Paper alert
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Paper Alert Source Type: research

Immunoglobulin G4-related gastric inflammatory pseudotumor presenting with gastrointestinal bleeding
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Dangerous interactions of gastrointestinal drugs with experimental treatments for COVID-19
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The role of coexisting cardiovascular disease on disease severity in patients with inflammatory bowel disease
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Serological exclusion of coeliac disease: an audit of anti-tissue transglutaminase and immunoglobulin A testing
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The use of balloon-assisted antegrade transvenous obliteration should be cautious
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Primary presentation of COVID-19 solely with gastrointestinal symptoms: a problem for the containment of the disease
An oligosymptomatic patient with initially exclusively gastrointestinal symptoms (massive nausea and mild pancreatitis) turned out to suffer from COVID-19 during the hospital stay. The patient did not exhibit the typical COVID-symptoms cough or fever despite lung involvement. The gastroenterological diagnostic investigations comprised abdominal ultrasound, gastroscopy and endoscopic ultrasound and first revealed no clear cause of these symptoms. In an abdominal computed tomography (CT) scan, patchy ground-glass opacities in both lungs were discovered and the following chest CT scan and a virus PCR test revealed the right a...
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Case Report Source Type: research

Endoscopic ultrasound-guided liver biopsy using a 20-gauge fine needle biopsy needle with the wet-heparinized suction technique
Conclusion Endoscopic ultrasound-guided liver biopsy with the wet-heparinized suction technique using a 20-gauge fine-needle biopsy needle is a safe alternative method in clinical practice. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Kinetic patterns of liver enzyme elevation with COVID-19 in the USA
In conclusion, abnormalities in aminotransferase, lactate dehydrogenase, and ferritin levels are commonly seen in COVID-19 related liver injury. Elevated aminotransferase levels often persist throughout the entire hospitalization. However, the clinical course of COVID-19 related liver injury appears benign. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure
Conclusion Infection (particularly HCAi) adds mortality risk to any level of liver dysfunction in decompensated liver cirrhosis patients. Mechanisms of long(er)-term effects (in acute episode survivors) seemingly include enhanced deterioration of liver function. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Analysis of the hemostatic therapy in liver transplantation guided by rotational thromboelastometry or conventional laboratory tests
Background Coagulopathy is quite common in chronic liver disease patients undergoing orthotopic liver transplantation (OLT). Diagnosis of intraoperative bleeding disorders is based on conventional laboratory tests (CLTs), and thus, the patients are frequently exposed to unnecessary transfusions of blood products. The present study aimed to analyze the intraoperative administration of blood products in patients undergoing OLT, using rotational thromboelastometry (ROTEM) or CLTs. Patients and methods A cohort comprising 153 patients undergoing OLT, of whom 82 were evaluated with ROTEM and 71 by CLTs. Both groups were an...
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Low prevalence of upper endoscopic gastrointestinal findings despite high frequency of alarm symptoms at the time of diagnosis in adult coeliac disease
Conclusions Despite the high prevalence of alarm symptoms at diagnosis, coincident major UGI endoscopic findings are rare in adult coeliac disease. These results may be relevant for future developments in coeliac disease diagnosis in adults. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Endoscopist-directed propofol is more efficient than anesthesiologist-administered propofol in patients at low-intermediate anesthetic risk
Conclusion In patients with low-intermediate anesthetic risk referred for an endoscopic examination, EDP appears to be more efficient than AAP. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Chronic inflammation and other changes are significant components of clinically fibrotic strictures in Crohn’s disease: a histological study of resected strictures clinically characterized as noninflamed
Conclusion The histological features of Crohn’s disease-related strictures show multiple changes in multiple layers and not simply fibrosis. In our cohort, despite the observation prior to surgery that strictures were clinically considered fibrotic, the finding of chronic inflammation as a dominant component at a histological level in the resection is important. The findings might suggest that one of the main drivers of progressive fibrosis is the inflammatory component, which probably is never fully resolved. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Oral manifestations of inflammatory bowel disease: the neglected piece of the puzzle
Inflammatory bowel disease (IBD) is a chronic relapsing remitting autoimmune disease including Crohn’s disease and ulcerative colitis. IBD is associated with various extra-intestinal manifestations including oral manifestation. To date, only limited studies addressing the characteristics of the oral manifestations are available. The aim of the present review is to report the oral manifestations and their characteristics in IBD. A Medline/PubMed and Embase databases search were conducted and all relevant studies were extracted and analyzed. Overall, the oral manifestations in IBD were mostly associated with Crohn&rsqu...
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Peroral endoscopic myotomy versus pneumatic dilation for achalasia: a systematic review and meta-analysis
Presently, the primary endoscopic options for the treatment of achalasia are peroral endoscopic myotomy (POEM) and pneumatic dilation. But the clinical outcomes of POEM and pneumatic dilation for achalasia have not yet to be fully evaluated. So, we aimed to compare the clinical outcomes between the two treatment modalities. We searched all the relevant studies published up to September 2019 examining the comparative efficacy between POEM and pneumatic dilation. Outcomes included success rate, Eckardt score, lower esophageal sphincter pressure and adverse events. Outcomes were documented by pooled risk ratios and mean diffe...
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Paper alert
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Paper Alert Source Type: research

The role of endoscopic ultrasound elastography in differentiating focal liver lesions
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Outcomes of sorafenib therapy in advanced hepatocellular carcinoma in a single center in Ethiopia
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Study of alcoholic chronic pancreatitis and alcoholic liver cirrhosis could be improved
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Association between nonalcoholic fatty liver disease and portal vein thrombosis: a systematic review and meta-analysis
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Single-step endoscopic ultrasound-guided multiple gateway drainage of complex walled-off necrosis with lumen apposing metal stents
In this study we analyzed the feasibility and safety of single-step multiple transluminal gateway drainage (MTGD) for complex walled-off necrosis (WON) using lumen-apposing metal stents (LAMSs). Six patients underwent endoscopic ultrasound (EUS)-guided MTGD using two LAMSs. Technical success was 100%. The mean procedure time was 29 min. The mean number of direct endoscopic necrosectomy sessions per patient was 2. Two of six patients developed adverse events, which was bleeding in both cases and treated endoscopically and surgically, respectively. The mean hospital stay was 52.5 days. No patients had residual ...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Case Report Source Type: research

Efficacy and safety study of direct-acting oral anticoagulants for the treatment of chronic portal vein thrombosis in patients with liver cirrhosis
This study is designed to investigate the efficacy and safety of direct-acting oral anticoagulants (DOACs) for the treatment of chronic portal vein thrombosis (PVT) in liver cirrhosis patients. Materials and methods In a prospective cohort study, patients were divided into DOACs group (oral rivaroxaban tablets or dabigatran etexilate capsules) and control group (no anticoagulant treatment). Based on propensity score matching method, 40 patients with cirrhosis and chronic PVT in each of the groups were recruited for this study. CT portal venography was used to monitor the portal vein area. Color Doppler ultrasound was us...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Liver steatosis is a risk factor for hepatotoxicity in inflammatory bowel disease patients treated with azathioprine
Background and aims The literature demonstrates that hepatic steatosis reduces the tolerance of immunosuppression in people with inflammatory bowel disease. It also shows that elevated methylmercaptopurine may be responsible for thiopurine-induced hepatitis. This exploratory study investigates the relationship between hepatic steatosis, methylmercaptopurine and alanine transaminase. Methods We performed a retrospective review of patients started on azathioprine treatment at University Hospitals Bristol NHS Foundation Trust between 2014 and 2017. There were 600 patients in total. Ninety-one patients met our inclusion c...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Cost effectiveness of treatment models of care for hepatitis C: the South Australian state-wide experience
Conclusion Decentralized care using GP and mixed consultant nurse models were cost-effective ways of promoting HCV treatment uptake in the setting of unrestricted access to new antivirals. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

A ‘real-world’ analysis of risk factors for post liver transplant delirium and the effect on length of stay
Conclusion Many of the risk factors previously described to be associated with the development of post-LTx delirium were not demonstrated to be significant in this study. Sepsis, renal failure, older age and DCD use are associated with delirium post-LTx. It is unclear if this syndrome is an independent risk factor for increased LOS or if it is a symptom of well established syndromes associated with increased LOS. The role for prophylactic strategies to reduce the incidence of post-LTx delirium is therefore unclear. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Biological response under treatment and prognostic value of protein induced by vitamin K absence or antagonist-II in a French cohort of patients with hepatocellular carcinoma
Conclusion PIVKA-II serum level seems to be a good prognostic and promising biomarker for early monitoring treatment outcomes for patients with HCC. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Low-free triiodothyronine is associated with poor prognosis of portal hypertension in cirrhosis
This study aimed to investigate the correlation between serum-free triiodothyronine (fT3) levels and the outcomes of cirrhotic portal hypertension. Methods A total of 385 cirrhotic patients with confirmed portal hypertension underwent computed tomography angiography and thyroid function test at a tertiary care referral center from January 2009 to December 2017. The patients were assigned to the low-fT3 (n = 98) and normal-fT3 groups (n = 287). Results Child-Pugh (8.88 ± 0.22 vs. 7.09 ± 0.12, P  (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Role of intensive dietary and lifestyle interventions in the treatment of lean nonalcoholic fatty liver disease patients
In this study, we investigated the effects of medical nutrition therapy (MNT) and intensive lifestyle interventions (ILIs) for NAFLD in lean versus obese patients. Methods In total, 35 patients (14 lean and 21 obese) were included in the study. All patients underwent transient elastography examinations, and controlled attenuation parameter (CAP) of>238 dB/m was indicative of hepatic steatosis. After 8 weeks of dietitian follow-up with MNT and ILI, the patients were compared with the baseline. Results Significant weight loss was recorded in both lean (5.4%) and obese patients (5.7%) with NAFLD. The me...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Detection of hepatitis C virus core antigen as an alternative method for diagnosis of hepatitis C virus infection in blood donors negative for hepatitis C virus antibody
Conclusion HCV-c-Ag detection is an efficient method for diagnosis of HCV infection during screening of blood donors with high specificity (95.6%) and high negative predictive value (95.6%). (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations
Conclusion We leveraged a big data approach to identify several associations between IBD and concurrent comorbid diagnoses. EMR and big data provide the opportunity to explore disease associations with large sample sizes. Further studies are warranted to refine the characterization of these associations and evaluate their usefulness for increasing our understanding of disease associations and mechanisms. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Relationship between atrophic gastritis, serum ghrelin and body mass index
Objective Atrophic gastritis may affect circulating ghrelin levels and, indirectly, body mass index. The aim of this study was to investigate the relationship between atrophic gastritis, focusing on autoimmune atrophic gastritis and advanced stages of atrophic gastritis, serum ghrelin levels and BMI. Methods Sixty-three patients, of whom 18 had autoimmune atrophic gastritis, 27 non-autoimmune antrum and corpus atrophic gastritis, and 18 non-atrophic gastritis or antrum-limited atrophic gastritis (control group) were assessed. All participants underwent endoscopy with multiple gastric biopsies. Atrophic gastritis was d...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Micronutrient deficits in patients with chronic pancreatitis: prevalence, risk factors and pitfalls
Objective We investigated the prevalence of micronutrient deficiencies and associated patient and disease-related risk factors in patients with chronic pancreatitis (CP). Methods We enrolled 115 consecutive CP outpatients. Micro-nutritional assessments included plasma levels of fat-soluble vitamins (A, D and E) and trace elements (magnesium and zinc). Bioelectrical impedance and muscle function tests were used to characterize the macro-nutritional status (sarcopenia and phase angle). Prevalence of micro-nutritional deficiencies was estimated and associated with a number of patient and disease characteristics including...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Study of serology and genetics of celiac disease in patients with juvenile systemic lupus erythematosus ‘celiac in juvenile systemic lupus’
Introduction Several case reports and case series have suggested a possible association between celiac disease (CD) and systemic lupus erythematosus (SLE). Patients with CD developing SLE and vice versa have been reported, highlighting a possible association. Up to 23% of patients with CD have raised anti-double-stranded DNA and likewise 5–22% of SLE patients are seropositive for CD. Objective Aim was to screen for CD in the serum of patients suffering from juvenile SLE (JSLE). Methods One hundred JSLE patients and 40 (age- and sex-matched) healthy subjects were subjected to laboratory screening for CD, endos...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Survival outcomes and rate of missed upper gastrointestinal cancers at routine endoscopy: a single centre retrospective cohort study
Conclusion Missed gastric cancer during oesophagogastroduodenoscopy may be associated with shorter 3-year survival compared to patients whose gastric cancer was diagnosed at index oesophagogastroduodenoscopy. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Paediatric inflammatory bowel disease in India: a prospective multicentre study
Background Paediatric inflammatory bowel disease (PIBD) is increasing across the world. However, information from India is sparse. This multicentre study evaluated the demographics, clinical phenotype and outcome of PIBD from India. Methods Data of children (≤18 years) with PIBD were collected using a proforma containing details of demographics, clinical profile, extraintestinal manifestations (EIM), investigations, disease extent and treatment. Results Three hundred twenty-five children [Crohn’s disease: 65.2%, ulcerative colitis: 28.0%, IBD unclassified (IBDU): 6.7%, median age at diagnosis: 11 (interqua...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Efficacy of endoscopic triage during the Covid-19 outbreak and infective risk
Conclusion The novel endoscopic triage significantly reduced the number of procedures and increased finding rates and diagnostic yields. However, a careful schedule of canceled procedures should be applied to avoid to miss relevant pathologies. No Covid-19 onset or infection has been noted after endoscopies. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Extrapancreatic infections are common in acute pancreatitis and they are related to organ failure: a population-based study
Background Although the impact of pancreatic infections in acute pancreatitis has been studied extensively, there are no population-based data on extrapancreatic infections and their potential relation to organ failure. We aimed to study the occurrence of pancreatic and extrapancreatic bacterial infections in acute pancreatitis and their relation to patient outcome. Patients and methods All patients with first-time acute pancreatitis from 2003 to 2012 in a defined area in Sweden were retrospectively evaluated. Data on acute pancreatitis severity, organ failure, infections, and in-hospital mortality were collected. Re...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Comparing endoscopic interventions to improve serrated adenoma detection rates during colonoscopy: a systematic review and network meta-analysis of randomized controlled trials
Conclusion In a network meta-analysis, add-on devices (particularly endocuff vision), narrow band imaging, WBT and chromoendoscopy were comparable to each other and improved SADR compared to high-definition colonoscopy. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Endoscopic drainage in patients with malignant extrahepatic biliary obstruction: when and how
The question of when and how to drain a malignant biliary obstruction (MBO), both intrinsic or extrinsic, remains a controversial point among endoscopists. An important factor that influences the decision to drain an MBO or not is if the patient is a surgical candidate or not and, in the former case, if the patients must undergo neoadiuvant chemotherapy or not. Other questions arising during biliary drainage in MBO patients is which type of stent should be chosen, plastic or metal, and if endoscopic biliary sphincterotomy must be performed or not when a stent is placed. The present review attempts to answer these questions...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Incidence of kidney cancer after liver transplantation: a meta-analysis
The purpose of this systematic review and meta-analysis was to investigate the relationship between liver transplantation and kidney cancer. Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines were followed. PubMed, the Web of Science, and the Cochrane databases were searched for peer-reviewed cohort studies in which standardized incidence of kidney cancer post-transplant was compared to the general population by means of standardized incidence ratio (SIR) with 95% confidence interval (CI). No limits were placed on language or year of publication. A fixed-effects model was used for pooling the dat...
Source: European Journal of Gastroenterology and Hepatology - August 28, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Paper alert
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Paper Alerts Source Type: research

Severe fistulizing pancreatitis in a patient with Merkel cell carcinoma treated with avelumab
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Multidetector computed tomography chest findings of coronavirus disease 2019 pneumonia in patient with hepatocellular carcinoma
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Follow-up study of the endoscopic retrograde cholangiopancreatography on cirrhotic patients with bile duct stones
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Microvascular attainment in the liver: a ‘new’ target-organ for diabetes?
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Coexistence of Crohn’s disease and systemic lupus erythematosus: a case report and literature review
Lupus enteritis and Crohn’s disease are two common immune diseases involving the gastrointestinal tract. There are many similar clinical manifestations, therefore it is very difficult to distinguish between them. The digestive system is involved anywhere from 8 to 40% of patients with systemic lupus erythematosus (SLE) and up to 53% of these go on to develop lupus enteritis. In patients with Crohn’s disease, 6–40% were presented with oral mucosa ulceration, nodular erythema of skin, arthritis, eye disease and other extraintestinal manifestations. The concomitant of Crohn’s disease and SLE is extreme...
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Case Reports Source Type: research

Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection
We present the unique opportunity we had to monitor the liver, IL-6 and immune cell course before, during and after COVID-19 in a boy with autoimmune hepatitis (AIH) and type 1 diabetes (T1D). CD4+ and CD8+ T cells frequencies decreased because of prednisolone, followed by a plateauing increase whereas CD19+CD20+ B cell increased strongly and was unaffected by COVID-19 infection. Moreover, the percentage of activated CD8+ T cells expressing HLA-DR (CD8+HLA-DR+) increased during COVID-19 and subsided after its clearance. Total regulatory T cells (Tregs: CD4+CD25+CD127lowFOXP3+) remained stable. Although activated Tregs (CD4...
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Case Reports Source Type: research

Case series and review of liver dysfunction in COVID-19 patients
Coronoviraus disease 2019 (COVID-19) has infected over two million people worldwide and the number keeps growing every day. While the pulmonary complications of COVID-19 are obvious, the effect of the virus on the other organs and the chronicity of the organ dysfunction remain unknown. The virus causes a debilitating infection with multiorgan injury and has a high mortality rate estimated to be around 3.70%. Several hypotheses are formulated to explain the liver dysfunction in COVID-19 patients which include collateral damage from cytokine storm, drug-induced liver injury, viral-induced hepatitis and hypoxia-induced damage...
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Case Reports Source Type: research

PTFE-covered TIPS is an effective treatment for secondary preventing variceal rebleeding in cirrhotic patients with high risks
Aim To compare the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) with endoscopic therapy plus non-selective β-blockers (NSBBs) for secondary prevention of gasroesophageal variceal bleeding (GEVB) in cirrhotic patients with high-risk factors of treatment failure. Methods and material: A total of 122 cirrhotic patients with history of gasroesophageal variceal bleeding and high factors including hepatic vein pressure gradient (HVPG) ≥ 20 mmHg, portal vein thrombosis (PVT), gastrorenal shunt (GRS), or extraluminal para-gastric veins (ep-GVs) detected by endos...
Source: European Journal of Gastroenterology and Hepatology - August 4, 2020 Category: Gastroenterology Tags: Case Reports Source Type: research