Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of asparagus against polycystic ovary syndrome
CONCLUSION: The therapeutic effect of ASP on PCOS is mainly achieved by targeting PRKCA through the 7 active components of ASP. Mechanistically, ASP alleviated the course of PCOS through antioxidant, anti-inflammatory effects, and PRKCA was its potential target.PMID:37393270 | PMC:PMC10315040 | DOI:10.1186/s13048-023-01210-5 (Source: Cell Research)
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Jinshan Xing Xin Luo Keran Jia Shuang Liu Shaokun Chen Gan Qiao Chunxiang Zhang Jingyan Yi Source Type: research
Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of asparagus against polycystic ovary syndrome
CONCLUSION: The therapeutic effect of ASP on PCOS is mainly achieved by targeting PRKCA through the 7 active components of ASP. Mechanistically, ASP alleviated the course of PCOS through antioxidant, anti-inflammatory effects, and PRKCA was its potential target.PMID:37393270 | DOI:10.1186/s13048-023-01210-5 (Source: Cell Research)
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Jinshan Xing Xin Luo Keran Jia Shuang Liu Shaokun Chen Gan Qiao Chunxiang Zhang Jingyan Yi Source Type: research
Incredible Combination of Lifestyle Modification and Herbal Remedies for Polycystic Ovarian Syndrome Management
In conclusion, combining lifestyle modifications with herbal remedies can be used in the management of PCOS as a holistic approach. Therefore, this review opens a new window for researchers all across the world to validate such findings.PMID:37383339 | PMC:PMC10299884 | DOI:10.1155/2023/3705508 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 29, 2023 Category: Complementary Medicine Authors: Acharya Balkrishna Maneesha Rana Shalini Mishra Deepika Srivastava Rohit Bhardwaj Shalini Singh Satyendra Kumar Rajput Vedpriya Arya Source Type: research
Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS
Chem Biodivers. 2023 Apr 25:e202201231. doi: 10.1002/cbdv.202201231. Online ahead of print.ABSTRACTIn the study, water, ethanol, methanol, dichloromethane, and acetone extracts of Asparagus officinalis L. were obtained by maceration. DPPH⋅, ABTS⋅+ , FRAP, and CUPRAC methods determined the antioxidant capacities of all extracts. Moreover, the in vitro effects of extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA)-I, CA-II and α-Glycosidase were investigated. At a 10 μg/ml concentration, the extract with the highest Fe3+ reduction capacity was ethanol (AE), and the extract wit...
Source: Chemistry and Biodiversity - April 25, 2023 Category: Biochemistry Authors: Veysel Çomaklı R üya Sağlamtaş M üslüm Kuzu Yal çın Karagöz Tuba Ayd ın Ramazan Demirda ğ Source Type: research
Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS
Chem Biodivers. 2023 Apr 25:e202201231. doi: 10.1002/cbdv.202201231. Online ahead of print.ABSTRACTIn the study, water, ethanol, methanol, dichloromethane, and acetone extracts of Asparagus officinalis L. were obtained by maceration. DPPH⋅, ABTS⋅+ , FRAP, and CUPRAC methods determined the antioxidant capacities of all extracts. Moreover, the in vitro effects of extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA)-I, CA-II and α-Glycosidase were investigated. At a 10 μg/ml concentration, the extract with the highest Fe3+ reduction capacity was ethanol (AE), and the extract wit...
Source: Chemistry and Biodiversity - April 25, 2023 Category: Biochemistry Authors: Veysel Çomaklı R üya Sağlamtaş M üslüm Kuzu Yal çın Karagöz Tuba Ayd ın Ramazan Demirda ğ Source Type: research
Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS
Chem Biodivers. 2023 Apr 25:e202201231. doi: 10.1002/cbdv.202201231. Online ahead of print.ABSTRACTIn the study, water, ethanol, methanol, dichloromethane, and acetone extracts of Asparagus officinalis L. were obtained by maceration. DPPH⋅, ABTS⋅+ , FRAP, and CUPRAC methods determined the antioxidant capacities of all extracts. Moreover, the in vitro effects of extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA)-I, CA-II and α-Glycosidase were investigated. At a 10 μg/ml concentration, the extract with the highest Fe3+ reduction capacity was ethanol (AE), and the extract wit...
Source: Chemistry and Biodiversity - April 25, 2023 Category: Biochemistry Authors: Veysel Çomaklı R üya Sağlamtaş M üslüm Kuzu Yal çın Karagöz Tuba Ayd ın Ramazan Demirda ğ Source Type: research
Steroidal saponin profiles and their key genes for synthesis and regulation in Asparagus officinalis L. by joint analysis of metabolomics and transcriptomics
Asparagus officinalis L. is a worldwide cultivated vegetable enrichened in both nutrient and steroidal saponins with multiple pharmacological activities. The upstream biosynthetic pathway of steroidal saponins (U... (Source: BMC Plant Biology)
Source: BMC Plant Biology - April 20, 2023 Category: Biology Authors: Qin Cheng, Liangqin Zeng, Hao Wen, Sylvia E. Brown, He Wu, Xingyu Li, Chun Lin, Zhengjie Liu and Zichao Mao Tags: Research Source Type: research
Molecules, Vol. 28, Pages 3435: Mechanistic Understanding of Tyrosinase Inhibition by Polymeric Proanthocyanidins from Acacia confusa Stem Bark and Their Effect on the Browning Resistance of Fresh-Cut Asparagus Lettuce
In this study, the capacity of Acacia confusa stem bark proanthocyanidins (ASBPs) to inhibit tyrosinase activity was evaluated. ASBPs were shown to be a high-potential inhibitor of tyrosinase with IC50 values of 92.49 ± 4.70 and 61.74 ± 8.93 μg/mL when using L-tyrosine and L-DOPA as the substrate, respectively. The structural elucidation performed with UV-vis, FT-IR spectroscopy, ESI-MS and thiolysis coupled to HPLC-ESI-MS suggested that ASBPs had structural heterogeneity in monomer units and interflavan linkages and consisted mainly of procyanidins dominant with B-type linkages. To...
Source: Molecules - April 13, 2023 Category: Chemistry Authors: Guanghui Li Yaying Zhao Zeya Qin Shudong Wei Dandan Liang Yun Liang Wei Song Baomiao Ding Tags: Article Source Type: research
Chemical Constituents of Asparagus officinalis
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - April 3, 2023 Category: Chemistry Source Type: research
Unravelling the seasonal dynamics of the metabolome of white asparagus spears using untargeted metabolomics
ConclusionThe dynamics of the white asparagus metabolome is influenced by a complex relationship between the onset of spear development, the moment of harvest and the genetic background. The typical perceived asparagus flavour profile is unlikely to be significantly affected by these dynamics. (Source: Metabolomics)
Source: Metabolomics - March 27, 2023 Category: Biology Source Type: research
AoSAP8-P encoding A20 and/or AN1 type zinc finger protein in Asparagus officinalis L. improving stress tolerance in transgenic Nicotiana sylvestris
Gene. 2023 Feb 11:147284. doi: 10.1016/j.gene.2023.147284. Online ahead of print.ABSTRACTThe full length CDS of an A20 and AN1 type zinc finger gene (named AoSAP8-P), located nearby the male specific Y chromosome (MSY) region of Asparagus officinalis (garden asparagus) was amplified by RT-PCR from purple passion. This gene, predicted as the stress associated protein (SAPs) gene families, encodes 172 amino acids with multiple cis elements including light, stress response box, MYB and ERF binding sites on its promoter. To analyze its function, the gene expression of different organs in different asparagus gender were analyze...
Source: Gene - February 13, 2023 Category: Genetics & Stem Cells Authors: Chun Lin Qiuqiu Huang Zhengjie Liu Sylvia E Brown Qing Chen Yuping Li Yumei Dong He Wu Zichao Mao Source Type: research
AoSAP8-P encoding A20 and/or AN1 type zinc finger protein in Asparagus officinalis L. improving stress tolerance in transgenic Nicotiana sylvestris
Gene. 2023 Feb 11:147284. doi: 10.1016/j.gene.2023.147284. Online ahead of print.ABSTRACTThe full length CDS of an A20 and AN1 type zinc finger gene (named AoSAP8-P), located nearby the male specific Y chromosome (MSY) region of Asparagus officinalis (garden asparagus) was amplified by RT-PCR from purple passion. This gene, predicted as the stress associated protein (SAPs) gene families, encodes 172 amino acids with multiple cis elements including light, stress response box, MYB and ERF binding sites on its promoter. To analyze its function, the gene expression of different organs in different asparagus gender were analyze...
Source: Gene - February 13, 2023 Category: Genetics & Stem Cells Authors: Chun Lin Qiuqiu Huang Zhengjie Liu Sylvia E Brown Qing Chen Yuping Li Yumei Dong He Wu Zichao Mao Source Type: research
AoSAP8-P encoding A20 and/or AN1 type zinc finger protein in Asparagus officinalis L. improving stress tolerance in transgenic Nicotiana sylvestris
Gene. 2023 Feb 11:147284. doi: 10.1016/j.gene.2023.147284. Online ahead of print.ABSTRACTThe full length CDS of an A20 and AN1 type zinc finger gene (named AoSAP8-P), located nearby the male specific Y chromosome (MSY) region of Asparagus officinalis (garden asparagus) was amplified by RT-PCR from purple passion. This gene, predicted as the stress associated protein (SAPs) gene families, encodes 172 amino acids with multiple cis elements including light, stress response box, MYB and ERF binding sites on its promoter. To analyze its function, the gene expression of different organs in different asparagus gender were analyze...
Source: Gene - February 13, 2023 Category: Genetics & Stem Cells Authors: Chun Lin Qiuqiu Huang Zhengjie Liu Sylvia E Brown Qing Chen Yuping Li Yumei Dong He Wu Zichao Mao Source Type: research
AoSAP8-P encoding A20 and/or AN1 type zinc finger protein in Asparagus officinalis L. improving stress tolerance in transgenic Nicotiana sylvestris
Gene. 2023 Feb 11:147284. doi: 10.1016/j.gene.2023.147284. Online ahead of print.ABSTRACTThe full length CDS of an A20 and AN1 type zinc finger gene (named AoSAP8-P), located nearby the male specific Y chromosome (MSY) region of Asparagus officinalis (garden asparagus) was amplified by RT-PCR from purple passion. This gene, predicted as the stress associated protein (SAPs) gene families, encodes 172 amino acids with multiple cis elements including light, stress response box, MYB and ERF binding sites on its promoter. To analyze its function, the gene expression of different organs in different asparagus gender were analyze...
Source: Gene - February 13, 2023 Category: Genetics & Stem Cells Authors: Chun Lin Qiuqiu Huang Zhengjie Liu Sylvia E Brown Qing Chen Yuping Li Yumei Dong He Wu Zichao Mao Source Type: research
