Antibiotic prophylaxis for leptospirosis
CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | PMC:PMC10938880 | DOI:10.1002/14651858.CD014959.pub2 (So...
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research
Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | PMC:PMC10938876 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research
Can the use of azithromycin during labour reduce the incidence of infection among puerperae and newborns? A systematic review and meta-analysis of randomized controlled trials
This systematic review and meta-analysis investigated whether the use of azithromycin during labour or caesarean section reduces the incidence of sepsis and infection among mothers and newborns. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - March 14, 2024 Category: OBGYN Authors: Haiyan Ye, Jinlu Hu, Bo Li, Xia Yu and Xuemei Zheng Tags: Research Source Type: research
Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)
This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp. A plasmid containing eight coding sequences (CDSs) was grouped in a β lineage. A chromosome sequence had approximately 1,018-1,031 CDSs. Chlamydial factors involving virulence were documented in terms of the presence of cytotoxins and several virulence factors in the chromosomes of Siamese crocodile Chlamydia. The analysis of antimicrobial resistance genes in the Ch...
Source: Acta Tropica - March 13, 2024 Category: Infectious Diseases Authors: Somjit Chaiwattanarungruengpaisan Metawee Thongdee Nlin Arya Weena Paungpin Wanna Sirimanapong Ladawan Sariya Source Type: research
Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)
This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp. A plasmid containing eight coding sequences (CDSs) was grouped in a β lineage. A chromosome sequence had approximately 1,018-1,031 CDSs. Chlamydial factors involving virulence were documented in terms of the presence of cytotoxins and several virulence factors in the chromosomes of Siamese crocodile Chlamydia. The analysis of antimicrobial resistance genes in the Ch...
Source: Acta Tropica - March 13, 2024 Category: Infectious Diseases Authors: Somjit Chaiwattanarungruengpaisan Metawee Thongdee Nlin Arya Weena Paungpin Wanna Sirimanapong Ladawan Sariya Source Type: research
Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)
This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp. A plasmid containing eight coding sequences (CDSs) was grouped in a β lineage. A chromosome sequence had approximately 1,018-1,031 CDSs. Chlamydial factors involving virulence were documented in terms of the presence of cytotoxins and several virulence factors in the chromosomes of Siamese crocodile Chlamydia. The analysis of antimicrobial resistance genes in the Ch...
Source: Acta Tropica - March 13, 2024 Category: Infectious Diseases Authors: Somjit Chaiwattanarungruengpaisan Metawee Thongdee Nlin Arya Weena Paungpin Wanna Sirimanapong Ladawan Sariya Source Type: research
Human Campylobacter spp. infections in Italy
ConclusionCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 12, 2024 Category: Microbiology Source Type: research
Antimicrobial susceptibilities of < em > Neisseria gonorrhoeae < /em > in Canada, 2021
CONCLUSION: The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment therapies are recommended.PMID:38463902 | PMC:PMC10919915 | DOI:10.14745/ccdr.v49i09a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 11, 2024 Category: Infectious Diseases Authors: Pamela Sawatzky Brigitte Lefebvre Mathew Diggle Linda Hoang Jason Wong Samir Patel Paul Van Caessele Jessica Minion Richard Garceau Sarah Jeffrey David Haldane Lillian Lourenco Genevieve Gravel Michael Mulvey Irene Martin Source Type: research
Antimicrobial susceptibilities of < em > Neisseria gonorrhoeae < /em > in Canada, 2021
CONCLUSION: The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment therapies are recommended.PMID:38463902 | PMC:PMC10919915 | DOI:10.14745/ccdr.v49i09a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 11, 2024 Category: Infectious Diseases Authors: Pamela Sawatzky Brigitte Lefebvre Mathew Diggle Linda Hoang Jason Wong Samir Patel Paul Van Caessele Jessica Minion Richard Garceau Sarah Jeffrey David Haldane Lillian Lourenco Genevieve Gravel Michael Mulvey Irene Martin Source Type: research
Mycobacterial spindle cell pseudotumor of the spinal cord: Case report and literature review
We report the first description of spinal cord mycobacterial spindle cell pseudotumor. A patient with newly diagnosed advanced HIV presented with recent-onset bilateral leg weakness and was found to have a hypermetabolic spinal cord mass on structural and molecular imaging. Biopsy and cultures from blood and cerebrospinal fluid confirmed spindle cell pseudotumor due to Mycobacterium avium-intracellulare. Despite control of HIV and initial reduction in pseudotumor volume on antiretrovirals and antimycobacterials (azithromycin, ethambutol, rifampin/rifabutin), he ultimately experienced progressive leg weakness due to pseudot...
Source: Journal of Neuroimmunology - March 11, 2024 Category: Allergy & Immunology Authors: Michael Tran Duong, Adam Ungemach, Faizan Malik, Melissa T. Duong, Noah Wasserman, Kumarasen Cooper, Austin R. Pantel, Jessica O'Neil, Zsofia Szep Source Type: research
Late-Onset Diffuse Lung Disease in an 8-Year-Old Girl
Chest. 2024 Mar;165(3):e71-e74. doi: 10.1016/j.chest.2023.08.005.ABSTRACTAn 8-year-old girl presented with a 34-day history of cough, fatigue, and impaired exercise tolerance. She experienced cyanosis on exertion but denied fever, hemoptysis, hematuria, or seizures. Her perinatal and family histories were unremarkable, and she had no history of exposure to TB. A chest radiogram from a local clinic showed diffuse pulmonary lesions. Tuberculin skin test, interferon-γ release assay, and HIV antibody test results were all negative. Immunoglobulin levels and lymphocyte subsets were normal. The patient did not respond to IV azi...
Source: Chest - March 9, 2024 Category: Respiratory Medicine Authors: Huiying Wang Yu Tang Yuelin Shen Source Type: research
‘Failure at every level’: How science sleuths exposed massive ethics violations at a famed French institute
With six studies published in the 2010s, French microbiologist Didier Raoult added to his already vast publication record. He and his colleagues conducted a wide range of investigations into infectious diseases and their treatments. They took stool samples from patients on long-term antibiotic treatment, looking for alterations in their gut microbiome. They swabbed the throats of pilgrims leaving France for Mecca, searching for evidence of a bacterium that causes brain abscesses. And they studied samples of heart valves and blood clots from patients with heart inflammation to refine tests for the bacteria that cause the co...
Source: Science of Aging Knowledge Environment - March 7, 2024 Category: Geriatrics Source Type: research
In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions that might impact ototoxicity would facilitate design of safer multi-drug regimens and mitigate unsafe polypharmacy by flagging combinations that potentially cause adverse interactions for monitoring. They may also identify protective agents that antagonize ototoxic injury.Methods: To address this need, we have developed a novel workflow that we call Parallelized Evaluation of...
Source: Frontiers in Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
Management of Acne in Pregnancy
AbstractAcne is one of the most common dermatological conditions to affect women of childbearing age, so it is important to consider the safety of long-term acne treatments on women who could become pregnant. In this review article, we clarify what management options are available to treat acne during pregnancy. Topical treatments, typically first-line for acne, such as azelaic acid, clindamycin, erythromycin, metronidazole, benzoyl peroxide, salicylic acid, dapsone, and retinoids, were reviewed. Systemic treatments, such as zinc supplements, cephalexin, cefadroxil, amoxicillin, azithromycin, erythromycin, and corticostero...
Source: American Journal of Clinical Dermatology - March 7, 2024 Category: Dermatology Source Type: research
Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods
ConclusionsChildren receiving early oral doxycycline had a shorter duration of fever and hospitalization in macrolide-resistantMycoplasma pneumoniae patients. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 5, 2024 Category: Pediatrics Source Type: research
