A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
Highly-efficient in vivo production of lacto-N-fucopentaose V by a regio-specific α1,3/4-fucosyltransferase from Bacteroides fragilis NCTC 9343
In this study, the biosynthetic pathway of LNFP V was examined in Escherichia coli. The previously constructed E. coli efficiently producing lacto-N-tetraose was used as the starting strain. GDP-fucose pathway module and a regio-specific glycosyltransferase with α1,3-fucosylation activity were introduced to realize the efficient synthesis of LNFP V. The α1,3/4-fucosyltransferase from Bacteroides fragilis was selected as the best enzyme for in vivo biosynthesis of LNFP V from nine candidates, with the highest titer and the lowest by-product accumulation. A beneficial variant K128D was obtained to further enhance LNFP V ti...
Source: International Journal of Biological Macromolecules - March 18, 2024 Category: Biochemistry Authors: Ningning Wang Yingying Zhu Liang Wang Zhaolin Huang Zeyu Li Wei Xu Wanmeng Mu Source Type: research
Characterization of a secreted aminopeptidase of M28 family from B. fragilis and its possible role in protein metabolism in the gut
Biochim Biophys Acta Gen Subj. 2024 Mar 16:130598. doi: 10.1016/j.bbagen.2024.130598. Online ahead of print.ABSTRACTProducts of microbial protein metabolism in the gut can influence the health of the host in many ways. Members of the Bacteriodales, major commensals of the human colon have been associated with long-term intake of high-protein diets. Undigested proteins or peptides that reach the colon can be hydrolyzed by extra-cellular proteases found in some Bacteroides species into amino acids and peptides which can be further catabolized. In this communication, we have characterized one such secreted aminopeptidase (BfA...
Source: Biochimica et Biophysica Acta - March 18, 2024 Category: Biochemistry Authors: Bhushan S Kulkarni Ravindra D Makde Sahayog N Jamdar Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
Highly-efficient in vivo production of lacto-N-fucopentaose V by a regio-specific α1,3/4-fucosyltransferase from Bacteroides fragilis NCTC 9343
In this study, the biosynthetic pathway of LNFP V was examined in Escherichia coli. The previously constructed E. coli efficiently producing lacto-N-tetraose was used as the starting strain. GDP-fucose pathway module and a regio-specific glycosyltransferase with α1,3-fucosylation activity were introduced to realize the efficient synthesis of LNFP V. The α1,3/4-fucosyltransferase from Bacteroides fragilis was selected as the best enzyme for in vivo biosynthesis of LNFP V from nine candidates, with the highest titer and the lowest by-product accumulation. A beneficial variant K128D was obtained to further enhance LNFP V ti...
Source: International Journal of Biological Macromolecules - March 18, 2024 Category: Biochemistry Authors: Ningning Wang Yingying Zhu Liang Wang Zhaolin Huang Zeyu Li Wei Xu Wanmeng Mu Source Type: research
Characterization of a secreted aminopeptidase of M28 family from B. fragilis and its possible role in protein metabolism in the gut
Biochim Biophys Acta Gen Subj. 2024 Mar 16;1868(5):130598. doi: 10.1016/j.bbagen.2024.130598. Online ahead of print.ABSTRACTProducts of microbial protein metabolism in the gut can influence the health of the host in many ways. Members of the Bacteriodales, major commensals of the human colon have been associated with long-term intake of high-protein diets. Undigested proteins or peptides that reach the colon can be hydrolyzed by extra-cellular proteases found in some Bacteroides species into amino acids and peptides which can be further catabolized. In this communication, we have characterized one such secreted aminopeptid...
Source: Biochimica et Biophysica Acta - March 18, 2024 Category: Biochemistry Authors: Bhushan S Kulkarni Ravindra D Makde Sahayog N Jamdar Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients
CONCLUSIONS: These findings suggest that BF839 has the potential to effectively mitigate myelosuppression and gastrointestinal toxicity associated with chemotherapy in breast cancer patients.PMID:38494684 | DOI:10.6133/apjcn.202403_33(1).0003 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Ting Zeng Yu-Hong Deng Chu-Hui Lin Xin-Xin Chen Hai-Xia Jia Xiao-Wu Hu Ting Xia Yun Ling Le-Hong Zhang Teng-Fei Cao Source Type: research
