Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men
Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.Digestion (Source: Digestion)
Source: Digestion - July 3, 2019 Category: Gastroenterology Source Type: research

Endoscopic Evaluation of Neoadjuvant Chemotherapeutic Efficacy in Gastric Cancer before Gastrectomy Might be as Useful as Histological Assessment after Gastrectomy
Conclusions: Most endoscopic responders showed JCGC histological responses. Evaluation of neoadjuvant chemotherapeutic efficacy by endoscopy in gastric cancer may be useful before gastrectomy. As this was a retrospective study, further investigations are required. The protocol was approved by the ethics review committee at Osaka Medical College (No. 2422) and was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000033088).Digestion (Source: Digestion)
Source: Digestion - June 28, 2019 Category: Gastroenterology Source Type: research

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis
Conclusions: We found that 4 weeks of IN suppository can be tolerated by UC patients, but its efficacy was limited by the severity of the disease. Further investigation will be needed in order to confirm the optimum dose of IN suppository for patients with UC.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research

Risk Factors and Nomogram for Pancreatic Stone Formation in Chronic Pancreatitis over a Long-Term Course: A Cohort of 2,153 Patients
Conclusions: The nomogram achieved an individualized prediction of pancreatic stones development in CP. It may help the management of pancreatic stones.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research

Testing of < b > < i > Helicobacter pylori < /i > < /b > by Endoscopic Biopsy: The Clinical Dilemma of Suppressive Conditions
Conclusion: Guidelines recommendH. pylori testing under non-suppressive conditions. However, this does not always meet the clinical practice. Our data show that de facto, many patients undergoing elective EGD are tested forH. pylori under suppressive conditions coming along with a higher risk of potentially false negative results. Particularly, concerning this issue, further research is needed to improve and clarify everyday clinical practice.Digestion (Source: Digestion)
Source: Digestion - June 19, 2019 Category: Gastroenterology Source Type: research

Current Status of < b > < i > Helicobacter pylori < /i > < /b > Diagnosis and Eradication Therapy in Japan Using a Nationwide Database
Conclusions: Diagnostic tests ofH.  pylori infection mostly followed Japanese Society forHelicobacter Research guidance, although some antibody measurements were timed inappropriately. Vonoprazan appears to increase the success rate of primary therapy.Digestion (Source: Digestion)
Source: Digestion - June 19, 2019 Category: Gastroenterology Source Type: research

Validation of Asia-Pacific Colorectal Screening Score for Asymptomatic Participants and Outpatients in Northwest District of China
Conclusion: APCS score is an effective method for ACRN screening in asymptomatic and also the outpatient subjects. Individuals with HR scores should be given priority for colonoscopy.Digestion (Source: Digestion)
Source: Digestion - June 14, 2019 Category: Gastroenterology Source Type: research

The Traditional Medicine Banhasasim-Tang Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through M3 Muscarinic and 5-HT3 Receptors in Murine Small Intestine
Conclusion: These results suggested that BHSST depolarizes the pacemaker potentials of ICCs in a dose-dependent manner through the M3 and 5-HT3 receptors via internal and external Ca2+-dependent and TRPM7- and ANO1-independent pathways in vitro. Moreover, BHSST increased ITR% in vivo in normal mice and GMD mouse models. Taken together, the results of this study showed that BHSST had the potential for development as a prokinetic agent in GI motility function.Digestion (Source: Digestion)
Source: Digestion - June 11, 2019 Category: Gastroenterology Source Type: research

Physicians ’ Knowledge and Application of Immunization Strategies in Patients with Inflammatory Bowel Disease: A Survey of the Italian Group for the Study of Inflammatory Bowel Disease
Conclusions: Efforts carried out by the scientific societies are required to increase the awareness of this relevant topic among physicians.Digestion (Source: Digestion)
Source: Digestion - June 5, 2019 Category: Gastroenterology Source Type: research

Contents Vol. 99, 2019
Digestion 2019;99:I –IV (Source: Digestion)
Source: Digestion - May 28, 2019 Category: Gastroenterology Source Type: research

Efficacy of Vonoprazan for 48-Week Maintenance Therapy of Patients with Healed Reflux Esophagitis
Conclusion: VPZ 10 mg is clinically effective for maintenance of healed RE for 48 weeks.Digestion (Source: Digestion)
Source: Digestion - May 24, 2019 Category: Gastroenterology Source Type: research

Poor Prognosis of Advanced Cholangiocarcinoma: Real-World Data from a Tertiary Referral Center
Conclusion: Prognosis in advanced stage CCA is still very poor. However, multimodal treatment in palliative patients significantly prolong survival.Digestion (Source: Digestion)
Source: Digestion - May 24, 2019 Category: Gastroenterology Source Type: research

Propofol Sedation in the Endoscopy Room versus Operation Room during Endoscopic Submucosal Dissection for Gastric Tumors: A Propensity Score-Matching Analysis
Conclusion: Sedation with propofol in the operation room might be required to ensure safer application of ESD for gastric tumors. However, a decrease in the desaturation rate was the only disadvantage of sedation in the endoscopy room.Digestion (Source: Digestion)
Source: Digestion - May 24, 2019 Category: Gastroenterology Source Type: research

Increasing Heme Oxygenase-1-Expressing Macrophages Indicates a Tendency of Poor Prognosis in Advanced Colorectal Cancer
Conclusion: In this study, the correlation between HO-1-expressing macrophages and clinicopathological parameters in the tumor microenvironment of colorectal cancer was studied for the first time, and the expression was associated with lymph node metastasis and shortening of DFS.Digestion (Source: Digestion)
Source: Digestion - May 22, 2019 Category: Gastroenterology Source Type: research

Long Noncoding RNA LINC00265 Promotes Glycolysis and Lactate Production of Colorectal Cancer through Regulating of miR-216b-5p/TRIM44 Axis
Conclusion: Our study highlighted the contribution of LINC00265/miR-216b-5p/TRIM44 signaling axis in CRC.Digestion (Source: Digestion)
Source: Digestion - May 10, 2019 Category: Gastroenterology Source Type: research

Efficacy of Endoscopic Evaluation of Acute Radiation Esophagitis during Chemoradiotherapy with Proton Beam Therapy Boost for Esophageal Cancer
Conclusion: Endoscopic evaluation of radiation esophagitis using FARE grades was safely performed and useful for adjusting added radiation to ensure the safety of escalations in CRT with PBT boost for esophageal cancer.Digestion (Source: Digestion)
Source: Digestion - May 8, 2019 Category: Gastroenterology Source Type: research

Effects of Proton Pump Inhibitor on the Distribution of < b > < i > Helicobacter pylori < /i > < /b > and Associated Gastritis in Patients with Gastric Atrophy
Conclusion: PPI treatment decreasedH. pylori both in the antrum and the corpus in patients with atrophic gastritis. Antral gastritis improved during PPI treatment, whereas no changes were found in the corpus.Digestion (Source: Digestion)
Source: Digestion - May 8, 2019 Category: Gastroenterology Source Type: research

Timing and Predictors of Recurrence of Dyspepsia Symptoms after Cessation of Acotiamide Therapy for Functional Dyspepsia: A Long-Term Observational Study
Conclusions: Dyspepsia symptoms recur about one year after cessation of acotiamide therapy. Patients with overlapped-type dyspepsia should be carefully followed after cessation. Patients should consult their treating physician before stopping acotiamide.Digestion (Source: Digestion)
Source: Digestion - May 7, 2019 Category: Gastroenterology Source Type: research

Does the 5-Aminosalicylate Concentration Correlate with the Efficacy of Oral 5-Aminosalicylate and Predict Response in Patients with Inflammatory Bowel Disease? A Systematic Review
Conclusions: An increase of the mucosal 5-ASA concentrations was observed during remission in patients with UC. No clear relationship between the faecal 5-ASA excretion and the therapeutic efficacy was identified.Digestion (Source: Digestion)
Source: Digestion - April 24, 2019 Category: Gastroenterology Source Type: research

A Potassium-Competitive Acid Blocker-Based Regimen as Second-Line Therapy Improves < b > < i > Helicobacter pylori < /i > < /b > Eradication
Conclusions: PCAB-based second-lineH. pylori eradication is significantly better than PPI-based therapy.Digestion (Source: Digestion)
Source: Digestion - April 17, 2019 Category: Gastroenterology Source Type: research

Changes of Dyspeptic Symptom after Successful Eradication in < b > < i > Helicobacter pylori- < /i > < /b > Associated Dyspepsia
Conclusions: Approximately 60% of HPD participants improved at 1 month after eradication. The questionnaire at 1 month helped diagnose HPD in advance and guided next treatment choice.Digestion (Source: Digestion)
Source: Digestion - April 17, 2019 Category: Gastroenterology Source Type: research

Assessment of the Quality and Content of Clinical Practice Guidelines on Irritable Bowel Syndrome Using the AGREE II Instrument
Conclusions: The guidelines on IBS varied in quality and there were discrepancies about recommendations and recommendation grades. There is some space to improvement the quality of methodological rigor in development and reporting within clinical guidelines.Digestion (Source: Digestion)
Source: Digestion - April 15, 2019 Category: Gastroenterology Source Type: research

An International Study on the Diagnostic Accuracy of the Japan Narrow-Band Imaging Expert Team Classification for Colorectal Polyps Observed with Blue Laser Imaging
Conclusions: The PPV for Type 3 differed between the 2 groups, suggesting the need to become familiar with differentiation between Type 2B and Type 3.Digestion (Source: Digestion)
Source: Digestion - April 15, 2019 Category: Gastroenterology Source Type: research

Evaluating the Accuracy of the Endoscopic ABC Classification System in Diagnosing < b > < i > Helicobacter pylori < /i > < /b > -Infected Gastritis
Conclusion: This study showed that the modified Endo ABC classification enables to accurately determine theH. pylori-infected gastritis status.Digestion (Source: Digestion)
Source: Digestion - April 15, 2019 Category: Gastroenterology Source Type: research

Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia
Conclusions: The current finding suggested that DNA methylation and accumulation of β-catenin were closely associated with tumor development from MIMN to non-MIMN.Digestion (Source: Digestion)
Source: Digestion - April 3, 2019 Category: Gastroenterology Source Type: research

Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma
Conclusions: Endoscopic resection can be selected for ­EP-SM1 lesions, regardless of whether the lesions are of the spreading type or nonspreading type.Digestion (Source: Digestion)
Source: Digestion - March 31, 2019 Category: Gastroenterology Source Type: research

Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions
Conclusion: CCE2 sensitivities for colorectal superficial and protruded lesions were not significantly different. However, flat-type SSA/Ps in the right colon, especially when the transit time is fast, have a risk of demonstrating CCE2 false-negative results.Digestion (Source: Digestion)
Source: Digestion - March 31, 2019 Category: Gastroenterology Source Type: research

Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality
Conclusions: CE may predict TRM in patients who developed gastrointestinal symptoms after allo-SCT.Digestion (Source: Digestion)
Source: Digestion - March 22, 2019 Category: Gastroenterology Source Type: research

Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux
Conclusion: In patients with PPI-refractory GERD, VPZ provides more potent gastric acid suppression, more effective EAE control, enhanced symptom improvement, and better esophagitis healing than PPIs.Digestion (Source: Digestion)
Source: Digestion - March 21, 2019 Category: Gastroenterology Source Type: research

Effect of EP1 Receptor Antagonist on Transient Lower Esophageal Sphincter Relaxations in Humans
Conclusions: ONO-8539 suppressed TLESRs mildly. EP1 receptor may be involved with the mechanism of human TLESRs.Digestion (Source: Digestion)
Source: Digestion - March 21, 2019 Category: Gastroenterology Source Type: research

Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine
Conclusion: Rikkunshito depolarized pacemaker potentials of ICCs via ghrelin receptor and G protein through internal or external Ca2+-, phospholipase C-, and inositol triphosphate-dependent and protein kinase C-, TRPM7-, and ANO1-independent pathways. The study shows that Rikkunshito may alleviate GI motility disorders through its depolarizing effects on ICCs.Digestion (Source: Digestion)
Source: Digestion - March 20, 2019 Category: Gastroenterology Source Type: research

Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy
Conclusions: The clinical factor related to missing colorectal polyp on CCE was the segmental transit time.Digestion (Source: Digestion)
Source: Digestion - March 20, 2019 Category: Gastroenterology Source Type: research

Learning Effect of Diagnosing Depth of Invasion Using Non-Extension Sign in Early Gastric Cancer
Conclusion: Nonexperts ’ diagnostic ability to determine the depth of invasion of EGC improved by learning to read the non-extension sign. Thus, the non-extension sign is considered a simple and useful diagnostic marker.Digestion (Source: Digestion)
Source: Digestion - March 20, 2019 Category: Gastroenterology Source Type: research

Histological Features of Gastric Mucosa Serologically Diagnosed as Gastric Atrophy without < b > < i > Helicobacter pylori < /i > < /b > Infection
Conclusions: Various histological features, with significant differences in gastric cancer risk, were identified in the gastric mucosa serologically diagnosed with atrophy withoutH. pylori infection. Therefore, serological screening for gastric cancer risk tests has several limitations, and additional evaluations should be considered.Digestion (Source: Digestion)
Source: Digestion - March 14, 2019 Category: Gastroenterology Source Type: research

Accuracy of Different Rapid Urease Tests in Comparison with Histopathology in Patients with Endoscopic Signs of Gastritis
Conclusions: In conclusion, we consider RUTs to be cheap and fast alternatives to histology in patients with endoscopic signs of gastritis, independently of whether PPIs or antibiotic are used. Histological evaluation is expensive, time consuming and may be unnecessary in some cases.Digestion (Source: Digestion)
Source: Digestion - March 7, 2019 Category: Gastroenterology Source Type: research

A Study on the Status of Proton Pump Inhibitor Prescriptions Using Diagnosis Procedure Combination Data in Japan
Conclusion: PPI use has increased substantially in hospitalized patients. The prevalence of PPI prescription by doctors other than gastroenterologists also increased.Digestion (Source: Digestion)
Source: Digestion - March 7, 2019 Category: Gastroenterology Source Type: research

Endoscopic Detachable Snare Ligation Improves the Treatment for Colonic Diverticular Hemorrhage
Conclusion: The results of this study suggest that EDSL is superior to EC as treatment for colonic diverticular hemorrhage. EDSL may provide improvements in the clinical course of patients with colonic diverticular hemorrhage.Digestion (Source: Digestion)
Source: Digestion - March 7, 2019 Category: Gastroenterology Source Type: research

Chenodeoxycholic Acid Releases Proinflammatory Cytokines from Small Intestinal Epithelial Cells Through the Farnesoid X Receptor
Conclusions: FXR expression was elevated at the terminal ileum in IBS patients. CDCA increased proinflammatory cytokines, while guggulsterone blocked these increases.Digestion (Source: Digestion)
Source: Digestion - March 7, 2019 Category: Gastroenterology Source Type: research

Effects of L-Menthol and Carbon Dioxide on the Adenoma Detection Rate during Colonoscopy: L-Menthol and Carbon Dioxide on Colonoscopy
Conclusions: The fact that CO2I was associated with significant decreases in the ADR was a problem. The combined use of L-mentholS and CO2I could help to suppress the decrease in the ADR.Digestion (Source: Digestion)
Source: Digestion - March 7, 2019 Category: Gastroenterology Source Type: research

Comparisons of the Mucosal Healing Process between Flat and Protruded Type after Endoscopic Submucosal Dissection for Gastric Neoplasms
Conclusions: The healing type of mucosal ulceration after ESD seemed to be influenced by location, specimen size, and the presence of anH. pylori infection.Digestion (Source: Digestion)
Source: Digestion - February 22, 2019 Category: Gastroenterology Source Type: research

Long-Term Outcomes after Surgical Resection for Synchronous or Metachronous Hepatic and Pulmonary Colorectal Cancer Metastases
Conclusions: Surgical resection of both hepatic and pulmonary metastases of CRC represents a safe and effective treatment. It might lead to rewarding long-term survival rates in high selected patients. Shorter DFIs between first metastasectomy and diagnosis of second metastases can determine worse prognoses. In addition, poor outcomes could be predicted also for patients affected by synchronously detected pulmonary CRC metastases, although further confirmatory analyses are strongly required.Digestion (Source: Digestion)
Source: Digestion - February 15, 2019 Category: Gastroenterology Source Type: research

A Nondilated Main Pancreatic Duct Predicts Type 2 Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses
Conclusions: In the setting of undetermined pancreatic focal mass, a nondilated MPD suggests the diagnosis of type 2 AIP.Digestion (Source: Digestion)
Source: Digestion - February 14, 2019 Category: Gastroenterology Source Type: research

Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer
Conclusion: RUNX3 immunostaining of non-neoplastic mucosa is useful for identifying UC patients at a high risk of developing CAC.Digestion (Source: Digestion)
Source: Digestion - February 14, 2019 Category: Gastroenterology Source Type: research

Metabolic Endoscopy: Development and Perspectives
This article will therefore highlight procedures with data on type 2 d iabetes mellitus (T2DM) as the most prominent component of the metabolic syndrome.Summary: Most procedures showed beneficial effects in terms of weight reduction. For gastric procedures, there were no systematic studies primarily addressing parameters of glucose metabolism or diabetes outcomes. Metabolic benefit, if there is any, is most likely a by-product of weight loss. By contrast, duodenal-jejunal bypass sleeve (DJBS) is conceptually an antidiabetic procedure. Although adverse events are frequent, recent data points to a positive benefit-risk ratio...
Source: Digestion - February 7, 2019 Category: Gastroenterology Source Type: research

Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects
Conclusions: The MAM profiles of the upper and lower gut were significantly different. The inter-individual differences in MAM were remarkable compared to the intra-individual differences.Digestion (Source: Digestion)
Source: Digestion - February 6, 2019 Category: Gastroenterology Source Type: research

Predictive Factors for Rebleeding after Negative Capsule Endoscopy among Patients with Overt Obscure Gastrointestinal Bleeding
Conclusions: Rebleeding is not a rare condition among patients with overt OGIB after negative CE. Patients with ongoing overt OGIB or severe anemia at the initial CE examination seem to have a higher risk of rebleeding.Digestion (Source: Digestion)
Source: Digestion - February 1, 2019 Category: Gastroenterology Source Type: research

MR Defecography in Assessing Functional Defecation Disorder: Diagnostic Value of the Defecation Phase in Detection of Dyssynergic Defecation and Pelvic Floor Prolapse in Females
Conclusion: The straining phase and the defecation phase have the same ability in assessing paradoxical puborectalis contraction of the DD. Compared with the straining phase, the defecation phase provides the maximum stress to the pelvic floor resulting in complete levator ani relaxation. In addition to diagnosing the abnormal anorectal function, the defecation phase with the discharge of the rectal filling demonstrates maximum anterior/middle pelvic organ descent in DD patients.Digestion (Source: Digestion)
Source: Digestion - January 31, 2019 Category: Gastroenterology Source Type: research

Erratum
Digestion (Source: Digestion)
Source: Digestion - January 28, 2019 Category: Gastroenterology Source Type: research

Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis: Japan Gastroenterological Association
Colonic diverticular disease has been increasing in prevalence in Japan due to the rapidly aging population. Colonic diverticular bleeding can result in hemorrhagic shock requiring blood transfusion, and it carries a high risk of recurrence within 1 year. Colonic diverticulitis can cause abscess, fistula formation, and perforation of the colon that may require surgery, and it often recurs. As a result, patients with colonic diverticular disease are often bothered by required frequent examinations, re-hospitalization, and a consequent decrease in quality of life. However, the management of diverticular disease differs betwe...
Source: Digestion - January 13, 2019 Category: Gastroenterology Source Type: research