Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy
This study aimed to establish an in vitro model of diabetic retinopathy by culturing human retinal endothelial cells (HREC) with high glucose (30 mmol/L), and to detect their transcriptome expression by RNA-seq, screen for key genes related to pyroptosis, and validate the sequencing results by subsequent experiments.METHODS: We used RNA-seq to detect the transcriptome expression differences between HREC cells cultured with high glucose and control group, and identified differentially expressed genes by GO/KEGG analysis. We constructed a PPI network and determined the key genes by Cytoscape software and CytoHubba plugin. We...
Source: Biochemical and Biophysical Research communications - March 30, 2024 Category: Biochemistry Authors: Yang Xian Xingli Wang Yong Yu XiaoLong Chen Source Type: research
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy
This study aimed to establish an in vitro model of diabetic retinopathy by culturing human retinal endothelial cells (HREC) with high glucose (30 mmol/L), and to detect their transcriptome expression by RNA-seq, screen for key genes related to pyroptosis, and validate the sequencing results by subsequent experiments.METHODS: We used RNA-seq to detect the transcriptome expression differences between HREC cells cultured with high glucose and control group, and identified differentially expressed genes by GO/KEGG analysis. We constructed a PPI network and determined the key genes by Cytoscape software and CytoHubba plugin. We...
Source: Biochemical and Biophysical Research communications - March 30, 2024 Category: Biochemistry Authors: Yang Xian Xingli Wang Yong Yu XiaoLong Chen Source Type: research
Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy
This study aimed to establish an in vitro model of diabetic retinopathy by culturing human retinal endothelial cells (HREC) with high glucose (30 mmol/L), and to detect their transcriptome expression by RNA-seq, screen for key genes related to pyroptosis, and validate the sequencing results by subsequent experiments.METHODS: We used RNA-seq to detect the transcriptome expression differences between HREC cells cultured with high glucose and control group, and identified differentially expressed genes by GO/KEGG analysis. We constructed a PPI network and determined the key genes by Cytoscape software and CytoHubba plugin. We...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Yang Xian Xingli Wang Yong Yu XiaoLong Chen Source Type: research
Direct reciprocity and reputation shape trust decisions similarly in blind and sighted individuals
This study addresses the effects of blindness on trust. Using an auditory version of the multi-round Trust Game, we investigated the effect of reputation and reciprocity on trust decisions in early blind and sighted participants. During each round of the game, participants were endowed with a sum of money and had to decide how much they wanted to invest in their partners, who were manipulated as a function of their good or bad reputation and individualistic or cooperative behavior. The data showed that negative first impression about the partner (bad reputation and/or selfish behavior) impacted more blind participants than...
Source: Consciousness and Cognition - March 29, 2024 Category: Neurology Authors: Maria Arioli Chiara Ferrari Lotfi B Merabet Zaira Cattaneo Source Type: research
Direct reciprocity and reputation shape trust decisions similarly in blind and sighted individuals
This study addresses the effects of blindness on trust. Using an auditory version of the multi-round Trust Game, we investigated the effect of reputation and reciprocity on trust decisions in early blind and sighted participants. During each round of the game, participants were endowed with a sum of money and had to decide how much they wanted to invest in their partners, who were manipulated as a function of their good or bad reputation and individualistic or cooperative behavior. The data showed that negative first impression about the partner (bad reputation and/or selfish behavior) impacted more blind participants than...
Source: Consciousness and Cognition - March 29, 2024 Category: Neurology Authors: Maria Arioli Chiara Ferrari Lotfi B Merabet Zaira Cattaneo Source Type: research
Assessment of Autism Spectrum Disorders in Children with Visual Impairment and Blindness: A Scoping Review
J Autism Dev Disord. 2024 Mar 28. doi: 10.1007/s10803-024-06300-x. Online ahead of print.ABSTRACTThere is a higher incidence of diagnosed Autism Spectrum Disorder (ASD) in children with visual impairment and blindness (VIB) than in typically sighted children. However, we currently lack appropriate assessment measures to fully understand the neurodevelopment of children with VIB. Numerous factors, such as common characteristics between children with VIB and ASD and the reliance of visual behaviours in assessments of ASD, complicate the clinical and diagnostic understanding of these children. This scoping review aims to desc...
Source: Journal of Autism and Developmental Disorders - March 28, 2024 Category: Psychiatry Authors: Moire Stevenson Emmanuela Tedone Source Type: research
Assessment of Autism Spectrum Disorders in Children with Visual Impairment and Blindness: A Scoping Review
J Autism Dev Disord. 2024 Mar 28. doi: 10.1007/s10803-024-06300-x. Online ahead of print.ABSTRACTThere is a higher incidence of diagnosed Autism Spectrum Disorder (ASD) in children with visual impairment and blindness (VIB) than in typically sighted children. However, we currently lack appropriate assessment measures to fully understand the neurodevelopment of children with VIB. Numerous factors, such as common characteristics between children with VIB and ASD and the reliance of visual behaviours in assessments of ASD, complicate the clinical and diagnostic understanding of these children. This scoping review aims to desc...
Source: Journal of Autism and Developmental Disorders - March 28, 2024 Category: Psychiatry Authors: Moire Stevenson Emmanuela Tedone Source Type: research
Assessment of Autism Spectrum Disorders in Children with Visual Impairment and Blindness: A Scoping Review
J Autism Dev Disord. 2024 Mar 28. doi: 10.1007/s10803-024-06300-x. Online ahead of print.ABSTRACTThere is a higher incidence of diagnosed Autism Spectrum Disorder (ASD) in children with visual impairment and blindness (VIB) than in typically sighted children. However, we currently lack appropriate assessment measures to fully understand the neurodevelopment of children with VIB. Numerous factors, such as common characteristics between children with VIB and ASD and the reliance of visual behaviours in assessments of ASD, complicate the clinical and diagnostic understanding of these children. This scoping review aims to desc...
Source: Journal of Autism and Developmental Disorders - March 28, 2024 Category: Psychiatry Authors: Moire Stevenson Emmanuela Tedone Source Type: research
Assessment of Autism Spectrum Disorders in Children with Visual Impairment and Blindness: A Scoping Review
J Autism Dev Disord. 2024 Mar 28. doi: 10.1007/s10803-024-06300-x. Online ahead of print.ABSTRACTThere is a higher incidence of diagnosed Autism Spectrum Disorder (ASD) in children with visual impairment and blindness (VIB) than in typically sighted children. However, we currently lack appropriate assessment measures to fully understand the neurodevelopment of children with VIB. Numerous factors, such as common characteristics between children with VIB and ASD and the reliance of visual behaviours in assessments of ASD, complicate the clinical and diagnostic understanding of these children. This scoping review aims to desc...
Source: Journal of Autism and Developmental Disorders - March 28, 2024 Category: Psychiatry Authors: Moire Stevenson Emmanuela Tedone Source Type: research
Diverse animal models for Chlamydia infections: unraveling pathogenesis through the genital and gastrointestinal tracts
Chlamydia trachomatis is responsible for infections in various mucosal tissues, including the eyes, urogenital, respiratory, and gastrointestinal tracts. Chronic infections can result in severe consequences such as blindness, ectopic pregnancy, and infertility. The underlying mechanisms leading to these diseases involve sustained inflammatory responses, yet thorough comprehension of the underlying mechanisms remains elusive. Chlamydial biologists employ in multiple methods, integrating biochemistry, cell biology, and genetic tools to identify bacterial factors crucial for host cell interactions. While numerous animal model...
Source: Frontiers in Microbiology - March 28, 2024 Category: Microbiology Source Type: research
Classification of diabetic retinopathy severity level using deep learning
ConclusionThe training and testing of our model are carried out on images from the Kaggle APTOS dataset, and this work can act as a base for the autonomous screening of DR. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 28, 2024 Category: Endocrinology Source Type: research
Characterization of the visually impaired patients with diabetes mellitus in Japan
ConclusionsIn Japan, blind patients with diabetes mellitus are characterized by severe conditions such as neovascular glaucoma and progressive proliferative diabetic retinopathy upon their initial visit to an advanced care facility. These results highlight the importance of monitoring retinopathy through regular ophthalmological examinations, internal medicine, and appropriate therapeutic intervention. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 27, 2024 Category: Endocrinology Authors: Yuka Sugihara,
Yoshihiro Takamura,
Yutaka Yamada,
Masakazu Morioka,
Makoto Gozawa,
Kumiko Kato,
Takao Hirano,
Fumiko Murao,
Miho Shimizu,
Sentaro Kusuhara,
Tomoya Murakami,
Yuki Takenaka,
Naoko Okabe,
Tatsuya Jujo,
Hiroto Terasaki,
Daisuke Tags: Original Article Source Type: research
Association Between Quantitative and Qualitative Imaging Biomarkers and Geographic Atrophy Growth Rate
Advanced age-related macular degeneration is one of the leading causes of blindness in the United States and worldwide.1 The advanced non-neovascular stage is characterized by the presence of geographic atrophy (GA), or complete retinal pigment epithelium and outer retina atrophy (cRORA), defined by atrophy of the retinal pigment epithelium (RPE) and retinal photoreceptors in the macula.2 As GA enlarges over time this leads to an irreversible decline in visual function and patient-reported outcomes. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - March 27, 2024 Category: Opthalmology Authors: Talisa E. de Carlo Forest, Zafar Gill, Andres Lisker-Cervantes, Ramya Gnanaraj, Nathan Grove, Jennifer L. Patnaik, Anne M. Lynch, Alan G. Palestine, Marc Mathias, Niranjan Manoharan, Naresh Mandava Source Type: research
Identification of potential core genes in pseudoexfoliation using bioinformatics analysis and retrospective analysis of 84 patients with this disease
ConclusionOur findings show a considerably biomarkers of XFS for diagnosis and treatment. (Source: International Ophthalmology)
Source: International Ophthalmology - March 27, 2024 Category: Opthalmology Source Type: research
Visual outcomes after cataract surgery in monocular compared to binocular patients: a case –control study
ConclusionsThis study illustrates that cataract surgery in monocular patients is not more complicated than in binocular patients, but that it is significantly delayed. (Source: International Ophthalmology)
Source: International Ophthalmology - March 27, 2024 Category: Opthalmology Source Type: research
