Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice. In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mild Mitochondrial Inhibition Slows Aging in Nematode Worms
Researchers here demonstrate that means of mildly inhibiting the production of some of the protein machinery used to generate chemical energy store molecules, adenosine triphosphate, in mitochondria can extend life by 50-70% in nematode worms - a species in which much larger life extension is possible, so this might be viewed as a moderate effect size. Many different approaches to adjusting mitochondrial function can slow aging and extend life in short-lived species. In some cases this works by provoking mitochondria into an alternative pathway for ATP generation that produces a little more oxidative stress than usual, tri...
Source: Fight Aging! - November 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

What's new in midwifery - 13th March 2023 - Global health
Four recent papers you might be interested to know about:Experiences of families and health professionals along the care continuum for low-birth weight neonates: A constructivist grounded theory study.  Study conducted in Ghana.Fortified balanced energy-protein supplementation during pregnancy and lactation and infant growth in rural Burkina Faso: A 2 x 2 factorial individually randomized controlled trial.World Health Organization: Strengthening implementation of home-based records for maternal, newborn and child health: a guide for country programme managers.  WHO publication, published in December 2022.Eff...
Source: Browsing - March 13, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs

Brain-eating amoeba
TL:DR – The brain-eating amoeba, Naegleria fowleri, does not eat brains but it can cause fatal brain swelling. Avoid it by only using sterile water for nasal irrigation and a noseclip when swimming in warm freshwater lakes. Mrs Sciencebase was a yoga teacher for 20 years or thereabouts and one of the most peculiar aspects of that art was the use of the neti pot. A kind of jug with a long spout that allowed to pour a little water into your nostrils as part of a cleansing ritual. Technically known as nasal irrigation, but put simply it’s nothing more than pouring water into your nose. It always struck me as a b...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 7, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs

Eliminating Trachoma with the Help of GIS Technology
Trachoma is the world’s leading infectious cause of blindness, yet for decades we have had the antibiotics to treat it. Sightsavers is an international charity dedicated to preventing avoidable blindness and is working in Africa and Asia to eliminate this disease. Their programs are having a significant positive impact. A key to their success is effective use of Geographic Information System (GIS) technology to track and manage both the disease and treatment coverage. We sat down with Andy Tate, Senior Data and Reporting Advisor for Neglected Tropical Diseases (NTD) at Sightsavers to learn more about their work and how t...
Source: EMR and HIPAA - October 20, 2022 Category: Information Technology Authors: Colin Hung Tags: Health IT Company Healthcare IT IT Infrastructure and Dev Ops Andy Tate ArcGIS esri Esri Quick Capture GIS technology Health GIS Healthcare GIS Healthcare Scene Featured Kenya neglected tropical diseases NTD Sightsavers Trach Source Type: blogs

Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging. A Popular Science Article on the State of Epigenetic Clocks https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/ This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Small Lifespan Study of Combined Interventions
My attention was drawn recently to a small mouse life span study run by one of the groups that has been in the longevity community for a while now. It is interesting for testing combinations of interventions that have in the past been demonstrated to modestly slow aging in mice (such as rapamycin), or modestly improve aspects of cell function in old tissues (such as nicotinamide mononucleotide). Combinatorial studies are rare in academia and industry, for reasons that have a lot to do with (a) the perverse incentives produced by the existence of intellectual property, in that the rights to use specific interventions can be...
Source: Fight Aging! - September 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Oil-Based Drug Gels Help Patients with Difficulty Swallowing
Researchers at MIT and Brigham and Women’s Hospital have developed a series of oil-based gels that are intended to help those with difficulty swallowing to take drugs orally. Some adults and many children have difficulty taking pills, and so developing other forms of medication for oral drugs is important. The gels could be particularly useful in low-resource regions, as they are low cost, and do not require refrigeration or a supply of clean water to suspend the drug. They can also be used to deliver a wide variety of drugs, including hydrophobic drugs that do not easily dissolve in water. For those with swallowi...
Source: Medgadget - June 6, 2022 Category: Medical Devices Authors: Conn Hastings Tags: ENT Geriatrics Medicine Source Type: blogs

TWiV 868: COVID-19 clinical update #102 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes. (Source: virology blog)
Source: virology blog - February 25, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

What your skin should expect when you ’re expecting
Are you pregnant or thinking of becoming pregnant? You’re probably prepared for morning sickness, weight gain, and an expanding belly. But did you know your skin can also undergo a variety of changes when you’re expecting? These changes are due to normal alterations in hormones that occur during pregnancy. Rest assured, most skin conditions that develop or worsen during pregnancy are benign, and tend to improve following delivery. Darkening of the skin A large majority of women experience darkening of their skin due to hormone shifts that occur during pregnancy. You may notice that the areas around your thighs, genital...
Source: Harvard Health Blog - October 27, 2020 Category: Consumer Health News Authors: Kristina Liu, MD, MHS Tags: Pregnancy Skin and Hair Care Source Type: blogs

Like Minds on COVID19
At the nearly the same time I posted yesterday, The Lancet published this editorial from Swedish epidemiologist Prof Johan Giesecke. Some excerpts: It has become clear that a hard lockdown does not protect old and frail people living in care homes—a population the lockdown was designed to protect. Neither does it decrease mortality from COVID-19, which is evident when comparing the UK’s experience with that of other European countries. … Everyone will be exposed to severe acute respiratory syndrome coronavirus, and most people will become infected — There is very little we can do to prevent this spread: a l...
Source: Dr John M - May 5, 2020 Category: Cardiology Authors: Dr John Source Type: blogs

Can We Discuss Flatten-the-Curve in COVID19? My Eight Assertions
Conclusion: I did not have a clear answer for my couple. But after thinking and writing about this question it seems that the most reasonable approach in this crisis is transparent information–no matter how stark. And, crucially, we must have space for public debate. I hate this virus. I wish it never came. But we can make it worse by avoiding hard discussions on tradeoffs, the limits of modern medicine and risk. JMM P.S. I am very interested in your rebuttals to any of my assertions but will block vitriol and politicized nonsense. Related posts: The Debacle of Hydroxychloroquine and Azithromycin for ...
Source: Dr John M - May 4, 2020 Category: Cardiology Authors: Dr John Source Type: blogs

Vendor To Research Benefits of Remote Monitoring To Test Drug Response
Deploying remote monitoring has been a steadily more viable option in recent years as the technology improves and analyzing the data becomes more practical. One way to digest and share this option is the use of AI, which if deployed effectively can automate the analytical process and even recommend clinical options for treating these patients. […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - May 4, 2020 Category: Information Technology Authors: Anne Zieger Tags: Clinical Health IT Company Healthcare IT Telemedicine and Remote Monitoring Azithromycin Cardiologs COVID-19 COVID-19 Studies Harvard Medical School Hydroxychloroquine Jag Singh University Hospital of Marseille Withings Source Type: blogs

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com.  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com.  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs