Targeting inflammasomes and pyroptosis in retinal diseases-molecular mechanisms and future perspectives
Prog Retin Eye Res. 2024 Apr 22:101263. doi: 10.1016/j.preteyeres.2024.101263. Online ahead of print.ABSTRACTRetinal diseases encompass various conditions associated with sight-threatening immune responses and are leading causes of blindness worldwide. These diseases include age-related macular degeneration, diabetic retinopathy, glaucoma and uveitis. Emerging evidence underscores the vital role of the innate immune response in retinal diseases, beyond the previously emphasized T-cell-driven processes of the adaptive immune system. In particular, pyroptosis, a newly discovered programmed cell death process involving inflam...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Yimeng Sun Fan Li Yunfei Liu Dijie Qiao Xinyu Yao Guei-Sheung Liu Dequan Li Chuanle Xiao Tao Wang Wei Chi Source Type: research
Diagnosis of Incomplete Congenital Stationary Night Blindness in a 2-year-old boy
Klin Monbl Augenheilkd. 2024 Apr 23. doi: 10.1055/a-2255-8098. Online ahead of print.NO ABSTRACTPMID:38653459 | DOI:10.1055/a-2255-8098 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: David A Merle Susanne Kohl Melanie Kempf Katarina Stingl Martin Kowalski Laura K ühlewein Source Type: research
Microbial keratitis in Southern Malawi: a microbiological pilot study
CONCLUSIONS: In a resource-poor setting, a CIM can be used to safely sample the cornea in patients presenting with suspected MK, enabling identification of causative microorganisms by culture and PCR. Although the microbiological spectrum found was limited to the dry season, these preliminary results could be used to guide empirical treatment.PMID:38653537 | DOI:10.1136/bmjophth-2024-001682 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Tobi F Somerville Shaffi Mdala Thokozani Zungu Moira Gandiwa Rose Herbert Dean Everett Caroline E Corless Nicholas A V Beare Timothy Neal Malcolm J Horsburgh Alistair Darby Stephen B Kaye Petros C Kayange Source Type: research
A Case of Congenital Stationary Night Blindness in a Healthy Female Infant: Emphasis on Electroretinography
Klin Monbl Augenheilkd. 2024 Apr;241(4):529-532. doi: 10.1055/a-2211-9248. Epub 2024 Apr 23.NO ABSTRACTPMID:38653284 | DOI:10.1055/a-2211-9248 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Dmitri Artemiev Margarita G Todorova Source Type: research
A new intelligent system based deep learning to detect DME and AMD in OCT images
This study introduces a novel Computer-Aided Diagnosis (CAD) system based on a Convolutional Neural Network (CNN) model, aiming to identify and classify OCT retinal images into AMD, DME, and Normal classes. Leveraging CNN efficiency, including feature learning and classification, various CNN, including pre-trained VGG16, VGG19, Inception_V3, a custom from scratch model, BCNN (VGG16)\(^{2}\), BCNN (VGG19)\(^{2}\), and BCNN (Inception_V3)\(^{2}\), are developed for the classification of AMD, DME, and Normal OCT images. The proposed approach has been evaluated on two datasets, including a DUKE public dataset and a Tunisian pr...
Source: International Ophthalmology - April 23, 2024 Category: Opthalmology Source Type: research
"The blinding disease". The history of trachoma in Italians between the 19th and 20th centuries: colonial or national blindness?
Pathog Glob Health. 2024 Apr 21:1-6. doi: 10.1080/20477724.2024.2342623. Online ahead of print.ABSTRACTTrachoma is one of the oldest known causes of blindness in humans and it is caused by the intracellular Gram-negative bacterium Chlamydia trachomatis serovars A, B, Ba and C. Its transmission has historically been related to poorness, overcrowded housing and scarce hygiene. We have traced the history of trachoma in Italy in the 19th and 20th centuries, among people living in Italy, those who immigrated to America and the population in the colonies, with a focus on Libya (1912-1943). Trachoma knowledge and perception in It...
Source: Pathogens and Global Health - April 22, 2024 Category: International Medicine & Public Health Authors: Mariano Martini Niccol ò Riccardi Omar Simonetti Davide Orsini Francesco Samassa Alessandra Parodi Source Type: research
Geniposide Attenuates Oxygen-glucose Deprivation/Recovery-induced Retinal Ganglion Cell Injury via Akt/Nrf-2 Signaling Pathway
CONCLUSION: Hence, it can be suggested that Gen provides neuroprotection against the OGD/R-induced injury of R28 cells by activating the Akt/Nrf-2 signaling pathway, which is beneficial for the clinical treatment of glaucoma.PMID:38644710 | DOI:10.2174/0109298673272406231212054710 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Minghai Hu Dekun Chen Xiuyu Wu Guo-Feng Ren Source Type: research
Emergency surgical decompression of the orbit may rescue impaired vision even in a patient presenting late with a retrobulbar haematoma: A case report from rural southwestern Uganda
Trop Doct. 2024 Apr 22:494755241244546. doi: 10.1177/00494755241244546. Online ahead of print.ABSTRACTRetrobulbar haematoma is a rare emergency that can potentially lead to blindness. Common causes include facial trauma and surgery. Timely surgical evacuation of the haematoma improves visual outcomes. In rural communities, patients often present to hospital after many hours and this increases the risk of poor visual outcomes. Radiological evaluation which is often not available in rural communities, results in further delay in surgical treatment. This case report highlights the need for urgent surgical intervention over ra...
Source: Tropical Doctor - April 22, 2024 Category: Tropical Medicine Authors: Robert Mugarura Mary Katushabe Nakitto Irene Kisakye Nek Arthur Jonathan Source Type: research
Molecules, Vol. 29, Pages 1904: Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus
In this study, we examined the effect of mutations on the Kir6.2 structure using bioinformatics tools and molecular dynamic simulations (SIFT, PolyPhen, SNAP2, PANTHER, PhD&SNP, SNP&Go, I-Mutant, MuPro, MutPred, ConSurf, HOPE, and GROMACS). Our results indicated that M199R, R201H, R206H, and Y330H mutations influence Kir6.2 structure and function and therefore may cause DM. We conclude that MD simulations are useful techniques to predict the effects of mutations on protein structure. In addition, the M199R, R201H, R206H, and Y330H variant in the Kir6.2 protein may be associated with DM. These result...
Source: Molecules - April 22, 2024 Category: Chemistry Authors: Mohamed E. Elangeeb Imadeldin Elfaki Ali M. S. Eleragi Elsadig Mohamed Ahmed Rashid Mir Salem M. Alzahrani Ruqaiah I. Bedaiwi Zeyad M. Alharbi Mohammad Muzaffar Mir Mohammad Rehan Ajmal Faris Jamal Tayeb Jameel Barnawi Tags: Article Source Type: research
Tear Protein Markers for Diabetic Retinopathy and Diabetic Macular Edema - Towards an Early Diagnosis and Better Prognosis
CONCLUSIONS: The review highlights major studies and their lacunae in the field of biomarkers discovery for DR and DME.PMID:38643349 | DOI:10.1080/08820538.2024.2342266 (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - April 21, 2024 Category: Opthalmology Authors: Sarmeela Sharma Akash Belenje Brijesh Takkar Ritesh Narula Varsha M Rathi Mudit Tyagi Padmaja Kumari Rani Raja Narayanan Inderjeet Kaur Source Type: research
Corneal fibrosis: From in vitro models to current and upcoming drug and gene medicines
Adv Drug Deliv Rev. 2024 Apr 18:115317. doi: 10.1016/j.addr.2024.115317. Online ahead of print.ABSTRACTFibrotic diseases are characterised by myofibroblast differentiation, uncontrolled pathological extracellular matrix accumulation, tissue contraction, scar formation and, ultimately tissue / organ dysfunction. The cornea, the transparent tissue located on the anterior chamber of the eye, is extremely susceptible to fibrotic diseases, which cause loss of corneal transparency and are often associated with blindness. Although topical corticosteroids and antimetabolites are extensively used in the management of corneal fibros...
Source: Advanced Drug Delivery Reviews - April 20, 2024 Category: Drugs & Pharmacology Authors: Laura Trujillo Cubillo Mehmet Gurdal Dimitrios I Zeugolis Source Type: research
Development of Cell Culture Platforms for Study of Trabecular Meshwork Cells and Glaucoma Development
AbstractBackground:Various cell culture platforms that could display native environmental cue-mimicking stimuli were developed, and effects of environmental cues on cell behaviors were studied with the cell culture platforms. Likewise, various cell culture platforms mimicking native trabecular meshwork (TM) composed of juxtacanalicular, corneoscleral and uveal meshwork located in internal scleral sulcus were used to study effects of environmental cues and/or drug treatments on TM cells and glaucoma development. Glaucoma is a disease that could cause blindness, and cause of glaucoma is not clearly identified yet. It appears...
Source: Tissue Engineering and Regenerative Medicine - April 20, 2024 Category: Biotechnology Source Type: research
Dexamethasone sodium phosphate loaded nanoparticles for prevention of nitrogen mustard induced corneal injury
Exp Eye Res. 2024 Apr 17:109902. doi: 10.1016/j.exer.2024.109902. Online ahead of print.ABSTRACTNitrogen mustard (NM) is a potent vesicating chemical warfare agent that is primarily absorbed through skin, inhalation, or ocular surface. Ocular exposure of NM can cause acute to chronic keratopathy which can eventually lead to blindness. There is a current lack of effective countermeasures against ocular exposure of NM despite their imperative need. Herein, we aim to explore the sustained effect of Dexamethasone sodium phosphate (DSP)-loaded polymeric nanoparticles (PLGA-DSP-NP) following a single subconjunctival injection in...
Source: Experimental Eye Research - April 19, 2024 Category: Opthalmology Authors: Sagun Poudel Ehsan Kaffash Long Zhao Rudra Pangeni Woon Nam Chow Qingguo Xu Source Type: research
Risk Factors for Retinopathy of Prematurity in Preterm Infants in Kerman, Iran
CONCLUSION: BW and duration of hospitalization were significant risk factors for ROP in the current study. BW was also strongly associated with the need for therapy.PMID:38638625 | PMC:PMC11022032 | DOI:10.18502/jovr.v19i1.15437 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Arash Daneshtalab Mahla Shadravan Amirreza Mobasherzadeh Mahani Azam Dehghani Mahdi Sharifzadeh Kermani Source Type: research
Contemporary Approach to Narrow Angles
J Ophthalmic Vis Res. 2024 Mar 14;19(1):88-108. doi: 10.18502/jovr.v19i1.15443. eCollection 2024 Jan-Mar.ABSTRACTGlaucoma is the leading cause of irreversible blindness worldwide. Among all glaucoma types, primary angle closure glaucoma (PACG) affects approximately 23 million people worldwide, and is responsible for 50% of glaucoma-related blindness, highlighting the devastating consequences of this disease. The main mechanism of PACG is relative pupillary block. High-risk populations are female gender, Asian ethnicity, high hyperopia, short axial length, and a thick/anteriorly positioned lens. This review discusses the cl...
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Wesam Shamseldin Shalaby Rohit Reddy Reza Razeghinejad L Jay Katz Source Type: research
