Bioavailability and swallowability of an age-appropriate, delayed-release mesalamine formulation in healthy volunteers
(Source: International Journal of COPD)
Source: International Journal of COPD - July 12, 2019 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Designing a novel perovskite-type strontium stannate (SrSnO3) and its potential as an electrode material for enhanced sensing of anti-inflammatory drug mesalamine in the biological samples
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ02197C, PaperBalamurugan Muthukutty, Raj Karthik, Shen Ming Chen, Abinaya Manickavasagan The enhanced electrocatalytic activity of electrode developed with a perovskite-type inorganic material is witnessed much because of their unique properties. In this view, we synthesized a new perovskite-type sphere like... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - June 26, 2019 Category: Chemistry Authors: Balamurugan Muthukutty Source Type: research
Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis
Conclusions: We found that 4 weeks of IN suppository can be tolerated by UC patients, but its efficacy was limited by the severity of the disease. Further investigation will be needed in order to confirm the optimum dose of IN suppository for patients with UC.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research
Oral 5-aminosalicylic acid for maintenance of surgically-induced remission in Crohn's disease.
CONCLUSIONS: 5-ASA preparations are superior to placebo for the maintenance of surgically-induced clinical remission in patients with CD (moderate certainty). The number needed to treat to prevent one relapse was 13 patients. The evidence for endoscopic remission is uncertain. The sulphasalazine class of 5-ASA agents failed to demonstrate superiority against placebo, 5-ASAs failed to demonstrate superiority compared to no treatment (very low and low certainty). The efficacy of two different doses of the same 5-ASA and the efficacy of 5-ASA compared to purine antimetabolites (azathioprine or 6-mercaptopurine) in maintaining...
Source: Cochrane Database of Systematic Reviews - June 19, 2019 Category: General Medicine Authors: Gjuladin-Hellon T, Gordon M, Iheozor-Ejiofor Z, Akobeng AK Tags: Cochrane Database Syst Rev Source Type: research
Comparative Efficacy of Anti-TNF Therapies For The Prevention of Postoperative Recurrence of Crohn’s Disease: A Systematic Review and Network Meta-Analysis of Prospective Trials
Conclusions:
On the basis of a NMA combining direct and indirect evidence either adalimumab or infliximab may be used in the postoperative prophylaxis of CD recurrence. There is currently a lack of evidence on the use of other anti-TNF agents in this setting. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 8, 2019 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research
Crohn ’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress
Conclusion: Plasma free thiols are reduced in patients with CD in clinical remission compared to healthy controls. Thus, subclinical CD disease activity is reflected by systemic oxidative stress and plasma free thiols may be a relevant therapeutic target and biomarker to monitor disease activity in CD.
Introduction
Crohn’s disease (CD) is an inflammatory bowel disease (IBD) characterized by chronic transmural intestinal inflammation that can affect any part of the gastro-intestinal tract (Sartor, 2008). Most patients follow a disease course of alternating exacerbations and remissions, which are difficult to ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research
P.07.24 azathioprine vs mesalamine for prevention of post-operative clinical relapse in crohn's disease patients with severe endoscopic recurrence: data on efficacy and safety from an ig-ibd multicenter randomized double-blind double-dummy trial
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 24, 2019 Category: Gastroenterology Authors: A. Orlando, F. Mocciaro, M. Ventimiglia, S. Renna, D. Scimeca, A. Rispo, M.L. Scribano, A. Testa, A. Aratari, F. Bossa, E. Angelucci, S. Onali, M. Cappello, M. Giunta, F. Castiglione, C. Papi, V. Annese, L. Biancone, A. Kohn, R. Di Mitri, M. Cottone Tags: Posters Source Type: research
Crohn ’s disease in a developing African mission hospital: a case report
ConclusionsCrohn ’s disease is uncommon in Africa, and this entity is encountered sparingly. The signs and symptoms of Crohn’s disease overlap with many other abdominal disorders, such as tuberculosis, ulcerative colitis, irritable bowel syndrome, and others. Several publications in the literature describe that it is difficult to make an accurate diagnosis of this disease, despite the fact that many diagnostic armamentaria are available to suggest its presence. Most of the patients with Crohn’s disease are treated conservatively, and a few may require surgical intervention, especially those presenting wi th complicat...
Source: Journal of Medical Case Reports - March 6, 2019 Category: General Medicine Source Type: research
High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?
CONCLUSIONS: High-DBP exposure from mesalamine increased the urinary concentrations of QA, which was largely reversed after removal of the high-DBP exposure for four months. This novel hypothesis should warrant new promising research considering the KP and QA concentrations as a plausible mediator for the neurotoxicity possibly linked with phthalate exposures.
PMID: 30826665 [PubMed - as supplied by publisher] (Source: Environmental Research)
Source: Environmental Research - February 21, 2019 Category: Environmental Health Authors: Nassan FL, Gunn JA, Hill MM, Coull BA, Hauser R Tags: Environ Res Source Type: research
Xylan from Pineapple Stem Waste: a Potential Biopolymer for Colonic Targeting of Anti-inflammatory Agent Mesalamine.
Abstract
We have successfully conjugated mesalamine (5-aminosalicylic acid, 5-ASA) with xylan, a biopolymer isolated from pineapple stem waste, to form xylan-5-ASA conjugate. The biopolymer was used to provide colon-targeting properties for 5-ASA, a golden standard anti-inflammatory agent commonly used for ulcerative colitis treatment. A series of data from FTIR spectroscopy, UV-Vis spectrophotometry, and HPLC confirmed the xylan-5-ASA conjugate formation. To ensure successful colon targeting properties, in vitro and in vivo drug release studies after oral administration of xylan-5-ASA conjugate to Wistar ...
Source: AAPS PharmSciTech - February 13, 2019 Category: Drugs & Pharmacology Authors: Anindya AL, Oktaviani RD, Praevina BR, Damayanti S, Kurniati NF, Riani C, Rachmawati H Tags: AAPS PharmSciTech Source Type: research
P128 inhibition of intestinal epithelial cell pyroptosis and associated mucosal barrier defects is a potential therapeutic mechanism of action for mesalamine in ibd
Mucosal barrier dysfunction to luminal microbes plays a crucial role in the development of intestinal inflammation in inflammatory bowel disease (IBD). Recently, intestinal epithelial cell (IEC) death resulting from a form of innate immune activation called pyroptosis was proposed as a possible cause of this barrier defect. We hypothesize that inhibition of IEC pyroptosis and prevention of associated barrier defects is a potential mechanism of action for mesalamine. The aim of this study was to determine the effect of mesalamine on recombinant caspase-1 enzyme activity, in vitrocell and spheroid IEC culture model undergoin...
Source: Gastroenterology - February 1, 2019 Category: Gastroenterology Authors: Elisabeth M. Davis, Di Zhang, Sarah C. Glover, Thaddeus Stappenbeck, Shanzhi Wang, Julia J. Liu Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis.
Abstract
Modified Apple Polysaccharide (MAP) has been reported to cure colorectal diseases by up-regulating apoptosis and down regulating metastasis. In the present study, mesalamine (MES) and MAP mini tablets have been prepared and co-administered with probiotics to provide site specific release of drug. Probiotics along with MAP, which acts as a prebiotic would replenish the colonic microflora that have been compromised due to colorectal pathology. MES mini tablets were prepared keeping guar gum in the core and coating them with Eudragit S100 and guar gum. The optimized batch was explored for its curativ...
Source: International Journal of Biological Macromolecules - December 17, 2018 Category: Biochemistry Authors: Mohanta S, Singh SK, Kumar B, Gulati M, Kumar R, Yadav AK, Wadhwa S, Jyoti J, Som S, Dua K, Pandey NK Tags: Int J Biol Macromol Source Type: research
Guideline recommendations for treatment of patients with inflammatory bowel diseases are not implemented in clinical practice —results of a non-representative survey
ConclusionsA large proportion of patients with IBD do not receive drug treatment in accordance with clinical practice guidelines. Quality improvement measures are much needed. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - December 7, 2018 Category: Gastroenterology Source Type: research
Neutropenia in glycogen storage disease Ib: outcomes for patients treated with granulocyte colony-stimulating factor
Purpose of review
Glycogen storage disease Ib (GSD Ib) is characterized by hepatomegaly, hypoglycemia, neutropenia, enterocolitis and recurrent bacterial infections. It is attributable to mutations in G6PT1, the gene for the glucose-6-phosphate transporter responsible for transport of glucose into the endoplasmic reticulum. Neutropenia in GSD Ib is now frequently treated with granulocyte colony-stimulating factor (G-CSF). We formed a cooperative group to review outcomes of the long-term treatment of GSD Ib patients treated with G-CSF.
Recent findings
The study enrolled 103 patients (48 men and 55 women), including 47 ...
Source: Current Opinion in Hematology - November 28, 2018 Category: Hematology Tags: MYELOID BIOLOGY: Edited by David C. Dale Source Type: research
Determination of Mesalamine levels in Human Milk as a Function of Dose
Breastfeeding Medicine, Ahead of Print. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - November 15, 2018 Category: Perinatology & Neonatology Authors: Palika Datta Kathleen Rewers-Felkins Raja Reddy Kallem Teresa Baker Thomas W. Hale Source Type: research
