Drugs for Allergic Rhinitis and Allergic Conjunctivitis
Date: April 19, 2021
Issue #:
1622Summary:
The choice of drugs for treatment of allergic rhinitis
depends on the severity of symptoms and whether
they are are intermittent or persistent (see Table 1). (Source: The Medical Letter)
Source: The Medical Letter - March 24, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Acular Aerius Afrin Alavert Alaway Alcaftadine Allegra Allergic rhinitis Alocril Alomide Antihistamines Avamys azelastine azelastine/fluticasone propionate Beclomethasone dipropionate Beconase AQ Benadryl Bepotastine Be Source Type: research
Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation
AbstractPrion diseases are caused by the propagation of PrPSc, the pathological conformation of the PrPC prion protein. The molecular mechanisms underlying PrPSc propagation are still unsolved and no therapeutic solution is currently available. We thus sought to identify new anti-prion molecules and found that flunarizine inhibited PrPSc propagation in cell culture and significantly prolonged survival of prion-infected mice. Using anin silico therapeutic repositioning approach based on similarities with flunarizine chemical structure, we tested azelastine, duloxetine, ebastine, loperamide and metixene and showed that they ...
Source: Neurotherapeutics - February 2, 2021 Category: Neurology Source Type: research
Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission
Conclusions: This study provides the first evidence that azelastine may be novel therapeutics for CRC treatment. ARF1 promotes colon tumorigenesis, representing a promising biomarker and therapeutic target in CRC. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Hui-Fang Hu, Wen Wen Xu, Yang-Jia Li, Yan He, Wei-Xia Zhang, Long Liao, Qi-Hua Zhang, Lei Han, Xing-Feng Yin, Xiao-Xu Zhao, Yun-Long Pan, Bin Li, Qing-Yu He Tags: Research Paper Source Type: research
Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study
ConclusionsThis study shows that the overall efficacy of treatments is similar during and outside the pollen season and indicates that medications are similarly effective during the year. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 9, 2020 Category: Allergy & Immunology Source Type: research
A 2019. évi ARIA kezelési irányelvek magyar adaptációja és a hazai alkalmazás lehetőségei allergiás rhinitisben.
Abstract
Összefoglaló. Az allergiás betegségekben szenvedő emberek száma világszerte, köztük Magyarországon is növekszik. Az egészségügyi ellátórendszerek azon dolgoznak, hogy minél hatékonyabban tudják felhasználni a rendelkezésre álló forrásokat. Az Allergic Rhinitis and its Impact on Asthma (ARIA) szervezet célja az allergiás náthában szenvedő betegek ellátásának javítása, szakmai ajánlások készítése, aktualizálása. Ennek egyik módja integrált betegellátási utak kidolgozása. Célunk ezek hazai elérhetővé tétele, az ajánlások széles körű elterjeszté...
Source: Orvosi Hetilap - December 6, 2020 Category: General Medicine Authors: Kraxner H, Hirschberg A, Nékám K Tags: Orv Hetil Source Type: research
Maraviroc, celastrol and azelastine alter Chlamydia trachomatis development in HeLa cells.
Conclusion. These observations indicate that distinct mechanisms might be involved in potential interactions of the drugs evaluated herein and highlight the need for continued investigation of the interaction of commonly used drugs with Chlamydia and its host.
PMID: 33180014 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - November 12, 2020 Category: Microbiology Authors: Kuratli J, Leonard CA, Nufer L, Marti H, Schoborg R, Borel N Tags: J Med Microbiol Source Type: research
Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy,
Gehad M. Elnagar,
Marwa M.Elsawy,
Abdelmoneim A. Ali,
Nabila Zein Tags: Research Paper Source Type: research
Identification of SARS-CoV-2 entry inhibitors among already approved drugs.
Abstract
To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped virus. An approved drug library of 1800 small molecular drugs was screened for SARS2 entry inhibitors and 15 active drugs were identified as specific SARS2-S pseudovirus entry inhibitors. Antiviral tests using native SARS-CoV-2 virus in Vero E6 cells confirmed that 7 of these drugs (clemastine, amiodarone, trimeprazine, bosutinib, toremifene, flupenthixol, and azelastine) significantly inhibited ...
Source: Acta Pharmacologica Sinica - October 28, 2020 Category: Drugs & Pharmacology Authors: Yang L, Pei RJ, Li H, Ma XN, Zhou Y, Zhu FH, He PL, Tang W, Zhang YC, Xiong J, Xiao SQ, Tong XK, Zhang B, Zuo JP Tags: Acta Pharmacol Sin Source Type: research
Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 2, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy,
Gehad M. Elnagar,
Marwa M.Elsawy,
Abdelmoneim A. Ali,
Nabila Zein Tags: Research Paper Source Type: research
Effect of Specific Immunoglobulin E Response and Comorbidities on Effectiveness of MP-AzeFlu in a Real-Life Study
Conclusion: MP-AzeFlu treatment reduced VAS severity and quality-of-life scores from baseline in the total population and ARPs, supporting MP-AzeFlu as an effective treatment for all patients with moderate-to-severe AR, regardless of AR phenotype or comorbidities.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - August 21, 2020 Category: Allergy & Immunology Source Type: research
Efficacy of histamine H1 receptor antagonists azelastine and fexofenadine against cutaneous < i > Leishmania major < /i > infection
by Alex G. Peniche, E. Yaneth Osorio, Peter C. Melby, Bruno L. Travi
Current drug therapies for cutaneous leishmaniasis are often difficult to administer and treatment failure is an increasingly common occurrence. The efficacy of antileishmanial therapy relies on a combination of anti-parasite activity of drugs and the patient’s immune response. Previous studies have reportedin vitro antimicrobial activity of histamine 1-receptor antagonists (H1RAs) against different pathogens. We used anex vivo explant culture of lymph nodes from mice infected withLeishmania major to screen H1RAs compounds. Azelastine (AZ) and Fexofena...
Source: PLoS Neglected Tropical Diseases - August 9, 2020 Category: Tropical Medicine Authors: Alex G. Peniche Source Type: research
Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients
ConclusionThe free combination therapies of mast cell stabilizers, decongestants, AHs and nasal GCs, frequently used in the routine care of patients with AR, cannot be recommended because they are not evidence-based. Due to the fact that over-the-counter antiallergic drugs are not reimbursable in Germany, there is no medical supervision of the therapy. In addition, there are doubts about appropriate treatment, especially of patients with persistent rhinitis with severe symptoms, as these patients often use several preparations at the same time to alleviate their symptoms. (Source: Allergo Journal International)
Source: Allergo Journal International - July 19, 2020 Category: Allergy & Immunology Source Type: research
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus.
Abstract
Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition, an appropriate mouse model should be developed. Therefore, here, we established a surgically-induced mouse model of cholestatic pruritus. The bile duct was ligated in order to block bile secretion from the anterior, right, and left lobes, with the exception of the caudate lobe. Serum levels of total bile acid increased after bile duc...
Source: Biological and Pharmaceutical Bulletin - July 3, 2020 Category: Drugs & Pharmacology Authors: Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y Tags: Biol Pharm Bull Source Type: research
Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model
. (Source: Archives of Physiology and Biochemistry)
Source: Archives of Physiology and Biochemistry - July 3, 2020 Category: Physiology Authors: Mohamed M. Elseweidy Gehad M. Elnagar Marwa M. Elsawy Nabila Zein Source Type: research
