Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Clinical features, treatment, and follow-up of OPPG and high-bone-mass disorders: LRP5 is a key regulator of bone mass
ConclusionThis study deepened the understanding of the clinical characteristics, treatment, and follow-up of OPPG and LRP5-HBM; expanded the pathogenic gene spectrum of OPPG; and confirmed that bisphosphonates were effective for OPPG. Additionally, it was found that Ala242Thr mutation could not protect LRP5-HBM patients from age-related bone loss. This phenomenon deserves further study. (Source: Osteoporosis International)
Source: Osteoporosis International - April 16, 2024 Category: Orthopaedics Source Type: research
AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?
Expert Rev Mol Med. 2024 Apr 15;26:e9. doi: 10.1017/erm.2024.4.ABSTRACTGlaucoma and uveitis are non-vascular ocular diseases which are among the leading causes of blindness and visual loss. These conditions have distinct characteristics and mechanisms but share a multifactorial and complex nature, making their management challenging and burdensome for patients and clinicians. Furthermore, the lack of symptoms in the early stages of glaucoma and the diverse aetiology of uveitis hinder timely and accurate diagnoses, which are a cause of poor visual outcomes under both conditions. Although current treatment is effective in mo...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Brenda Castro Jason C Steel Christopher J Layton Source Type: research
Herpes simplex keratitis: A brief clinical overview
World J Virol. 2024 Mar 25;13(1):89934. doi: 10.5501/wjv.v13.i1.89934.ABSTRACTThe aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Mutali Musa Ehimare Enaholo Gladness Aluyi-Osa George Nnamdi Atuanya Leopoldo Spadea Carlo Salati Marco Zeppieri Source Type: research
AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?
Expert Rev Mol Med. 2024 Apr 15;26:e9. doi: 10.1017/erm.2024.4.ABSTRACTGlaucoma and uveitis are non-vascular ocular diseases which are among the leading causes of blindness and visual loss. These conditions have distinct characteristics and mechanisms but share a multifactorial and complex nature, making their management challenging and burdensome for patients and clinicians. Furthermore, the lack of symptoms in the early stages of glaucoma and the diverse aetiology of uveitis hinder timely and accurate diagnoses, which are a cause of poor visual outcomes under both conditions. Although current treatment is effective in mo...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Brenda Castro Jason C Steel Christopher J Layton Source Type: research
