High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?

CONCLUSIONS: High-DBP exposure from mesalamine increased the urinary concentrations of QA, which was largely reversed after removal of the high-DBP exposure for four months. This novel hypothesis should warrant new promising research considering the KP and QA concentrations as a plausible mediator for the neurotoxicity possibly linked with phthalate exposures. PMID: 30826665 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30826665?dopt=Abstract

Source: Environmental Research - February 21, 2019 Category: Environmental Health Authors: Nassan FL, Gunn JA, Hill MM, Coull BA, Hauser R Tags: Environ Res Source Type: research