Week 2 Symptomatic Response with Vedolizumab as a Predictive Factor in Japanese Anti-TNF α-Naive Patients with Ulcerative Colitis: A post hoc Analysis of a Randomized, Placebo-Controlled Phase 3 Trial
Conclusions: Our results indicate that vedolizumab induces a rapid symptomatic response, particularly in anti-TNF α-naive patients, and suggest that early symptomatic improvement predicts treatment response at Week 10 (NCT02039505).Digestion (Source: Digestion)
Source: Digestion - January 15, 2021 Category: Gastroenterology Source Type: research

S100P Expression via DNA Hypomethylation Promotes Cell Growth in the Sessile Serrated Adenoma/Polyp-Cancer Sequence
Conclusion: These results suggest that DNA hypomethylation, including S100P hypomethylation, is supposedly associated with the SSA/P-cancer sequence. S100P overexpression via DNA hypomethylation plays an important role in promoting cell growth in the SSA/P-cancer sequence.Digestion (Source: Digestion)
Source: Digestion - January 4, 2021 Category: Gastroenterology Source Type: research

Double-Balloon Enteroscopy in Detecting Small-Bowel Neuroendocrine Neoplasms: A Single-Center Prospective Study
Conclusions: In line with data from the literature, the present series showed that DBE is a safe and effective procedure in the diagnosis of sbNENs. Further studies are needed to better clarify the diagnostic role of DBE in the neuroendocrine tumor setting and its relationship with other techniques.Digestion (Source: Digestion)
Source: Digestion - December 23, 2020 Category: Gastroenterology Source Type: research

Endoscopic Submucosal Dissection Using EndoTrac, a Novel Traction Device
Conclusions: Use of the EndoTrac device appears to be a feasible approach to ESD for GI neoplasms.Digestion (Source: Digestion)
Source: Digestion - December 22, 2020 Category: Gastroenterology Source Type: research

Questionnaire-Based Survey on Epidemiology of Functional Gastrointestinal Disorders and Current Status of Gastrointestinal Motility Testing in Asian Countries
Conclusions: This survey revealed epidemiology of FGIDs and current status of gastrointestinal motility testing in some East and Southeast Asian countries.Digestion (Source: Digestion)
Source: Digestion - December 16, 2020 Category: Gastroenterology Source Type: research

Clinicopathological and Endoscopic Features of Raspberry-Shaped Gastric Cancer in < b > < i > Helicobacter pylori < /i > < /b > -Uninfected Patients
Background: Gastric adenocarcinoma of foveolar type (GA-FV) is a raspberry-shaped gastric cancer (RSGC) and garners much attention asH. pylori (Hp)-uninfected gastric cancer. However, the classification and clinicopathological and endoscopic features of RSGCs inHp-uninfected patients are poorly defined. We designed a new histopathological classification of RSGC and compared them via endoscopic and clinicopathological characteristics.Summary: From 996 patients with early gastric cancers resected by endoscopy in our hospital, we studied 24 RSGC lesions from 21 (2.4%)Hp-uninfected patients. RSGCs were classified into 3 histol...
Source: Digestion - December 15, 2020 Category: Gastroenterology Source Type: research

Near-Infrared Photoimmunotherapy for Cancers of the Gastrointestinal Tract
Background: Cancers of the gastrointestinal (GI) tract are the common leading cause of cancer-related death in the world. Recent advances in cancer therapies such as intensive multidrug chemotherapy and molecular targeted treatment have improved therapeutic efficacy; however, the outcomes are not satisfied. Moreover, these therapies also cause severe side effects. New type of cancer therapies is urgently needed to improve the outcomes and to reduce side effects of GI tract cancers.Summary: This account is a comprehensive review article on the newly developed, photochemistry-based cancer therapy named as near-infrared photo...
Source: Digestion - December 14, 2020 Category: Gastroenterology Source Type: research

The 16th Annual Meeting of the Japanese Gastroenterological Association
Digestion (Source: Digestion)
Source: Digestion - December 8, 2020 Category: Gastroenterology Source Type: research

IGICS: JGA Keynote Program. The 13th International Gastrointestinal Consensus Symposium (GICS). Gastrointestinal Disease: From Basics to Translational and Clinical Research: Abstracts
Digestion (Source: Digestion)
Source: Digestion - December 4, 2020 Category: Gastroenterology Source Type: research

Mucosa-Associated Microbiota in Patients with Irritable Bowel Syndrome: A Comparison of Subtypes
Conclusion: Dysbiosis pattern and the function of the microbiome seem to be different among subtypes of IBS, and MAM may play a crucial role in IBS symptom generation.Digestion (Source: Digestion)
Source: Digestion - December 3, 2020 Category: Gastroenterology Source Type: research

Recent Advances in Molecular Imaging of Colorectal Tumors
Background: Recent endoscopic studies have revealed that small colorectal tumors are often overlooked during colonoscopy, indicating that more sensitive detection methods are needed.Summary: Molecular imaging has received considerable attention as a new endoscopic technique with high sensitivity. It generally employs a fluorescence-labeled compound that specifically binds to a molecule on the tumor. Fluorescent probes for molecular imaging are largely classified as 2 types: a fluorescence-labeled antibody targeting a molecule specifically expressed on the tumor cell surface such as epidermal growth factor receptor or vascu...
Source: Digestion - December 3, 2020 Category: Gastroenterology Source Type: research

A Novel Noninvasive Method for Quantitative Detection of Colonic Dysmotility Using Real-Time Ultrasonography
Conclusions: These findings suggest that ultrasonography is a useful in vivo method for objectively monitoring changes in colonic motility caused by drugs and diseases.Digestion (Source: Digestion)
Source: Digestion - December 1, 2020 Category: Gastroenterology Source Type: research

Approach to the Seamless Management of Inflammatory Bowel Disease, Considering Special Situations, Shared Decision-Making, and Disease Burden
Background: While the number of inflammatory bowel disease (IBD) patients has been steadily increasing, a lot of effective treatments have become available, including biological drugs. However, there still exists no effective treatment universally for all types of IBD patients. We have continuously discussed “Total Care” for IBD patients in the 3 consecutive annual meetings of the Japanese Gastroenterological Association from the 14th meeting to the 16th meeting in 2018–2020.Summary: In the 14th meeting, we summarized cross-sectional issues under the title “From Total Care to Microbiota” as fo...
Source: Digestion - November 25, 2020 Category: Gastroenterology Source Type: research

Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms
Conclusion: All 3 modalities presented similar diagnostic yield. Inter- and intra-observer agreements of the ES-CRN were substantial, even for non-expert endoscopists. Therefore, EUS-EG may be a useful modality in determining the depth of invasion in colorectal neoplasms.Digestion (Source: Digestion)
Source: Digestion - November 18, 2020 Category: Gastroenterology Source Type: research

Clinical Characteristics and Treatment Outcomes of Patients with Eosinophilic Esophagitis and Eosinophilic Gastroenteritis
Conclusions: We found different clinical characteristics and treatment strategies in the present EoE and EGE cases. Most of the EoE patients responded to and were maintained by acid suppressive therapy, using PPI or vonoprazan. For EGE patients, glucocorticoid administration was mainly used though food-elimination diet therapy also showed beneficial effects.Digestion (Source: Digestion)
Source: Digestion - November 17, 2020 Category: Gastroenterology Source Type: research

Effects of Colchicine on NSAID-Induced Severe Small Intestinal Damage: A Pilot Study
Conclusions: Colchicine treatment achieved a high rate of complete healing in patients with NSAID-induced severe small intestinal damage.Digestion (Source: Digestion)
Source: Digestion - November 17, 2020 Category: Gastroenterology Source Type: research

Contents Vol. 101, 2020
Digestion 2020;101:I –VIII (Source: Digestion)
Source: Digestion - November 12, 2020 Category: Gastroenterology Source Type: research

Acknowledgement to Referees
Digestion 2020;101:807 –808 (Source: Digestion)
Source: Digestion - November 12, 2020 Category: Gastroenterology Source Type: research

The Cutting Edge Research of Functional Gastrointestinal Disorders in Japan: Review on JGA Core Symposium 2018 –2020
Highly impacted articles on functional gastrointestinal (GI) disorders research presented at the core symposium held in the Japanese Gastroenterological Association (JGA) annual meeting 2018 –2020 are selected and summarized. Regarding visceral hypersensitivity and sensor in GI tracts, transient receptor potential vanilloid 4 ion channel and acid-sensitive ion channel were candidates for hypersensitivity in GI tracts. ATP release from vesicular nucleotide transporter may be a key path way to sensitize the nerve endings. Regarding inflammation and mucosal immune responses, patients infected withH. pylori having Ser70 ...
Source: Digestion - October 20, 2020 Category: Gastroenterology Source Type: research

Lipoprotein and Metabolic Profiles Indicate Similar Cardiovascular Risk of Liver Steatosis and NASH
Conclusion: We show in this study that cholesterol profiles, apolipoproteins, and amino acids could function as a potential noninvasive test to screen for NAFLD or even NASH in larger populations. However, few differences in cholesterol profiles were identified between the NAFL and NASH groups, indicating similar cardiovascular risk profiles.Digestion (Source: Digestion)
Source: Digestion - October 20, 2020 Category: Gastroenterology Source Type: research

Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation
Conclusions: We support the screening of all AAG patients with CeD autoantibodies. Findings of isolated IEL or villous atrophy are not exclusively related to CeD.Digestion (Source: Digestion)
Source: Digestion - October 19, 2020 Category: Gastroenterology Source Type: research

DNA Methylation and Genetic Aberrations in Gastric Cancer
Background: Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. GC is a pathologically and molecularly heterogeneous disease. DNA hypermethylation in promoter CpG islands causes silencing of tumor-suppressor genes and thus contributes to gastric carcinogenesis. In addition, various molecular aberrations, including aberrant chromatin structures, gene mutations, structural variants, and somatic copy number alterations, are involved in gastric carcinogenesis.Summary: Comprehensive DNA methylation analyses revealed multiple DNA methylation patterns in GCs and classified GC into distinct molecul...
Source: Digestion - October 16, 2020 Category: Gastroenterology Source Type: research

Immunohistochemical Analysis of Mismatch Repair Gene Proteins in Early Gastric Cancer Based on Microsatellite Status
Conclusion: Although immunostaining of MMR proteins could help predict MSI in EGCs, immunostaining did not have the same value as genetic testing for determination of MSI.Digestion (Source: Digestion)
Source: Digestion - October 14, 2020 Category: Gastroenterology Source Type: research

Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma
Conclusions: Serum exosomal Dicer is a potential noninvasive diagnostic biomarker for early detection of differentiated gastric adenocarcinoma.Digestion (Source: Digestion)
Source: Digestion - October 13, 2020 Category: Gastroenterology Source Type: research

Safety of Endoscopic Mucosal Resection Using a Bipolar Snare for Superficial Nonampullary Duodenal Epithelial Tumors and the Predictive Factors of Piecemeal Resection
Conclusion: Endoscopic resection for small superficial nonampullary duodenal epithelial tumors can cause perforation; however, endoscopic mucosal resection using a bipolar snare can be a safe treatment option as it does not cause perforations. The nonlifting sign after submucosal injection is a predictive factor for piecemeal resection.Digestion (Source: Digestion)
Source: Digestion - October 12, 2020 Category: Gastroenterology Source Type: research

Transitional Care for Patients with Inflammatory Bowel Disease: Japanese Experience
Background: Transition-related healthcare intervention has recently been receiving worldwide attention. Given the increasing incidence of pediatric inflammatory bowel disease (IBD) and its lifelong impact, transitional care has become an important issue. In Japan, guidelines to support the autonomy of IBD patients during transition were recently published.Summary: Here, we review current issues regarding care for IBD patients during transition from the pediatric to adult period in order to identify the barriers and key elements for successful transition in the context of the Japanese system. Although no single optimal mode...
Source: Digestion - October 8, 2020 Category: Gastroenterology Source Type: research

Chest Pain after Endoscopic Submucosal Dissection for Esophageal Cancer: The Simple and Clinically Useful Surrogate Marker for Transmural Thermal Injury by Electrocoagulation
Conclusions: The incidence of chest pain after ESD was only associated with postoperative elevation of WBC day 1. In considering the elevation of WBC count associated with procedure-related factors, chest pain possibly reflected transmural thermal injury by electrocoagulation during ESD. Post-esophageal ESD chest pain is a simple and clinically useful surrogate marker for transmural thermal injury and is a vital sign of post-esophageal ESD CS.Digestion (Source: Digestion)
Source: Digestion - October 8, 2020 Category: Gastroenterology Source Type: research

Efficacy and Safety of Fingerroot ( < b > < i > Boesenbergia rotunda < /i > < /b > ) Extract in Patients with Functional Dyspepsia: A Randomized, Placebo-Controlled Trial
Conclusions: BR extract represents an effective and safe alternative to manage dyspepsia symptoms in FD patients.Digestion (Source: Digestion)
Source: Digestion - September 30, 2020 Category: Gastroenterology Source Type: research

Subject Index Vol. 101, No. S1, 2020
Digestion 2020;101(suppl 1):147 (Source: Digestion)
Source: Digestion - September 29, 2020 Category: Gastroenterology Source Type: research

Author Index Vol. 101, No. S1, 2020
Digestion 2020;101(suppl 1):146 (Source: Digestion)
Source: Digestion - September 29, 2020 Category: Gastroenterology Source Type: research

Title Page / Table of Contents
Digestion 2020;101(suppl 1):I –IV (Source: Digestion)
Source: Digestion - September 29, 2020 Category: Gastroenterology Source Type: research

Effectiveness of Chemoradiotherapy for Metachronous Esophageal Squamous Cell Carcinoma
Conclusion: CRT may be effective in preventing metachronous ESCC.Digestion (Source: Digestion)
Source: Digestion - September 29, 2020 Category: Gastroenterology Source Type: research

Mechanism of Chinese Medicinal-Medicated Leaven for Preventing and Treating Gastrointestinal Tract Diseases
In recent times, there has been an increased attention on gastrointestinal tract (GIT) diseases, with GIT diseases becoming one of the greatest crises to human health. In China, traditional Chinese medicine, Medicated leaven (ML), has been applied to treat gastrointestinal diseases for thousands of years. However, its mechanism remains unclear till date. Here we review both the antibacterial and antiviral effects of ML, the mechanisms for improving human immunity, antioxidant and anti-inflammatory activities, the role of digestive function, and the role of its secondary metabolite. ML may be a new hope for GIT diseases.Dig...
Source: Digestion - September 25, 2020 Category: Gastroenterology Source Type: research

Predictive Factors for Short-Term Survival after Non-Curative Endoscopic Submucosal Dissection for Early Gastric Cancer
Conclusions: Severe comorbidity indicated by a high CCI score ( ≥3) was the independent predictor for short-term survival for EGC patients without additional gastrectomy after non-curative ESD. Since the cause of death for most patients was not gastric cancer, observational follow-ups without additional gastrectomy might be a reasonable option for patients wit h a poor general status indicated by a CCI ≥3.Digestion (Source: Digestion)
Source: Digestion - September 15, 2020 Category: Gastroenterology Source Type: research

Gut Microbiota Dysbiosis Drives the Development of Colorectal Cancer
Background: The gut microbiota is a diverse community of microbes that maintain the stability of the intestinal environment. Dysbiosis of the gut microbiota has been linked to gastrointestinal diseases, such as colorectal cancer (CRC) – a leading cause of death for cancer patients.Summary: Candidate pathogens have been identified using bacterial culture and high-throughput sequencing techniques. Currently, there is evidence to show that specific intestinal microbes drive CRC development and progression, yet their pathogenic mechanisms are still unclear.Key Messages: In this review, we describe the known healthy gut m...
Source: Digestion - September 15, 2020 Category: Gastroenterology Source Type: research

Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus
Conclusions: Among patients with dysphagia, the frequency of minor esophageal motility disorders was higher in DM patients than in non-DM patients. Abnormal esophageal motility related to poor esophageal clearance was associated with higher prevalence of diabetic complications.Digestion (Source: Digestion)
Source: Digestion - September 9, 2020 Category: Gastroenterology Source Type: research

Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection
Conclusions: CCI and PNI can be prognostic predictors of patients with superficial ESCC indicated for ESD. Observation without ESD might be an acceptable strategy among patients with CCI ≥ 6.Digestion (Source: Digestion)
Source: Digestion - September 7, 2020 Category: Gastroenterology Source Type: research

Expert Opinions on the Current Therapeutic Management of Inflammatory Bowel Disease during the COVID-19 Pandemic: Japan IBD COVID-19 Taskforce, Intractable Diseases, the Health and Labor Sciences Research
Background: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a dramatic challenge for all healthcare systems worldwide. This outbreak immediately affected gastroenterologists as well as global physicians worldwide because COVID-19 can be associated with not only triggering respiratory inflammation but also gastrointestinal (GI) inflammation based on the mechanism by which SARS-CoV-2 enters cells via its receptor the angiotensin-converting enzyme 2, which is expressed on GI cells. However, the comorbidity spectrum of digestive system in patients with COVID-19 rema...
Source: Digestion - September 4, 2020 Category: Gastroenterology Source Type: research

Factors Associated with Fibrosis during Colorectal Endoscopic Submucosal Dissection: Does Pretreatment Biopsy Potentially Elicit Submucosal Fibrosis and Affect Endoscopic Submucosal Dissection Outcomes?
Conclusions: Pretreatment biopsy causes submucosal fibrosis resulting in prolonged procedure times and incomplete resection. These findings suggest important benefits of avoiding biopsy before ESD.Digestion (Source: Digestion)
Source: Digestion - August 31, 2020 Category: Gastroenterology Source Type: research

Efficacy of Magnifying Narrow Band Imaging with Acetic Acid Spray in Diagnosing Superficial Non-Ampullary Duodenal Epithelial Tumors
Conclusion: MA-NBI may be useful in differentiating between category 3 and category 4/5 lesions of SNADETs.Digestion (Source: Digestion)
Source: Digestion - August 26, 2020 Category: Gastroenterology Source Type: research

Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease
Conclusions: Repeated use of lusutrombopag might be safe and effective against thrombocytopenia in patients with CLD undergoing multi-cycle invasive procedures, although long-term data from more patients are required.Digestion (Source: Digestion)
Source: Digestion - August 25, 2020 Category: Gastroenterology Source Type: research

Publisher's Note
Digestion (Source: Digestion)
Source: Digestion - August 24, 2020 Category: Gastroenterology Source Type: research

Malignancies in Inflammatory Bowel Disease
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily of, but not restricted to, the gut. Association between IBD and cancer has been clearly established and is uniformly accepted.Summary: IBD patients are at particular risk for intestinal and extraintestinal cancers. There are 2 underlying mechanisms: (1) IBD-related inflammation triggers initiation and progression of tumor formation. This particularly results in the development of colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, anal cancer, and cholangiocarcinoma. (2) Immunosuppressive drugs exhibit carcinogenic pr...
Source: Digestion - August 14, 2020 Category: Gastroenterology Source Type: research

Clinical Characteristics of Intramucosal Gastric Cancers with Lymphovascular Invasion Resected by Endoscopic Submucosal Dissection
Conclusion: Careful follow-up may be appropriate for MGCs with LVI due to the low risk of LNM. Additionally, the pap component is a significant factor in MGCs with LVI.Digestion (Source: Digestion)
Source: Digestion - August 13, 2020 Category: Gastroenterology Source Type: research

Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease
Conclusions: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.Digestion (Source: Digestion)
Source: Digestion - August 12, 2020 Category: Gastroenterology Source Type: research

Special Issue of Digestion: Inflammatory Bowel Disease
Digestion (Source: Digestion)
Source: Digestion - August 5, 2020 Category: Gastroenterology Source Type: research

Role of Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Subscore (MES) in Predicting Patients ′ Response to Biological Therapy and the Need for Colectomy
Conclusion: UCEIS may be superior to MES because of its accuracy and predictive role. Therefore, UCEIS should be considered for use in daily clinical practice.Digestion (Source: Digestion)
Source: Digestion - July 31, 2020 Category: Gastroenterology Source Type: research

TNF-Alpha Blockers in Inflammatory Bowel Diseases: Practical Recommendations and a User ’s Guide: An Update
Background: Anti-tumour necrosis factor-alpha (anti-TNF) antagonists have been the mainstay in the treatment of inflammatory bowel diseases (IBDs) for over 20 years.Summary: This review article aimed to provide an update on recent advances in TNF antagonist therapy for IBDs.Key Messages: Their position in the treatment algorithm has evolved to “rapid step-up therapy” or “top-down therapy” according to disease severity and patients’ characteristics. Limitations of anti-TNF antagonists include loss of response in up to 30–50% of patients with or without the development of antibodies. Thera...
Source: Digestion - July 31, 2020 Category: Gastroenterology Source Type: research

Contribution of Serotonin 3A Receptor to Motor Function and Its Expression in the Gastrointestinal Tract
Conclusions: These results show that 5-HT3AR is highly expressed in the stomach and large intestine and that the activation of 5-HT3AR accelerates gastric emptying and large intestine transit. Additionally, 5-HT3AR is highly expressed in cholinergic neurons and some interstitial cells, such as PDGFR α+ cells.Digestion (Source: Digestion)
Source: Digestion - July 29, 2020 Category: Gastroenterology Source Type: research

Role of a Rare Variant in < b > < i > APC < /i > < /b > Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis
Conclusions: The variant (c.-190G#x3e;A) in theAPC promoter 1B region is able to cause FAP with a classic phenotype, but this kind of variant in the noncoding region could be missed by conventional genetic testing. Thus, utilizing sequencing technologies covering a larger area can help us to further explore the pathogenesis in variant-negative FAP cases.Digestion (Source: Digestion)
Source: Digestion - July 23, 2020 Category: Gastroenterology Source Type: research