Prevalence and determinants of antibiotics self-medication among indigenous people of Bangladesh: a cross-sectional study
Conclusion
Male gender, family income, place of residence and knowledge of antibiotics were the significant predictors of antibiotic self-medication. Hence, it is important to streamline awareness-raising campaigns at the community level to mitigate the practice of SMA in indigenous people and ultimately address the devastating effects of Antimicrobial resistance (AMR) in Bangladesh. (Source: BMJ Open)
Source: BMJ Open - March 5, 2024 Category: General Medicine Authors: Mannan, A., Chakma, K., Dewan, G., Saha, A., Chy, N. U. H. A., Mehedi, H. M. H., Hossain, A., Wnaiza, J., Ahsan, M. T., Rana, M. M., Alam, N. Tags: Open access, Epidemiology Source Type: research
Azithromycin induced asthma remission in adults with persistent uncontrolled asthma: a secondary analysis of a randomised, double-blind, placebo-controlled trial
Chest. 2024 Feb 29:S0012-3692(24)00284-8. doi: 10.1016/j.chest.2024.02.048. Online ahead of print.ABSTRACTBACKGROUND: Asthma remission is a potential treatment goal.RESEARCH QUESTION: Does adding azithromycin to standard therapy in patients with persistent uncontrolled asthma induce remission compared to placebo?STUDY DESIGN AND METHODS: This secondary analysis used data from the AMAZES clinical trial - a double-blind placebo-controlled trial that evaluated the safety and efficacy of azithromycin on asthma exacerbations. The primary remission definition (referred to as clinical remission) was zero exacerbations and zero or...
Source: Chest - March 2, 2024 Category: Respiratory Medicine Authors: Dennis Thomas Vanessa M McDonald Sean Stevens Melissa Baraket Sandra Hodge Alan James Christine Jenkins Guy B Marks Matthew Peters Paul Reynolds John W Upham Ian A Yang Peter G Gibson Source Type: research
Antibiotic resistance and virulence genes profile of Non typhodial Salmonella species isolated from poultry enteritis in India
AbstractSalmonella species (spp) is the most important gastrointestinal pathogen present ubiquitously. Non typhoidal Salmonella (NTS) is commonly associated with gastroenteritis in humans. Layer birds once get infection with NTS, can become persistently infected withSalmonella Typhimurium and intermittently shed the bacteria. It results in a high risk of potential exposure of eggs to the bacteria. The current study was conducted to determine the serotype diversity, presence of virulence genes, antibiotic resistance pattern, and genes of NTS from poultry enteritis. Out of 151 intestinal swabs from poultry total 118 NTS w...
Source: Tropical Animal Health and Production - March 2, 2024 Category: Veterinary Research Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
Macrolide antibiotics (including azithromycin) for cystic fibrosis
CONCLUSIONS: Azithromycin therapy is associated with a small but consistent improvement in respiratory function, a decreased risk of exacerbation and longer time to exacerbation at six months; but evidence for treatment efficacy beyond six months remains limited. Azithromycin appears to have a good safety profile (although a weekly dose was associated with more gastrointestinal side effects, which makes it less acceptable for long-term therapy), with a relatively minimal treatment burden for people with CF, and it is inexpensive. A wider concern may be the emergence of macrolide resistance reported in the most recent study...
Source: Cochrane Database of Systematic Reviews - February 27, 2024 Category: General Medicine Authors: Kevin W Southern Arturo Solis-Moya Dominiki Kurz Sherie Smith Source Type: research
Macrolide antibiotics (including azithromycin) for cystic fibrosis
CONCLUSIONS: Azithromycin therapy is associated with a small but consistent improvement in respiratory function, a decreased risk of exacerbation and longer time to exacerbation at six months; but evidence for treatment efficacy beyond six months remains limited. Azithromycin appears to have a good safety profile (although a weekly dose was associated with more gastrointestinal side effects, which makes it less acceptable for long-term therapy), with a relatively minimal treatment burden for people with CF, and it is inexpensive. A wider concern may be the emergence of macrolide resistance reported in the most recent study...
Source: Cochrane Database of Systematic Reviews - February 27, 2024 Category: General Medicine Authors: Kevin W Southern Arturo Solis-Moya Dominiki Kurz Sherie Smith Source Type: research
Comparison of gradient diffusion and molecular methods using Allplex ™ NG & amp;DR assay (Seegene ®) for macrolide and fluoroquinolone screening resistance in Neisseria gonorrhoeae
AbstractAntimicrobial resistance inNeisseria gonorrhoeae (NG) is increasing worldwide. Second-line treatments with macrolides or fluoroquinolones are an option for NG infections in some cases following the STI guideline recommendations. In our study, we compared the gradient diffusion test using EUCAST 2024 breakpoints with a new molecular method using the Allplex ™ NG&DR assay (Seegene®) including A2059G/C2611 mutations (23S rRNA) associated with high/moderate-level macrolide resistance and S91F mutation (gyrA) relationship with fluoroquinolone resistance in NG isolates (n = 100). We calculated the sensitivity,...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 26, 2024 Category: Microbiology Source Type: research
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Eur J Pharm Biopharm. 2024 Feb 20:114233. doi: 10.1016/j.ejpb.2024.114233. Online ahead of print.ABSTRACTThe aim of this study was to develop azithromycin (AZT)-loaded liposomes (LP) and niosomes (NS) useful for the treatment of bacterial skin infections and acne. LP based on phosphatidylcholine from egg yolk (EPC) or from soybean lecithin (SPC), and NS composed of sorbitan monopalmitate (Span 40) or sorbitan monostearate (Span 60) were prepared through the thin film hydration (TFH) and the ethanol injection (EI) methods. The formulations were subsequently characterized for their physico-chemical and functional properties....
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 22, 2024 Category: Drugs & Pharmacology Authors: A Abruzzo R Pucci P M Abruzzo S Canaider C Parolin B Vitali F Valle M Brucale T Cerchiara B Luppi F Bigucci Source Type: research
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Eur J Pharm Biopharm. 2024 Feb 20:114233. doi: 10.1016/j.ejpb.2024.114233. Online ahead of print.ABSTRACTThe aim of this study was to develop azithromycin (AZT)-loaded liposomes (LP) and niosomes (NS) useful for the treatment of bacterial skin infections and acne. LP based on phosphatidylcholine from egg yolk (EPC) or from soybean lecithin (SPC), and NS composed of sorbitan monopalmitate (Span 40) or sorbitan monostearate (Span 60) were prepared through the thin film hydration (TFH) and the ethanol injection (EI) methods. The formulations were subsequently characterized for their physico-chemical and functional properties....
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 22, 2024 Category: Drugs & Pharmacology Authors: A Abruzzo R Pucci P M Abruzzo S Canaider C Parolin B Vitali F Valle M Brucale T Cerchiara B Luppi F Bigucci Source Type: research
A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient
AbstractA 50-year-old man who had undergone a living-donor kidney transplant 12 years prior for chronic renal failure due to autosomal dominant polycystic kidney disease contracted coronavirus disease 19 (COVID-19). He had a positive antigen test, mild symptoms, sore throat, and fever of 37.9 ℃. The patient was treated with molnupiravir for 5 days, and the symptoms disapp eared 5 days after onset. However, 10 days after onset, he developed a fever of approximately 37 ℃ and a non-productive cough; 27 days after onset, the patient was hospitalized for anorexia and a worsening respiratory condition. The severe acu...
Source: CEN Case Reports - February 17, 2024 Category: Urology & Nephrology Source Type: research
The effects of prenatal azithromycin exposure on offspring ovarian development at different stages, doses, and courses
Biomed Pharmacother. 2024 Feb 14;172:116246. doi: 10.1016/j.biopha.2024.116246. Online ahead of print.ABSTRACTAzithromycin, a commonly used macrolide antibiotic for treating chlamydial infections during pregnancy, has sparked investigations into its potential effects on offspring development. Despite these inquiries, there remains uncertainty about the specific impact of prenatal azithromycin exposure (PAzE) on offspring ovarian development and the precise "effect window". Pregnant mice, following clinical guidelines for azithromycin dosing, were orally administered azithromycin at different gestational stages [(gestationa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 15, 2024 Category: Drugs & Pharmacology Authors: Yating Li Jing Huang Caiyun Ge Sen Zhu Hui Wang Yuanzhen Zhang Source Type: research
