Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Cell Host Microbe. 2024 Feb 23:S1931-3128(24)00042-8. doi: 10.1016/j.chom.2024.02.003. Online ahead of print.ABSTRACTReversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented...
Source: Cell Host and Microbe - February 29, 2024 Category: Microbiology Authors: Shaqed Carasso Rawan Zaatry Haitham Hajjo Dana Kadosh-Kariti Nadav Ben-Assa Rawi Naddaf Noa Mandelbaum Sigal Pressman Yehuda Chowers Tal Gefen Kate L Jeffrey Juan Jofre Michael J Coyne Laurie E Comstock Itai Sharon Naama Geva-Zatorsky Source Type: research
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Cell Host Microbe. 2024 Feb 23:S1931-3128(24)00042-8. doi: 10.1016/j.chom.2024.02.003. Online ahead of print.ABSTRACTReversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented...
Source: Cell Host and Microbe - February 29, 2024 Category: Microbiology Authors: Shaqed Carasso Rawan Zaatry Haitham Hajjo Dana Kadosh-Kariti Nadav Ben-Assa Rawi Naddaf Noa Mandelbaum Sigal Pressman Yehuda Chowers Tal Gefen Kate L Jeffrey Juan Jofre Michael J Coyne Laurie E Comstock Itai Sharon Naama Geva-Zatorsky Source Type: research
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Cell Host Microbe. 2024 Feb 23:S1931-3128(24)00042-8. doi: 10.1016/j.chom.2024.02.003. Online ahead of print.ABSTRACTReversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented...
Source: Cell Host and Microbe - February 29, 2024 Category: Microbiology Authors: Shaqed Carasso Rawan Zaatry Haitham Hajjo Dana Kadosh-Kariti Nadav Ben-Assa Rawi Naddaf Noa Mandelbaum Sigal Pressman Yehuda Chowers Tal Gefen Kate L Jeffrey Juan Jofre Michael J Coyne Laurie E Comstock Itai Sharon Naama Geva-Zatorsky Source Type: research
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Cell Host Microbe. 2024 Feb 23:S1931-3128(24)00042-8. doi: 10.1016/j.chom.2024.02.003. Online ahead of print.ABSTRACTReversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented...
Source: Cell Host and Microbe - February 29, 2024 Category: Microbiology Authors: Shaqed Carasso Rawan Zaatry Haitham Hajjo Dana Kadosh-Kariti Nadav Ben-Assa Rawi Naddaf Noa Mandelbaum Sigal Pressman Yehuda Chowers Tal Gefen Kate L Jeffrey Juan Jofre Michael J Coyne Laurie E Comstock Itai Sharon Naama Geva-Zatorsky Source Type: research
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Cell Host Microbe. 2024 Feb 23:S1931-3128(24)00042-8. doi: 10.1016/j.chom.2024.02.003. Online ahead of print.ABSTRACTReversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented...
Source: Cell Host and Microbe - February 29, 2024 Category: Microbiology Authors: Shaqed Carasso Rawan Zaatry Haitham Hajjo Dana Kadosh-Kariti Nadav Ben-Assa Rawi Naddaf Noa Mandelbaum Sigal Pressman Yehuda Chowers Tal Gefen Kate L Jeffrey Juan Jofre Michael J Coyne Laurie E Comstock Itai Sharon Naama Geva-Zatorsky Source Type: research
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Cell Host Microbe. 2024 Feb 23:S1931-3128(24)00042-8. doi: 10.1016/j.chom.2024.02.003. Online ahead of print.ABSTRACTReversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented...
Source: Cell Host and Microbe - February 29, 2024 Category: Microbiology Authors: Shaqed Carasso Rawan Zaatry Haitham Hajjo Dana Kadosh-Kariti Nadav Ben-Assa Rawi Naddaf Noa Mandelbaum Sigal Pressman Yehuda Chowers Tal Gefen Kate L Jeffrey Juan Jofre Michael J Coyne Laurie E Comstock Itai Sharon Naama Geva-Zatorsky Source Type: research
Profiling the Gut Microbiome Unraveled Signature Bacterial Groups in Autoimmune Diabetes, which Remain Unperturbed by the Low Ionic Strength of the Drinking Water in NOD mice
CONCLUSIONS: The data presented herein validate the lack of influence of acidic drinking water on T1D development in female NOD mice. Diabetes was associated with the lower representation of Lactobacillus sp. throughout life, which was not influenced by the differing pH of the drinking water. Significantly, segmented filamentous bacteria and A. muciniphila, previously implicated in protection against T1D, were not perturbed by the varying pH of the water consumed. These data indicate that although acidified water consumption was reported previously to diminish specific gastrointestinal pathogens, it failed to perturb gut c...
Source: Discovery Medicine - February 27, 2024 Category: Research Authors: Sundararajan Jayaraman Meghana Babu Tha Aung Saw Arathi K Jayaraman Source Type: research
