The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice
This study aims to investigate the effects of GUP on glucose and lipid metabolism as well as the intestinal microbiota in HFD/STZ-induced T2D. The results demonstrated that GUP could significantly ameliorate hyperglycemia, insulin resistance, oxidative stress, and reduce liver lipid levels in T2D mice. Furthermore, it also enhanced the integrity of the intestinal barrier in T2D mice by reducing the levels of pro-inflammatory cytokines and serum LPS levels. Interestingly, GUP treatment significantly lowered serum creatinine and urea nitrogen levels, mitigating renal function deterioration and interstitial fibrosis. Addition...
Source: International Journal of Biological Macromolecules - March 6, 2024 Category: Biochemistry Authors: Jianming Ye Jie Ma Parhat Rozi Lingming Kong Jianzhong Zhou Yane Luo Haiyan Yang Source Type: research
Urbanization influences the indoor transfer of airborne antibiotic resistance genes, which has a seasonally dependent pattern
Environ Int. 2024 Mar 1;185:108545. doi: 10.1016/j.envint.2024.108545. Online ahead of print.ABSTRACTOver the last few years, the cumulative use of antibiotics in healthcare institutions, as well as the rearing of livestock and poultry, has resulted in the accumulation of antibiotic resistance genes (ARGs). This presents a substantial danger to human health worldwide. The characteristics of airborne ARGs, especially those transferred from outdoors to indoors, remains largely unexplored in neighborhoods, even though a majority of human population spends most of their time there. We investigated airborne ARGs and mobile gene...
Source: Environment International - March 6, 2024 Category: Environmental Health Authors: Chang Zhao Xinxin Liu Haoxin Tan Yucheng Bian Muhammad Khalid Aki Sinkkonen Ari Jumpponen Saeed Ur Rahman Baoming Du Nan Hui Source Type: research
The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice
This study aims to investigate the effects of GUP on glucose and lipid metabolism as well as the intestinal microbiota in HFD/STZ-induced T2D. The results demonstrated that GUP could significantly ameliorate hyperglycemia, insulin resistance, oxidative stress, and reduce liver lipid levels in T2D mice. Furthermore, it also enhanced the integrity of the intestinal barrier in T2D mice by reducing the levels of pro-inflammatory cytokines and serum LPS levels. Interestingly, GUP treatment significantly lowered serum creatinine and urea nitrogen levels, mitigating renal function deterioration and interstitial fibrosis. Addition...
Source: International Journal of Biological Macromolecules - March 6, 2024 Category: Biochemistry Authors: Jianming Ye Jie Ma Parhat Rozi Lingming Kong Jianzhong Zhou Yane Luo Haiyan Yang Source Type: research
Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms
ConclusionsThere was no difference in the response to FMT between severe and moderate IBS when a 90-g transplant was administered to the small intestine. The difference in the bacterial profile between severe and moderate IBS may explain the difference in symptoms between these patients. (www.clinicaltrials.gov: NCT04236843). (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 6, 2024 Category: Gastroenterology Source Type: research
The impact of gut microbiota on autoimmune thyroiditis and relationship with pregnancy outcomes: a review
This article reviews the characteristics of the gut microbiota in patients with AITD and the current research on its impact in pregnancy. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 5, 2024 Category: Microbiology Source Type: research
The critical role of toll-like receptor 4 in bone remodeling of osteoporosis: from inflammation recognition to immunity
Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers of studies have demonstrated that Toll-like receptor 4 (TLR4, a receptor located on the surface of osteoclasts and osteoblasts) plays a pivotal role in the development of osteoporosis. Herein, we performed a comprehensive review to summarize the findings from the relevant studies within this topic. Clinical data showed that TLR4 polymorphisms and aberrant TLR4 expression have been associated with the clinical significance of osteoporosis. Mechanistically, dysregulation of osteoblasts and osteoclasts induced by abnormal expression of TLR4...
Source: Frontiers in Immunology - March 5, 2024 Category: Allergy & Immunology Source Type: research
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1
Protein Cell. 2024 Mar 4:pwae005. doi: 10.1093/procel/pwae005. Online ahead of print.ABSTRACTTumor-resident microbiota in breast cancer promote cancer initiation and malignant progression. However, targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail. Here, we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis (ETBF) was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant chemotherapy. ETBF, albeit at low biomass, secreted the toxic protein BFT-1 to promote breast cancer cell stem...
Source: Protein and Cell - March 4, 2024 Category: Cytology Authors: Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng Yifei Yang Tingting Feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu Quentin Liu Yi-Zhou Jiang Shu Zhu Source Type: research
Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome
ConclusionDiarrhea with kidney-yang deficiency syndrome significantly affects the physiological status, digestive enzyme activity, CutC activity, TMAO levels, and inflammatory response in mice. Additionally, there are changes in the composition and function of cecal microbiota, indicating an important impact of diarrhea with kidney-yang deficiency syndrome on the host intestinal microbiota balance. The occurrence of diarrhea with kidney-yang deficiency syndrome may be associated with dysbiosis of intestinal microbiota, increased CutC activity, elevated TMAO levels, and heightened inflammatory factor levels. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 4, 2024 Category: Microbiology Source Type: research
Effects of Chronic Unpredictable Mild Stress on Gut Microbiota and Fecal Amino Acid and Short-Chain Fatty Acid Pathways in Mice
In this study, we used 16S rDNA to examine changes in gut microbiota and predict related pathways in depression-like mice. Additionally, we employed liquid chromatography-mass spectrometry (LC-MS) to identify changes in amino acids and gas chromatography-mass spectrometry (GC-MS) to identify changes in short-chain fatty acids (SCFAs) in fecal samples. We conducted Pearson/Spearman correlation analysis to investigate the associations between changes in amino acids/SCFAs and behavioral outcomes. The 16S rDNA sequencing revealed significant alterations in gut microbiota at the phylum and genus levels in mice subjected to chro...
Source: Behavioural Brain Research - March 3, 2024 Category: Neurology Authors: Mengjing Chen Lingfeng Wang Yeliang Lou Zhen Huang Source Type: research
Effects of Chronic Unpredictable Mild Stress on Gut Microbiota and Fecal Amino Acid and Short-Chain Fatty Acid Pathways in Mice
In this study, we used 16S rDNA to examine changes in gut microbiota and predict related pathways in depression-like mice. Additionally, we employed liquid chromatography-mass spectrometry (LC-MS) to identify changes in amino acids and gas chromatography-mass spectrometry (GC-MS) to identify changes in short-chain fatty acids (SCFAs) in fecal samples. We conducted Pearson/Spearman correlation analysis to investigate the associations between changes in amino acids/SCFAs and behavioral outcomes. The 16S rDNA sequencing revealed significant alterations in gut microbiota at the phylum and genus levels in mice subjected to chro...
Source: Brain Research - March 3, 2024 Category: Neurology Authors: Mengjing Chen Lingfeng Wang Yeliang Lou Zhen Huang Source Type: research
Molecules, Vol. 29, Pages 1108: Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism
In conclusion, our results suggest that ginsenoside Rb1, CK, and PPD supplementation offer promising prebiotic interventions for managing HFD-induced hyperlipidemia in rats, with ginsenoside Rb1 demonstrating superior efficacy. (Source: Molecules)
Source: Molecules - March 1, 2024 Category: Chemistry Authors: Kang-Xi Zhang Yue Zhu Shu-Xia Song Qing-Yun Bu Xiao-Yan You Hong Zou Guo-Ping Zhao Tags: Article Source Type: research
Clinical evidence of the link between gut microbiome and myalgic encephalomyelitis/chronic fatigue syndrome: a retrospective review
AbstractMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As a vital environmental factor, the gut microbiome is increasingly emphasized in various refractory diseases including ME/CFS. The present study is aimed to enhance our understanding of the relationship between the gut microbiome and ME/CFS through data analysis of various clinical studies. We conducted a literature search in four databases (PubMed, Cochrane Library, Web of Science, and Google Scholar) until May 31, 2023. Our analysis encompa...
Source: European Journal of Medical Research - March 1, 2024 Category: Research Source Type: research
Alterations in gut microbiome associated with severity of atopic dermatitis in infants
CONCLUSION: Discrepancies in gut microbial composition and functional pathways were observed in infants with mild-to-severe AD. Alterations in butyrate-producing bacteria (Clostridium sensu stricto), sphingolipid-producing bacteria (Parabacteroides, Bacteroides), and related functional pathways were associated with the severity of AD infants.PMID:38419203 | DOI:10.1111/ajd.14237 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - February 29, 2024 Category: Dermatology Authors: Xiaoyi Liu Meiqin Cai Meiru Chen Ji Chen Tingyu Zhu Shiyin Wu Jie Jia Source Type: research
