Assessment of receptor affinities of ophthalmic and systemic agents in dry eye disease
Purpose of review
To explore our current understanding of receptor profiles acted upon by medications used to treat dry eye disease (DED).
Recent findings
Research into histaminic and muscarinic receptor affinities for drugs targeting the ocular surface has not kept up with bench research pertaining to the receptor profile of the ocular surface. These insights are necessary for better evaluation of medications used in DED and other allergic disorders.
Summary
At the H1 receptor, Ketotifen (pKa = 9.2), pyrilamine (pKa = 9.0), and epinastine (pKa = 8.0) had the highest affinities, whereas raniti...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: EYE ALLERGY: Edited by Leonard Bielory and Abraham Solomon Source Type: research
Comparison of the Effects of Azelastine and Fluticasone Nasal Sprays in the Treatment of Allergic Rhinitis
This study compares effects of Azelastine and Fluticasone nasal spray in patients with allergic rhinitis. Prospective comparative study including 240 patients with allergic rhinitis was conducted with 120 each in fluticasone and azelastine group. Nasal sprays were given for period of three months along with an oral antihistamine. Follow up was done after three months. Pre and post treatment symptom assessment were done using Total nasal symptom score. The median TNSS in pre and post treatment of group A (fluticasone) is 10(4) and 1(3) which shows statistical significance withp value < 0.001. Median TNSS in pre and...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - August 2, 2021 Category: ENT & OMF Source Type: research
DrugWAS: Drug-wide association studies for COVID-19 drug repurposing
In conclusion, this cohort study leveraged EHR data to identify a list of drugs that could be repurposed to improve COVID-19 outcomes. Further randomized clinical trials are needed to investigate the efficacy of the proposed drugs.PMID:34314511 | DOI:10.1002/cpt.2376 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - July 27, 2021 Category: Drugs & Pharmacology Authors: Cosmin A Bejan Katherine N Cahill Patrick J Staso Leena Choi Josh F Peterson Elizabeth J Phillips Source Type: research
DrugWAS: Drug-wide association studies for COVID-19 drug repurposing
In conclusion, this cohort study leveraged EHR data to identify a list of drugs that could be repurposed to improve COVID-19 outcomes. Further randomized clinical trials are needed to investigate the efficacy of the proposed drugs.PMID:34314511 | DOI:10.1002/cpt.2376 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - July 27, 2021 Category: Drugs & Pharmacology Authors: Cosmin A Bejan Katherine N Cahill Patrick J Staso Leena Choi Josh F Peterson Elizabeth J Phillips Source Type: research
MP-AzeFlu in Moderate-to-Severe Allergic Rhinitis: A Literature Review
Allergic rhinitis (AR) is prevalent, and many patients present with moderate-to-severe symptomatic disease. The majority of patients are not satisfied with their AR treatment, despite the use of concurrent medications. These gaps underscore the need for treatment with more effective options for moderate-to-severe AR. The authors ’ objective was to review systematically the efficacy and safety of MP-AzeFlu for the treatment of AR. The primary outcomes studied were nasal, ocular, and total symptoms. Other outcomes included time to onset and of AR control, quality of life, and safety. Searches of PubMed and Cochrane databas...
Source: International Archives of Allergy and Immunology - June 3, 2021 Category: Allergy & Immunology Source Type: research
Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2
Virology. 2021 May 25;560:110-115. doi: 10.1016/j.virol.2021.05.009. Online ahead of print.ABSTRACTA recent study have reported that pre-use of azelastine is associated with a decrease in COVID-19 positive test results among susceptible elderly people. Besides, it has been reported that antihistamine drugs could prevent viruses from entering cells. The purpose of this study is to investigate whether azelastine have antiviral activity against SARS-CoV-2 in vitro and the possible mechanism. Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equil...
Source: Virology - May 30, 2021 Category: Virology Authors: Shuai Ge Jiayu Lu Yajing Hou Yuexin Lv Cheng Wang Huaizhen He Source Type: research
Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2
Virology. 2021 May 25;560:110-115. doi: 10.1016/j.virol.2021.05.009. Online ahead of print.ABSTRACTA recent study have reported that pre-use of azelastine is associated with a decrease in COVID-19 positive test results among susceptible elderly people. Besides, it has been reported that antihistamine drugs could prevent viruses from entering cells. The purpose of this study is to investigate whether azelastine have antiviral activity against SARS-CoV-2 in vitro and the possible mechanism. Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equil...
Source: Virology - May 30, 2021 Category: Virology Authors: Shuai Ge Jiayu Lu Yajing Hou Yuexin Lv Cheng Wang Huaizhen He Source Type: research
Comparison Table: Some Nasal Sprays for Allergic Rhinitis (online only)
Date: April 19, 2021
Issue #:
1622Summary:
View the Comparison Table: Some Nasal Sprays for Allergic Rhinitis (Source: The Medical Letter)
Source: The Medical Letter - April 1, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Allergic rhinitis Antihistamines azelastine azelastine/fluticasone propionate Beclomethasone Beconase AQ Budesonide ciclesonide Cromolyn Dymista Flonase Allergy Relief Flonase Sensimist Flunisolide fluticasone furoate Intranasa Source Type: research
Comparison Table: Some Oral Drugs for Allergic Rhinitis (online only)
Date: April 19, 2021
Issue #:
1622Summary:
View the Comparison Table: Some Oral Drugs for Allergic Rhinitis (Source: The Medical Letter)
Source: The Medical Letter - April 1, 2021 Category: Drugs & Pharmacology Authors: admin Tags: 1622c Alavert Allegra Allergic rhinitis Antihistamines azelastine azelastine/fluticasone propionate Beclomethasone Beconase AQ Budesonide cetirizine ciclesonide Clarinex Claritin Cromolyn Desloratadine Dymista Fexofenadin Source Type: research
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning
Biol Pharm Bull. 2021;44(4):550-556. doi: 10.1248/bpb.b20-00889.ABSTRACTWe previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM drugs for drug repositioning. The method, T-cell activation-inhibitory assay, is based on inductive logic. Most of CRM such as resveratrol have been reported to suppress T-cell activation and have anti-inflammatory functions. Here, we assessed the activity of 12 antiallergic drugs through T-cell activation-i...
Source: Biological and Pharmaceutical Bulletin - April 1, 2021 Category: Drugs & Pharmacology Authors: Shouma Ishikawa Atsushi Sawamoto Satoshi Okuyama Mitsunari Nakajima Source Type: research
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning
Biol Pharm Bull. 2021;44(4):550-556. doi: 10.1248/bpb.b20-00889.ABSTRACTWe previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM drugs for drug repositioning. The method, T-cell activation-inhibitory assay, is based on inductive logic. Most of CRM such as resveratrol have been reported to suppress T-cell activation and have anti-inflammatory functions. Here, we assessed the activity of 12 antiallergic drugs through T-cell activation-i...
Source: Biological and Pharmaceutical Bulletin - April 1, 2021 Category: Drugs & Pharmacology Authors: Shouma Ishikawa Atsushi Sawamoto Satoshi Okuyama Mitsunari Nakajima Source Type: research
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning
Biol Pharm Bull. 2021;44(4):550-556. doi: 10.1248/bpb.b20-00889.ABSTRACTWe previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM drugs for drug repositioning. The method, T-cell activation-inhibitory assay, is based on inductive logic. Most of CRM such as resveratrol have been reported to suppress T-cell activation and have anti-inflammatory functions. Here, we assessed the activity of 12 antiallergic drugs through T-cell activation-i...
Source: Biological and Pharmaceutical Bulletin - April 1, 2021 Category: Drugs & Pharmacology Authors: Shouma Ishikawa Atsushi Sawamoto Satoshi Okuyama Mitsunari Nakajima Source Type: research
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning
Biol Pharm Bull. 2021;44(4):550-556. doi: 10.1248/bpb.b20-00889.ABSTRACTWe previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM drugs for drug repositioning. The method, T-cell activation-inhibitory assay, is based on inductive logic. Most of CRM such as resveratrol have been reported to suppress T-cell activation and have anti-inflammatory functions. Here, we assessed the activity of 12 antiallergic drugs through T-cell activation-i...
Source: Biological and Pharmaceutical Bulletin - April 1, 2021 Category: Drugs & Pharmacology Authors: Shouma Ishikawa Atsushi Sawamoto Satoshi Okuyama Mitsunari Nakajima Source Type: research
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning
Biol Pharm Bull. 2021;44(4):550-556. doi: 10.1248/bpb.b20-00889.ABSTRACTWe previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM drugs for drug repositioning. The method, T-cell activation-inhibitory assay, is based on inductive logic. Most of CRM such as resveratrol have been reported to suppress T-cell activation and have anti-inflammatory functions. Here, we assessed the activity of 12 antiallergic drugs through T-cell activation-i...
Source: Biological and Pharmaceutical Bulletin - April 1, 2021 Category: Drugs & Pharmacology Authors: Shouma Ishikawa Atsushi Sawamoto Satoshi Okuyama Mitsunari Nakajima Source Type: research
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning
Biol Pharm Bull. 2021;44(4):550-556. doi: 10.1248/bpb.b20-00889.ABSTRACTWe previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM drugs for drug repositioning. The method, T-cell activation-inhibitory assay, is based on inductive logic. Most of CRM such as resveratrol have been reported to suppress T-cell activation and have anti-inflammatory functions. Here, we assessed the activity of 12 antiallergic drugs through T-cell activation-i...
Source: Biological and Pharmaceutical Bulletin - April 1, 2021 Category: Drugs & Pharmacology Authors: Shouma Ishikawa Atsushi Sawamoto Satoshi Okuyama Mitsunari Nakajima Source Type: research
