Patient Satisfaction and Sensory Attributes of Nasal Spray Treatments of Olopatadine Hydrochloride/Mometasone Furoate Monohydrate and Azelastine Hydrochloride/Fluticasone Propionate for Allergic Rhinitis in Australia – An Observational Real-World Clinical Study
(Source: Patient Preference and Adherence)
Source: Patient Preference and Adherence - January 14, 2023 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
Effect of MP ‐AzeFlu compared to monotherapy on COX‐2, PGE2, and EP2 gene expression in upper airway mucosa
In this study, we investigated the effect of intranasal fluticasone and azelastine (MP-AzeFlu) and fluticasone propionate (FP) on arachidonic acid metabolism as measured by changes in regulation of cyclooxygenase (COX) isoforms, prostaglandin (PG) D2, PGE2, PGE2 receptor (EP) 2, and EP3. Both MP-AzeFlu and FP inhibited interleukin-1 β-induced COX-2 messenger RNA (mRNA) and protein expression and PGE2 secretion in vitro. MP-AzeFlu and FP both upregulated EP2 mRNA expression, though neither upregulated EP2 protein expression. AbstractMP-AzeFlu (intranasal fluticasone and azelastine) has been widely studied and has demonstra...
Source: Immunity, Inflammation and Disease - December 15, 2022 Category: Allergy & Immunology Authors: Sonia Vicens ‐Artes,
Jordi Roca‐Ferrer,
Valeria Tubita,
Mireya Fuentes,
Isam Alobid,
Antonio Valero,
Ferdinand Kopietz,
DucTung Nguyen,
Joaquim Mullol Tags: SHORT REPORT Source Type: research
Molecules, Vol. 27, Pages 8322: Chemical Stability Study of H1 Antihistaminic Drugs from the First and the Second Generations, Diphenhydramine, Azelastine and Bepotastine, in Pure APIs and in the Presence of Two Excipients, Citric Acid and Polyvinyl Alcohol
Data
The chemical stability of diphenhydramine (DIPH), azelastine (AZE) and bepotastine (BEPO) was examined in solutions and solids. The drugs were subjected to high temperature (70 °C for 35 h) or UV/VIS light (18.902–94.510 kJ/m2) at pH 1–13, to examine their percentage degradation and kinetics of degradation. Further, the stability of solid DIPH, AZE and BEPO was examined in the presence of excipients of different reactivity, i.e., citric acid (CA) and polyvinyl alcohol (PVA) under high temperature/high humidity (70 °C/80% RH) or UV/VIS light (94.510 kJ/m2). Under...
Source: Molecules - November 29, 2022 Category: Chemistry Authors: Anna Gumieniczek Karolina Lejwoda Natalia Data Tags: Article Source Type: research
Eustachian Tube Dysfunction in Children with Adenoid Hypertrophy: The Effect of Intranasal Azelastine-Fluticasone Spray Treatment on Middle Ear Ventilation and Adenoid Tissue
CONCLUSIONS: AH significantly increases the frequency of ETD. In this study, it was observed that Aze-Flu treatment was significantly effective in both regression of the adenoid tissue and Eustachian tube dysfunction. We believe that it can be applied as an initial therapy in children with AH and associated ETD.PMID:36416201 | DOI:10.1177/01455613221140281 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - November 23, 2022 Category: ENT & OMF Authors: Ahmet Mert Bilgili Hac ı Ömer Durmaz Muhammet Dilber Source Type: research
Eustachian Tube Dysfunction in Children with Adenoid Hypertrophy: The Effect of Intranasal Azelastine-Fluticasone Spray Treatment on Middle Ear Ventilation and Adenoid Tissue
CONCLUSIONS: AH significantly increases the frequency of ETD. In this study, it was observed that Aze-Flu treatment was significantly effective in both regression of the adenoid tissue and Eustachian tube dysfunction. We believe that it can be applied as an initial therapy in children with AH and associated ETD.PMID:36416201 | DOI:10.1177/01455613221140281 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - November 23, 2022 Category: ENT & OMF Authors: Ahmet Mert Bilgili Hac ı Ömer Durmaz Muhammet Dilber Source Type: research
Onset of action of azelastine hcl nasal spray 0.15% evaluated in an environmental exposure chamber
The objective of this single center, double-blinded, placebo-controlled study was to evaluate the time to onset of efficacy of azelastine HCl 0.15% in the relief of nasal symptoms of SAR in an environmental exposure chamber (EEC). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: S. Hsu, D. Stevens, F. Sajjad, A. Salapatek Tags: Rhinitis, Other Upper Airway Disorders Source Type: research
Efficacy of Topical Azelastine and Fluticasone Dipropionate Combination in Children With Adenoid Hypertrophy
CONCLUSION: In this study, the effectiveness of AZE-FLU nasal spray on AH was investigated for the first time. This treatment provides an effective alternative to the surgical approach in children with uncomplicated adenoid hypertrophy. Using this protocol, 96% of patients were removed from the surgery list.LEVEL OF EVIDENCE: is IV.PMID:36053218 | DOI:10.1177/01455613221123860 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - September 2, 2022 Category: ENT & OMF Authors: Ahmet Mert Bilgili Hac ı Ömer Durmaz Muhammed Dilber Source Type: research
Efficacy of Topical Azelastine and Fluticasone Dipropionate Combination in Children With Adenoid Hypertrophy
CONCLUSION: In this study, the effectiveness of AZE-FLU nasal spray on AH was investigated for the first time. This treatment provides an effective alternative to the surgical approach in children with uncomplicated adenoid hypertrophy. Using this protocol, 96% of patients were removed from the surgery list.LEVEL OF EVIDENCE: is IV.PMID:36053218 | DOI:10.1177/01455613221123860 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - September 2, 2022 Category: ENT & OMF Authors: Ahmet Mert Bilgili Hac ı Ömer Durmaz Muhammed Dilber Source Type: research
Efficacy of Topical Azelastine and Fluticasone Dipropionate Combination in Children With Adenoid Hypertrophy
CONCLUSION: In this study, the effectiveness of AZE-FLU nasal spray on AH was investigated for the first time. This treatment provides an effective alternative to the surgical approach in children with uncomplicated adenoid hypertrophy. Using this protocol, 96% of patients were removed from the surgery list.LEVEL OF EVIDENCE: is IV.PMID:36053218 | DOI:10.1177/01455613221123860 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - September 2, 2022 Category: ENT & OMF Authors: Ahmet Mert Bilgili Hac ı Ömer Durmaz Muhammed Dilber Source Type: research
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
Conclusion and Implications: Azelastine, an antihistamine available as nasal sprays developed against allergic rhinitis may be considered as a topical prevention or treatment of nasal colonization by SARS-CoV-2. A Phase 2 efficacy indicator study with azelastine-containing nasal spray that was designed based on the findings reported here has been concluded recently, confirming accelerated viral clearance in SARS-CoV-2 positive subjects. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 30, 2022 Category: Drugs & Pharmacology Source Type: research
Suppressing leukocyte Kv1.3-channels by commonly used drugs: A novel therapeutic target for schizophrenia?
Drug Discov Ther. 2022 Apr 21. doi: 10.5582/ddt.2022.01031. Online ahead of print.ABSTRACTRecent studies revealed the involvement of "chronic inflammation" in the pathogenesis of schizophrenia. In schizophrenia and some neurodegenerative disorders that are caused by inflammation, T-lymphocytes and macrophages were hyperactivated or proliferated in the central nervous system, being accompanied by the overexpression of delayed rectifier K+-channels (Kv1.3) within the cells. In our previous basic studies, in addition to nonsteroidal anti-inflammatory drugs (NSAIDs) and statins, antibiotics (clarithromycin, chloroquine), anti-...
Source: Drug Discoveries and Therapeutics - April 21, 2022 Category: Drugs & Pharmacology Authors: Yasuhiro Sato Ryo Kuwana Itsuro Kazama Source Type: research
A Comparative Study of Montelukast and Azelastine add on Therapy in Moderate to Severe Allergic Rhinitis Treatment: A Double-Blind Randomized Clinical Trial
CONCLUSION: Based on our findings, we recommend Azelastine in conjunction with an intranasal corticosteroid for the treatment of moderate to severe allergic rhinitis. In moderate to severe AR or even asthma management, Montelukast has no greater impact than INCS.PMID:35300506 | DOI:10.1177/19458924221086268 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 18, 2022 Category: ENT & OMF Authors: Hossein Esmaeilzadeh Nasrin Mortazavi Far Seyed Hesamedin Nabavizadeh Masroor Babaeian Maryam Hadipour Soheila Alyasin Source Type: research
