Asparagus Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of immunological adjuvant activities of saponin rich fraction from the fruits of Asparagus adscendens Roxb. with less adverse reactions
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - April 29, 2022 Category: Toxicology Authors: Rahul Singh Rinku Sharma Rajat Varshney Gorakh Mal Mayukh Ghosh Birbal Singh Source Type: research

Comparative Plastome Analysis of Three Amaryllidaceae Subfamilies: Insights into Variation of Genome Characteristics, Phylogeny, and Adaptive Evolution
In this study, we sequenced 18 Allioideae plastomes and combined them with publicly available data (a total of 41 plastomes), including 21 Allioideae species, 1 Agapanthoideae species, 14 Amaryllidoideae species, and 5 Asparagaceae species. Comparative analyses were performed including basic characteristics of genome structure, codon usage, repeat elements, IR boundary, and genome divergence. Phylogenetic relationships were detected using single-copy genes (SCGs) and ribosomal internal transcribed spacer sequences (ITS), and the branch-site model was also employed to conduct the positive selection analysis. The results ind...
Source: Biomed Res - April 4, 2022 Category: Research Authors: Rui-Yu Cheng Deng-Feng Xie Xiang-Yi Zhang Xiao Fu Xing-Jin He Song-Dong Zhou Source Type: research

Acute toxicity, analgesic, and smooth muscle relaxant effects of the aqueous root extract of Asparagus racemosus from Kenya
The plant Asparagus racemosus is used traditionally in Kenya for a variety of medicinal purposes including in the management of pain, asthma, and premature labour. However, a dearth of empirical studies means that there is limited information on the acute toxicity and pharmacological effects to support these uses by the local variety of the plant. The aim of this study was, therefore, to eva... (Source: Journal of Medicinal Plants Research)
Source: Journal of Medicinal Plants Research - March 18, 2022 Category: Complementary Medicine Source Type: research

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression
Front Pharmacol. 2022 Feb 22;13:835616. doi: 10.3389/fphar.2022.835616. eCollection 2022.ABSTRACTChemotherapy-induced myelosuppression is one of the major challenges in cancer treatment. Ayurveda-based immunomodulatory botanicals Asparagus racemosus Willd (AR/Shatavari) and Withania somnifera (L.). Dunal (WS/Ashwagandha) have potential role to manage myelosuppression. We have developed a method to study the effects of AR and WS as therapeutic adjuvants to counter paclitaxel (PTX)-induced myelosuppression. Sixty female BALB/c mice were divided into six groups-vehicle control (VC), PTX alone, PTX with aqueous and hydroalcoho...
Source: Cancer Control - March 11, 2022 Category: Cancer & Oncology Authors: Akash Saggam Prathamesh Kale Sushant Shengule Dada Patil Manish Gautam Girish Tillu Kalpana Joshi Sunil Gairola Bhushan Patwardhan Source Type: research

Molecules, Vol. 27, Pages 1535: In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients
This study extracted A. racemosus using the supercritical carbon dioxide fluid technique with ethanol and investigated its biological compounds and activities. The A. racemosus root extract had a high content of polyphenolic compounds, including quercetin, naringenin, and p-coumaric acid, and DPPH scavenging activity comparable to that of the standard L-ascorbic acid. A. racemosus root extract showed not only a significant reduction in SRD5A1 and SRD5A2 mRNA expression by about 45.45% and 90.86%, respectively, but also a reduction in the in vivo anti-sebum efficacy in male volunteers, with significantly superior percentage...
Source: Molecules - February 24, 2022 Category: Chemistry Authors: Ruksiriwanich Khantham Linsaenkart Chaitep Jantrawut Chittasupho Rachtanapun Jantanasakulwong Phimolsiripol Sommano Arjin Berrada Barba Sringarm Tags: Article Source Type: research

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression
Chemotherapy-induced myelosuppression is one of the major challenges in cancer treatment. Ayurveda-based immunomodulatory botanicals Asparagus racemosus Willd (AR/Shatavari) and Withania somnifera (L.). Dunal (WS/Ashwagandha) have potential role to manage myelosuppression. We have developed a method to study the effects of AR and WS as therapeutic adjuvants to counter paclitaxel (PTX)-induced myelosuppression. Sixty female BALB/c mice were divided into six groups—vehicle control (VC), PTX alone, PTX with aqueous and hydroalcoholic extracts of AR (ARA, ARH) and WS (WSA, WSH). The myelosuppression was induced in mice by in...
Source: Frontiers in Pharmacology - February 22, 2022 Category: Drugs & Pharmacology Source Type: research

Bioactive small-molecule constituents of Lao plants
J Med Plant Res. 2021 Dec;15(12):540-559. doi: 10.5897/jmpr2021.7137. Epub 2021 Dec 31.ABSTRACTLaos has a rich plant diversity, and medicinal plants are used extensively in Lao traditional medicine for the treatment of a variety of human diseases. However, only a relatively small number of these plants have been investigated for their major components with potential antitumor, anti-infective, and other types of bioactivities. These species include Asparagus cochinchinensis, Diospyros quaesita, Gongronema napalense, Marsypopetalum modestum, Nauclea orientalis, Rourea minor, Stemona pierrei, and Stemona tuberosa. Thus far, t...
Source: Cell Research - February 18, 2022 Category: Cytology Authors: Yulin Ren Bethany G Elkington Joshua M Henkin Kongmany Sydara A Douglas Kinghorn Djaja D Soejarto Source Type: research

Distribution of flagellin CD2-1, flg22, and flgII-28 recognition systems in plant species and regulation of plant immune responses through these recognition systems
Biosci Biotechnol Biochem. 2022 Jan 18:zbac007. doi: 10.1093/bbb/zbac007. Online ahead of print.ABSTRACTThe first layer of active plant immunity relies upon the recognition of PAMPs or MAMPs, and the induction of PTI. Flagellin is the major protein component of the bacterial flagellum. Flagellin-derived peptide fragments such as CD2-1, flg22, and flgII-28 function as PAMPs in most higher plants. To determine the distribution of CD2-1, flg22, and flgII-28 recognition systems within plant species, the inducibility of PTI by CD2-1, flg22, and flgII-28 in eight plant species, including monocotyledonous and dicotyledonous plant...
Source: Bioscience, Biotechnology, and Biochemistry - January 18, 2022 Category: Biochemistry Authors: Takahiko Murakami Yuya Katsuragi Hiroyuki Hirai Koki Wataya Machiko Kondo Fang-Sik Che Source Type: research

Antiglycation activity of β- glucogallin from Asparagus racemosus 
Nat Prod Res. 2022 Jan 13:1-7. doi: 10.1080/14786419.2022.2025799. Online ahead of print.ABSTRACTThe increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in pathogenesis of various chronic ailments, including diabetes-associated secondary complications, atherosclerosis, aging, inflammatory and neurodegenerative diseases. Therefore, inhibition of AGEs formation is an imperative strategy for alleviating diverse pathologies. Here, we have demonstrated the AGEs inhibitory activity of β-glucogallin, isolated for the first time from the roots of Asparagus racemosus. β-glucogallin s...
Source: Natural Product Research - January 13, 2022 Category: Biochemistry Authors: Shadab Ahmad Alka Raj Pandey Suriya Pratap Singh Sushmita Singh Koneni V Sashidhara Akhilesh K Tamrakar Source Type: research

Antiglycation activity of β- glucogallin from Asparagus racemosus 
Nat Prod Res. 2022 Jan 13:1-7. doi: 10.1080/14786419.2022.2025799. Online ahead of print.ABSTRACTThe increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in pathogenesis of various chronic ailments, including diabetes-associated secondary complications, atherosclerosis, aging, inflammatory and neurodegenerative diseases. Therefore, inhibition of AGEs formation is an imperative strategy for alleviating diverse pathologies. Here, we have demonstrated the AGEs inhibitory activity of β-glucogallin, isolated for the first time from the roots of Asparagus racemosus. β-glucogallin s...
Source: Atherosclerosis - January 13, 2022 Category: Cardiology Authors: Shadab Ahmad Alka Raj Pandey Suriya Pratap Singh Sushmita Singh Koneni V Sashidhara Akhilesh K Tamrakar Source Type: research