Astragaloside IV inhibits idiopathic pulmonary fibrosis through activation of autophagy by miR-21-mediated PTEN/PI3K/AKT/mTOR pathway
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):128-136. doi: 10.14715/cmb/2024.70.2.18.ABSTRACTAs the main active ingredient of Astragalus, Astragaloside IV (AS-IV) can ameliorate pulmonary fibrosis. In this experiment, we studied how AS-IV reduces idiopathic pulmonary fibrosis (IPF). Bleomycin (BLM) or TGF-β1 was treated in mice or alveolar epithelial cells to mimic IPF in vivo as well as in vitro. ASV-IV alleviated levels of inflammatory cytokines and fibrosis markers in IPF model. Through detection of autophagy-related genes, ASV-IV was observed to induce autophagy in IPF. Besides, ASV-IV inhibited miR-21 expression...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Tiaohao Li Xiaojuan Gao Rui Jia Yanling Sun Yeli Ding Fei Wang Yujuan Wang Source Type: research
Astragaloside IV inhibits idiopathic pulmonary fibrosis through activation of autophagy by miR-21-mediated PTEN/PI3K/AKT/mTOR pathway
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):128-136. doi: 10.14715/cmb/2024.70.2.18.ABSTRACTAs the main active ingredient of Astragalus, Astragaloside IV (AS-IV) can ameliorate pulmonary fibrosis. In this experiment, we studied how AS-IV reduces idiopathic pulmonary fibrosis (IPF). Bleomycin (BLM) or TGF-β1 was treated in mice or alveolar epithelial cells to mimic IPF in vivo as well as in vitro. ASV-IV alleviated levels of inflammatory cytokines and fibrosis markers in IPF model. Through detection of autophagy-related genes, ASV-IV was observed to induce autophagy in IPF. Besides, ASV-IV inhibited miR-21 expression...
Source: Mol Biol Cell - March 2, 2024 Category: Molecular Biology Authors: Tiaohao Li Xiaojuan Gao Rui Jia Yanling Sun Yeli Ding Fei Wang Yujuan Wang Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Research progress of the effective active ingredients of Astragalus mongholicus in the treatment of diabetic peripheral neuropathy
Biomed Pharmacother. 2024 Mar 1;173:116350. doi: 10.1016/j.biopha.2024.116350. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is one of the most prevalent consequences of diabetes, with a high incidence and disability rate. The DPN's pathogenesis is extremely complex and yet to be fully understood. Persistent high glucose metabolism, nerve growth factor deficiency, microvascular disease, oxidative stress, peripheral nerve cell apoptosis, immune factors, and other factors have been implicated in the pathogenesis of DPN. Astragalus mongholicus is a commonly used plant used to treat DPN in clinical setting...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2024 Category: Drugs & Pharmacology Authors: Yulian Liu Runyuan Yu Xiaoyu Wang Yuexia Chen Tao Yin Qiang Gao Limin Sun Zuncheng Zheng Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
