The Pseudotumor Cerebri Syndrome
This study addresses the diagnosis and management of IIH including new insights into the pathobiology of IIH, updates in therapeutics and causes of overdiagnosis. (Source: Neurologic Clinics)
Source: Neurologic Clinics - April 3, 2024 Category: Neurology Authors: Deborah I. Friedman Source Type: research
Variant in EZR leads to defects in lens development
CONCLUSIONS: The study suggests that ezrin may be involved in the enucleation and differentiation of lens epithelial cells.PMID:38563525 | DOI:10.1080/13816810.2024.2330391 (Source: Ophthalmic Genetics)
Source: Ophthalmic Genetics - April 2, 2024 Category: Opthalmology Authors: Nan Zhou Mingyan He Guangkai Zhou Qiuyang Fan Yanhua Qi Source Type: research
Decreasing mitochondrial fission ameliorates HIF-1 α-dependent pathological retinal angiogenesis
In this study, we investigated the role of mitochondrial dynamics in pathological retinal angiogenesis. We showed that treatment with vascular endothelial growth factor (VEGF; 20 ng/ml) induced mitochondrial fission in HUVECs by promoting the phosphorylation of dynamin-related protein 1 (DRP1). DRP1 knockdown or pretreatment with the DRP1 inhibitor Mdivi-1 (5 μM) blocked VEGF-induced cell migration, proliferation, and tube formation in HUVECs. We demonstrated that VEGF treatment increased mitochondrial ROS production in HUVECs, which was necessary for HIF-1α-dependent glycolysis, as well as proliferation, migration, and ...
Source: Acta Pharmacologica Sinica - April 2, 2024 Category: Drugs & Pharmacology Authors: Shu-Qi Huang Kai-Xiang Cao Cai-Ling Wang Pei-Ling Chen Yi-Xin Chen Yu-Ting Zhang Shi-Hui Yu Zai-Xia Bai Shuai Guo Mu-Xi Liao Qiao-Wen Li Guo-Qi Zhang Jun He Yi-Ming Xu Source Type: research
Variant in EZR leads to defects in lens development
CONCLUSIONS: The study suggests that ezrin may be involved in the enucleation and differentiation of lens epithelial cells.PMID:38563525 | DOI:10.1080/13816810.2024.2330391 (Source: Ophthalmic Genetics)
Source: Ophthalmic Genetics - April 2, 2024 Category: Opthalmology Authors: Nan Zhou Mingyan He Guangkai Zhou Qiuyang Fan Yanhua Qi Source Type: research
Microglia in retinal angiogenesis and diabetic retinopathy
AbstractDiabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the growth of new blood vessels in the retina at an advanced, proliferative stage. Microglia are a resident immune population in the central nervous system, known to play a crucial role in regulating retinal angiogenesis in both physiological and pathological conditions, including diabetic retinopathy. Physiologically, they are located close to blood vessels and are essential for forming new blood vessels (neovascularization). In diabetic retinopathy, microglia become wide...
Source: Angiogenesis - April 2, 2024 Category: Molecular Biology Source Type: research
The Role of Polygenic Risk Scores in Glaucoma Management
The study by Singh and colleagues heralds a substantial leap in our understanding and management of primary open-angle glaucoma (POAG) with polygenic risk scores (PRSs). POAG is one of the leading causes of irreversible blindness globally, often progressing without noticeable symptoms until extensive vision loss occurs. The study ’s key finding—that a PRS can independently predict the onset of POAG in individuals with ocular hypertension—is both groundbreaking and timely. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Safely Viewing a Solar Eclipse
The Patient Page published online today in JAMA provides safety recommendations for viewing the next total solar eclipse, which will cross major US cities on Monday afternoon, April 8. A solar eclipse can be one of nature ’s most extraordinary astronomical displays, but as many ophthalmologists know, improper viewing can cause serious eye damage, even blindness, if certain steps are not taken to protect the eyes. It may not be safe to view a total eclipse without added eye protection, even during the 90 seconds whe n an eclipse is total, unless one is certain that one is viewing during totality. The totality of an eclips...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
The nature and distribution of putative non-functional alleles suggest only two independent events at the origins of Astyanax mexicanus cavefish populations
Several studies suggested that cavefish populations of Astyanax mexicanus settled during the Late Pleistocene. This implies that the cavefish ’s most conspicuous phenotypic changes, blindness and depigmentation, a... (Source: BMC Evolutionary Biology)
Source: BMC Evolutionary Biology - April 1, 2024 Category: Molecular Biology Authors: Maxime Policarpo, Laurent Legendre, Isabelle Germon, Philippe Lafargeas, Luis Espinasa, Sylvie R étaux and Didier Casane Tags: Research Source Type: research
