Real-world evidence of quality of life improvement in patients with distal ulcerative colitis treated by mesalazine: the Quartz study
Background
Distal ulcerative colitis (UC) is responsible for distressing symptoms and reduces quality of life (QoL). Oral and topical formulations of 5-amino-salicylic acid are the first line therapy for mild to moderate distal UC.
Objective
Our aim was to evaluate the impact of mesalazine treatment for mild to moderate ulcerative proctitis and proctosigmoiditis on patient QoL.
Methods
Ninety-three patients with mild to moderate ulcerative proctitis and proctosigmoiditis, initiating a treatment with Pentasa, were prospectively included. The primary endpoint was the change from baseline to W8 in patient he...
Source: European Journal of Gastroenterology and Hepatology - November 8, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research
Novel Nanostructured Lipid Carriers Co-Loaded with Mesalamine and Curcumin: Formulation, Optimization and In Vitro Evaluation
CONCLUSION: The outcomes of study deciphered successful formulation of Mes-Cur NLCs.PMID:36195824 | DOI:10.1007/s11095-022-03401-z (Source: Cell Research)
Source: Cell Research - October 4, 2022 Category: Cytology Authors: Ankit Awasthi Bimlesh Kumar Monica Gulati Sukriti Vishwas Leander Corrie Jaskiran Kaur Rubiya Khursheed Rozhan Arif Muhammed Duran Kala Omji Porwal Malakapogu Ravindra Babu M V N L Chaitanya Ankit Kumar Narendra Kumar Pandey Harish Dureja Dinesh Kumar Che Source Type: research
Novel Nanostructured Lipid Carriers Co-Loaded with Mesalamine and Curcumin: Formulation, Optimization and In Vitro Evaluation
ConclusionThe outcomes of study deciphered successful formulation of Mes-Cur NLCs. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - October 4, 2022 Category: Drugs & Pharmacology Source Type: research
Pre-clinical Investigation of Protective Effect of Nutraceutical D-Glucosamine on TNBS-induced Colitis
Immunopharmacol Immunotoxicol. 2022 Sep 26:1-33. doi: 10.1080/08923973.2022.2128370. Online ahead of print.ABSTRACTThe level of precursors involved in the biosynthesis of glycosaminoglycan (GAG), glucosamine synthase, and N-acetyl glucosamine (NAG), are significantly reduced in inflammatory bowel disease (IBD). This results in deficient GAG content in mucosa, which eventually disrupts the gut wall integrity, provoking abnormal immunological responses. This is characterized by colossal liberation of inflammatory mediators including tumor necrosis factor-alpha (TNF-α), interleukins (IL), and reactive oxygen species provokin...
Source: Immunopharmacology and Immunotoxicology - September 26, 2022 Category: Allergy & Immunology Authors: Supriya Roy Suneela Dhaneshwar Tarique Mahmood Swatantra Kumar Shailendra K Saxena Source Type: research
[ASAP] Experimental Study and Thermodynamic Modeling of Mesalamine and Azathioprine Solubility in Some Choline Chloride-Based Deep Eutectic Solvents
Journal of Chemical& Engineering DataDOI: 10.1021/acs.jced.2c00408 (Source: Journal of Chemical and Engineering Data)
Source: Journal of Chemical and Engineering Data - September 12, 2022 Category: Chemistry Authors: Tahereh Amini, Ali Haghtalab, and Jaber Yousefi Seyf Source Type: research
Pharmacological Management of Inflammatory Bowel Disease: a Century of Expert Opinions in Cecil Textbook of Medicine
Conclusions:
The pharmacological management of IBD has been the focus of intense research and development in the past 60 years. The pillars of drug treatment have been 5-aminosalicylates and corticosteroids. Recent pharmacological innovations (immunomodulators and biologicals) constitute an encouraging paradigm shift in the treatment of UC and Crohn disease. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research
A Hydrogen-Sulfide Derivative of Mesalamine Reduces Severity of Intestinal and Lung Injury in Necrotizing Enterocolitis via Endothelial Nitric Oxide Synthase
CONCLUSIONS: An H2S-derivative of mesalamine improves outcomes in experimental NEC. Protective effects appear to be mediated through eNOS. Further research is warranted to explore whether ATB-429 may be an effective oral therapy to combat NEC.PMID:35912999 | DOI:10.1152/ajpregu.00229.2021 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 1, 2022 Category: Physiology Authors: Brian D Hosfield Chelsea E Hunter Hongge Li Natalie A Drucker Anthony R Pecoraro Krishna Manohar W Christopher Shelley Troy A Markel Source Type: research
A Hydrogen-Sulfide Derivative of Mesalamine Reduces Severity of Intestinal and Lung Injury in Necrotizing Enterocolitis via Endothelial Nitric Oxide Synthase
CONCLUSIONS: An H2S-derivative of mesalamine improves outcomes in experimental NEC. Protective effects appear to be mediated through eNOS. Further research is warranted to explore whether ATB-429 may be an effective oral therapy to combat NEC.PMID:35912999 | DOI:10.1152/ajpregu.00229.2021 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 1, 2022 Category: Physiology Authors: Brian D Hosfield Chelsea E Hunter Hongge Li Natalie A Drucker Anthony R Pecoraro Krishna Manohar W Christopher Shelley Troy A Markel Source Type: research
Relapse rates after withdrawal of thiopurines in patients with inflammatory bowel disease
ConclusionApproximately 50% patients with IBD in remission would relapse after 5 years of thiopurine withdrawal. Male sex and shorter treatment duration predict relapse. Treatment should be continued in patients who tolerate and maintain remission on long-term thiopurine. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - July 14, 2022 Category: Gastroenterology Source Type: research
