health - January 28, 2022 Category: Environmental Health Authors: Simone M. Lee Vincent L. Versace Kehinde Obamiro Tags: Article Source Type: research
Prevalence and Spectrum of Predisposition Genes With Germline Mutations Among Chinese Patients With Bowel Cancer
Conclusion: Chinese patients with bowel cancer exhibited a distinct spectrum of germline variants, with distinct molecular characteristics such as TMB and DDR. Furthermore, the information on somatic mutations obtained from TCGA database indicated that a deeper understanding of the interactions among DDR and immune cells would be useful to further investigate the role of DDR in bowel cancer. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - January 27, 2022 Category: Genetics & Stem Cells Source Type: research
Cancers, Vol. 14, Pages 469: Gall Bladder Disease and the Risk of Small Bowel Cancer & mdash;Results from a Nationwide Swedish Cohort Study
Conclusions: In this nationwide cohort study, GBD was associated with an increased risk of small bowel cancer. The excess risk of small bowel adenocarcinoma was mainly seen during the first years of follow-up while small bowel carcinoid risk peaked 11–16 years after GBD diagnosis. (Source: Cancers)
Source: Cancers - January 18, 2022 Category: Cancer & Oncology Authors: Louise Emilsson Cecilia Radkiewicz Carol E. Semrad Amit D. Joshi Jonas F. Ludvigsson Tags: Article Source Type: research
The SMARTscreen Trial: a randomised controlled trial investigating the efficacy of a GP-endorsed narrative SMS to increase participation in the Australian National Bowel Cancer Screening Program
Increasing participation in the Australian National Bowel Cancer Screening Program (NBCSP) is the most efficient and cost-effective way of reducing mortality associated with colorectal cancer by detecting and ... (Source: Trials)
Source: Trials - January 12, 2022 Category: General Medicine Authors: Anna Wood, Jon D. Emery, Mark Jenkins, Patty Chondros, Tina Campbell, Edweana Wenkart, Clare O ’Reilly, Tony Cowie, Ian Dixon, Julie Toner, Hourieh Khalajzadeh, Javiera Martinez Gutierrez, Linda Govan, Gemma Buckle and Jennifer G. McIntosh Tags: Study protocol Source Type: research
Impact of Tumor Location on Patient Outcomes in Small Bowel Cancers
CONCLUSION: Survival differences exist when small bowel cancers were assessed by tumor location, and jejunal tumors portended better prognosis overall.PMID:34972663 | DOI:10.1016/j.clcc.2021.11.006 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - January 1, 2022 Category: Cancer & Oncology Authors: Irene S Yu Zamzam Al-Hashami Parv Chapani Caroline Speers Janine M Davies Howard J Lim Daniel J Renouf Sharlene Gill Heather C Stuart Jonathan M Loree Source Type: research
Impact of Tumor Location on Patient Outcomes in Small Bowel Cancers
CONCLUSION: Survival differences exist when small bowel cancers were assessed by tumor location, and jejunal tumors portended better prognosis overall.PMID:34972663 | DOI:10.1016/j.clcc.2021.11.006 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - January 1, 2022 Category: Cancer & Oncology Authors: Irene S Yu Zamzam Al-Hashami Parv Chapani Caroline Speers Janine M Davies Howard J Lim Daniel J Renouf Sharlene Gill Heather C Stuart Jonathan M Loree Source Type: research
Colorectal resections during the COVID-19 pandemic: a national survey of practice during first lockdown
CONCLUSIONS: Our study demonstrates variability in the MDT management of colorectal cancer during the initial COVID-19 lockdown, incorporating adaptive patient behaviour and initially limited data on oncological safety profiles leading to challenging decision-making.PMID:34941446 | DOI:10.1308/rcsann.2021.0261 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - December 23, 2021 Category: Surgery Authors: K Rajput R E Clifford R Barter R Rajaganeshan R Kalaiselvan Source Type: research
