Paper alert
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Paper Alert Source Type: research

Association between diabetes mellitus and hepatocellular carcinoma
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The significance of paired biopsies in estimating disease progression in patients with nonalcoholic steatohepatitis
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Association between acute pancreatitis and pancreatic cancer
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food
We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. To better investigate the state of allergic sensitization to wheat in our patient, we then performed the component resolved diagnosis, which showed Tri a19 2 kU/l and Tri a14 0.3 kU/l. These results demonstrated the association of IgE-mediated allergy to wheat and coeliac disease. The natural course of specific IgE in allergic patients who are on a food-free diet needs fur...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Case Report Source Type: research

Early recurrence detected in hepatocellular carcinoma patients after transcatheter arterial chemoembolization treatment with plasma cell-free DNA
Conclusion The mutation burden in plasma cfDNA may serve as a novel prognostic biomarker by providing early evidence of residual disease and identifying high risk of recurrence in patients with HCC following TACE therapy. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation?
Background The aim of this study was to elucidate the efficacy of the combination of L-carnitine and exercise, reported to prevent muscle wasting, for muscle complications (function, volume, and cramping) in patients with liver cirrhosis (LC) who received branched-chain amino acid supplementation. Materials and methods From December 2017 to April 2018, 18 patients with LC who had been given branched-chain amino acid granule supplementation (12.45 g/day) were enrolled (mean age 68.4±10.8 years; 10 males and eight females; Child–Pugh A : B=9 : 9). After evaluating the aver...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Comparison of mycophenolate mofetil with standard treatment for autoimmune hepatitis: a meta-analysis
Objective To systematically evaluate the efficacy of mycophenolate mofetil (MMF) compared with the standard treatment for autoimmune hepatitis. Methods Medline (PubMed), Embase, and Cochrane Library databases were searched between 1966 and June 2018 for studies on prednisone and/or azathioprine/mycophenolate mofetil in autoimmune hepatitis. The keywords and descriptor terms used were ‘hepatitis’, ‘autoimmunity’, ‘prednisone’, ‘prednisolone’, ‘azathioprine’, and ‘mycophenolate mofetil’. The Z test and Cochrane Q test were used in the statistical an...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Prediction model for hepatocellular carcinoma risk in treatment-naive chronic hepatitis B patients receiving entecavir/tenofovir
Conclusions The AASL-HCC model was simple and reliable for HCC risk prediction in treatment-naive CHB patients receiving ETV/TDF, and is easily applicable in the clinical setting. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes
Conclusions Our study demonstrated that serum fetuin-B had an independent association with NAFLD in patients with T2DM. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Comparison of transjugular intrahepatic portosystemic shunt for treatment of variceal bleeding in patients with cirrhosis with or without spontaneous portosystemic shunt
Conclusion TIPS combined with antegrade embolization is safe, effective, and feasible for patients with SPSSs, with safety and long-term outcomes comparable to patients without SPSSs. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Risk factors for resistance development against lamivudine during long-term treatment of chronic hepatitis B virus infections
Conclusion Even after long-term response to lamivudine more than 10 years, resistance may still develop. Our findings further discourage the use of lamivudine for the treatment of CHB. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Prognostic predictors for patients with hepatocellular carcinoma receiving adjuvant transcatheter arterial chemoembolization
Conclusion The treatment effectiveness of adjuvant transcatheter arterial chemoembolization for patients with hepatocellular carcinoma after surgery was validated in this study, and the best candidates for PA-TACE were identified as well, including patients with late-stage tumor, portal hypertension, and high preoperative serum levels of α-fetoprotein, alkaline phosphatase, γ-glutamyl transpeptidase, and monocytes. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Tenofovir and telbivudine combination therapy rapidly decreases viral loads in immune-tolerant chronic hepatitis B patients awaiting assisted reproduction: an open-label, randomized, controlled study
Conclusion TDF and LdT combination therapy shows a rapid antivirological response in immune-tolerant CHB patients awaiting AR, which provide an alternative for this group at AR centers. However, the HBeAg seroconversion rate is unsatisfactory in the short term. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Prognostic value of international normalized ratio to albumin ratio among critically ill patients with cirrhosis
Background and aim Critically ill patients with cirrhosis are at an increased risk of mortality. Our study aimed to externally validate the ability of the prothrombin time–international normalized ratio to albumin ratio (PTAR), an objective and simple scoring system, to predict 90-day mortality in critically ill patients with cirrhosis. Patients and methods A total of 865 patients were entered into the study, and all the participants were followed up for at least 90 days. Clinical parameters on the first day of intensive care unit admission were included to compare survivors with nonsurvivors. Results After m...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Serum alkaline phosphatase levels as a simple and useful test in screening for significant fibrosis in treatment-naive patients with hepatitis B e-antigen negative chronic hepatitis B
Conclusion Serum ALP levels can identify significant fibrosis (S≥2) in treatment-naive HBeAg(−) CHB patients and could potentially reduce the need for liver biopsies and help to guide the clinical treatment of CHB. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Diagnostic accuracy of intestinal ultrasound and magnetic resonance enterography for the detection of endoscopy-based disease activity in ileocolonic Crohn’s disease
The objective of this study was to compare the diagnostic accuracy of intestinal ultrasound (IUS) and magnetic resonance enterography (MRE) for the assessment of disease activity in CD using a simple endoscopic score for CD as a reference standard. Patients and methods A prospective observational study was carried out in 71 consecutive adult patients with known CD, attending our tertiary inflammatory bowel disease clinic, between November 2014 and July 2016. Ileocolonoscopy, IUS and MRE were performed within 1 month prospectively. The simple endoscopic score-CD 0–2 was accepted as remission. Results The sensiti...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Intravenous iron versus oral iron or observation for gastrointestinal malignancies: a systematic review
Conclusion Despite the limitations of the current body of evidence, there is a likely benefit to the use of intravenous iron in this patient population. Further confirmatory research is needed to draw empirical conclusions. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Arteriovenous malformations respond poorly to argon plasma coagulation in patients with continuous flow left ventricular assist devices
Conclusion The use of APC alone for the treatment of AVMs in LVAD patients had a high failure rate. The presence of gastric AVMs was a significant risk factor for rebleeding in LVAD patients. Management decisions should take these factors into account. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Laparoscopic-assisted colorectal surgery benefits visceral obesity patients: a propensity-matched analysis
Conclusion LAS in visceral obesity patients with CRC was a safer and less invasive alternative than open surgery, with fewer complications within the first 30 days postoperatively. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Comparison of risk scores and shock index in hemodynamically stable patients presenting to the emergency department with nonvariceal upper gastrointestinal bleeding
Conclusion Pre-existing risk scores have shown suboptimal predictive ability for adverse events in normotensive patients with nonvariceal UGIB. The GBS (≥8) might help to identify patients prone to adverse events; however, further studies with risk scores or new scores are needed because of the low accuracy of these scores. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Inflammatory bowel disease and mycobacteria: how much can we trust isoniazid prophylaxis during antitumor necrosis factor therapy?
Conclusion INH chemoprophylaxis may not prevent the reactivation of TB during anti-TNF therapy in the long-term. Patients should be carefully and periodically screened for TB reactivation during anti-TNF therapy. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Prevalence of Clostridium difficile infection among hospitalized inflammatory bowel disease patients in Greece
Conclusion The prevalence of CDI is higher in hospitalized IBD patients than those without IBD and AZA monotherapy increases the risk of CDI. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Small bowel capsule endoscopy in ulcerative colitis: the capcolitis study: a prospective observational study
Conclusion Systematic examination of 125 consecutive UC-patients failed to confirm a clinically important phenotype overlap with CD, as suggested by genetic aetiology studies. In five patients (4%) with small bowel lesions, the diagnosis was changed to CD. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Higher odds of irritable bowel syndrome among hospitalized patients using cannabis: a propensity-matched analysis
Conclusion: Our findings suggest that CUD is significantly associated with IBS among the general population. Males, Caucasians, and Hispanics might be more impacted by CUD associated IBS. Additional biomedical studies are required to elucidate this relationship. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Competing risks and cause-specific mortality in patients with pancreatic neuroendocrine tumors
Conclusion Our nomogram allows selection of a patient population at high risk for cancer-specific mortality and thus facilitates the design of prevention trials for the affected population. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Hepatocellular carcinoma in the noncirrhotic liver: a literature review
Development of hepatocellular carcinoma (HCC) is usually preceded by chronic liver injury and ongoing liver diseases. Liver cirrhosis reflects the outcome of long-term liver injury and is associated with an increased risk of developing HCC. However, HCC also arises in individuals without cirrhosis and bears several characteristics distinct from HCC in the cirrhotic liver. The molecular characteristics, prognosis, and surveillance of noncirrhotic HCC have not been adequately studied. In this review, we update readers and researchers in the field with the latest understanding of the epidemiology, etiology, clinical features,...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Review Articles Source Type: research

Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: a systemic review and meta-analysis
Although clinical studies have shown possible links of Helicobacter pylori infection with the development of nonalcoholic fatty liver disease (NAFLD), the results remain controversial. The aim of this meta-analysis is to investigate the association between H. pylori infection and NAFLD. A comprehensive search of relevant studies was performed up to November 2018. Data on H. pylori infection in NAFLD patients and controls were extracted. Odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. Twelve studies involving 27 400 NAFLD patients and 60 347 controls were included...
Source: European Journal of Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Tags: Review Articles Source Type: research

Paper alert
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Paper Alert Source Type: research

Protocol for the transition of pediatrics for adult medicine in celiac disease: a proposal approach
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Letter to the Editor Source Type: research

Indication for treatment and severity of disease in treatment-naive patients with chronic hepatitis B virus infection
Conclusion In HBV-infected patients referred to one of the largest ID clinics in Berlin, only 26% met EASL treatment criteria and 7% had suspected cirrhosis at presentation. Only in 4% of all patients, a treatment indication could not be determined by a noninvasive approach. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Clinicopathological study of occult hepatitis B virus infection in hepatitis C virus-associated hepatocellular carcinoma
Conclusion OBI was detected in 50% of HCV-infected patients with HCC. OBI was strongly associated with the presence of anti-HBc antibodies. Patients with HCC with positive OBI were younger and had more advanced HCC histological grades. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

The promising role of probiotic and synbiotic therapy in aminotransferase levels and inflammatory markers in patients with nonalcoholic fatty liver disease – a systematic review and meta-analysis
Conclusion Probiotic/synbiotic use improves aminotransaminase levels and reduces proinflammatory marker high-sensitivity C-reactive protein and liver fibrosis in NAFLD patients. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Clinical utility of urinary neutrophil gelatinase-associated lipocalin and serum cystatin C in a cohort of liver cirrhosis patients with renal dysfunction: a challenge in the diagnosis of hepatorenal syndrome
This study aimed to assess urinary neutrophil gelatinase-associated lipocalin (uNGAL) and serum cystatin C (sCys C) in liver cirrhosis patients with renal dysfunction and to evaluate their role in the diagnosis of the hepatorenal syndrome (HRS). Patients and methods Forty-five liver cirrhosis patients were enrolled in the study and they were divided into three groups; the first group included 15 patients with normal renal function, the second group included 15 patients with HRS; and the third group included 15 patients with chronic kidney disease (CKD). There was a fourth group, which included 15 healthy controls. Liver...
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Liver stiffness measurement changes following hepatocellular carcinoma treatment with percutaneous microwave ablation or transarterial chemoembolization: a cohort study
This study aims to assess the changes in LSM following HCC treatment. Patients and methods This study included 150 patients with hepatitis C virus related HCC attending the multidisciplinary HCC clinic, Kasr Al-Ainy Hospital between March 2014 and October 2015 who underwent either transarterial chemoembolization (TACE) or microwave ablation (MWA). Baseline LSM was carried out 3 and 6 months after treatment. The response rate was calculated according to the modified Response Evaluation Criteria in Solid Tumors criteria; overall survival and LSM changes were then compared between the two procedures. Results MWA showed ...
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Epidemiology of intrahepatic, perihilar, and distal cholangiocarcinoma in the French population
The objective of this study was to investigate the differences between cholangiocarcinoma (CC) subtypes in terms of incidence rate, clinical presentation, management and survival by applying a stable anatomical classification in a population-based study. Patients and methods Cancer data for the period 2000–2012 were obtained from a specialized digestive cancer registry in the Department of Calvados, France. Patients’ files were checked, and the diagnosis was verified by two hepatobiliary surgeons. This approach prevents classifying perihilar cholangiocarcinoma (PHCC) as intrahepatic cholangiocarcinoma (ICC),...
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

The role of plasma exchange in hypertriglyceridemia-induced acute pancreatitis
Background Hypertriglyceridemia (HTG)-induced acute pancreatitis (AP) leads to higher morbidity and mortality compared with other etiologies. The role of plasma exchange (PE) in this context is still not well established. We aimed to assess the clinical outcomes of patients with HTG-induced AP who underwent PE and compare it with those who did not. Patients and methods We retrospectively evaluated the data of patients who were admitted with HTG-induced AP between January 2013 and May 2018. The endpoint of the study was to assess the clinical outcomes, which included complication rates, mortality, and pancreatitis recu...
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Clostridium difficile infection in inflammatory bowel disease: epidemiology over two decades
Conclusion In the past two decades, the incidence of CDI in IBD and non-IBD patients has increased. However, the overall outcome of CDI in IBD patients was favourable compared with non-IBD patients. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Comparative effectiveness of antitumour necrosis factor agents and vedolizumab in ulcerative colitis
Conclusion The efficacy of anti-TNF and vedolizumab in UC appear comparable. We could not identify any predictors of response and remission. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

A randomized double-blinded sham-controlled cross-over trial of tined-lead sacral nerve stimulation testing for chronic constipation
Conclusion ePNE is a poor predictor of treatment response at 6 months. This suggests a strong and persistent placebo response during both SNS PNE and treatment. An extended 6-week PNE poses a high risk of infection. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Paper alert
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Paper Alert Source Type: research

The creative destruction: the reason why the Turkish Gastroenterology community is ready for the new era: a mini-brainstorm to support the fast-growing and encouraging environment in Turkey
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Hepatitis D virus infection in patients with hepatitis B virus occult infection
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

A rare presentation of hypovolemic shock secondary to Whipple’s disease
We present a very rare but near-fatal case of hypovolemic shock secondary to protein-losing enteropathy and gastrointestinal bleeding from small bowel T. whippelii infection. Furthermore, the epidemiology, clinical presentation, diagnosis, and management of Whipple’s disease is reviewed. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Case Report Source Type: research

Serum cytokeratin-18 and its relation to liver fibrosis and steatosis diagnosed by FibroScan and controlled attenuation parameter in nonalcoholic fatty liver disease and hepatitis C virus patients
Background Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common cause of chronic liver disease worldwide. Multiple diagnostic noninvasive methods for NAFLD were studied (both serological and imaging), either single or combined. Attention has been focused on cytokeratin-18 (CK18) as a novel serological marker for the diagnosis of steatosis/fibrosis in NAFLD and hepatitis C virus (HCV) patients. Aim The aim of this study was to evaluate serum CK18 in NAFLD and HCV fibrosis/steatosis and also to correlate its performance with the diagnostic accuracy of transient elastography (TE) and controlled attenua...
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Morbidity and mortality after transjugular intrahepatic portosystemic shunt placement in patients with cirrhosis
This study aimed to assess predictors of hepatic encephalopathy (HE) development and cumulative transplant-free survival after TIPS placement in patients with cirrhosis complicated by refractory ascites and major gastroesophageal bleeding. Materials and methods Sixty-three cirrhotic patients who underwent TIPS positioning as a secondary prophylaxis of major upper gastroesophageal bleeding (N=30) or to control refractory ascites (N=33) were enrolled. Results After a median follow-up of 26 months following TIPS insertion, only 1/30 (3.3%) patients developed reoccurrence of bleeding. Complete control of refractory ascit...
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Organ dysfunction in cirrhosis: a mechanism involving the microcirculation
Conclusion Our results suggest a mechanism of organ damage in cirrhosis, where microcirculatory dysfunction could be correlated to inflammatory and endothelial biomarkers, and loss of multiorgan function. IL-6 seems to be an important survival marker of inflammation. Liver transplantation improved microcirculatory dysfunction, corroborating this hypothesis. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial
Discussion and conclusion This randomized double-blinded placebo-controlled clinical trial suggested a significant benefit of silymarin, pioglitazone, and vitamin E in improving liver aminotransferases in patients with NAFLD after only 3 months, without exerting any specific side effects. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Entecavir and other nucleos(t)ide analogs prophylaxis in hepatitis B virus-related liver transplantation: long-term efficacy and safety
Conclusion ETV and other NUCs were effective and safe as a long-term prophylaxis of HBV recurrence after LTx, leading to a good graft function. HBsAg temporally reappeared in a minority of patients, where all showed HBsAb seroconversion without detectable HBV-DNA or clinical hepatitis. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Diagnostic accuracy of γ-glutamyl transpeptidase-to-platelet ratio for predicting hepatitis B-related fibrosis: a meta-analysis
Conclusion GPR has moderate diagnostic accuracy for predicting HBV-related significant fibrosis, severe fibrosis, and cirrhosis, and further studies with large sample size, rigorous design, multicenter study population are urgently needed. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - March 31, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research