Dietary chlorogenic acid alleviates high-fat diet-induced steatotic liver disease by regulating metabolites and gut microbiota
Int J Food Sci Nutr. 2024 Feb 22:1-16. doi: 10.1080/09637486.2024.2318590. Online ahead of print.ABSTRACTThe high-fat diet would lead to excessive fat storage in the liver to form metabolic dysfunction-associated steatotic liver disease (MASLD), and the trend is burgeoning. The aim of the study is to investigate the effects of chlorogenic acid (CGA) on metabolites and gut microorganisms in MASLD mice induced by a high-fat diet. In comparison to the HF group, the TC (total cholesterol), TG (total triglycerides), LDL-C (low-density lipoprotein cholesterol), AST (aspartate aminotransferase) and ALT (alanine transaminase) leve...
Source: International Journal of Food Sciences and Nutrition - February 23, 2024 Category: Nutrition Authors: Yujuan Yu Fumao Zeng Peiheng Han Li Zhang Ling Yang Feng Zhou Qing Liu Zheng Ruan Source Type: research
Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPAR γ/NF-κB inhibition
This study preliminarily confirmed its significant anti-UC activity superior to Salicylazosulfapyridine. The average molecular weight of PPs was 3.10 × 105 Da, and PPs mainly comprised Mannose, Rhamnose, Galacturonic acid, Galactosamine, Glucose, and Xylose with molar ratios of 1.58:3.51:34.54:1.00:3.25:3.02. PPs (50, 100 mg/kg) could significantly resist dextran sodium sulfate induced UC on C57BL/6 mice by improving gut microbiota dysbiosis, such as the changes of relative abundance of Bacteroides, Culturomica, Mucispirillum, Escherichia-Shigella, Alistipes and Helicobacter. PPs also reverse the abnormal inflammatory rea...
Source: International Journal of Biological Macromolecules - February 23, 2024 Category: Biochemistry Authors: Minglan Wu Qi Wang Xiaodong Li Songxia Yu Fan Zhao Xia Wu Li Fan Xueling Liu Qingwei Zhao Xuelin He Weifen Li Qiao Zhang Xingjiang Hu Source Type: research
Dietary chlorogenic acid alleviates high-fat diet-induced steatotic liver disease by regulating metabolites and gut microbiota
Int J Food Sci Nutr. 2024 Feb 22:1-16. doi: 10.1080/09637486.2024.2318590. Online ahead of print.ABSTRACTThe high-fat diet would lead to excessive fat storage in the liver to form metabolic dysfunction-associated steatotic liver disease (MASLD), and the trend is burgeoning. The aim of the study is to investigate the effects of chlorogenic acid (CGA) on metabolites and gut microorganisms in MASLD mice induced by a high-fat diet. In comparison to the HF group, the TC (total cholesterol), TG (total triglycerides), LDL-C (low-density lipoprotein cholesterol), AST (aspartate aminotransferase) and ALT (alanine transaminase) leve...
Source: International Journal of Food Sciences and Nutrition - February 23, 2024 Category: Nutrition Authors: Yujuan Yu Fumao Zeng Peiheng Han Li Zhang Ling Yang Feng Zhou Qing Liu Zheng Ruan Source Type: research
Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPAR γ/NF-κB inhibition
This study preliminarily confirmed its significant anti-UC activity superior to Salicylazosulfapyridine. The average molecular weight of PPs was 3.10 × 105 Da, and PPs mainly comprised Mannose, Rhamnose, Galacturonic acid, Galactosamine, Glucose, and Xylose with molar ratios of 1.58:3.51:34.54:1.00:3.25:3.02. PPs (50, 100 mg/kg) could significantly resist dextran sodium sulfate induced UC on C57BL/6 mice by improving gut microbiota dysbiosis, such as the changes of relative abundance of Bacteroides, Culturomica, Mucispirillum, Escherichia-Shigella, Alistipes and Helicobacter. PPs also reverse the abnormal inflammatory rea...
Source: International Journal of Biological Macromolecules - February 23, 2024 Category: Biochemistry Authors: Minglan Wu Qi Wang Xiaodong Li Songxia Yu Fan Zhao Xia Wu Li Fan Xueling Liu Qingwei Zhao Xuelin He Weifen Li Qiao Zhang Xingjiang Hu Source Type: research
Dietary chlorogenic acid alleviates high-fat diet-induced steatotic liver disease by regulating metabolites and gut microbiota
Int J Food Sci Nutr. 2024 Feb 22:1-16. doi: 10.1080/09637486.2024.2318590. Online ahead of print.ABSTRACTThe high-fat diet would lead to excessive fat storage in the liver to form metabolic dysfunction-associated steatotic liver disease (MASLD), and the trend is burgeoning. The aim of the study is to investigate the effects of chlorogenic acid (CGA) on metabolites and gut microorganisms in MASLD mice induced by a high-fat diet. In comparison to the HF group, the TC (total cholesterol), TG (total triglycerides), LDL-C (low-density lipoprotein cholesterol), AST (aspartate aminotransferase) and ALT (alanine transaminase) leve...
Source: International Journal of Food Sciences and Nutrition - February 23, 2024 Category: Nutrition Authors: Yujuan Yu Fumao Zeng Peiheng Han Li Zhang Ling Yang Feng Zhou Qing Liu Zheng Ruan Source Type: research
Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients
Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients. Understanding the carcinogenic mechanism of bacteria and their impact on c... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - February 23, 2024 Category: Gastroenterology Authors: Nooshin Nazarinejad, Bahareh Hajikhani, Amir Abbas Vaezi, Farzaneh Firoozeh, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi and Masoud Dadashi Tags: Research Source Type: research
Potential biomarkers of acute myocardial infarction based on the composition of the blood microbiome
CONCLUSION: In this study, the composition of blood microorganisms in the groups of patients with AMI and UA has been analyzed, providing novel insights for understanding the pathogenesis of AMI; Blood microbiome may serve as novel diagnostic biomarkers of AMI.PMID:38387830 | DOI:10.1016/j.cca.2024.117843 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 22, 2024 Category: Chemistry Authors: Rishou Chen Yonglong Ye Yali Ding Zhidong Wan Xinyu Ye Jun Liu Source Type: research
Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity
This study sought to identify drugs specifically targeting the gut microbiota to mitigate UC. We initiated a meta-analysis on gut microbiota in UC patients to identify UC-associated bacterial strains. Subsequently, we screened 164 dietary herbal medicines in vitro to identify potential prebiotics for the UC-associated bacterium, Bacteroides thetaiotaomicron. The DSS-induced colitis mouse model was utilized to evaluate the anti-colitis efficacy of the identified dietary herbal medicine. Full-length 16 S rRNA amplicon sequencing was employed to observe changes in gut microbiota following dietary herbal medicine intervention....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 22, 2024 Category: Drugs & Pharmacology Authors: Lin-En Zou Ya-Nan Yang Jiaguo Zhan Jiale Cheng Yu Fu Ying Cao Xingxu Yan Yuming Wang Chongming Wu Source Type: research
Potential biomarkers of acute myocardial infarction based on the composition of the blood microbiome
CONCLUSION: In this study, the composition of blood microorganisms in the groups of patients with AMI and UA has been analyzed, providing novel insights for understanding the pathogenesis of AMI; Blood microbiome may serve as novel diagnostic biomarkers of AMI.PMID:38387830 | DOI:10.1016/j.cca.2024.117843 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 22, 2024 Category: Chemistry Authors: Rishou Chen Yonglong Ye Yali Ding Zhidong Wan Xinyu Ye Jun Liu Source Type: research
Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity
This study sought to identify drugs specifically targeting the gut microbiota to mitigate UC. We initiated a meta-analysis on gut microbiota in UC patients to identify UC-associated bacterial strains. Subsequently, we screened 164 dietary herbal medicines in vitro to identify potential prebiotics for the UC-associated bacterium, Bacteroides thetaiotaomicron. The DSS-induced colitis mouse model was utilized to evaluate the anti-colitis efficacy of the identified dietary herbal medicine. Full-length 16 S rRNA amplicon sequencing was employed to observe changes in gut microbiota following dietary herbal medicine intervention....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 22, 2024 Category: Drugs & Pharmacology Authors: Lin-En Zou Ya-Nan Yang Jiaguo Zhan Jiale Cheng Yu Fu Ying Cao Xingxu Yan Yuming Wang Chongming Wu Source Type: research
Flash extraction of ulvan polysaccharides from marine green macroalga Ulva linza and evaluation of its antioxidant and gut microbiota modulation activities
In this study, flash extraction was used to rapidly extract water-soluble polysaccharides from Ulva linza. The optimal extraction process for the flash extraction was determined by Box-Behnken design with extraction temperature 80 °C, extraction time 117 s, liquid-solid ratio 46:1 (mL/g) and a corresponding yield of 18.5 %. The crude Ulva linza polysaccharides (CULP) were subsequently isolated by chromatography technology to obtain purified Ulva linza polysaccharide (ULP) and characterized by monosaccharide composition and molecular weight determination analysis. Furthermore, the antioxidant bioactivity of ULP was studied...
Source: International Journal of Biological Macromolecules - February 15, 2024 Category: Biochemistry Authors: Yi Liang Wanguo Yu Huatian Wang Lingyun Yao Zengyang He Min Sun Tao Feng Chuang Yu Heng Yue Source Type: research
Novel and rare β-lactamase genes of Bacteroides fragilis group species: Detection of the genes and characterization of their genetic backgrounds
CONCLUSIONS: Based on these observations, β-lactamases produced by rare β-lactamase genes in B. fragilis group strains should not be overlooked because they could encode important resistance phenotypes.PMID:38360202 | DOI:10.1016/j.anaerobe.2024.102832 (Source: Anaerobe)
Source: Anaerobe - February 15, 2024 Category: Microbiology Authors: Bakhtiyar Mahmood K ároly Péter Sárvári Laszl ó Orosz Elisabeth Nagy J ózsef Sóki Source Type: research
Milk to mucus: How B. fragilis colonizes the gut
Cell Host Microbe. 2024 Feb 14;32(2):149-150. doi: 10.1016/j.chom.2024.01.007.ABSTRACTHuman milk oligosaccharide (HMO) consumption by the infant microbiota is positively associated with immune health. In this issue of Cell Host & Microbe, Buzun et al. report a mechanism for HMO digestion by Bacteroides fragilis and demonstrate how the same pathway works on intestinal mucus to establish long-term gut residency.PMID:38359795 | DOI:10.1016/j.chom.2024.01.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Matthew R Olm Noel T Mueller Source Type: research
A study on the association between gut microbiota, inflammation, and type 2 diabetes
Appl Microbiol Biotechnol. 2024 Feb 15;108(1):213. doi: 10.1007/s00253-024-13041-5.ABSTRACTType 2 diabetes mellitus (T2DM) was reported to be associated with impaired immune response and alterations in microbial composition and function. However, the underlying mechanism remains elusive. To investigate the association among retinoic acid-inducible gene-I-like receptors (RLRs) signaling pathway, intestinal bacterial microbiome, microbial tryptophan metabolites, inflammation, and a longer course of T2DM, 14 patients with T2DM and 7 healthy controls were enrolled. 16S rRNA amplicon sequencing and untargeted metabolomics were ...
Source: Applied Microbiology and Biotechnology - February 15, 2024 Category: Microbiology Authors: Nannan Liu Xuehua Yan Bohan Lv Yanxiang Wu Xuehong Hu Chunyan Zheng Siyu Tao Ruxue Deng Jinfang Dou Binfang Zeng Guangjian Jiang Source Type: research
Gut microbiota compositional profile in patients with posner-schlossman syndrome
This study demonstrated the gut microbiota compositional profile of PSS patients and speculated the risk microbiota of PSS, which is expected to provide new insights for the diagnosis and treatment of PSS.PMID:38360087 | DOI:10.1016/j.exer.2024.109825 (Source: Experimental Eye Research)
Source: Experimental Eye Research - February 15, 2024 Category: Opthalmology Authors: Ning Wang Chengyang Sun Yahan Ju Lulu Huang Yixin Liu Mengyang Gu Chenrui Xu Minghan Wang Yue Wu Dandan Zhang Li Xu Wenyi Guo Source Type: research
