Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NF κB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia
CONCLUSION: After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.PMID:38419443 | DOI:10.31083/j.jin2302034 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - February 29, 2024 Category: Neuroscience Authors: Wenjuan Li Huachun Miao Zeyin Nie Feng Wu Huaibin Li Source Type: research
The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia –reperfusion injury by inhibiting the STING pathway
Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and Salvia miltiorrhiza Bunge, respectively, both of which hav... (Source: Chinese Medicine)
Source: Chinese Medicine - February 28, 2024 Category: Complementary Medicine Authors: Pan Zhai, Qianyun Chen, Xunxun Wang, Xiaohu Ouyang, Mengling Yang, Yalan Dong, Junyi Li, Yiming Li, Shanshan Luo, Yue Liu, Xiang Cheng, Rui Zhu and Desheng Hu Tags: Research Source Type: research
Investigation of the molecular mechanism of Danggui Buxue tang in treating lung cancer using network pharmacology and molecular docking techniques
This study used network pharmacology and molecular docking techniques to investigate the molecular targets and pathways of Danggui Buxue Tang (DBT) in treating lung cancer. The compound-target network was constructed using the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and a lung cancer-specific network was created using the GEO database and Cytoscape software. GO and KEGG pathway analyses were performed to understand the biological processes associated with DBT. The key compounds from Astragalus, kaempferol, and quercetin, and the potential targets are IL-6, IL-1β, FOS, ICAM1, and CCL2. GO enrich...
Source: Natural Product Research - February 26, 2024 Category: Biochemistry Authors: Dantong Zhu Shun Li Long Xu Xijing Ren Shudong Wang Jianjun Chen Ershu Zhao Zhendong Zheng Source Type: research
Astraoleanosides E-P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity
In this study, a phytochemical characterization of the aerial parts of A. membranaceusled to the isolation of 29 oleanane-type triterpenoid saponins, including 11 new compounds named astraoleanosides E-P (6-9, 13, 14, 18-22), as well as 18 known ones. The structures of these compounds were elucidated using nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. Among them, astraoleanoside H (9) and cloversaponin III (15) demonstrated the most potent β-glucuronidase inhibitory activities, with IC50 values of 21.20 ± 0.75 and 9.05 ± 0.47 µM, respectively, compared to the positive control d-sa...
Source: Bioorganic Chemistry - February 22, 2024 Category: Chemistry Authors: Manh Khoa Nguyen Viet Phong Nguyen Seo Young Yang Byung Sun Min Jeong Ah Kim Source Type: research
Astraoleanosides E-P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity
In this study, a phytochemical characterization of the aerial parts of A. membranaceusled to the isolation of 29 oleanane-type triterpenoid saponins, including 11 new compounds named astraoleanosides E-P (6-9, 13, 14, 18-22), as well as 18 known ones. The structures of these compounds were elucidated using nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. Among them, astraoleanoside H (9) and cloversaponin III (15) demonstrated the most potent β-glucuronidase inhibitory activities, with IC50 values of 21.20 ± 0.75 and 9.05 ± 0.47 µM, respectively, compared to the positive control d-sa...
Source: Bioorganic Chemistry - February 22, 2024 Category: Chemistry Authors: Manh Khoa Nguyen Viet Phong Nguyen Seo Young Yang Byung Sun Min Jeong Ah Kim Source Type: research
Astragalus root increases Treg and Th17 involvement in embryo implantation and pregnancy maintenance by decreasing CTLA-4 < sup > + < /sup > Tregs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01100. Online ahead of print.ABSTRACTMaintenance of pregnancy is highly dependent on the maternal immune system. High levels of regulatory T cells (Tregs) accumulate in the maternal placenta to suppress immunoreactivity against fetal antigens. We assessed whether Astragalus root (AsR) and AsR-containing Kampo medicines modulate immunoreactivity and thereby increase mouse litter size. AsR-exposed murine splenocytes exhibited significantly increased IL-2 secretion. In AsR-exposed mice, total Tregs were significantly increased, whereas cytotoxic T lymphocyte antigen 4 (CTLA...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Kyoko Kobayashi Kenroh Sasaki Source Type: research
Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease
Diabetic kidney disease (DKD) is a prevalent complication of diabetes and the leading cause of end-stage renal disease. Recent evidence suggests that total flavonoids of Astragalus (TFA) has promising effects ... (Source: Chinese Medicine)
Source: Chinese Medicine - February 16, 2024 Category: Complementary Medicine Authors: Pei-Yu Liu, Kin-Fong Hong, Ya-Di Liu, Zhong-Yan Sun, Ting-Ting Zhao, Xu-Ling Li, Chi-Chou Lao, Shu-Feng Tan, Hai-Ying Zhang, Yong-Hua Zhao, Ying Xie and You-Hua Xu Tags: Research Source Type: research
