Impact and Assessment of Sleep Disturbance in Adults and Children with Allergic Rhinitis
AbstractPurpose of ReviewIn this article, we review the impact and the treatment of sleep disturbance caused by allergic rhinitis (AR) in adult and pediatric patients.Recent FindingsAlthough intranasal corticosteroids (INS) remain the mainstay treatments for AR-induced sleep disturbance, allergen immunotherapy (AIT) has been suggested to be effective in altering the course and progression of moderate-to-severe AR that is refractory to pharmacotherapy. MP-AzeFlu is a recently developed formulation containing azelastine, an intranasal antihistamine (INAH), and fluticasone propionate, an INS. MP-AzeFlu has been reported to ha...
Source: Current Treatment Options in Allergy - April 20, 2018 Category: Allergy & Immunology Source Type: research
Onset of action of the fixed combination intranasal azelastine-fluticasone propionate in an allergen exposure chamber
Conclusion MP-AzeFlu had a more rapid onset of action (5 minutes) and was more effective than LORA/INFP. Registration of the trial ClinicalTrials.gov Identifier: NCT03004131; Key words: allergic rhinitis, azelastine, environmental exposure chamber, fluticasone propionate, loratadine, onset of action (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research
Evaluation of the in Vitro Penetration of Fluticasone Propionate (FP) from Azelastine Hydrochloride –Fluticasone Propionate Nasal Spray (MP-AzeFlu) & Fluticasone Propionate Nasal Spray through Epiairway ™606 Tissues Using Vertical Diffusion Cells
This study used normal human-derived tracheal/bronchial epithelial cells mounted in a vertical diffusion cell system to evaluate in vitro penetration of FP from MP-AzeFlu vs FP nasal spray into and across EpiAirway ™606 tissues from aqueous suspension. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: William E. Berger, Alex D'Addio, Robert Allara, Bindu Upadhyay, Arkady Koltun, Ferdinand Kopietz, Joachim Maus Source Type: research
Fixed-Dose Combination Intranasal Azelastine-Fluticasone Propionate Versus Oral Loratadine with Intranasal Fluticasone Propionate: Assessment of Onset of Action in the Treatment of Allergen-Induced Allergic Rhinitis Symptoms
This study compared MP-AzeFlu with 2 sequential monotherapies of oral loratadine and intranasal fluticasone propionate (LORA/INFP). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Jean Bousquet, David Price, Eli O. Meltzer, Duc Tung Nguyen, Hans-Christian Kuhl, Arkady Koltun, Ferdinand Kopietz, Ullrich Munzel Source Type: research
Intranasal Association of Fluticasone propionate/Azelastine hydrochloride is Effective in Children with Allergic Rhinitis
This intranasal anti-histamines and/or corticosteroids are effective in controlling allergic rhinitis symptoms (AR) but may interfere with skin prick tests (SPT). The aim of this study was to verify efficacy of intranasal Fluticasone propionate/Azelastine hydrochloride (FLU/AZE) in AR as well as SPT inhibition. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Nelson Augusto Rosario, Tatiane gs Scaliante, Cristine S. Rosario, Herberto J. Chong Neto, Carlos a Riedi Source Type: research
Inhibition of hepatic apolipoprotein A-I gene expression by histamine.
Abstract
In a recent high throughput analysis to identify drugs that alter hepatic apolipoprotein A-I (apo A-I) expression, histamine receptor one (H1) antagonists emerged as potential apo A-1 inducing drugs. Thus the present study was undertaken to identify some of the underlying molecular mechanisms of the effect of antihistaminic drugs on apo AI production. Apo A-I levels were measured by enzyme immunoassay and Western blots. Apo A-I mRNA levels were measured by reverse transcription real-time PCR using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as the internal control. The effects of histami...
Source: European Journal of Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Authors: Haas MJ, Plazarte M, Chamseddin A, Onstead-Haas L, Wong NCW, Plazarte G, Mooradian AD Tags: Eur J Pharmacol Source Type: research
MP29 ‐02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite‐allergic rhinitis
ConclusionMP29‐02 treatment reduces inflammatory mediators and NHR in AR. The effects of AZE + FP on MC degranulation, nasal epithelial barrier integrity, and TRP channels provide novel insights into the pathophysiology of allergic rhinitis. (Source: Allergy)
Source: Allergy - January 17, 2018 Category: Allergy & Immunology Authors: I. Kortekaas Krohn, I. Callebaut, Y. A. Alpizar, B. Steelant, L. Van Gerven, P. S. Skov, A. Kasran, K. Talavera, M. M. Wouters, J. L. Ceuppens, S. F. Seys, P. W. Hellings Tags: ORIGINAL ARTICLE Source Type: research
MP29 ‐02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite allergic rhinitis
ConclusionMP29‐02 treatment reduces inflammatory mediators and NHR in AR. The effects of AZE+FP on MC degranulation, nasal epithelial barrier integrity and TRP channels provide novel insights into the pathophysiology of allergic rhinitis.This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - November 1, 2017 Category: Allergy & Immunology Authors: Inge Kortekaas Krohn, Ina Callebaut, Yeranddy A. Alpizar, Brecht Steelant, Laura Van Gerven, Per Stahl Skov, Ahmad Kasran, Karel Talavera, Mira M Wouters, Jan L Ceuppens, Sven F Seys, Peter W Hellings Tags: Original Article: Airway Diseases Source Type: research
A Cost Minimization Analysis of Azelastine/Fluticasone Combination Nasal Spray Versus Azelastine And Fluticasone Nasal Sprays Monotherapy In Moderate To Severe Allergic Rhinitis: An Experience From Islamic Republic of Iran
Allergic Rhinitis (AR) is a symptomatic disorder which is due to allergen exposure and IgE inflammatory pathway activation in respiratory tract. AR is categorized upon symptoms` type aand duration and its impact on patients` health related quality of life into mild and moderate to severe. AR treatment is based on allergen avoidance, medical therapy and immune therapy. Medical therapy includes oral and intranasal antihistamines and intranasal corticosteroids. Intranasal corticoste roids are first-line treatment in moderate to severe AR. (Source: Value in Health)
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: P Zaboli, S Nikfar, N Ayati, E Rohani, M Toroski, D Babaie Source Type: research
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation
Background: Nonallergic vasomotor rhinitis (NAVMR) has been considered a diagnosis by exclusion due to unknown mechanisms or lack of diagnostic biomarkers.Methods: To determine clinical responses and biological pathways in NAVMR subjects challenged to cold dry air (CDA) in an environmental exposure chamber (EEC) pre- and posttreatment with azelastine/fluticasone (AzeFlu), 30 NAVMR subjects, prescreened for CDA-induced symptoms (approx. 14 °C, (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - August 8, 2017 Category: Allergy & Immunology Source Type: research
Effects of ophthalmologic solutions on sinonasal ciliated epithelium
ConclusionAll solutions tested appear to have moderate effects on ciliated cell surfaces for a period of time typical of mucociliary clearance (10 to 20 minutes). Both active drugs and excipients can play a role in ciliary modulation, and specific formulations can show unique or unexpected properties. Any other individual ophthalmologic solutions to be used in a nasal drug delivery system should be tested in this manner to evaluate potential ciliary effects before clinical use. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 23, 2017 Category: Allergy & Immunology Authors: Alan D. Workman, Ryan M. Carey, Michael A. Kohanski, Nithin D. Adappa, James N. Palmer, Noam A. Cohen Tags: ORIGINAL ARTICLE Source Type: research
Involvement of Leukotriene B4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice.
Abstract
A recent study suggests that interleukin-31 (IL-31) exerts its effect via indirect mechanisms rather than through direct stimulation of cutaneous nerves. However, the underlying peripheral mechanisms of IL-31-induced itch in the skin remain unclear. Therefore, the present study investigated the peripheral mechanisms underlying IL-31-induced itch in mice. IL-31-induced itch-related response was inhibited by anti-allergic drugs (tranilast and azelastine), but not by an H1 histamine receptor antagonist (terfenadine). Furthermore, a 5-lipoxygenase inhibitor (zileuton), but not a cyclooxygenase inhibit...
Source: Acta Dermato-Venereologica - May 17, 2017 Category: Dermatology Authors: Andoh T, Harada A, Kuraishi Y Tags: Acta Derm Venereol Source Type: research
Multicentre, non-interventional study to assess the profile of patients with uncontrolled rhinitis prescribed a novel formulation of azelastine hydrochloride and fluticasone propionate in a single spray in routine clinical practice in the UK
Conclusions
In the UK, MP-AzeFlu was prescribed for individuals (≥12 years) with moderate/severe AR irrespective of (1) previous AR treatment (mono or multiple), (2) previous or likely treatment failure, (3) phenotype, (4) number of previous physician visits for AR and (5) for the relief of both acute symptoms and in anticipation of allergen exposure. (Source: BMJ Open)
Source: BMJ Open - April 24, 2017 Category: Journals (General) Authors: Scadding, G., Price, D., El-Shanawany, T., Ahmed, S., Ray, J., Sargur, R., Kumar, N. Tags: Open access, Ear, nose and throat/otolaryngology, Epidemiology, Respiratory medicine Research Source Type: research
Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells
AbstractBoth glucocorticoids and H1-antihistamines are widely used on patients with airway diseases. However, their direct effects on airway epithelial cells are not fully explored. Therefore, we use the primary culture of human nasal epithelial cells (HNEpC) to delineate in vitro mucosal responses to above two drugs. HNEpC cells were cultured with/without budesonide and azelastine. The growth rate at each group was recorded and measured as population double time (PDT). The histamine1-receptor (H1R), muscarinic1-receptor (M1R) and M3R were measured using immunocytochemistry and western blotting after 7-days treatment. Then...
Source: European Archives of Oto-Rhino-Laryngology - January 30, 2017 Category: ENT & OMF Source Type: research
An algorithm recommendation for the pharmacological management of allergic rhinitis in the UK: a consensus statement from an expert panel.
Abstract
Allergic rhinitis is a frequent presenting problem in primary care in the UK, and has increased in prevalence over the last 30 years. When symptomatic, patients report significant reduction in their quality of life and impairment in school and work performance. Achieving adequate symptom control is pivotal to successful allergic rhinitis management, and relies mostly on pharmacotherapy. While it is recognised that most mild-moderate allergic rhinitis symptoms can be managed successfully in primary care, important gaps in general practitioner training in relation to allergic rhinitis have been iden...
Source: Primary Care - January 26, 2017 Category: Primary Care Authors: Lipworth B, Newton J, Ram B, Small I, Schwarze J Tags: NPJ Prim Care Respir Med Source Type: research
