Safflower polysaccharide ameliorates acute ulcerative colitis by regulating STAT3/NF- κB signaling pathways and repairing intestinal barrier function
This study is to investigate the effect of SPS on the UC model. An animal model of UC induced by DSS was developed using C57BL/6 mice. The body weight was recorded every day, and the symptoms related to UC were detected. H&E staining, AB-PAS staining and PSR staining were used to evaluate the histopathological changes of the colon. Inflammation and mucosal barrier indicators were detected by qRT-PCR, and the 16 S rRNA sequence was used to detect the intestinal flora. SPS can significantly prevent and treat DSS-induced ulcerative colitis in animals. SPS significantly improved clinical symptoms, alleviated pathological d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2024 Category: Drugs & Pharmacology Authors: Man Qi Shenghui Chu Wenxuan Wang Xianglei Fu Chao Jiang Liang Zhang Md Hasan Ali Yating Lu Mengwei Jia Dilraba Ubul Hui Tang Jian Li Min Liu Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
A universal plasma metabolites-derived signature predicts cardiovascular disease risk in MAFLD
CONCLUSIONS: Simple MAFLD patients and MAFLD patients with CVD risk had divergent gut microbes and plasma metabolites. The predictive model based on metabolites and 9 clinical parameters could effectively discriminate MAFLD patients with CVD risk at a very early stage.PMID:38581738 | DOI:10.1016/j.atherosclerosis.2024.117526 (Source: Atherosclerosis)
Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Zhonglin Li Rui Gong Huikuan Chu Junchao Zeng Can Chen Sanping Xu Lilin Hu Wenkang Gao Li Zhang Hang Yuan Zilu Cheng Cheng Wang Meng Du Qingjing Zhu Li Zhang Lin Rong Xiaoqing Hu Ling Yang Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Protective effect of cellulose and soluble dietary fiber from Saccharina japonica by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice
This study aimed to investigate the physicochemical properties of soluble dietary fiber (SDF) and cellulose enriched in Saccharina japonica by-products and to evaluate their anti-colitis effects. The water-holding capacity (WHC), swelling capacity (SC), cation exchange capacity (CEC), and antioxidant properties of SDF were superior to cellulose. The ΔH of SDF and cellulose was 340.73 J/g and 134.56 J/g, and the average particle size of them was 43.858 μm and 97.350 μm. The viscosity of SDF was positively correlated with the content. SEM revealed that the microstructure of SDF was porous, whereas cellulose was folded. SD...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Junhan Cao Ling Qin Liping Zhang Kai Wang Mengke Yao Changfeng Qu Jinlai Miao Source Type: research
Effects of dietary selenized glucose on intestinal microbiota and tryptophan metabolism in rats: Assessing skatole reduction potential
In this study, a diverse range of dietary SeGlu-treated levels, including SeGlu-deficient (CK), SeGlu-adequate (0.15 mg Se per L), and SeGlu-supranutritional (0.4 mg Se per L) conditions, were used to investigate the complex interaction of SeGlu on intestinal microbiome and serum metabolome changes in male Sprague-Dawley (SD) rats. The study showed that SeGlu supplementation enhanced the antioxidant ability in rats, significantly manifested in the increases of the activity of catalase (CAT) and glutathione peroxidase (GSH-Px), while no change in the level of malonaldehyde (MDA). Metagenomic sequencing analysis verified tha...
Source: Environmental Research - April 5, 2024 Category: Environmental Health Authors: Zhi Zeng Bo Lv Yun-E Tang Huimin Sun Shunfeng Li Yuan He Juan Wang Zhi Wang Source Type: research
Protective effect of cellulose and soluble dietary fiber from Saccharina japonica by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice
This study aimed to investigate the physicochemical properties of soluble dietary fiber (SDF) and cellulose enriched in Saccharina japonica by-products and to evaluate their anti-colitis effects. The water-holding capacity (WHC), swelling capacity (SC), cation exchange capacity (CEC), and antioxidant properties of SDF were superior to cellulose. The ΔH of SDF and cellulose was 340.73 J/g and 134.56 J/g, and the average particle size of them was 43.858 μm and 97.350 μm. The viscosity of SDF was positively correlated with the content. SEM revealed that the microstructure of SDF was porous, whereas cellulose was folded. SD...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Junhan Cao Ling Qin Liping Zhang Kai Wang Mengke Yao Changfeng Qu Jinlai Miao Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
