Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3
Food Chem Toxicol. 2023 Nov 7:114156. doi: 10.1016/j.fct.2023.114156. Online ahead of print.ABSTRACTHigh glucose induces Schwann cells death and neurotoxicity. Formononetin was originally found in Astragalus membranaceus and showed anti-tumor and anti-neuroinflammation properties. The aim of this study is to explore the molecular mechanism underlying the neuroprotective effects of formononetin and identify its direct protein target. The effects of formononetin on oxidative stress and mitochondrial dysfunction in Schwann cells induced by high glucose were investigated. High glucose treatment significantly induced oxidative ...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Wen Jiang Ting Hu Chen Ye Man Hu Qingqing Yu Lijuan Sun Jichao Liang Yong Chen Source Type: research
Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3
Food Chem Toxicol. 2023 Nov 7:114156. doi: 10.1016/j.fct.2023.114156. Online ahead of print.ABSTRACTHigh glucose induces Schwann cells death and neurotoxicity. Formononetin was originally found in Astragalus membranaceus and showed anti-tumor and anti-neuroinflammation properties. The aim of this study is to explore the molecular mechanism underlying the neuroprotective effects of formononetin and identify its direct protein target. The effects of formononetin on oxidative stress and mitochondrial dysfunction in Schwann cells induced by high glucose were investigated. High glucose treatment significantly induced oxidative ...
Source: Food and Chemical Toxicology - November 9, 2023 Category: Food Science Authors: Wen Jiang Ting Hu Chen Ye Man Hu Qingqing Yu Lijuan Sun Jichao Liang Yong Chen Source Type: research
Herbal Leaves Can Suppress Oxidation of Perilla Oil
This study investigated the antioxidative profiles of 15 plant materials, including herbs, and examined methods to suppress the oxidation of perilla oil using these plant materials. These plant materials had wide ranges of phenolic, carotenoid, and chlorophyll contents. They exhibit radical scavenging activities and suppress lipid peroxidation, which show highly positive correlations with the phenolic contents. Dipping most of the plant materials examined in perilla oil suppressed its oxidation, and the peroxide values of the oil mixtures indicated a negative correlation with the carotenoid and chlorophyll contents of the ...
Source: Journal of Nutritional Science and Vitaminology - November 8, 2023 Category: Nutrition Authors: Shinji Yamashita Azusa Miwa Yu Hinata Koji Urita Kazuo Miyashita Mikio Kinoshita Source Type: research
