Fluticasone Furoate versus Fluticasone Propionate/Azelastine in Moderate-to-Severe Persistent Perennial Allergic Rhinitis from Thai Adult chronic Rhinitis prospective Cohort (TARhiC)
According to the 2-week randomized trials in patients with seasonal allergic rhinitis, intranasal corticosteroid (INCS)/intranasal antihistamine was more effective than INCS monotherapy. However, studies longer than 2-week duration in perennial allergic rhinitis (PAR) comparing their efficacy are limited. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Piyaporn Chokevittaya, Chamard Wongsa, Irin Vichara-Anont, Thanachit Krikeerati, Mongkhon Sompornrattanaphan, Kawita Atipas, Dichapong Kanjanawasee, Triphoom Suwanwech, Pongsakorn Tantilipikorn, Torpong Thongngarm Source Type: research
Viruses, Vol. 15, Pages 2300: Antiviral Potential of Azelastine against Major Respiratory Viruses
Valeria Szijarto
The Coronavirus Disease 2019 (COVID-19) pandemic and the subsequent increase in respiratory viral infections highlight the need for broad-spectrum antivirals to enable a quick and efficient reaction to current and emerging viral outbreaks. We previously demonstrated that the antihistamine azelastine hydrochloride (azelastine-HCl) exhibited in vitro antiviral activity against SARS-CoV-2. Furthermore, in a phase 2 clinical study, a commercial azelastine-containing nasal spray significantly reduced the viral load in SARS-CoV-2-infected individuals. Here, we evaluate the efficacy of azelastine-HCl agains...
Source: Viruses - November 23, 2023 Category: Virology Authors: Katrin Fischhuber Zolt án Bánki Janine Kimpel Natalie Kragl Annika R össler Annika Bolze Brigitte Muellauer Joachim Angerer G ábor Nagy Eszter Nagy Valeria Szijarto Tags: Article Source Type: research
Analysis of the efficacy of azelastine nasal spray combined with mussel mucin in the treatment of allergic rhinitis and the influence of peripheral blood CCL26 and CCR3 levels
CONCLUSIONS: Azelastine nasal spray combined with mussel mucin is effective in the treatment of allergic rhinitis, which can effectively improve patients' clinical symptoms, alleviate nasal ventilation disorders, reduce inflammatory reactions, and improve sleep quality. This strategy of combined treatment is safe and, therefore, worth advocating.PMID:37916337 | DOI:10.26355/eurrev_202310_34145 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 2, 2023 Category: Drugs & Pharmacology Authors: Y Liu S Liu S-F Lu G-M Zang Source Type: research
Analysis of the efficacy of azelastine nasal spray combined with mussel mucin in the treatment of allergic rhinitis and the influence of peripheral blood CCL26 and CCR3 levels
CONCLUSIONS: Azelastine nasal spray combined with mussel mucin is effective in the treatment of allergic rhinitis, which can effectively improve patients' clinical symptoms, alleviate nasal ventilation disorders, reduce inflammatory reactions, and improve sleep quality. This strategy of combined treatment is safe and, therefore, worth advocating.PMID:37916337 | DOI:10.26355/eurrev_202310_34145 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 2, 2023 Category: Drugs & Pharmacology Authors: Y Liu S Liu S-F Lu G-M Zang Source Type: research
The efficiency of azelastine hydrochloride and fluticasone propionate nasal spray to improve PAP adherence in patients with obstructive sleep apnea
Conclusion: The preliminary findings of this study evaluating the effectiveness of azelastine hydrochloride and fluticasone propionate nasal spray in enhancing PAP adherence indicate that this combination may improve PAP usage and reduce CPAP-induced rhinitis symptoms. Further recruitment is underway to confirm these results (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Wongchan, R., Tepwimonpetkun, C., Kitsongsermthon, J., Sapankaew, T., Yotsombut, K., Chittiwan, W. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
