Clinical Characteristics of Intramucosal Gastric Cancers with Lymphovascular Invasion Resected by Endoscopic Submucosal Dissection
Conclusion: Careful follow-up may be appropriate for MGCs with LVI due to the low risk of LNM. Additionally, the pap component is a significant factor in MGCs with LVI.Digestion (Source: Digestion)
Source: Digestion - August 13, 2020 Category: Gastroenterology Source Type: research

Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease
Conclusions: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.Digestion (Source: Digestion)
Source: Digestion - August 12, 2020 Category: Gastroenterology Source Type: research

Special Issue of Digestion: Inflammatory Bowel Disease
Digestion (Source: Digestion)
Source: Digestion - August 5, 2020 Category: Gastroenterology Source Type: research

Role of Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Subscore (MES) in Predicting Patients ′ Response to Biological Therapy and the Need for Colectomy
Conclusion: UCEIS may be superior to MES because of its accuracy and predictive role. Therefore, UCEIS should be considered for use in daily clinical practice.Digestion (Source: Digestion)
Source: Digestion - July 31, 2020 Category: Gastroenterology Source Type: research

TNF-Alpha Blockers in Inflammatory Bowel Diseases: Practical Recommendations and a User ’s Guide: An Update
Background: Anti-tumour necrosis factor-alpha (anti-TNF) antagonists have been the mainstay in the treatment of inflammatory bowel diseases (IBDs) for over 20 years.Summary: This review article aimed to provide an update on recent advances in TNF antagonist therapy for IBDs.Key Messages: Their position in the treatment algorithm has evolved to “rapid step-up therapy” or “top-down therapy” according to disease severity and patients’ characteristics. Limitations of anti-TNF antagonists include loss of response in up to 30–50% of patients with or without the development of antibodies. Thera...
Source: Digestion - July 31, 2020 Category: Gastroenterology Source Type: research

Contribution of Serotonin 3A Receptor to Motor Function and Its Expression in the Gastrointestinal Tract
Conclusions: These results show that 5-HT3AR is highly expressed in the stomach and large intestine and that the activation of 5-HT3AR accelerates gastric emptying and large intestine transit. Additionally, 5-HT3AR is highly expressed in cholinergic neurons and some interstitial cells, such as PDGFR α+ cells.Digestion (Source: Digestion)
Source: Digestion - July 29, 2020 Category: Gastroenterology Source Type: research

Role of a Rare Variant in < b > < i > APC < /i > < /b > Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis
Conclusions: The variant (c.-190G#x3e;A) in theAPC promoter 1B region is able to cause FAP with a classic phenotype, but this kind of variant in the noncoding region could be missed by conventional genetic testing. Thus, utilizing sequencing technologies covering a larger area can help us to further explore the pathogenesis in variant-negative FAP cases.Digestion (Source: Digestion)
Source: Digestion - July 23, 2020 Category: Gastroenterology Source Type: research

Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis
Conclusions: HAG sheets induced post-ESD ulcer healing with less submucosal inflammation and muscularis propria injury and have the potential to decrease excess scarring.Digestion (Source: Digestion)
Source: Digestion - July 22, 2020 Category: Gastroenterology Source Type: research

Monocyte-Derived Hepatocyte-Like Cell Test: A Novel Tool for in vitro Identification of Drug-Induced Liver Injury in Patients with Herbal or Dietary Supplements
Conclusions: Our data provide evidence that the MH cell test can be a useful tool to identify the role of HDS in causing DILI and therefore support causality assessment in patients consuming HDS.Digestion (Source: Digestion)
Source: Digestion - July 20, 2020 Category: Gastroenterology Source Type: research

Histologic and Clinical Effects of Different Topical Corticosteroids for Eosinophilic Esophagitis: Lessons from an Updated Meta-Analysis of Placebo-Controlled Randomized Trials
Conclusions: TS are effective for short-term induction of histological remission in EoE with less impressive clinical response rates. The mode of drug delivery to the esophagus may be a relevant factor for the degree of histologic remission. Further trials should use uniform assessment criteria and long-term patient-centered outcomes.Digestion (Source: Digestion)
Source: Digestion - July 1, 2020 Category: Gastroenterology Source Type: research

Clinical Outcomes of Vonoprazan-Treated Patients after Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Multicenter Observation Study
Conclusions: VPZ therapy showed an efficacy and feasibility in preventing a delayed bleeding after ESD similar to the PPI therapy. VPZ for 6 weeks and PPI for 8 weeks were similarly effective for an artificial ulcer healing after ESD.Digestion (Source: Digestion)
Source: Digestion - June 25, 2020 Category: Gastroenterology Source Type: research

An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications
This study aimed to provide gastroenterologists with novel insights into the evaluation of esophageal involvement with eosinophils and to pay special attention to the etiological factors, coexisting clinical diseases, and complications.Digestion (Source: Digestion)
Source: Digestion - June 22, 2020 Category: Gastroenterology Source Type: research

Emerging Treatment Options in Inflammatory Bowel Disease: Janus Kinases, Stem Cells, and More
Background: Treatment of inflammatory bowel diseases (IBD) has tremendously improved during the last 20 years; however, a substantial fraction of patients does not respond to available therapies or lose response, and new strategies are needed.Summary: Two pharmacological principles have been successfully used for IBD treatment: inhibition of cellular signaling and interference with leukocyte trafficking. Besides tumor necrosis factor, interleukin (IL)-23 is a promising drug target, and antibodies for the combined inhibition of IL-23 and IL-12 (ustekinumab and briakinumab) or selective IL-23 inhibition (brazikumab, risankiz...
Source: Digestion - June 22, 2020 Category: Gastroenterology Source Type: research

Current Opinion about Hepatocellular Carcinoma & #x3c;10 mm
Background: Early detection of hepatocellular carcinoma (HCC) is important. Advances in liver imaging techniques have facilitated the detection of HCC at an early stage. However, there is a controversial discussion on how to diagnose very small HCC by imaging. The aim of the current review is to present current published data on HCC ≤10 mm and discuss on how to best diagnose and treat such lesions.Summary: It is still challenging, however, to accurately characterize HCC #x3c;10 mm. The accuracy of contrast-enhanced ultrasound may be critical for early treatment decisions for cancer patients, particularly when CECT and/o...
Source: Digestion - June 9, 2020 Category: Gastroenterology Source Type: research

Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes
Conclusions: SNADETs showed distinct endoscopic/clinicopathological features according to the mucin phenotype. Tumor location, coloration, macroscopic type, and endoscopic findings including M-NBI are useful to distinguish the mucin phenotypes of SNADETs.Digestion (Source: Digestion)
Source: Digestion - June 9, 2020 Category: Gastroenterology Source Type: research

A Prospective Multicenter Study on the Prevalence of Fructose Malabsorption in Patients with Chronic Inflammatory Bowel Disease
Conclusions: Fructose malabsorption is not more common among patients with IBD than healthy subjects. However, the greater prevalence of patient-reported symptoms among patients with IBD may be of pathological and therapeutic relevance.Digestion (Source: Digestion)
Source: Digestion - June 9, 2020 Category: Gastroenterology Source Type: research

How Much Liver Tissue Is Required for Sufficient Histological Staging in Patients with Primary Biliary Cholangitis?
Conclusion: ARFI and MLFS are probably well suited for the assessment of liver fibrosis in patients with PBC. A minimum of 10 portal fields could improve the histological assessment in PBC and can probably be achieved by obtaining two 16G biopsies.Digestion (Source: Digestion)
Source: Digestion - June 3, 2020 Category: Gastroenterology Source Type: research

Erratum
Digestion (Source: Digestion)
Source: Digestion - May 20, 2020 Category: Gastroenterology Source Type: research

Interleukin-1 β as a Predictor of Glucocorticoid Response in Ulcerative Colitis
Conclusions: Mucosally expressed IL-1 β can be used as a predictor of GC response in patients with UC.Digestion (Source: Digestion)
Source: Digestion - May 20, 2020 Category: Gastroenterology Source Type: research

Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men
Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.Digestion (Source: Digestion)
Source: Digestion - July 3, 2019 Category: Gastroenterology Source Type: research

Endoscopic Evaluation of Neoadjuvant Chemotherapeutic Efficacy in Gastric Cancer before Gastrectomy Might be as Useful as Histological Assessment after Gastrectomy
Conclusions: Most endoscopic responders showed JCGC histological responses. Evaluation of neoadjuvant chemotherapeutic efficacy by endoscopy in gastric cancer may be useful before gastrectomy. As this was a retrospective study, further investigations are required. The protocol was approved by the ethics review committee at Osaka Medical College (No. 2422) and was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000033088).Digestion (Source: Digestion)
Source: Digestion - June 28, 2019 Category: Gastroenterology Source Type: research

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis
Conclusions: We found that 4 weeks of IN suppository can be tolerated by UC patients, but its efficacy was limited by the severity of the disease. Further investigation will be needed in order to confirm the optimum dose of IN suppository for patients with UC.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research

Risk Factors and Nomogram for Pancreatic Stone Formation in Chronic Pancreatitis over a Long-Term Course: A Cohort of 2,153 Patients
Conclusions: The nomogram achieved an individualized prediction of pancreatic stones development in CP. It may help the management of pancreatic stones.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research

Testing of < b > < i > Helicobacter pylori < /i > < /b > by Endoscopic Biopsy: The Clinical Dilemma of Suppressive Conditions
Conclusion: Guidelines recommendH. pylori testing under non-suppressive conditions. However, this does not always meet the clinical practice. Our data show that de facto, many patients undergoing elective EGD are tested forH. pylori under suppressive conditions coming along with a higher risk of potentially false negative results. Particularly, concerning this issue, further research is needed to improve and clarify everyday clinical practice.Digestion (Source: Digestion)
Source: Digestion - June 19, 2019 Category: Gastroenterology Source Type: research

Current Status of < b > < i > Helicobacter pylori < /i > < /b > Diagnosis and Eradication Therapy in Japan Using a Nationwide Database
Conclusions: Diagnostic tests ofH.  pylori infection mostly followed Japanese Society forHelicobacter Research guidance, although some antibody measurements were timed inappropriately. Vonoprazan appears to increase the success rate of primary therapy.Digestion (Source: Digestion)
Source: Digestion - June 19, 2019 Category: Gastroenterology Source Type: research

Validation of Asia-Pacific Colorectal Screening Score for Asymptomatic Participants and Outpatients in Northwest District of China
Conclusion: APCS score is an effective method for ACRN screening in asymptomatic and also the outpatient subjects. Individuals with HR scores should be given priority for colonoscopy.Digestion (Source: Digestion)
Source: Digestion - June 14, 2019 Category: Gastroenterology Source Type: research

The Traditional Medicine Banhasasim-Tang Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through M3 Muscarinic and 5-HT3 Receptors in Murine Small Intestine
Conclusion: These results suggested that BHSST depolarizes the pacemaker potentials of ICCs in a dose-dependent manner through the M3 and 5-HT3 receptors via internal and external Ca2+-dependent and TRPM7- and ANO1-independent pathways in vitro. Moreover, BHSST increased ITR% in vivo in normal mice and GMD mouse models. Taken together, the results of this study showed that BHSST had the potential for development as a prokinetic agent in GI motility function.Digestion (Source: Digestion)
Source: Digestion - June 11, 2019 Category: Gastroenterology Source Type: research

Physicians ’ Knowledge and Application of Immunization Strategies in Patients with Inflammatory Bowel Disease: A Survey of the Italian Group for the Study of Inflammatory Bowel Disease
Conclusions: Efforts carried out by the scientific societies are required to increase the awareness of this relevant topic among physicians.Digestion (Source: Digestion)
Source: Digestion - June 5, 2019 Category: Gastroenterology Source Type: research

Contents Vol. 99, 2019
Digestion 2019;99:I –IV (Source: Digestion)
Source: Digestion - May 28, 2019 Category: Gastroenterology Source Type: research

Efficacy of Vonoprazan for 48-Week Maintenance Therapy of Patients with Healed Reflux Esophagitis
Conclusion: VPZ 10 mg is clinically effective for maintenance of healed RE for 48 weeks.Digestion (Source: Digestion)
Source: Digestion - May 24, 2019 Category: Gastroenterology Source Type: research

Poor Prognosis of Advanced Cholangiocarcinoma: Real-World Data from a Tertiary Referral Center
Conclusion: Prognosis in advanced stage CCA is still very poor. However, multimodal treatment in palliative patients significantly prolong survival.Digestion (Source: Digestion)
Source: Digestion - May 24, 2019 Category: Gastroenterology Source Type: research

Propofol Sedation in the Endoscopy Room versus Operation Room during Endoscopic Submucosal Dissection for Gastric Tumors: A Propensity Score-Matching Analysis
Conclusion: Sedation with propofol in the operation room might be required to ensure safer application of ESD for gastric tumors. However, a decrease in the desaturation rate was the only disadvantage of sedation in the endoscopy room.Digestion (Source: Digestion)
Source: Digestion - May 24, 2019 Category: Gastroenterology Source Type: research

Increasing Heme Oxygenase-1-Expressing Macrophages Indicates a Tendency of Poor Prognosis in Advanced Colorectal Cancer
Conclusion: In this study, the correlation between HO-1-expressing macrophages and clinicopathological parameters in the tumor microenvironment of colorectal cancer was studied for the first time, and the expression was associated with lymph node metastasis and shortening of DFS.Digestion (Source: Digestion)
Source: Digestion - May 22, 2019 Category: Gastroenterology Source Type: research

Long Noncoding RNA LINC00265 Promotes Glycolysis and Lactate Production of Colorectal Cancer through Regulating of miR-216b-5p/TRIM44 Axis
Conclusion: Our study highlighted the contribution of LINC00265/miR-216b-5p/TRIM44 signaling axis in CRC.Digestion (Source: Digestion)
Source: Digestion - May 10, 2019 Category: Gastroenterology Source Type: research

Efficacy of Endoscopic Evaluation of Acute Radiation Esophagitis during Chemoradiotherapy with Proton Beam Therapy Boost for Esophageal Cancer
Conclusion: Endoscopic evaluation of radiation esophagitis using FARE grades was safely performed and useful for adjusting added radiation to ensure the safety of escalations in CRT with PBT boost for esophageal cancer.Digestion (Source: Digestion)
Source: Digestion - May 8, 2019 Category: Gastroenterology Source Type: research

Effects of Proton Pump Inhibitor on the Distribution of < b > < i > Helicobacter pylori < /i > < /b > and Associated Gastritis in Patients with Gastric Atrophy
Conclusion: PPI treatment decreasedH. pylori both in the antrum and the corpus in patients with atrophic gastritis. Antral gastritis improved during PPI treatment, whereas no changes were found in the corpus.Digestion (Source: Digestion)
Source: Digestion - May 8, 2019 Category: Gastroenterology Source Type: research

Timing and Predictors of Recurrence of Dyspepsia Symptoms after Cessation of Acotiamide Therapy for Functional Dyspepsia: A Long-Term Observational Study
Conclusions: Dyspepsia symptoms recur about one year after cessation of acotiamide therapy. Patients with overlapped-type dyspepsia should be carefully followed after cessation. Patients should consult their treating physician before stopping acotiamide.Digestion (Source: Digestion)
Source: Digestion - May 7, 2019 Category: Gastroenterology Source Type: research

Does the 5-Aminosalicylate Concentration Correlate with the Efficacy of Oral 5-Aminosalicylate and Predict Response in Patients with Inflammatory Bowel Disease? A Systematic Review
Conclusions: An increase of the mucosal 5-ASA concentrations was observed during remission in patients with UC. No clear relationship between the faecal 5-ASA excretion and the therapeutic efficacy was identified.Digestion (Source: Digestion)
Source: Digestion - April 24, 2019 Category: Gastroenterology Source Type: research

A Potassium-Competitive Acid Blocker-Based Regimen as Second-Line Therapy Improves < b > < i > Helicobacter pylori < /i > < /b > Eradication
Conclusions: PCAB-based second-lineH. pylori eradication is significantly better than PPI-based therapy.Digestion (Source: Digestion)
Source: Digestion - April 17, 2019 Category: Gastroenterology Source Type: research

Changes of Dyspeptic Symptom after Successful Eradication in < b > < i > Helicobacter pylori- < /i > < /b > Associated Dyspepsia
Conclusions: Approximately 60% of HPD participants improved at 1 month after eradication. The questionnaire at 1 month helped diagnose HPD in advance and guided next treatment choice.Digestion (Source: Digestion)
Source: Digestion - April 17, 2019 Category: Gastroenterology Source Type: research

Assessment of the Quality and Content of Clinical Practice Guidelines on Irritable Bowel Syndrome Using the AGREE II Instrument
Conclusions: The guidelines on IBS varied in quality and there were discrepancies about recommendations and recommendation grades. There is some space to improvement the quality of methodological rigor in development and reporting within clinical guidelines.Digestion (Source: Digestion)
Source: Digestion - April 15, 2019 Category: Gastroenterology Source Type: research

An International Study on the Diagnostic Accuracy of the Japan Narrow-Band Imaging Expert Team Classification for Colorectal Polyps Observed with Blue Laser Imaging
Conclusions: The PPV for Type 3 differed between the 2 groups, suggesting the need to become familiar with differentiation between Type 2B and Type 3.Digestion (Source: Digestion)
Source: Digestion - April 15, 2019 Category: Gastroenterology Source Type: research

Evaluating the Accuracy of the Endoscopic ABC Classification System in Diagnosing < b > < i > Helicobacter pylori < /i > < /b > -Infected Gastritis
Conclusion: This study showed that the modified Endo ABC classification enables to accurately determine theH. pylori-infected gastritis status.Digestion (Source: Digestion)
Source: Digestion - April 15, 2019 Category: Gastroenterology Source Type: research

Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia
Conclusions: The current finding suggested that DNA methylation and accumulation of β-catenin were closely associated with tumor development from MIMN to non-MIMN.Digestion (Source: Digestion)
Source: Digestion - April 3, 2019 Category: Gastroenterology Source Type: research

Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma
Conclusions: Endoscopic resection can be selected for ­EP-SM1 lesions, regardless of whether the lesions are of the spreading type or nonspreading type.Digestion (Source: Digestion)
Source: Digestion - March 31, 2019 Category: Gastroenterology Source Type: research

Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions
Conclusion: CCE2 sensitivities for colorectal superficial and protruded lesions were not significantly different. However, flat-type SSA/Ps in the right colon, especially when the transit time is fast, have a risk of demonstrating CCE2 false-negative results.Digestion (Source: Digestion)
Source: Digestion - March 31, 2019 Category: Gastroenterology Source Type: research

Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality
Conclusions: CE may predict TRM in patients who developed gastrointestinal symptoms after allo-SCT.Digestion (Source: Digestion)
Source: Digestion - March 22, 2019 Category: Gastroenterology Source Type: research

Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux
Conclusion: In patients with PPI-refractory GERD, VPZ provides more potent gastric acid suppression, more effective EAE control, enhanced symptom improvement, and better esophagitis healing than PPIs.Digestion (Source: Digestion)
Source: Digestion - March 21, 2019 Category: Gastroenterology Source Type: research

Effect of EP1 Receptor Antagonist on Transient Lower Esophageal Sphincter Relaxations in Humans
Conclusions: ONO-8539 suppressed TLESRs mildly. EP1 receptor may be involved with the mechanism of human TLESRs.Digestion (Source: Digestion)
Source: Digestion - March 21, 2019 Category: Gastroenterology Source Type: research

Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine
Conclusion: Rikkunshito depolarized pacemaker potentials of ICCs via ghrelin receptor and G protein through internal or external Ca2+-, phospholipase C-, and inositol triphosphate-dependent and protein kinase C-, TRPM7-, and ANO1-independent pathways. The study shows that Rikkunshito may alleviate GI motility disorders through its depolarizing effects on ICCs.Digestion (Source: Digestion)
Source: Digestion - March 20, 2019 Category: Gastroenterology Source Type: research