Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
CONCLUSIONS: Collectively, this study showed that calycosin might attenuate OVA-induced airway inflammation and remodeling in asthmatic mice via preventing ILC2 activation and macrophage M2 polarization. Our study might contribute to further study of asthmatic therapy.PMID:38650035 | DOI:10.1186/s40360-024-00751-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 22, 2024 Category: Drugs & Pharmacology Authors: Chunyan Tian Qi Liu Xiaoyu Zhang Zhuying Li Source Type: research
Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
Calycosin, a flavonoid compound extracted from Astragalus membranaceus, has shown anti-asthma benefits in house dust mite-induced asthma. Recent studies have suggested that innate-type cells, including group 2 in... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 22, 2024 Category: Drugs & Pharmacology Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang and Zhuying Li Tags: Research Source Type: research
Use of Transcriptome Sequencing to Analyze the Effects of Different Doses of an Astragalus-Rhubarb-Saffron Mixture in Mice with Diabetic Kidney Disease
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 18, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Activates B lymphocytes and enhanced immune response: A promising adjuvant based on PLGA nanoparticle to improve the sensitivity of ZEN monoclonal antibody
Talanta. 2024 Apr 9;274:126005. doi: 10.1016/j.talanta.2024.126005. Online ahead of print.ABSTRACTIn preparing monoclonal antibodies by hybridoma cell technology, the quality of B lymphocytes used for cell fusion directly affects the sensitivity of monoclonal antibodies. To obtain B-lymphocytes producing high-quality specific antibodies for cell fusion during the immunization phase of the antigen, we prepared a TH2-Cell stimulatory delivery system as a novel adjuvant. Astragalus polysaccharide has a good ability to enhance antigenic immune response, and it was encapsulated in biocompatible materials PLGA as an immunostimul...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Chengchen Pang Bei Yuan Keyun Ren Haitao Xu Kunying Nie Chunlei Yu Zhanli Liu Yanyan Zhang Sibel A Ozkan Qingqing Yang Source Type: research
Activates B lymphocytes and enhanced immune response: A promising adjuvant based on PLGA nanoparticle to improve the sensitivity of ZEN monoclonal antibody
Talanta. 2024 Apr 9;274:126005. doi: 10.1016/j.talanta.2024.126005. Online ahead of print.ABSTRACTIn preparing monoclonal antibodies by hybridoma cell technology, the quality of B lymphocytes used for cell fusion directly affects the sensitivity of monoclonal antibodies. To obtain B-lymphocytes producing high-quality specific antibodies for cell fusion during the immunization phase of the antigen, we prepared a TH2-Cell stimulatory delivery system as a novel adjuvant. Astragalus polysaccharide has a good ability to enhance antigenic immune response, and it was encapsulated in biocompatible materials PLGA as an immunostimul...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Chengchen Pang Bei Yuan Keyun Ren Haitao Xu Kunying Nie Chunlei Yu Zhanli Liu Yanyan Zhang Sibel A Ozkan Qingqing Yang Source Type: research
Molecules, Vol. 29, Pages 1691: The Antioxidant Action of Astragali radix: Its Active Components and Molecular Basis
Yongqi Liu
Astragali radix is a traditional medicinal herb with a long history and wide application. It is frequently used in prescriptions with other medicinal materials to replenish Qi. According to the classics of traditional Chinese medicine, Astragali radix is attributed with properties such as Qi replenishing and surface solidifying, sore healing and muscle generating, and inducing diuresis to reduce edema. Modern pharmacological studies have demonstrated that some extracts and active ingredients in Astragali radix function as antioxidants. The polysaccharides, saponins, and flavonoids in Astragali radix offer b...
Source: Molecules - April 9, 2024 Category: Chemistry Authors: Juan Yao Ting Peng Changxin Shao Yuanyuan Liu Huanhuan Lin Yongqi Liu Tags: Review Source Type: research
Corrigendum to "Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides" [Int. J. Biol. Macromol. volume 221, 30 November 2022, pages 8-15]
Int J Biol Macromol. 2024 Mar 27:131073. doi: 10.1016/j.ijbiomac.2024.131073. Online ahead of print.NO ABSTRACTPMID:38548498 | DOI:10.1016/j.ijbiomac.2024.131073 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 28, 2024 Category: Biochemistry Authors: Linqing Yue Xiaoxiao Song Xian Cui Qi Zhang Xiaojie Tian Xiuhua Yang Qiuhao Wu Yuhuan Liu Roger Ruan Yunpu Wang Source Type: research
< em > Astragalus membranaceus < /em > Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice
In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure and physical activity of 23-month-old C57BL6/J mice were recorded using a metabolic cage system. Pathological changes in the intestine were evaluated using Alcian blue staining. The protein levels of leucine-rich repeats containing G protein-coupled receptor 5 (Lgr5) and Stat3 in the small intestine were determined using immunohistochemistry. The intestinal cell migration...
Source: The American Journal of Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Jia-Ting Yin Ming-Ruo Zhang Shu Zhang Shu-Hui Yang Jian-Ping Li Yun Liu Jin-Ao Duan Jian-Ming Guo Source Type: research
< em > Astragalus membranaceus < /em > Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice
In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure and physical activity of 23-month-old C57BL6/J mice were recorded using a metabolic cage system. Pathological changes in the intestine were evaluated using Alcian blue staining. The protein levels of leucine-rich repeats containing G protein-coupled receptor 5 (Lgr5) and Stat3 in the small intestine were determined using immunohistochemistry. The intestinal cell migration...
Source: The American Journal of Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Jia-Ting Yin Ming-Ruo Zhang Shu Zhang Shu-Hui Yang Jian-Ping Li Yun Liu Jin-Ao Duan Jian-Ming Guo Source Type: research
< em > Astragalus membranaceus < /em > Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice
In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure and physical activity of 23-month-old C57BL6/J mice were recorded using a metabolic cage system. Pathological changes in the intestine were evaluated using Alcian blue staining. The protein levels of leucine-rich repeats containing G protein-coupled receptor 5 (Lgr5) and Stat3 in the small intestine were determined using immunohistochemistry. The intestinal cell migration...
Source: The American Journal of Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Jia-Ting Yin Ming-Ruo Zhang Shu Zhang Shu-Hui Yang Jian-Ping Li Yun Liu Jin-Ao Duan Jian-Ming Guo Source Type: research
Formononetin Restrains Tumorigenesis of Breast Tumor by Restraining STING-NF- κB and Interfering with the Activation of PD-L1
CONCLUSION: Formononetin can restrain the proliferation of BC cells, which may be mediated through the interference of PD-L1 and suppression of the activation of the STING-NF-κB pathway.PMID:38531802 | DOI:10.24976/Discov.Med.202436182.58 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Hongmei Liu Zhipeng Wang Zhigang Liu Source Type: research
