Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.PMID:38430163 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Cheng Lu Huiling Li Xinting Wang Huiying Wang Lei Song Jingru Zhao Yongming Liu Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Dual-channel hypergraph convolutional network for predicting herb-disease associations
Brief Bioinform. 2024 Jan 22;25(2):bbae067. doi: 10.1093/bib/bbae067.ABSTRACTHerbs applicability in disease treatment has been verified through experiences over thousands of years. The understanding of herb-disease associations (HDAs) is yet far from complete due to the complicated mechanism inherent in multi-target and multi-component (MTMC) botanical therapeutics. Most of the existing prediction models fail to incorporate the MTMC mechanism. To overcome this problem, we propose a novel dual-channel hypergraph convolutional network, namely HGHDA, for HDA prediction. Technically, HGHDA first adopts an autoencoder to projec...
Source: Briefings in Bioinformatics - March 1, 2024 Category: Bioinformatics Authors: Lun Hu Menglong Zhang Pengwei Hu Jun Zhang Chao Niu Xueying Lu Xiangrui Jiang Yupeng Ma Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
