Metabonomics Study on Orthotopic Xenograft Mice Model of Colon Cancer treated with Astragalus membranaceus-Curcuma wenyujin in Different Proportions via UPLC-Q-TOF/MS
Publication date: Available online 18 October 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Ruolan Sun, Junfei Gu, Xiangwei Chang, Fuyan Liu, Yan Liang, Xinyue Yang, Li Liang, Decai Tang (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - October 19, 2020 Category: Drugs & Pharmacology Source Type: research

Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway
Publication date: Available online 15 October 2020Source: PhytomedicineAuthor(s): Liu Yang, Xinyan Han, Faping Xing, Hui Wu, Hailian Shi, Fei Huang, Qi Xu, Xiaojun Wu (Source: Phytomedicine)
Source: Phytomedicine - October 15, 2020 Category: Drugs & Pharmacology Source Type: research

Using milk vetch (Astragalus sinicus L.) to promote rice straw decomposition by regulating enzyme activity and bacterial community.
This study concluded that co-incorporating RS and MV may be recommended as a promising practice for the efficient utilization of RS resources. PMID: 33049439 [PubMed - as supplied by publisher] (Source: Bioresource Technology)
Source: Bioresource Technology - October 6, 2020 Category: Biotechnology Authors: Zhou G, Gao S, Chang D, Rees RM, Cao W Tags: Bioresour Technol Source Type: research

Viruses, Vol. 12, Pages 1068: Genome Analysis of a Novel Clade b Betabaculovirus Isolated from the Legume Pest Matsumuraeses phaseoli (Lepidoptera: Tortricidae)
In this study, using next-generation sequencing, we report the complete genome of MaphGV. MaphGV genome comprises a double-stranded DNA of 116,875 bp, with 37.18% GC content. It has 128 hypothetical open reading frames (ORFs). Among them, 38 are baculovirus core genes, 18 are lepidopteran baculovirus conserved genes, and 5 are unique to Baculoviridae. MaphGV has one baculovirus repeat ORF (bro) and three inhibitors of apoptosis proteins (iap), including a newfound iap-6. We found two atypical baculoviral homologous regions (hrs) and four direct repeats (drs) in the MaphGV genome. Based on phylogenetic analysis, MaphGV belo...
Source: Viruses - September 22, 2020 Category: Virology Authors: Ruihao Shu Qian Meng Lin Miao Hongbin Liang Jun Chen Yuan Xu Luqiang Cheng Wenyi Jin Qilian Qin Huan Zhang Tags: Article Source Type: research

Phase I study to evaluate the maximum tolerated dose of the combination of SH003 and docetaxel in patients with solid cancer: A study protocol
This study aimed to determine the maximum tolerated dose of SH003 combined with docetaxel in patients with lung or breast cancer. Methods: This is an open-label, dose-escalation study to evaluate the safety of SH003 combined with docetaxel. Patients with lung or breast cancer will be recruited. The participants will be divided into 3 groups based on SH003 daily dose (2400, 3600, and 4800 mg); the medication will be taken orally for 21 days. The traditional 3 + 3 design will be adopted for the dose escalation. Dose-limiting toxicities are defined as grade 3 or 4 adverse events according to the Common Terminology Cr...
Source: Medicine - September 18, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Astragalus Polysaccharide (PG2) Suppresses Macrophage Migration Inhibitory Factor and Aggressiveness of Lung Adenocarcinoma Cells.
In this study, we explored the effects of PG2 in lung adenocarcinoma A549 and CL1-2 cells and investigated its anticancer activity, and the results were validated in severe combined immunodeficiency (SCID) mice. Although PG2 did not inhibit the growth of these cells, it dose-dependently suppressed their migration and invasion, accompanied by reduced vimentin and AXL and induced epithelial cadherin (E-cadherin) expression. Regarding the underlying molecular mechanism, PG2 treatment reduced the macrophage migration inhibitory factor (MIF), an inflammatory cytokine that promotes the epithelial-mesenchymal transition and aggre...
Source: The American Journal of Chinese Medicine - September 12, 2020 Category: Complementary Medicine Authors: Liao CH, Yong CY, Lai GM, Chow JM, Cheng CF, Fang CL, Lin PC, Chang CL, Zheng YM, Chuang SE, Whang-Peng J, Yao CJ Tags: Am J Chin Med Source Type: research

Astragaloside IV, a saponin from Astragalus membranaceus var. mongholicus, induces expressions of heme recycle proteins via signaling of Nrf2/ARE in cultured macrophages
Publication date: Available online 11 September 2020Source: Journal of EthnopharmacologyAuthor(s): Guowei Gong, Huiru Yu, Yuzhong Zheng, Baohui Qi, Huan He, Tianpeng Yin, Tina TX. Dong, Karl WK. Tsim (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 12, 2020 Category: Drugs & Pharmacology Source Type: research

Preliminary study on the anti-apoptotic mechanism of Astragaloside IV on radiation-induced brain cells.
In this study, the mechanism of AS-IV against radiation-induced apoptosis of brain cells in vitro and in vivo was explored by radiation modeling, which provided a theoretical basis for the development of anti-radiation Chinese herbal active molecules and brain health products. In order to study the protective mechanism of AS-IV on radiation-induced brain cell apoptosis in mice, the paper constructed a radiation-induced brain cell apoptosis model, using TUNEL staining, flow cytometry, Western blotting to analyze AS-IV resistance mechanism to radiation-induced brain cell apoptosis. The results of TUNEL staining and flow cyto...
Source: International Journal of Immunopathology and Pharmacology - September 11, 2020 Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research

An Astragalus membranaceus based eco-friendly biomimetic synthesis approach of ZnO nanoflowers with an excellent antibacterial, antioxidant and electrochemical sensing effect
Publication date: January 2021Source: Materials Science and Engineering: C, Volume 118Author(s): Faheem Ullah Khan, Zia Ul Haq Khan, Junxian Ma, Arif Ullah Khan, Muhammad Sohail, Yongmei Chen, Yatao Yang, Xiaofang Pan (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - September 8, 2020 Category: Materials Science Source Type: research

Postnatal ossification sequences in Acrocephalus scirpaceus and Chroicocephalus ridibundus (Aves: Neognathae): The precocial-altricial spectrum and evolution of compound bones in birds.
Abstract Although the development of the avian skeleton has attracted considerable attention, most of the studies have been concentrated on the embryonic period, while studies on the postnatal period are rare. We studied the postnatal development of the skeleton in two phylogenetically distant birds, an altricial passerine Acrocephalus scirpaceus and a semiprecocial charadriiform Chroicocephalus ridibundus. The neonates of the former, despite being altricial, have well-ossified skeleton-the degree of development approaches that of the semiprecocial gull. However, after hatching the limb bones (particularly those o...
Source: Journal of Anatomy - August 31, 2020 Category: Anatomy Authors: Skawiński T, Borczyk B, Hałupka L Tags: J Anat Source Type: research

Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms
Publication date: Available online 18 August 2020Source: Journal of EthnopharmacologyAuthor(s): Shuai Tang, Wei Liu, Qianqian Zhao, Kaidong Li, Jingyi Zhu, Wenbing Yao, Xiangdong Gao (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 20, 2020 Category: Drugs & Pharmacology Source Type: research

Astragaloside IV sensitizes non-small cell lung cancer cells to cisplatin by suppressing endoplasmic reticulum stress and autophagy.
Conclusions: AS-IV sensitized NSCLC cells to cisplatin through suppressing ER stress and autophagy. This study provides a novel strategy of cisplatin combined with AS-IV for the treatment of cisplatin-resistant NSCLC patients. PMID: 32802451 [PubMed - as supplied by publisher] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - August 18, 2020 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Comparison of the inhibition of high phosphate-induced smooth muscle cell calcification by Porphyra yezoensis and Astragalus polysaccharides
Publication date: October 2020Source: Journal of Functional Foods, Volume 73Author(s): Fang Huang, Jia-Yun Chen, Jian-Ming Ouyang (Source: Journal of Functional Foods)
Source: Journal of Functional Foods - August 18, 2020 Category: Nutrition Source Type: research

Protective Effects of Astragalus membranaceus and Ligustrazine on Rat Brain Microvascular Endothelial Cell Injury after Oxygen-Glucose Depri-vation/Reoxygenation by Supressing the PKC δ/MARCKS Pathway.
Protective Effects of Astragalus membranaceus and Ligustrazine on Rat Brain Microvascular Endothelial Cell Injury after Oxygen-Glucose Depri-vation/Reoxygenation by Supressing the PKCδ/MARCKS Pathway. Comb Chem High Throughput Screen. 2020 Aug 18;: Authors: Tang X, Wang H, Chen H, Sun S, Chen H, Pan R Abstract AIM AND OBJECTIVE: Cell death is a main pathological change in brain ischemia. Astragalus membranaceus (Ast) and ligustrazine (Lig), as traditional Chinese herbs, have a protective effect against ischemia-reperfusion injury.we aim to find whether the underlying protective mechanism of Astr...
Source: Combinatorial Chemistry and High Throughput Screening - August 17, 2020 Category: Chemistry Authors: Tang X, Wang H, Chen H, Sun S, Chen H, Pan R Tags: Comb Chem High Throughput Screen Source Type: research

Multi-element Characteristics of Chinese Medical Baishao (Paeoniae Radix Alba) and Their Decoctions.
Abstract Adopting ICP-AES and ICP-MS to determine the content of 53 elements (6 macro-elements, 47 trace elements), which used HNO3 (5 mL) and H2O2 (2 mL) to digest Baishao (Paeoniae Radix Alba) by microwave. These herbs obtained from six producing areas in China, namely Xuanwu (Henan province), Shihezi (Xinjiang province), Zhongjiang (Sichuan province), Panan (Zhejiang province), Bozhou (Anhui province), and Heze (Shandong province). A certified reference material of Astragalus (GBW 10028, GSB-19) was used to assess the accuracy of the method. Except the slight change of Na and S in Xuanwu, the content ...
Source: Biological Trace Element Research - August 17, 2020 Category: Biology Authors: Xue X, Liu G, Wei Y, Fu B, Li F, Wu D, Zhang W Tags: Biol Trace Elem Res Source Type: research

Effect of Ganduqing on common cold: A protocol for systematic review and meta-analysis based on existing evidence
Conclusions: This systematic review will provide evidence for the efficacy and safety of Ganduqing in treating common colds. Trial registration number: INPLASY202060073 (Source: Medicine)
Source: Medicine - August 14, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Characterization of lipids, proteins, and bioactive compounds in the seeds of three Astragalus species
Publication date: Available online 12 August 2020Source: Food ChemistryAuthor(s): Maher Mahmoudi, Raoudha Abdellaoui, Fayçal Boughalleb, Boutheina Yahia, Mahmoud Mabrouk, Nizar Nasri (Source: Food Chemistry)
Source: Food Chemistry - August 14, 2020 Category: Food Science Source Type: research

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients.
Conclusion: HbA1c and HCY are related risk factors for DPN. Numbness is a typical syndrome characteristic. Astragalus membranaceus is a monarch CHM and is used most frequently. PMID: 32724325 [PubMed - as supplied by publisher] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 30, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Astragaloside IV prevents A β1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway.
In this study, we found that amyloid β protein fragment 1-42 oligomers (AβO) suppressed BDNF and PPARγ expression, and inhibited tyrosine receptor kinase B (TrkB) phosphorylation in cultured hippocampal neurons; these changes were ameliorated by treatment with AS-IV. Inhibition of PPARγ by genetic and pharmacological methods also blocked the effect of AS-IV on BDNF expression in AβO-treated cells. Importantly, exogenous BDNF protected against neurotoxicity and apoptosis induced by AβO, whereas inhibition of PPARγ reversed protective effects of AS-IV against these outcomes. In vivo data...
Source: Brain Research - July 29, 2020 Category: Neurology Authors: Wang X, Xu W, Chen H, Li W, Li W, Zhu G Tags: Brain Res Source Type: research

Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway.
In this study, the neurobehavioral tests (Ludmila Belayev 12-point scoring, Screen test, fore limb placing test) had been employed to investigate the effect of AST treatment against functional deficit of MCAO rats. The immunofluorescence staining, western-blot and qRT-PCR was performed to evaluate the effects of AST on proliferation, differentiation and maturity of neural stemr cells in hippocampus. Moreover, we investigated the possible mechanism of the AST treatment in promoting neurogenesis after ischemic stroke. The findings indicated that AST treatment ameliorated the neurobehavior of MCAO rats. The results indicated ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 15, 2020 Category: Drugs & Pharmacology Authors: Ni GX, Liang C, Wang J, Duan CQ, Wang P, Wang YL Tags: Biomed Pharmacother Source Type: research

Astragaloside protects rat brain from microwave-induced functional injuries via restoring acetylcholine and normalizing electroencephalogram.
In conclusion, astragaloside protected the morphological structures and restored acetylcholine level in rat hippocampus, which could improve brain functions via normalizing brain EEG. Therefore, astragaloside might be a promising candidate to treat microwave-induced injuries of central nervous system (CNS). PMID: 32677014 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - July 15, 2020 Category: Environmental Health Authors: Zhao L, Sun Y, Yu C, Chen J, Xu X, Zhang X, Wang H, Zhang J, Wang H, Dong J, Yao B, Zhou H, Liu S, Peng R Tags: Environ Sci Pollut Res Int Source Type: research

Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis
Allergic contact dermatitis (ACD) is characterized by itching, skin inflammation, and allergic responses caused by release of immunoglobulin E and T helper 2-specific cytokines. The aim of this study is to investigate the ameliorative and synergic effects of herbal formula, Derma-H, containing Astragalus membranaceus Fisch. ex Bunge (AM) and Nepeta tenuifolia Benth (NT) which have been used as traditional medicinal herbs for the cure of dryness, edema, and pruritus. 2,4-Dinitrochlorobenzene (DNCB) was applied for ACD induction. AM, NT, and a mixture of AM and NT was topically applied to skin lesions for 11 days. Dermatitis...
Source: Frontiers in Pharmacology - July 13, 2020 Category: Drugs & Pharmacology Source Type: research

Cycloartane-type triterpenoids from the root of Astragalus membranaceus var. mongholicus
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - July 10, 2020 Category: Complementary Medicine Authors: Luo-Min Xiao Pei-Hong Cao Zhi-Hui Luo Xue-Feng Bao Zheng-Qun Zhou Shuang Li Sen-Sen Zhao Jun-Xia Zheng Hao Gao Hui Zhi Source Type: research

Molecular Characterization of a Fungal Ketide Synthase Gene Among Swainsonine-Producing Alternaria Species in the USA.
Abstract Locoweeds are toxic leguminous plants in Astragalus and Oxytropis genera that contain fungal endophytes of Alternaria section Undifilum species. These fungi produce swainsonine, an alkaloid α-mannosidase inhibitor that causes a neurological syndrome, locoism in grazing animals. A SWN gene cluster has been identified in many swainsonine-producing fungi. The swnK gene, which is an essential component of the swainsonine biosynthetic pathway, encodes a polyketide synthase-nonribosomal peptide synthase (PKS-NRPS). To determine if swnK was conserved among Alternaria section Undifilum endophytes of locowee...
Source: Current Microbiology - July 8, 2020 Category: Microbiology Authors: Noor AI, Neyaz M, Cook D, Creamer R Tags: Curr Microbiol Source Type: research

Changes of Anti-tuberculosis Herbs Formula During Past Three Decades in Contrast to Ancient Ones
ConclusionsAlthough there were wide variations in the herb groups and herb combinations in the formulae, half of the top 30 herbs were found in both modern and ancient prescriptions. The core herb combinations in modern and ancient prescriptions could help us to improve the priscription for treatment of TB. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 8, 2020 Category: Internal Medicine Source Type: research

Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice
Conclusions: Our study demonstrate that formononetin can substantially attenuate the development of atherosclerosis via regulation of interplay between KLF4 and SRA, which suggests the formononetin might be a novel therapeutic approach for inhibition of atherosclerosis. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Chuanrui Ma, Ronglin Xia, Shu Yang, Lipei Liu, Jing Zhang, Ke Feng, Yuna Shang, Jingtian Qu, Lingwei Li, Ning Chen, Shixin Xu, Wenwen Zhang, Jingyuan Mao, Jihong Han, Yuanli Chen, Xiaoxiao Yang, Yajun Duan, Guanwei Fan Tags: Research Paper Source Type: research

The Role of Endophytic/Epiphytic Bacterial Constituents in the Immunostimulatory Activity of the Botanical, Astragalus membranaceus.
Authors: Koehler H, Puchalski K, Ruiz G, Jacobs B, Langland J Abstract Astragalus membranaceus is a staple of Traditional Chinese Medicine being one of the oldest medicinal herbs listed in the material medica of Chinese herbal medicine. Chinese herbalists have used Astragalus to help the human body fight a variety of diseases. Modern herbalists utilize Astragalus primarily as an immunostimulant to prevent common infection and aid in the recovery following infection. Historically, the biological activities associated with Astragalus have been accounted for, at least in part, to several constituents present in the bo...
Source: The Yale Journal of Biology and Medicine - July 2, 2020 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
This study aims to investigate the effect and antioxidant mechanism of Compound Centella on DKD rats. High-performance liquid chromatography (HPLC) was applied to analyse 3 herbs in Compound Centella. Sprague-Dawley rats were divided into the normal group (NG), DKD group (DKDG), Compound Centella group (CCG), and losartan group (LG), with 8 rats in each group. On the first day of the experiment, rats in the NG were fed with ordinary -feed, while the other groups were fed with high-fat and high-sugar feed. On the 29th day, except the NG, the other 3 groups received a single intraperitoneal injection of streptozocin (STZ, 35...
Source: Evidence-based Complementary and Alternative Medicine - July 2, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The relationship between structural properties and activation of RAW264.7 and natural killer (NK) cells by sulfated polysaccharides extracted from Astragalus membranaceus roots
Publication date: Available online 26 June 2020Source: Process BiochemistryAuthor(s): Changsheng Li, Natchanok Talapphet, Subramanian Palanisamy, Nan Ma, Myoung Lae Cho, Sangguan You (Source: Process Biochemistry)
Source: Process Biochemistry - June 28, 2020 Category: Biochemistry Source Type: research

Luhong Formula Has a Cardioprotective Effect on Left Ventricular Remodeling in Pressure-Overloaded Rats.
Conclusion: LHF can improve left ventricular remodeling in a pressure-overloaded heart failure rat model; this cardiac protective ability may be due to cardiac fibrosis and attenuated apoptosis. Upregulated eNOS expression and downregulated Col1a1, Col3a1, TGF-β1, caspase-3, VEGF, and VEGFR2 expression may play a role in the observed LHF cardioprotective effect. PMID: 32565857 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chinese herbal decoction Astragalus and Angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways
Publication date: Available online 21 June 2020Source: Genes & DiseasesAuthor(s): Hao Yuan, Xuelian Wu, Xiaomin Wang, Chengfu Yuan (Source: Genes and Diseases)
Source: Genes and Diseases - June 22, 2020 Category: Genetics & Stem Cells Source Type: research

Vacuolar phosphate transporters account for variation in phosphate accumulation in Astragalus sinicus cultivars
Publication date: Available online 19 June 2020Source: The Crop JournalAuthor(s): Zhenhui Guo, Wenyuan Ruan, Qingyu Wu, Yuhu Lyu, Keke Yi (Source: The Crop Journal)
Source: The Crop Journal - June 19, 2020 Category: Food Science Source Type: research

The immune adjuvant effect of Astragalus polysaccharide on in ovo injection of Newcastle disease vaccine
In this study, immunogenic efficacies ofin ovo administration ofAstragalus polysaccharide (APS) along with live Newcastle disease vaccine (live ND vaccine) (live VG/GA strain) were evaluated. Four hundred fertilized eggs were randomly divided into four groups (n = 100/group), and vaccinatedin ovo, respectively, with solutions of APS, live ND vaccine, live ND vaccine combined with APS, and 0.9% physiological saline into their amniotic fluid on d 18.5 of incubation. Significant improvement of chicks ’ development was displayed in those vaccinated with live ND vaccine adjuvanted with APSin ovo, manifested as e...
Source: Journal of Animal Physiology and Animal Nutrition - June 16, 2020 Category: Zoology Authors: Ligang Xue, Dan Wang, Dongxing Zhang, Anqi Ju, Aoyi Duan, Junhong Xing, Yanjun Qin, Shubao Yang, Weimin Luan Tags: ORIGINAL ARTICLE Source Type: research

Chinese herbal medicine Baoyuan Jiedu decoction inhibits the accumulation of myeloid derived suppressor cells in pre-metastatic niche of lung via TGF- β/CCL9 pathway.
Chinese herbal medicine Baoyuan Jiedu decoction inhibits the accumulation of myeloid derived suppressor cells in pre-metastatic niche of lung via TGF-β/CCL9 pathway. Biomed Pharmacother. 2020 Jun 15;129:110380 Authors: Tian S, Song X, Wang Y, Wang X, Mou Y, Chen Q, Zhao H, Ma K, Wu Z, Yu H, Han X, Wang H, Wang S, Ji X, Zhang Y Abstract Baoyuan Jiedu (BYJD for short) decoction, a traditional Chinese medicine formula, is composed of Astragalus, Ginseng, Aconite root, Honeysuckle, Angelica, Licorice, which has the functions of nourishing qi and blood, enhancing immune function, improving quality of ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 14, 2020 Category: Drugs & Pharmacology Authors: Tian S, Song X, Wang Y, Wang X, Mou Y, Chen Q, Zhao H, Ma K, Wu Z, Yu H, Han X, Wang H, Wang S, Ji X, Zhang Y Tags: Biomed Pharmacother Source Type: research

Astragalus mongholicus Bunge and Panax notoginseng (Burkill) F.H. Chen Formula for Renal Injury in Diabetic Nephropathy —In Vivo and In Vitro Evidence for Autophagy Regulation
ConclusionAPF may protect the kidneys from inflammation injuries in DN by upregulating autophagy via suppressing mTOR and activating PINK1/Parkin signaling. This experimental evidence strongly supports APF as a potential option for the prevention and treatment of DN. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 11, 2020 Category: Drugs & Pharmacology Source Type: research

Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis.
Abstract Four previously undescribed hydroxypropionylated d-glucose derivatives, astrabhotins A-D (1-4), along with ten known compounds α-d-glucose (5), β-d-glucose (6), quebrachitol (7), 3-hydroxypropionic acid (8), oleic acid (9), isoliquiritigenin (10), liquiritigenin (11), odoratin (12), 7β-hydroxysitosterol (13) and daucosterol (14), were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. Astrabhotin A (1) reduced the writhing response remarkably with 52.5% inhibition by aceti...
Source: Natural Product Research - June 10, 2020 Category: Biochemistry Authors: Qiu L, Xiao CJ, Shen Y, Xu W, Liu XB, Dong X, Jiang B Tags: Nat Prod Res Source Type: research

Astragalus polysaccharides reverse gefitinib resistance by inhibiting mesenchymal transformation in lung adenocarcinoma cells.
This study was designed to investigate the reversal effect of astragalus polysaccharides (APS) on gefitinib resistance (GR) and to elucidate the underlying mechanisms. PC9 and HCC827 lung cancer cells were stimulated by TGF-β1 to develop EMT-associated GR cells. Cell proliferation, migration and apoptosis assays were used to confirm the effect of gefitinib on GR cells and the therapeutic effect of APS on GR cells after knockdown and over-expression of related signaling pathways. Reverse transcription polymerase chain reaction, western blotting, and immunofluorescent staining assays were used to evaluate the expression...
Source: American Journal of Translational Research - June 10, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Integrated Metagenomic and Metabolomic Analyses of the Effect of Astragalus Polysaccharides on Alleviating High-Fat Diet –Induced Metabolic Disorders
Most herbal polysaccharides possess multiple benefits against metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and obesity. However, the underlying mechanisms are largely unknown. Here, male C57BL/6J mice were fed with chow or high-fat diet (HFD) with or without Astragalus polysaccharides (APS) supplementation, and gut microbial profile and metabolite profile were studied by metagenomic sequencing and untargeted metabolomics, respectively. APS was effective in alleviating HFD-induced metabolic disorders, with the alteration of gut microbiota composition and function. A total of 188 species, which main...
Source: Frontiers in Pharmacology - June 9, 2020 Category: Drugs & Pharmacology Source Type: research

2,5-Diketopiperazines from Aspergillus sp., the Endophytic Fungus of Astragalus membranaceus and their Anticancer Assay
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 4, 2020 Category: Chemistry Source Type: research

A comparative study on chemical profile and biological activities of aerial parts (stems, flowers, leaves, pods and seeds) of Astragalus gombiformis
Publication date: Available online 3 June 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Sabrina Lekmine, Samira Boussekine, Kenza Kadi, Antonio Ignacio Martín-García, Asma Kheddouma, Kamel Nagaz, Chawki Bensouici (Source: Biocatalysis and Agricultural Biotechnology)
Source: Biocatalysis and Agricultural Biotechnology - June 4, 2020 Category: Biotechnology Source Type: research

Fe3+ detection, bioimaging, and patterning based on bright blue-fluorescent N-doped carbon dots
Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN01042A, PaperLin Li, Lihong Shi, Jing Jia, Chuan Dong, Shaomin Shuang, Dan Chang The bright blue fluorescent N-doped carbon dots (N-CDs) with satisfactory yield (54%) was successfully fabricated by one-step hydrothermal treatment of astragalus. The obtained N-CDs possessed superior stability, favorite solubility and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 4, 2020 Category: Chemistry Authors: Lin Li Source Type: research

Treatment of Post-mastectomy Lymphedema with Herbal Medicine: An Innovative Pilot Study
Source: Plastic and Reconstructive Surgery Global Open - June 1, 2020 Category: Cosmetic Surgery Tags: Reconstructive: Original Article Source Type: research

Secondary reconstruction of pseudoarthrosis of the astragalus body after undiagnosed fracture
Publication date: May–June 2020Source: Revista Española de Cirugía Ortopédica y Traumatología (English Edition), Volume 64, Issue 3Author(s): S. Corró, G. Duarri, R. Busquets (Source: Revista Espanola de Cirugia Ortopedica y Traumatologia)
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - May 23, 2020 Category: Orthopaedics Source Type: research

Amelioration of age-related alterations in rat liver: Effects of curcumin C3 complex, Astragalus membranaceus and blueberry.
This study aimed to investigate the potential ameliorating effects of curcumin C3 complex, Astragalus membranaceus and blueberry on certain age-related biochemical alterations in rat liver. Four groups of rats, aged 12 months-old, were used. The first group; aged control group in which rats were left without any treatment until the age of 17 months. The other three groups received daily by oral gavage for 5 months the following supplements; curcumin C3 complex (110 mg/kg), Astragalus membranaceus (100 mg/kg) and blueberry (100 mg/kg) respectively. Additionally, a fifth group of rats, aged 5 months-old, was us...
Source: Experimental Gerontology - May 21, 2020 Category: Geriatrics Authors: Selim AM, Nooh Mohamed MM, El-Sawalhi MM, Ismail NA Tags: Exp Gerontol Source Type: research

A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1 α/MMP2 Pathway in Hypoxic Microenvironment
In this study, we found that HCT-116 and LoVo could form a VM network. Additionally, hypoxia increases the intracellular reactive oxygen species (ROS) level and accelerates migration, VM formation in colorectal cancer cells, while N-Acetylcysteine (NAC) could reverse these phenomena. Notably, further mechanical exploration confirmed that the matrix metalloprotease 2 (MMP2) induction is ROS dependent under hypoxic condition. On the basis, we found that AAM could effectively inhibit hypoxia-induced ROS generation, migration, VM formation as well as HIF-1α and MMP2 expression. In vivo, AAM significantly inhibits metasta...
Source: Frontiers in Pharmacology - May 14, 2020 Category: Drugs & Pharmacology Source Type: research

Astragaloside IV protects human cardiomyocytes from hypoxia/reoxygenation injury by regulating miR-101a.
Abstract Astragaloside IV (AS/IV) is one of the extracted components from the traditional Chinese medicine Astragalus which has been demonstrated to have potential capacity for anti-inflammation activity and for treating cardiovascular disease. Our purpose was to determine the function and underlying molecular mechanism of AS/IV in hypoxia/reoxygenation (H/R) injured in cardiomyocytes. Differentially expressed genes (DEGs) were screened using bioinformatic analysis, and the molecular targeting relationship was verified by the dual-luciferase report system. H/R injured cardiomyocytes were employed to explore the ef...
Source: Molecular and Cellular Biochemistry - May 10, 2020 Category: Biochemistry Authors: Wu Y, Fan Z, Chen Z, Hu J, Cui J, Liu Y, Wang Y, Guo B, Shen J, Xie L Tags: Mol Cell Biochem Source Type: research

TRIF is essential for the anti-inflammatory effects of Astragalus polysaccharides on LPS-infected Caco2 cells.
Abstract As an immune-regulator, Astragalus polysaccharides (APS) could effectively modulate the activity of toll-like receptor 4 (TLR4) signaling pathway, and induce anti-inflammatory response in intestinal. Our research before indicated that toll/interleukin 1 receptor-domain-containing adapter-inducing interferon-b (TRIF) might be a critical regulator for APS. So, in this experiment, we analyzed the effects of APS on lipopolysaccharide (LPS)-infected Caco2 cells in the circumstances of TRIF knockout. By using qRT-PCR and flow cytometry method, we analyzed the genes expression at transcriptional and translationa...
Source: International Journal of Biological Macromolecules - May 5, 2020 Category: Biochemistry Authors: Li Y, Xu Y, Pan C, Ren Z, Yang X Tags: Int J Biol Macromol Source Type: research

Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer
Astragalus polysaccharides (APS) is a traditional Chinese medicine and have been proved to involve in multiple biological processes, including inflammation, metabolism, and carcinogenics. However, the specific mechanisms by which APS on prostate cancer (PCa) remains largely unknown. In the current study, we found APS greatly inhibited the proliferation and invasion of PCa cells in a dose-dependent and time-dependent manner in vitro and in vivo. In addition, cellular triglyceride and cholesterol levels were also decreased significantly under APS treatment. Microarray data revealed the SIRT1 expression was markably suppresse...
Source: Frontiers in Pharmacology - May 4, 2020 Category: Drugs & Pharmacology Source Type: research

Astragalus saponin IV promotes osteogenic differentiation of bone marrow mesenchymal stem cells via miR-21/NGF/BMP2/Runx2 pathway.
CONCLUSION: AS- IV might be used as a therapeutic agent for bone fracture or other orthopedic disorders. PMID: 32381364 [PubMed - as supplied by publisher] (Source: Acta Histochemica)
Source: Acta Histochemica - May 3, 2020 Category: Biochemistry Authors: Wu XH, Dou B, Sun NY, Gao J, Liu XL Tags: Acta Histochem Source Type: research