Effects of ad libitum free-choice access to freshly squeezed domestic white asparagus juice on intestinal microbiota composition and universal biomarkers of immuno-metabolic homeostasis and general health in middle-aged female and male C57BL/6 mice
DISCUSSION: To the best of our knowledge, this is the first study aiming at evaluating the effect of freshly squeezed German domestic white asparagus juice on universal markers of metabolic- and liver function in middle-aged mice and the role of gut microbiota in this regard. The effectiveness of asparagus juice to improve metabolism in middle-aged mice was associated with alterations in intestinal microbiota but maybe also due to uptake of higher amounts of SCFAs. Hence, the key signal pathways corresponding to improved immune-metabolic homeostasis will be an important research scheme in the future.PMID:34463231 | DOI:10....
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 31, 2021 Category: Drugs & Pharmacology Authors: Darab Ghadimi Sven Olaf Frahm Christoph R öcken Michael Ebsen Andreas Schwiertz Regina F ölster-Holst Wilhelm Bockelmann Knut J Heller Source Type: research
Alteration in biochemical constituents and nutrients partitioning of Asparagus racemosus in response to elevated atmospheric CO < sub > 2 < /sub > concentration
This study will be helpful in anticipating the effect of rising atmospheric CO2 concentration on medicinal and threatened plants and require further intensive studies to comprehend the effects of elevated CO2 concentration.PMID:34458971 | DOI:10.1007/s11356-021-16050-3 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - August 30, 2021 Category: Environmental Health Authors: Rupali Sharma Hukum Singh Source Type: research
High-performance thin-layer chromatography based approach for bioassay and ATR-FTIR spectroscopy for the evaluation of antioxidant compounds from Asparagus racemosus Willd. aerial parts
In this study, arial parts of A. racemosus were investigated for total phenolic content, total flavonoid content, antioxidative potential. A high-performance thin-layer chromatography (HPTLC) method combined with effect-directed-analysis (EDA) was also developed to screen the antioxidant effects of A. racemosus and quantify biological active compounds on chromatogram from A. racemosus. Total phenolic (154 mg GAE/gm), flavonoids content (497 mg QR/gm) and IC50 (15.25 μg/ml) were found high in methanolic extract of A. racemosus than n-hexane, chloroform and ethyl acetate extract. HPTLC hyphenated with chemical derivatizatio...
Source: Biomedical Chromatography : BMC - August 18, 2021 Category: Biomedical Science Authors: Gouhar Jahan Ashraf Priya Das Tarun Kumar Dua Paramita Paul Dua Gouranga Nandi Ranabir Sahu Source Type: research
High-performance thin-layer chromatography based approach for bioassay and ATR-FTIR spectroscopy for the evaluation of antioxidant compounds from Asparagus racemosus Willd. aerial parts
In this study, arial parts of A. racemosus were investigated for total phenolic content, total flavonoid content, antioxidative potential. A high-performance thin-layer chromatography (HPTLC) method combined with effect-directed-analysis (EDA) was also developed to screen the antioxidant effects of A. racemosus and quantify biological active compounds on chromatogram from A. racemosus. Total phenolic (154 mg GAE/gm), flavonoids content (497 mg QR/gm) and IC50 (15.25 μg/ml) were found high in methanolic extract of A. racemosus than n-hexane, chloroform and ethyl acetate extract. HPTLC hyphenated with chemical derivatizatio...
Source: Biomedical Chromatography : BMC - August 18, 2021 Category: Biomedical Science Authors: Gouhar Jahan Ashraf Priya Das Tarun Kumar Dua Paramita Paul Dua Gouranga Nandi Ranabir Sahu Source Type: research
Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis
Bioorg Chem. 2021 Aug 4;115:105237. doi: 10.1016/j.bioorg.2021.105237. Online ahead of print.ABSTRACTIn the ongoing research on potent antitumor agents from the rhizomes of Asparagus cochinchinensis, seven undescribed steroidal saponins asparagusoside A-G (1-7), along with twenty known ones (8-27), were isolated and elucidated via analyzing their 1D, 2D NMR, mass spectroscopic data and chemical methods. All isolated compounds were evaluated for their cytotoxic effects against human large cell lung carcinoma cells (NCI-H460) in vitro. Among them, compounds 7, 9 and 27 showed more significant antitumor activities than the po...
Source: Bioorganic Chemistry - August 13, 2021 Category: Chemistry Authors: Bo Liu Bingxin Li Di Zhou Xiaoyan Wen Yajun Wang Gang Chen Ning Li Source Type: research
HIF-1 < em > α < /em > RNAi Combined with Asparagus Polysaccharide Exerts an Antiangiogenesis Effect on Hepatocellular Carcinoma In Vitro and In Vivo
CONCLUSION: Our study indicates that HIF-1α RNAi combined with ASP inhibits angiogenesis in HCC via the PI3K and MAPK signaling pathways. Thus, we suggest that this combination may be an effective method for the comprehensive treatment of HCC, which may provide new ideas for the treatment of other malignant tumors.PMID:34335854 | PMC:PMC8324350 | DOI:10.1155/2021/9987383 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 2, 2021 Category: Complementary Medicine Authors: Tingting Zhu Ziwei Cheng Xiaolin Peng Dongwei Xing Minguang Zhang Source Type: research
[ASAP] Tandem Mass Spectrum Similarity-Based Network Analysis Using < sup > 13 < /sup > C-Labeled and Non-labeled Metabolome Data to Identify the Biosynthetic Pathway of the Blood Pressure-Lowering Asparagus Metabolite Asparaptine A
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.1c01183 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - July 16, 2021 Category: Food Science Authors: Ryo Nakabayashi, Yutaka Yamada, Tomoko Nishizawa, Tetsuya Mori, Takashi Asano, Masanari Kuwabara, and Kazuki Saito Source Type: research
Ethnopharmacological Survey on Medicinal Plants Used for Cosmetic Treatments in Traditional and Ayurveda Systems of Medicine in Sri Lanka
In conclusion, acquired information could ultimately be utilized for the development of the herbal cosmetic industry through the isolation and characterization of bioactive compounds from the documented plants while preserving the traditional knowledge.PMID:34257686 | PMC:PMC8257331 | DOI:10.1155/2021/5599654 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Dehel Gamage Nadeeshani Dilhara Gamage Rathnayaka Mudiyanselage Dharmadasa Don Chandana Abeysinghe Rathnayaka Gamlathge Saman Wijesekara Gamika A Prathapasinghe Takao Someya Source Type: research
Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer
Ovarian cancer is one of the leading causes of female cancer death. Emerging evidence suggests that many dietary natural products have anti-tumorigenic activity, including that of asparagus officinalis. The current study aimed to assess the anti-tumorigenic and anti-metastatic effects of asparagus officinalis on serous ovarian cancer cell lines and a transgenic mouse model of high grade serous ovarian cancer. Asparagus officinalis decreased cellular viability, caused cell cycle G1 phase arrest and induced apoptosis in the OVCAR5 and SKOV3 cells. Induction of apoptosis and inhibition of cell proliferation was rescued by the...
Source: Frontiers in Oncology - July 14, 2021 Category: Cancer & Oncology Source Type: research
